foxa3

Summary

Gene Symbol: foxa3
Description: forkhead box A3
Alias: Zffkh1, fa11c04, fkd2, forkhead-2, wu:fa11c04, wu:fc37a08, zf-FKH1, fc37a08, fork head domain protein 2, hepatocyte nuclear factor 3-gamma
Species: zebrafish

Top Publications

  1. pmc The subcellular localization of TRPP2 modulates its function
    Xiao Fu
    Renal Division, University Hospital Freiburg, Hugstetter Strasse 55, D 79106 Freiburg, Germany
    J Am Soc Nephrol 19:1342-51. 2008
  2. pmc FACS-assisted microarray profiling implicates novel genes and pathways in zebrafish gastrointestinal tract development
    Carsten Stuckenholz
    Department of Medicine, Division of Hematology Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Gastroenterology 137:1321-32. 2009
  3. doi Notch signalling regulates left-right asymmetry through ciliary length control
    Susana S Lopes
    Instituto de Medicina Molecular e Instituto de Histologia e Biologia do Desenvolvimento, Faculdade de Medicina da Universidade de Lisboa, 1649 028 Lisboa, Portugal
    Development 137:3625-32. 2010
  4. ncbi Induction of the mesendoderm in the zebrafish germ ring by yolk cell-derived TGF-beta family signals and discrimination of mesoderm and endoderm by FGF
    A Rodaway
    Developmental Biology Research Centre, Randall Institute, King s College London, London, WC2B 5RL, UK
    Development 126:3067-78. 1999
  5. pmc CCDC103 mutations cause primary ciliary dyskinesia by disrupting assembly of ciliary dynein arms
    Jennifer R Panizzi
    Nephrology Division, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Nat Genet 44:714-9. 2012
  6. doi APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development
    Wolfram Goessling
    Stem Cell Program and Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, HHMI, Harvard Medical School, Boston, MA 02115, USA
    Dev Biol 320:161-74. 2008
  7. pmc Oda16/Wdr69 is essential for axonemal dynein assembly and ciliary motility during zebrafish embryogenesis
    Chunlei Gao
    State University of New York Upstate Medical University, Department of Cell and Developmental Biology, Syracuse, New York 13210, USA
    Dev Dyn 239:2190-7. 2010
  8. pmc Noncanonical Wnt signaling regulates midline convergence of organ primordia during zebrafish development
    Takaaki Matsui
    Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Genes Dev 19:164-75. 2005
  9. pmc FGF-dependent left-right asymmetry patterning in zebrafish is mediated by Ier2 and Fibp1
    Sung Kook Hong
    Laboratory of Molecular Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:2230-5. 2009
  10. pmc Dnmt2 functions in the cytoplasm to promote liver, brain, and retina development in zebrafish
    Kunal Rai
    Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah 84112, USA
    Genes Dev 21:261-6. 2007

Scientific Experts

Detail Information

Publications97

  1. pmc The subcellular localization of TRPP2 modulates its function
    Xiao Fu
    Renal Division, University Hospital Freiburg, Hugstetter Strasse 55, D 79106 Freiburg, Germany
    J Am Soc Nephrol 19:1342-51. 2008
    ..Taken together, these findings support the hypothesis that TRPP2 assumes distinct subcellular localizations to exert tissue-specific functions...
  2. pmc FACS-assisted microarray profiling implicates novel genes and pathways in zebrafish gastrointestinal tract development
    Carsten Stuckenholz
    Department of Medicine, Division of Hematology Oncology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Gastroenterology 137:1321-32. 2009
    ..To identify differentially regulated genes important in gastrointestinal organogenesis, we profiled the transcriptome of the zebrafish developing gastrointestinal tract...
  3. doi Notch signalling regulates left-right asymmetry through ciliary length control
    Susana S Lopes
    Instituto de Medicina Molecular e Instituto de Histologia e Biologia do Desenvolvimento, Faculdade de Medicina da Universidade de Lisboa, 1649 028 Lisboa, Portugal
    Development 137:3625-32. 2010
    ..Notch signalling brings together ciliary length control and fluid flow hydrodynamics with transcriptional activation of laterality genes. In addition, our deltaD mutant analysis discloses an uncoupling between gut and heart laterality...
  4. ncbi Induction of the mesendoderm in the zebrafish germ ring by yolk cell-derived TGF-beta family signals and discrimination of mesoderm and endoderm by FGF
    A Rodaway
    Developmental Biology Research Centre, Randall Institute, King s College London, London, WC2B 5RL, UK
    Development 126:3067-78. 1999
    ....
  5. pmc CCDC103 mutations cause primary ciliary dyskinesia by disrupting assembly of ciliary dynein arms
    Jennifer R Panizzi
    Nephrology Division, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Nat Genet 44:714-9. 2012
    ..Chlamydomonas Ccdc103/Pr46b functions as a tightly bound, axoneme-associated protein. These results identify Ccdc103 as a dynein arm attachment factor that causes primary ciliary dyskinesia when mutated...
  6. doi APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development
    Wolfram Goessling
    Stem Cell Program and Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, HHMI, Harvard Medical School, Boston, MA 02115, USA
    Dev Biol 320:161-74. 2008
    ..These studies reveal an important and time-dependent role for wnt signaling during liver development and regeneration...
  7. pmc Oda16/Wdr69 is essential for axonemal dynein assembly and ciliary motility during zebrafish embryogenesis
    Chunlei Gao
    State University of New York Upstate Medical University, Department of Cell and Developmental Biology, Syracuse, New York 13210, USA
    Dev Dyn 239:2190-7. 2010
    ..Analysis of cilium ultrastructure revealed loss of outer dynein arms in morphant embryos. These results support a remarkable level of functional conservation for Oda16/Wdr69...
  8. pmc Noncanonical Wnt signaling regulates midline convergence of organ primordia during zebrafish development
    Takaaki Matsui
    Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Genes Dev 19:164-75. 2005
    ..Overall, our results uncover a late, previously unexpected role of noncanonical Wnt signaling in the control of midline assembly of organ precursors during vertebrate embryo development...
  9. pmc FGF-dependent left-right asymmetry patterning in zebrafish is mediated by Ier2 and Fibp1
    Sung Kook Hong
    Laboratory of Molecular Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:2230-5. 2009
    ..We conclude that Ier2 and Fibp1 mediate FGF signaling in ciliogenesis in Kupffer's Vesicle and in the establishment of laterality in the zebrafish embryo...
  10. pmc Dnmt2 functions in the cytoplasm to promote liver, brain, and retina development in zebrafish
    Kunal Rai
    Howard Hughes Medical Institute, University of Utah, Salt Lake City, Utah 84112, USA
    Genes Dev 21:261-6. 2007
    ..Furthermore, zebrafish Dnmt2 methylates an RNA species of approximately 80 bases, consistent with tRNA methylation. Thus, Dnmt2 promotes zebrafish development, likely through cytoplasmic RNA methylation...
  11. ncbi Nil per os encodes a conserved RNA recognition motif protein required for morphogenesis and cytodifferentiation of digestive organs in zebrafish
    Alan N Mayer
    Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Development 130:3917-28. 2003
    ..Antisense-mediated knockdown of npo results in organ hypoplasia, and overexpression of npo causes an overgrowth of gastrointestinal organs. Thus, npo is a gene essential for a key step in the gut morphogenetic sequence...
  12. ncbi Zebrafish curly up encodes a Pkd2 ortholog that restricts left-side-specific expression of southpaw
    Jodi Schottenfeld
    Department of Molecular Biology, Princeton University, Princeton, NJ 08550, USA
    Development 134:1605-15. 2007
    ..pkd2 also appears to play a role in the propagation of Nodal signals in the LPM. Based on morpholino studies, we propose an additional role for maternal pkd2 in general mesendoderm patterning...
  13. pmc Mutations in zebrafish leucine-rich repeat-containing six-like affect cilia motility and result in pronephric cysts, but have variable effects on left-right patterning
    Fabrizio C Serluca
    Massachusetts General Hospital, Charlestown, MA 02129, USA
    Development 136:1621-31. 2009
    ..Combined with recently published results, our alleles suggest that the function of seahorse in cilia motility is separable from its function in other cilia-related phenotypes...
  14. doi Histone deacetylase 3 (hdac3) is specifically required for liver development in zebrafish
    Muhammad Farooq
    Department of Biological Sciences, National University of Singapore, 117543, Singapore
    Dev Biol 317:336-53. 2008
    ..These results revealed a novel and specific role of hdac3 in liver development and the distinct functions between hdac1 and hdac3 in zebrafish embryonic development...
  15. doi Fgf4 is required for left-right patterning of visceral organs in zebrafish
    Hajime Yamauchi
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    Dev Biol 332:177-85. 2009
    ..The present findings indicate that Fgf4 plays a unique role in the LR patterning of visceral organs in zebrafish...
  16. ncbi Mutations affecting development of the midline and general body shape during zebrafish embryogenesis
    M Brand
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Development 123:129-42. 1996
    ..As a working hypothesis, we propose that midline-group genes may act to maintain proper structure and inductive function of zebrafish midline tissues...
  17. doi Mypt1-mediated spatial positioning of Bmp2-producing cells is essential for liver organogenesis
    Honghui Huang
    Laboratory of Functional Genomics, Institute of Molecular and Cell Biology, Proteos, Singapore
    Development 135:3209-18. 2008
    ....
  18. ncbi fork head domain genes in zebrafish
    J Odenthal
    MPI für Entwicklungsbiologie, Spemannstrasse 35 III, D 72076 Tubingen, Germany
    Dev Genes Evol 208:245-58. 1998
    ..Members of class I (fkd1/axial, fkd2/Zffkh1, fkd4 and fkd7) are differentially transcribed in unsegmented dorsal axial structures such as the floor plate, the ..
  19. ncbi Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio
    M Hammerschmidt
    Max Planck Institut fur Entwicklungsbiologie, Abteilung fur Genetik, Tubingen, Germany
    Development 123:143-51. 1996
    ..Mutants in kugelig (kgg) do not form the yolk tube at the posterior side of the yolk sac...
  20. pmc Zebra fish Dnmt1 and Suv39h1 regulate organ-specific terminal differentiation during development
    Kunal Rai
    Department of Oncological Sciences, University of Utah, Salt Lake City, Utah 84112, USA
    Mol Cell Biol 26:7077-85. 2006
    ..Our results suggest that Dnmt1 activity helps direct histone methylation by Suv39h1 and that, together, Dnmt1 and Suv39h1 help guide the terminal differentiation of particular tissues...
  21. pmc Polycystin-2 immunolocalization and function in zebrafish
    Tomoko Obara
    Nephrology Division, Massachusetts General Hospital 149 8000 and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    J Am Soc Nephrol 17:2706-18. 2006
    ....
  22. ncbi Inositol polyphosphates regulate zebrafish left-right asymmetry
    Bhaskarjyoti Sarmah
    Department of Cell and Developmental Biology, Vanderbilt University Medical Center, U 3209 MRBIII, 465 21 st Avenue South, Nashville, Tennessee 37232, USA
    Dev Cell 9:133-45. 2005
    ..Our data suggest that the pathway for inositol hexakisphosphate production is a key regulator of asymmetric Ca(2+) flux during LR specification...
  23. ncbi Polaris and Polycystin-2 in dorsal forerunner cells and Kupffer's vesicle are required for specification of the zebrafish left-right axis
    Brent W Bisgrove
    Huntsman Cancer Institute Center for Children, Department of Oncological Sciences, University of Utah, Salt Lake City, UT 84112, USA
    Dev Biol 287:274-88. 2005
    ..Our data suggest that the functions of polaris and pkd2 in LR patterning are conserved between zebrafish and mice and that Kupffer's vesicle functions as a ciliated organ of asymmetry...
  24. ncbi Bmp and Fgf signaling are essential for liver specification in zebrafish
    Donghun Shin
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Liver Center, University of California, San Francisco, CA 94158, USA
    Development 134:2041-50. 2007
    ....
  25. ncbi Unified nomenclature for the winged helix/forkhead transcription factors
    K H Kaestner
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Genes Dev 14:142-6. 2000
  26. ncbi Origin and development of the zebrafish endoderm
    R M Warga
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Spemannstrasse 35, Germany
    Development 126:827-38. 1999
    ..This suggests that a common pathway initially specifies germ layers together before a progressive sequence of determinative events segregate endoderm and mesoderm into morphologically distinct germ layers...
  27. ncbi Zebrafish Bmp4 regulates left-right asymmetry at two distinct developmental time points
    Sonja Chocron
    Cardiac Development and Genetics Group, Hubrecht Laboratory, Uppsalalaan 8, Utrecht, The Netherlands
    Dev Biol 305:577-88. 2007
    ..The identification of these two distinct and opposing activities of BMP signaling provides new insight into how BMP signaling can regulate LR patterning...
  28. ncbi A cellular framework for gut-looping morphogenesis in zebrafish
    Sally Horne-Badovinac
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics, and Human Genetics, University of California, San Francisco, CA 94143, USA
    Science 302:662-5. 2003
    ..Finally, reducing left-sided Nodal activity randomizes the pattern of LPM migration and gut looping. These results reveal a cellular framework for the regulation of organ laterality by asymmetrically expressed genes...
  29. pmc Laminin β1a controls distinct steps during the establishment of digestive organ laterality
    Tatiana Hochgreb-Hägele
    Department of Biochemistry and Biophysics, Programs in Developmental and Stem Cell Biology, Genetics and Human Genetics, Liver Center and Diabetes Center, Institute for Regeneration Medicine, University of California, San Francisco, CA 94158, USA
    Development 140:2734-45. 2013
    ..Loss of Lamb1a function also results in aberrant protrusion of LPM cells into the gut. Collectively, our results provide cellular and molecular mechanisms by which extracellular matrix proteins regulate left-right organ morphogenesis...
  30. doi Zebrafish bcl2l is a survival factor in thyroid development
    Immacolata Porreca
    IRGS, BIOGEM, Via Camporeale, 83031 Ariano Irpino, Avellino, Italy
    Dev Biol 366:142-52. 2012
    ..This is the first demonstration of an active mechanism to ensure survival of the thyroid primordium during morphogenesis...
  31. pmc Fast homozygosity mapping and identification of a zebrafish ENU-induced mutation by whole-genome sequencing
    Marianne L Voz
    Laboratoire de Biologie Moléculaire et de Génie Génétique, Universite de Liege, Sart Tilman, Belgium
    PLoS ONE 7:e34671. 2012
    ..In conclusion, this study constitutes a proof-of-concept that whole-genome sequencing is a fast and effective alternative to the classical positional cloning strategies in zebrafish...
  32. doi β-Catenin 1 and β-catenin 2 play similar and distinct roles in left-right asymmetric development of zebrafish embryos
    Min Zhang
    State Key Laboratory of Biomembrane and Membrane Engineering, Tsinghua Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China
    Development 139:2009-19. 2012
    ..Taken together, our findings suggest that ctnnb1 and ctnnb2 regulate multiple processes of laterality development in zebrafish embryos through similar and distinct mechanisms...
  33. pmc DEAD-box protein Ddx46 is required for the development of the digestive organs and brain in zebrafish
    Shunya Hozumi
    Department of Biological Science, Graduate School of Science, Hiroshima University, Higashi Hiroshima, Hiroshima, Japan
    PLoS ONE 7:e33675. 2012
    ..Therefore, our results suggest a model in which zebrafish Ddx46 is required for the development of the digestive organs and brain, possibly through the control of pre-mRNA splicing...
  34. pmc Augmenter of liver regeneration (alr) promotes liver outgrowth during zebrafish hepatogenesis
    Yan Li
    Department of Biological Sciences, National University of Singapore, Singapore, Singapore
    PLoS ONE 7:e30835. 2012
    ..The dose-dependent and partial suppression of alr expression through MO-mediated knockdown allows the identification of its late developmental role in vertebrate liver organogenesis...
  35. pmc The zebrafish orthologue of the dyslexia candidate gene DYX1C1 is essential for cilia growth and function
    Gayathri Chandrasekar
    Center for Biosciences, Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
    PLoS ONE 8:e63123. 2013
    ..Considering all these results, we propose an essential role for dyx1c1 in cilia growth and function...
  36. pmc Functional redundancy between Cdc14 phosphatases in zebrafish ciliogenesis
    Aurélie Clément
    Howard Hughes Medical Institute and Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Dev Dyn 241:1911-21. 2012
    ..However, the question of whether CDC14 paralogs can functionally compensate for each other has yet to be addressed...
  37. pmc RFX2 is essential in the ciliated organ of asymmetry and an RFX2 transgene identifies a population of ciliated cells sufficient for fluid flow
    Brent W Bisgrove
    Department of Neurobiology and Anatomy, University of Utah School of Medicine, USA
    Dev Biol 363:166-78. 2012
    ....
  38. pmc Cep70 and Cep131 contribute to ciliogenesis in zebrafish embryos
    Christopher J Wilkinson
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, CB2 3DY, UK
    BMC Cell Biol 10:17. 2009
    ..In a number of human diseases, such Bardet-Biedl syndrome, centrosome/cilium proteins are mutated, leading to polycystic kidney disease, situs inversus, and neurological problems, amongst other symptoms...
  39. doi Pbx1 is essential for growth of zebrafish swim bladder
    Pick Har Teoh
    School of Biological Sciences, Universiti Sains Malaysia, Penang, Malaysia
    Dev Dyn 239:865-74. 2010
    ..The knockdown of pbx1 did not perturb the expression of prdc and foxA3, with both early swim bladder markers appearing normally at 36 and 48 hpf, respectively...
  40. pmc Extra-embryonic syndecan 2 regulates organ primordia migration and fibrillogenesis throughout the zebrafish embryo
    Cammon B Arrington
    Division of Pediatric Cardiology, University of Utah, Salt Lake City, UT 84112, USA
    Development 136:3143-52. 2009
    ....
  41. pmc Massively parallel sequencing identifies the gene Megf8 with ENU-induced mutation causing heterotaxy
    Zhen Zhang
    Laboratory of Developmental Biology, National Heart Lung and Blood Institute, Bethesda, MD 20892 1583, USA
    Proc Natl Acad Sci U S A 106:3219-24. 2009
    ..Overall, through the recovery of an ENU-induced mutation, we uncovered Megf8 as an essential regulator of left-right patterning...
  42. pmc The PAF1 complex component Leo1 is essential for cardiac and neural crest development in zebrafish
    Catherine T Nguyen
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Dev Biol 341:167-75. 2010
    ..Taken together, these results provide the first genetic evidence of the requirement for Leo1 in the development of the heart and neural crest cell populations...
  43. pmc Fish-specific duplicated dmrt2b contributes to a divergent function through Hedgehog pathway and maintains left-right asymmetry establishment function
    Sha Liu
    State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Graduate School of Chinese Academy of Sciences, Wuhan, China
    PLoS ONE 4:e7261. 2009
    ..Together, these data indicate that fish-specific duplicated dmrt2b contributes to a divergent function in somitogenesis through Hedgehog pathway and maintains the common function for left-right asymmetry establishment...
  44. pmc Dnmt3 and G9a cooperate for tissue-specific development in zebrafish
    Kunal Rai
    Department of Oncological Sciences, oward Hughes Medical Institute, and Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA
    J Biol Chem 285:4110-21. 2010
    ..We propose a model wherein specific DNMT-histone methyltransferase networks are utilized to silence critical regulators of cell fate in a tissue-specific manner...
  45. pmc G protein-coupled receptor signaling and sphingosine-1-phosphate play a phylogenetically conserved role in endocrine pancreas morphogenesis
    Ioannis Serafimidis
    Developmental Biology Laboratory, Biomedical Research Foundation of the Academy of Athens, Soranou Ephessiou 4, Athens 11527, Greece
    Mol Cell Biol 31:4442-53. 2011
    ..Finally, we identified sphingosine-1-phosphate (S1P) as a ligand mediating islet cell aggregation in both species acting through distinct but closely related receptors...
  46. pmc The zebrafish transcriptome during early development
    Liselotte Vesterlund
    Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden
    BMC Dev Biol 11:30. 2011
    ..In this study RNA-Seq is used to compare the transcription profiles of four early developmental stages in zebrafish (Danio rerio) on a global scale...
  47. pmc The exocyst protein Sec10 interacts with Polycystin-2 and knockdown causes PKD-phenotypes
    Ben Fogelgren
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS Genet 7:e1001361. 2011
    ..Our work supports a model in which the exocyst is required for the ciliary localization of polycystin-2, thus allowing for polycystin-2 function in cellular processes...
  48. pmc Regulation of endoderm formation and left-right asymmetry by miR-92 during early zebrafish development
    Nan Li
    Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA
    Development 138:1817-26. 2011
    ....
  49. pmc Restriction of hepatic competence by Fgf signaling
    Donghun Shin
    Department of Biochemistry and Biophysics, Liver Center, Institute for Regeneration Medicine, University of California, San Francisco, CA 94158, USA
    Development 138:1339-48. 2011
    ..These data provide in vivo evidence that endodermal cells outside the liver-forming region retain hepatic competence and show that an extrinsic signal, Fgf10a, negatively regulates hepatic competence...
  50. pmc BMP signaling modulates hepcidin expression in zebrafish embryos independent of hemojuvelin
    Yann Gibert
    Division of Hematology Oncology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e14553. 2011
    ..Taken together, these data support an alternative mechanism for hepcidin regulation during zebrafish embryonic development, which is independent of hjv...
  51. doi Seson, a novel zinc finger protein, controls cilia integrity for the LR patterning during zebrafish embryogenesis
    Nami Kang
    Department of Biology, Chungnam National University, Daejeon 305 764, Republic of Korea
    Biochem Biophys Res Commun 401:169-74. 2010
    ..Seson function was also required for ciliogenesis in other tissues such as the pronephros and olfactory organs. Collectively, our data suggest that Seson has critical roles in ciliogenesis and LR body axis patterning...
  52. doi The activation of membrane targeted CaMK-II in the zebrafish Kupffer's vesicle is required for left-right asymmetry
    Ludmila Francescatto
    Department of Biology, Virginia Commonwealth University, Richmond, VA 23284 2012, USA
    Development 137:2753-62. 2010
    ....
  53. pmc Hand2 regulates extracellular matrix remodeling essential for gut-looping morphogenesis in zebrafish
    Chunyue Yin
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics, and Human Genetics, Cardiovascular Research Institute, Liver Center, University of California, San Francisco, San Francisco, CA 94158, USA
    Dev Cell 18:973-84. 2010
    ..Our study reveals an unexpected role for Hand2, a key regulator of cell specification and differentiation, in modulating ECM remodeling during organogenesis...
  54. pmc Zebrafish mnx1 controls cell fate choice in the developing endocrine pancreas
    Gokhan Dalgin
    Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL 60637, USA
    Development 138:4597-608. 2011
    ..In Mnx1-deficient embryos, precursor cells that are normally destined to differentiate as beta cells instead take on an alpha cell fate. Our findings suggest that Mnx1 functions to promote beta and suppress alpha cell fates...
  55. pmc Nephrocystin-3 is required for ciliary function in zebrafish embryos
    Weibin Zhou
    Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA
    Am J Physiol Renal Physiol 299:F55-62. 2010
    ..Thus nphp3, cooperating with nphp2/inversin, plays an essential role related to ciliary function, and the knockdown provides an animal model that may be used for studies of the pathogenesis and therapy for this disease...
  56. doi Hgf/c-met expression and functional analysis during zebrafish embryogenesis
    Andrew J Latimer
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Dev Dyn 237:3904-15. 2008
    ..Similar to mouse, knockdown of zebrafish Met reduces liver size. Our results suggest a role for Met during endoderm specification and indicate that mechanisms of liver development are conserved between mammals and bony fish...
  57. ncbi spadetail-dependent cell compaction of the dorsal zebrafish blastula
    R M Warga
    Abteilung für Genetics, Max Planck Institut fur Entwicklungsbiologie, Spemannstrasse 35, Tubingen, 72706, Germany
    Dev Biol 203:116-21. 1998
    ..This early process may be necessary for the correct location of the boundary separating axial and paraxial cells...
  58. doi Two novel type II receptors mediate BMP signalling and are required to establish left-right asymmetry in zebrafish
    Rui Monteiro
    Hubrecht Institute, Netherlands Institute for Developmental Biology, Utrecht, The Netherlands
    Dev Biol 315:55-71. 2008
    ..We propose a mechanism whereby this differential interpretation of BMP signalling through bmpr2a and bmpr2b is essential for the establishment of LR asymmetry in the zebrafish embryo...
  59. ncbi Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination
    Camila V Esguerra
    Center for Transgene Technology and Gene Therapy, VIB, Herestraat 49, B 3000 Leuven, Belgium
    Development 134:4381-93. 2007
    ....
  60. pmc Localized rbp4 expression in the yolk syncytial layer plays a role in yolk cell extension and early liver development
    Zhen Li
    Department of Biological Sciences, National University of Singapore, Singapore
    BMC Dev Biol 7:117. 2007
    ....
  61. ncbi Formation of the digestive system in zebrafish: III. Intestinal epithelium morphogenesis
    Annie N Y Ng
    Colon Molecular and Cell Biology Laboratory, Ludwig Institute for Cancer Research, Post Office Box 2008, Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    Dev Biol 286:114-35. 2005
    ..At 126 hpf, the posterior intestine remains an unfolded monolayer of simple columnar epithelium...
  62. pmc Prevalence of the EH1 Groucho interaction motif in the metazoan Fox family of transcriptional regulators
    Sergey Yaklichkin
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, 1110 Biomedical Research Building II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    BMC Genomics 8:201. 2007
    ..Defining conserved functional domains that mediate the transcriptional activity of Fox proteins will contribute to a comprehensive understanding of the biological function of Fox family genes...
  63. ncbi FoxA3 and goosecoid promote anterior neural fate through inhibition of Wnt8a activity before the onset of gastrulation
    Iban Seiliez
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 1, rue Laurent Fries, BP10142, 67404 Illkirch Cedex, France
    Dev Biol 290:152-63. 2006
    ..Here, we show that, in zebrafish embryos, two transcription factors, FoxA3 and Goosecoid, coexpressed at the dorsal blastula margin, are required for the definition of anterior neural fate...
  64. pmc A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development
    Gang Lu
    Department of Anesthesiology, University of California at Los Angeles, Los Angeles, California 90095, USA
    Genes Dev 21:784-96. 2007
    ..These data suggest that PP2Cm is a novel mitochondrial protein phosphatase that has a critical function in cell death and survival, and may play a role in regulating the MPTP opening...
  65. ncbi Vhnf1 acts downstream of Bmp, Fgf, and RA signals to regulate endocrine beta cell development in zebrafish
    Jianbo Song
    Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, CA 90095, USA
    Dev Biol 303:561-75. 2007
    ..Taken together, our data establish that vhnf1 acts downstream of the signaling pathways of RA, Bmp, and Fgf to regulate pancreas development in zebrafish...
  66. ncbi Expression of the protein related to Dan and Cerberus gene--prdc--During eye, pharyngeal arch, somite, and swim bladder development in zebrafish
    Iris I Müller
    Vanderbilt University Medical Center, Division of Genetic Medicine, Nashville, Tennessee, USA
    Dev Dyn 235:2881-8. 2006
    ..Moreover, the complexity of the prdc expression pattern suggests possible roles in eye development, pharyngeal arch remodeling, somitogenesis, and swim bladder organogenesis...
  67. doi Regulation and function of foxe3 during early zebrafish development
    Eric C Swindell
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genesis 46:177-83. 2008
    ....
  68. ncbi Retinoids signal directly to zebrafish endoderm to specify insulin-expressing beta-cells
    David Stafford
    The Committee on Developmental Biology, The University of Chicago, 1027 East 57th Street, IL 60637, USA
    Development 133:949-56. 2006
    ..These findings suggest that RA will have important applications in the quest to induce islets from stem cells for therapeutic uses...
  69. pmc Wdr18 is required for Kupffer's vesicle formation and regulation of body asymmetry in zebrafish
    Wei Gao
    Key Laboratory of Cell Proliferation and Differentiation of Ministry of Education, Center of Developmental Biology and Genetics, College of Life Sciences, Peking University, Beijing, People s Republic of China
    PLoS ONE 6:e23386. 2011
    ..Thus, we reveal a new and essential role for WD-repeat proteins in the determination and regulation of L-R asymmetry and propose a potential mechanism for wdr18 in the regulation of DFC clustering and migration and KV formation...
  70. ncbi casanova plays an early and essential role in endoderm formation in zebrafish
    J Alexander
    Programs in Developmental Biology and Human Genetics, Department of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, California 94143 0448, USA
    Dev Biol 215:343-57. 1999
    ..The early endodermal expression of genes such as axial, gata5, and fkd2 does not initiate in casanova mutants, indicating that the endoderm is defective from the onset of gastrulation...
  71. doi The orphan G protein-coupled receptor 161 is required for left-right patterning
    Tinchung Leung
    Weis Center for Research, Geisinger Clinic, Danville, PA 17822, USA
    Dev Biol 323:31-40. 2008
    ..Taken together, these data support a model in which gpr161 plays an essential role in left-right (L-R) patterning by modulating Ca(2+) levels in the cells surrounding the Kupffer's vesicle...
  72. pmc Chemokine signaling controls endodermal migration during zebrafish gastrulation
    Sreelaja Nair
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA
    Science 322:89-92. 2008
    ..This process may have relevance to human gastrointestinal bifurcations and other organ defects...
  73. doi Sdf1/Cxcr4 signaling controls the dorsal migration of endodermal cells during zebrafish gastrulation
    Takamasa Mizoguchi
    Department of Biological Science, Graduate School of Science, Hiroshima University, Kagamiyama 1 3 1, Higashi Hiroshima, Hiroshima, Japan
    Development 135:2521-9. 2008
    ....
  74. ncbi Endothelial signaling in kidney morphogenesis: a role for hemodynamic forces
    Fabrizio C Serluca
    Cardiovascular Research Center and Developmental Biology Laboratory, Boston, MA 02119, USA
    Curr Biol 12:492-7. 2002
    ..Thus, vascular flow is required for glomerular assembly, most probably acting via a stretch-responsive signaling system in the vessel wall...
  75. ncbi Zebrafish pou5f1/pou2, homolog of mammalian Oct4, functions in the endoderm specification cascade
    Karen Lunde
    Developmental Biology, Institute Biology 1, University of Freiburg, Hauptstrasse 1, D 79104, Freiburg, Germany
    Curr Biol 14:48-55. 2004
    ..We propose that pou5f1 plays an activating role in zebrafish endodermal development, where it maintains sox32 expression during gastrulation and acts with sox32 to induce sox17 expression in endodermal precursor cells...
  76. pmc Wnt5 signaling in vertebrate pancreas development
    Hyon J Kim
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    BMC Biol 3:23. 2005
    ..Signaling by the Wnt family of secreted glycoproteins through their receptors, the frizzled (Fz) family of seven-pass transmembrane proteins, is critical for numerous cell fate and tissue polarity decisions during development...
  77. ncbi One-eyed pinhead regulates cell motility independent of Squint/Cyclops signaling
    Rachel M Warga
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Dev Biol 261:391-411. 2003
    ..We conclude that, in addition to a role in Nodal signaling, One-eyed pinhead is required for aspects of cell movement, possibly by regulating cell adhesion...
  78. ncbi Perp is required for tissue-specific cell survival during zebrafish development
    M Nowak
    Max Planck Institute for Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Cell Death Differ 12:52-64. 2005
    ..We conclude that, in contrast to its proapoptotic function in stressed cells, Perp plays an antiapoptotic role during normal zebrafish development to regulate tissue-specific cell survival...
  79. ncbi Modulation of zebrafish pitx3 expression in the primordia of the pituitary, lens, olfactory epithelium and cranial ganglia by hedgehog and nodal signaling
    Carolyn A Zilinski
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genesis 41:33-40. 2005
    ..In mutants with impaired hedgehog signaling, the lens placode frequently extends into more anterior ventral regions of the embryo...
  80. ncbi Endoderm development in vertebrates: fate mapping, induction and regional specification
    Kimiko Fukuda
    Department of Biological Sciences, Tokyo Metropolitan University, 1 1 Minamiohsawa, Hachioji, Tokyo 192 0397, Japan
    Dev Growth Differ 47:343-55. 2005
    ..We discuss the classical fate mapping of the endoderm and the more recent progress in characterizing its induction, segregation and regional specification...
  81. pmc fsi zebrafish show concordant reversal of laterality of viscera, neuroanatomy, and a subset of behavioral responses
    K Anukampa Barth
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Curr Biol 15:844-50. 2005
    ..Revealing a link between visceral and brain asymmetry and lateralized behavior, our studies help to explain the complexity of the relationship between the lateralities of visceral and neural asymmetries...
  82. ncbi Relationships among characiform fishes inferred from analysis of nuclear and mitochondrial gene sequences
    Daniela Calcagnotto
    Division of Vertebrate Zoology, American Museum of Natural History, Central Park West at 79th St, New York, NY 10024 5192, USA
    Mol Phylogenet Evol 36:135-53. 2005
    ....
  83. pmc lessen encodes a zebrafish trap100 required for enteric nervous system development
    Jacy Pietsch
    Department of Biology, Emory University, Rollins Research Center, Atlanta, GA 30322, USA
    Development 133:395-406. 2006
    ..These studies demonstrate that lsn/trap100 is not required for initial steps of cranial neural crest development and migration, but is essential for later proliferation of ENS precursors in the intestine...
  84. ncbi Retinoic acid is required for endodermal pouch morphogenesis and not for pharyngeal endoderm specification
    Daniel Kopinke
    University of Utah, Department of Neurobiology and Anatomy, Salt Lake City, Utah, USA
    Dev Dyn 235:2695-709. 2006
    ..These results demonstrate that the developmental processes underlying pharyngeal arch defects differ depending on when RA signaling is disturbed during development...
  85. doi Intestinal differentiation in zebrafish requires Cdx1b, a functional equivalent of mammalian Cdx2
    Maria Vega C Flores
    Department of Molecular Medicine and Pathology, School of Medical Sciences, The University of Auckland, Auckland, New Zealand
    Gastroenterology 135:1665-75. 2008
    ..We used the zebrafish, a valuable model for studying gut development, to generate a system to further understanding of the role of Cdx2 in normal intestinal function and in disease states...
  86. pmc Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis
    Christopher W Wilson
    Cardiovascular Research Institute, University of California, San Francisco, California 94158, USA
    Nature 459:98-102. 2009
    ..Our results delineate a new pathway for central pair apparatus assembly, identify common regulators of Hh signalling and motile ciliogenesis, and provide insights into the evolution of the Hh cascade...
  87. pmc Zebrafish eaf1 and eaf2/u19 mediate effective convergence and extension movements through the maintenance of wnt11 and wnt5 expression
    Jing Xia Liu
    Key Laboratory of Biodiversity and Conservation of Aquatic Organisms, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China
    J Biol Chem 284:16679-92. 2009
    ..However, the ectopic expression of wnt11 and wnt5 did not affect eaf1 and eaf2/u19 expression. These data indicate that eaf1 and eaf2/u19 act upstream of noncanonical Wnt signaling to mediate convergence and extension movements...
  88. pmc Endoderm-derived Sonic hedgehog and mesoderm Hand2 expression are required for enteric nervous system development in zebrafish
    Bettina Reichenbach
    Department of Developmental Biology, University of Freiburg, Biology I, Hauptstrasse 1, 79104 Freiburg, Germany
    Dev Biol 318:52-64. 2008
    ..Furthermore we show that endoderm and HH signaling, but not hand2, regulate gdnf expression in the intestine, highlighting a central role of endoderm and SHH in patterning the intestine and the ENS...
  89. pmc Hematopoietic stem cell development is dependent on blood flow
    Trista E North
    Stem Cell Program and Hematology Oncology, Children s Hospital, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA
    Cell 137:736-48. 2009
    ..This work links blood flow to AGM hematopoiesis and identifies NO as a conserved downstream regulator of HSC development...
  90. pmc Multiple roles for Med12 in vertebrate endoderm development
    Chong Hyun Shin
    Department of Biochemistry and Biophysics, Liver Center, University of California, San Francisco, CA 94158, USA
    Dev Biol 317:467-79. 2008
    ....
  91. doi A zebrafish model for the Shwachman-Diamond syndrome (SDS)
    Narayanan Venkatasubramani
    Department of Pediatrics and Children s Research Institute, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Pediatr Res 63:348-52. 2008
    ..These data provide novel insight into the role of the sbds gene and support using zebrafish as a model system to study sbds gene function and for evaluation of novel therapies...
  92. ncbi Calcium fluxes in dorsal forerunner cells antagonize beta-catenin and alter left-right patterning
    Igor Schneider
    Department of Biological Sciences, University of Iowa, Iowa City, IA 52242, USA
    Development 135:75-84. 2008
    ..As in zebrafish, manipulation of Ca(2+) release results in ectopic nuclear beta-catenin and altered laterality. Overall, our data support a conserved early Ca(2+) requirement in DFC-like cell function in zebrafish and Xenopus...
  93. pmc Wnt/Axin1/beta-catenin signaling regulates asymmetric nodal activation, elaboration, and concordance of CNS asymmetries
    Matthias Carl
    Department of Anatomy and Developmental Biology, UCL, Gower Street, London WC1E 6BT, UK
    Neuron 55:393-405. 2007
    ..We identify a second role for the Wnt pathway in the left/right regulation of LPM Nodal pathway gene expression, and finally, we show that at later stages Axin1 is required for the elaboration of concordant neuroanatomical asymmetries...
  94. ncbi Na,K-ATPase alpha2 and Ncx4a regulate zebrafish left-right patterning
    Xiaodong Shu
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Development 134:1921-30. 2007
    ....
  95. pmc Alpha2 macroglobulin-like is essential for liver development in zebrafish
    Sung Kook Hong
    Laboratory of Molecular Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA
    PLoS ONE 3:e3736. 2008
    ....
  96. ncbi Early developmental specification of the thyroid gland depends on han-expressing surrounding tissue and on FGF signals
    Thomas Wendl
    Institute for Developmental Biology, University of Cologne, Gyrhofstrasse 17, 50923 Koln, Germany
    Development 134:2871-9. 2007
    ..FGF-soaked beads can restore thyroid development in han mutants, showing that FGFs act downstream of or in parallel to han. These data suggest that loss of FGF-expressing tissue in han mutants is responsible for the thyroid defects...