foxa

Summary

Gene Symbol: foxa
Description: forkhead box A sequence
Alias: fkd4, forkhead-4, zf-FKH2, zgc:100769, forkhead box A sequence, fork head domain protein 4
Species: zebrafish

Top Publications

  1. Flowers G, Topczewska J, Topczewski J. A zebrafish Notum homolog specifically blocks the Wnt/?-catenin signaling pathway. Development. 2012;139:2416-25 pubmed publisher
    ..Notum 1a does not interact with Glypican 4, an essential component of the Wnt/planar cell polarity (PCP) pathway. Our results suggest a surprising specific role of Notum in the developing vertebrate embryo. ..
  2. Tay S, Ingham P, Roy S. A homologue of the Drosophila kinesin-like protein Costal2 regulates Hedgehog signal transduction in the vertebrate embryo. Development. 2005;132:625-34 pubmed
  3. Wilson C, Nguyen C, Chen M, Yang J, Gacayan R, Huang J, et al. Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis. Nature. 2009;459:98-102 pubmed publisher
    ..Our results delineate a new pathway for central pair apparatus assembly, identify common regulators of Hh signalling and motile ciliogenesis, and provide insights into the evolution of the Hh cascade. ..
  4. Odenthal J, Nusslein Volhard C. fork head domain genes in zebrafish. Dev Genes Evol. 1998;208:245-58 pubmed
    ..Members of class I (fkd1/axial, fkd2/Zffkh1, fkd4 and fkd7) are differentially transcribed in unsegmented dorsal axial structures such as the floor plate, the ..
  5. Wolff C, Roy S, Lewis K, Schauerte H, Joerg Rauch G, Kirn A, et al. iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo. Genes Dev. 2004;18:1565-76 pubmed
  6. Tyurina O, Guner B, Popova E, Feng J, Schier A, Kohtz J, et al. Zebrafish Gli3 functions as both an activator and a repressor in Hedgehog signaling. Dev Biol. 2005;277:537-56 pubmed
    ..These results reveal a conserved role for Gli3 in vertebrate development and uncover novel regional functions and regulatory interactions among gli genes. ..
  7. Kawakami A, Nojima Y, Toyoda A, Takahoko M, Satoh M, Tanaka H, et al. The zebrafish-secreted matrix protein you/scube2 is implicated in long-range regulation of hedgehog signaling. Curr Biol. 2005;15:480-8 pubmed
    ..We further show that Bmp activity can be attenuated by the coexpression of Scube2. Our data support the idea that Scube2 can modulate the long-range action of Bmp-dependent signaling in the neural tube and somites. ..
  8. Han Y, Xiong Y, Shi X, Wu J, Zhao Y, Jiang J. Regulation of Gli ciliary localization and Hedgehog signaling by the PY-NLS/karyopherin-?2 nuclear import system. PLoS Biol. 2017;15:e2002063 pubmed publisher
    ..Our study unravels the molecular mechanism and cellular machinery regulating Gli ciliary localization and identifies Kap?2 as a critical regulator of the Hh pathway and a potential drug target for Hh-driven cancers. ..
  9. Norton W, Mangoli M, Lele Z, Pogoda H, Diamond B, Mercurio S, et al. Monorail/Foxa2 regulates floorplate differentiation and specification of oligodendrocytes, serotonergic raphé neurones and cranial motoneurones. Development. 2005;132:645-58 pubmed
    ..In mol-/- mutants, expression of Foxa and Hh family genes is not maintained in floorplate cells and lateral expansion of the floorplate fails to occur...

More Information

Publications20

  1. Maurya A, Ben J, Zhao Z, Lee R, Niah W, Ng A, et al. Positive and negative regulation of Gli activity by Kif7 in the zebrafish embryo. PLoS Genet. 2013;9:e1003955 pubmed publisher
  2. Zhang Z, Feng J, Pan C, Lv X, Wu W, Zhou Z, et al. Atrophin-Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR. J Cell Biol. 2013;203:575-83 pubmed publisher
    ..Furthermore, Rerea, a homologue of Atro in zebrafish, repressed the expression of Hh-responsive genes. We propose that the Atro-Rpd3 complex plays a conserved role to function as a Ci(R) corepressor...
  3. Kotani T, Iemura S, Natsume T, Kawakami K, Yamashita M. Mys protein regulates protein kinase A activity by interacting with regulatory type Ialpha subunit during vertebrate development. J Biol Chem. 2010;285:5106-16 pubmed publisher
  4. Odenthal J, van Eeden F, Haffter P, Ingham P, Nusslein Volhard C. Two distinct cell populations in the floor plate of the zebrafish are induced by different pathways. Dev Biol. 2000;219:350-63 pubmed
    ..by the expression patterns of several marker genes, including sonic hedgehog (shh) and the fork head-domain gene fkd4: a single row of medial floor plate (MFP) cells, expressing both shh and fkd4, is flanked by rows of lateral floor ..
  5. Nakano Y, Kim H, Kawakami A, Roy S, Schier A, Ingham P. Inactivation of dispatched 1 by the chameleon mutation disrupts Hedgehog signalling in the zebrafish embryo. Dev Biol. 2004;269:381-92 pubmed
  6. Hauptmann G, Söll I, Gerster T. The early embryonic zebrafish forebrain is subdivided into molecularly distinct transverse and longitudinal domains. Brain Res Bull. 2002;57:371-5 pubmed
    ..Furthermore, we identified a series of eight transverse diencephalic domains which may indicate a prosomeric organization of the rostral zebrafish brain. ..
  7. Kondrychyn I, Garcia Lecea M, Emelyanov A, Parinov S, Korzh V. Genome-wide analysis of Tol2 transposon reintegration in zebrafish. BMC Genomics. 2009;10:418 pubmed publisher
    ..This information will influence the development of various applications involving DNA transposons and Tol2 in particular. ..
  8. Barth K, Kishimoto Y, Rohr K, Seydler C, Schulte Merker S, Wilson S. Bmp activity establishes a gradient of positional information throughout the entire neural plate. Development. 1999;126:4977-87 pubmed
    ..These results are consistent with there being a gradient of Bmp-dependent positional information extending throughout the entire neural and non-neural ectoderm. ..
  9. Pinheiro P, Gering M, Patient R. The basic helix-loop-helix transcription factor, Tal2, marks the lateral floor plate of the spinal cord in zebrafish. Gene Expr Patterns. 2004;4:85-92 pubmed
    ..This is to our knowledge the first report of a gene expressed specifically in lateral cells of the floor plate in the spinal cord. ..
  10. Shakes L, Du H, Wolf H, HATCHER C, Norford D, Precht P, et al. Using BAC transgenesis in zebrafish to identify regulatory sequences of the amyloid precursor protein gene in humans. BMC Genomics. 2012;13:451 pubmed publisher
    ..It suggests potential human APP gene regulatory pathways, not on the basis of comparing DNA primary sequences with zebrafish appb but on the model of conservation of transcription factors. ..
  11. Nelson A, Cutty S, Niini M, Stemple D, Flicek P, Houart C, et al. Global identification of Smad2 and Eomesodermin targets in zebrafish identifies a conserved transcriptional network in mesendoderm and a novel role for Eomesodermin in repression of ectodermal gene expression. BMC Biol. 2014;12:81 pubmed publisher
    ..Eomesa therefore regulates the formation of all three germ layers in the early zebrafish embryo. ..