focal adhesion kinase


Gene Symbol: focal adhesion kinase
Description: protein tyrosine kinase 2ab
Alias: fak, fak1a, ptk2, ptk2.1, ptk2a, wu:fa18c04, zgc:66114, focal adhesion kinase 1, faka, focal adhesion kinase, protein tyrosine kinase 2.1, protein tyrosine kinase 2a
Species: zebrafish
Products:     focal adhesion kinase

Top Publications

  1. Crawford B, Henry C, Clason T, Becker A, Hille M. Activity and distribution of paxillin, focal adhesion kinase, and cadherin indicate cooperative roles during zebrafish morphogenesis. Mol Biol Cell. 2003;14:3065-81 pubmed
    ..Novel observations showed that focal adhesion kinase and paxillin concentrate at sites of cell-cell adhesion in the epithelial enveloping layer and may ..
  2. Semina E, Bosenko D, Zinkevich N, Soules K, Hyde D, Vihtelic T, et al. Mutations in laminin alpha 1 result in complex, lens-independent ocular phenotypes in zebrafish. Dev Biol. 2006;299:63-77 pubmed
    ..Analysis of components of focal adhesion signaling complexes suggests that reduced focal adhesion kinase activation underlies the anterior segment dysgenesis in lama1 mutants...
  3. Hayes J, Hartsock A, Clark B, Napier H, Link B, Gross J. Integrin ?5/fibronectin1 and focal adhesion kinase are required for lens fiber morphogenesis in zebrafish. Mol Biol Cell. 2012;23:4725-38 pubmed publisher
    ..Analysis of the intracellular mediators of integrin ?5/Fn1 activity focal adhesion kinase (FAK) and integrin-linked kinase (ILK) reveals that FAK, but not ILK, is also required for lens fiber ..
  4. Choi Y, Kim H, Kim J, Kim H, Kang M, Lee M, et al. TM4SF5 suppression disturbs integrin ?5-related signalling and muscle development in zebrafish. Biochem J. 2014;462:89-101 pubmed publisher
    ..reduced muscle fibre masses, where integrin ?5-related signalling molecules, including fibronectin, FAK (focal adhesion kinase), vinculin and actin were aberrantly localized, compared with those in control fish...
  5. Kok F, Oster E, Mentzer L, Hsieh J, Henry C, Sirotkin H. The role of the SPT6 chromatin remodeling factor in zebrafish embryogenesis. Dev Biol. 2007;307:214-26 pubmed
    ..However, additional Spt6 mutant phenotypes are likely caused by vital functions of Spt6 in other pathways. ..
  6. Lange M, Kaynak B, Forster U, Tönjes M, Fischer J, Grimm C, et al. Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex. Genes Dev. 2008;22:2370-84 pubmed publisher
    ..Furthermore, this shows that plant homeodomain proteins play a yet unexplored role in recruiting chromatin remodeling complexes to acetylated histones. ..
  7. Woo S, Rowan D, Gomez T. Retinotopic mapping requires focal adhesion kinase-mediated regulation of growth cone adhesion. J Neurosci. 2009;29:13981-91 pubmed publisher
    ..Ephrin-A1 activates focal adhesion kinase (FAK) in an integrin- and Src-dependent manner and the effects of ephrin-A1 on growth cone motility ..
  8. Hirth S, Bühler A, Bührdel J, Rudeck S, Dahme T, Rottbauer W, et al. Paxillin and Focal Adhesion Kinase (FAK) Regulate Cardiac Contractility in the Zebrafish Heart. PLoS ONE. 2016;11:e0150323 pubmed publisher
    ..However, we found that Paxillin deficiency leads to the destabilization of its known binding partner Focal Adhesion Kinase (FAK) and vice versa resulting in degradation of Vinculin and thereby heart failure...
  9. Yu S, Li C, Biswas L, Hu X, Liu F, Reilly J, et al. CERKL gene knockout disturbs photoreceptor outer segment phagocytosis and causes rod-cone dystrophy in zebrafish. Hum Mol Genet. 2017;26:2335-2345 pubmed publisher
    ..We conclude that CERKL deficiency in zebrafish may cause rod-cone dystrophy, but not cone-rod dystrophy, while interfering with the phagocytosis function of RPE associated with down-regulation of the expression of MERTK. ..

More Information


  1. Kara N, Wei C, Commanday A, Patton J. miR-27 regulates chondrogenesis by suppressing focal adhesion kinase during pharyngeal arch development. Dev Biol. 2017;429:321-334 pubmed publisher
    ..b>Focal adhesion kinase (FAK) is a key regulator in integrin-mediated extracellular matrix (ECM) adhesion and has been proposed to ..