Gene Symbol: fn1a
Description: fibronectin 1a
Alias: fb80d10, fn1, fn2, wu:fb80d10, fibronectin, fibronectin 1, fn1l, nat, natter
Species: zebrafish

Top Publications

  1. Chen J, Haffter P, Odenthal J, Vogelsang E, Brand M, van Eeden F, et al. Mutations affecting the cardiovascular system and other internal organs in zebrafish. Development. 1996;123:293-302 pubmed
    ..The mutations presented here could serve as an entry point to the establishment of a genetic hierarchy underlying organogenesis. ..
  2. Garavito Aguilar Z, Riley H, Yelon D. Hand2 ensures an appropriate environment for cardiac fusion by limiting Fibronectin function. Development. 2010;137:3215-20 pubmed publisher
    ..Gene expression profiles reveal heightened expression of fibronectin 1 (fn1) in hand2 mutant embryos. Reciprocally, overexpression of hand2 leads to decreased Fibronectin levels...
  3. Yin C, Kikuchi K, Hochgreb T, Poss K, Stainier D. Hand2 regulates extracellular matrix remodeling essential for gut-looping morphogenesis in zebrafish. Dev Cell. 2010;18:973-84 pubmed publisher
    ..Our study reveals an unexpected role for Hand2, a key regulator of cell specification and differentiation, in modulating ECM remodeling during organogenesis. ..
  4. Trinh L, Yelon D, Stainier D. Hand2 regulates epithelial formation during myocardial diferentiation. Curr Biol. 2005;15:441-6 pubmed
    ..Furthermore, these results demonstrate that two independent processes, the polarizaton of myocardial precursors and the allocation of proper cell number, contribute to myocardial development. ..
  5. Jülich D, Geisler R, Holley S. Integrinalpha5 and delta/notch signaling have complementary spatiotemporal requirements during zebrafish somitogenesis. Dev Cell. 2005;8:575-86 pubmed
    ..somite defects along the entire body axis, with a complete loss of the mesenchymal-to-epithelial transition and Fibronectin matrix assembly in the posterior...
  6. Snow C, Peterson M, Khalil A, Henry C. Muscle development is disrupted in zebrafish embryos deficient for fibronectin. Dev Dyn. 2008;237:2542-53 pubmed publisher
    ..b>Fibronectin (Fn) is a major component of the extracellular matrix in both boundaries...
  7. Latimer A, Jessen J. Extracellular matrix assembly and organization during zebrafish gastrulation. Matrix Biol. 2010;29:89-96 pubmed publisher
    ..Here, we describe for the first time the assembly of a fibronectin (FN) and laminin containing ECM in the early zebrafish embryo...
  8. Trinh L, Stainier D. Fibronectin regulates epithelial organization during myocardial migration in zebrafish. Dev Cell. 2004;6:371-82 pubmed
    ..We positionally cloned nat and show that it encodes Fibronectin. During myocardial migration, Fibronectin is deposited at the midline between the endoderm and endocardial ..
  9. Koshida S, Kishimoto Y, Ustumi H, Shimizu T, Furutani Seiki M, Kondoh H, et al. Integrinalpha5-dependent fibronectin accumulation for maintenance of somite boundaries in zebrafish embryos. Dev Cell. 2005;8:587-98 pubmed
    ..By a genetic screening procedure with zebrafish, we identified two genes, integrinalpha5 (itga5) and fibronectin (fn), required for these processes...

More Information


  1. Jülich D, Mould A, Koper E, Holley S. Control of extracellular matrix assembly along tissue boundaries via Integrin and Eph/Ephrin signaling. Development. 2009;136:2913-21 pubmed publisher
    ..During zebrafish somite morphogenesis, segmental assembly of an ECM composed of Fibronectin (FN) depends on the FN receptor Integrin alpha5beta1...
  2. Sakaguchi T, Kikuchi Y, Kuroiwa A, Takeda H, Stainier D. The yolk syncytial layer regulates myocardial migration by influencing extracellular matrix assembly in zebrafish. Development. 2006;133:4063-72 pubmed
    ..Mtx1 in the extra-embryonic YSL appears to regulate the embryonic expression of fibronectin, a gene previously implicated in myocardial migration...
  3. Beis D, Stainier D. In vivo cell biology: following the zebrafish trend. Trends Cell Biol. 2006;16:105-12 pubmed
    ..Although this model system has been predominantly appreciated for its amenability to forward genetics, current advances in imaging technology and an increasing number of transgenic lines are bringing it closer to its full potential. ..
  4. Langenbacher A, Huang J, Chen Y, Chen J. Sodium pump activity in the yolk syncytial layer regulates zebrafish heart tube morphogenesis. Dev Biol. 2012;362:263-70 pubmed publisher
    ..behavior of cardiac precursors, defects in the elongation of the heart tube, and a severe reduction in ECM/Fibronectin deposition around the myocardium, despite the presence of normal cell polarity and junctions in the myocardial ..
  5. Mould A, Koper E, Byron A, Zahn G, Humphries M. Mapping the ligand-binding pocket of integrin alpha5beta1 using a gain-of-function approach. Biochem J. 2009;424:179-89 pubmed publisher
    Integrin alpha5beta1 is a key receptor for the extracellular matrix protein fibronectin. Antagonists of human integrin alpha5beta1 have therapeutic potential as anti-angiogenic agents in cancer and diseases of the eye...
  6. Arrington C, Yost H. Extra-embryonic syndecan 2 regulates organ primordia migration and fibrillogenesis throughout the zebrafish embryo. Development. 2009;136:3143-52 pubmed publisher
    ..layer (YSL) acts locally at the YSL-embryo interface to direct organ primordia migration, and is required for fibronectin and laminin matrix assembly throughout the embryo...
  7. Chou C, Chiu C, Liu Y. Fibronectin mediates correct positioning of the interrenal organ in zebrafish. Dev Dyn. 2013;242:432-43 pubmed publisher
    b>Fibronectin (Fn) forms a centripetal gradient during the fetal adrenal gland organogenesis, and modulates hormone responsiveness of adrenocortical cells in the primary culture...
  8. Li Z, Korzh V, Gong Z. Localized rbp4 expression in the yolk syncytial layer plays a role in yolk cell extension and early liver development. BMC Dev Biol. 2007;7:117 pubmed
    ..rbp4 appears also to regulate the extracellular matrix protein Fibronectin1 (Fn1) specifically in the ventro-lateral yolk, indicating a role of Fn1 in liver progenitor migration...
  9. Jenkins M, Alrowaished S, Goody M, Crawford B, Henry C. Laminin and Matrix metalloproteinase 11 regulate Fibronectin levels in the zebrafish myotendinous junction. Skelet Muscle. 2016;6:18 pubmed publisher
    ..One such shift involves the replacement of Fibronectin (Fn)-rich matrix, which is essential for both somite and early muscle development, with laminin-rich matrix ..
  10. Mokalled M, Patra C, Dickson A, Endo T, Stainier D, Poss K. Injury-induced ctgfa directs glial bridging and spinal cord regeneration in zebrafish. Science. 2016;354:630-634 pubmed
    ..Our study reveals that CTGF is necessary and sufficient to stimulate glial bridging and natural spinal cord regeneration. ..
  11. Burczyk M, Burkhalter M, Blätte T, Matysik S, Caron M, BARAK L, et al. Phenotypic regulation of the sphingosine 1-phosphate receptor miles apart by G protein-coupled receptor kinase 2. Biochemistry. 2015;54:765-75 pubmed publisher
    ..The ability of reduced GRK2 activity to reverse a developmental phenotype associated with constitutive desensitization supports efforts to genetically or pharmacologically target this kinase in diseases involving biased GPCR signaling. ..
  12. Lin C, Huang C, Wang W, Hsiao C, Cheng C, Wu Y, et al. Low temperature mitigates cardia bifida in zebrafish embryos. PLoS ONE. 2013;8:e69788 pubmed publisher
    ..mitigates cardia bifida by regulating the expression of genes encoding components of the extracellular matrix (fibronectin 1, tenascin-c, tenascin-w)...
  13. Zhao Q, Liu X, Collodi P. Identification and characterization of a novel fibronectin in zebrafish. Exp Cell Res. 2001;268:211-9 pubmed
    Sequence analysis of zebrafish fibronectin (FN) cDNAs indicates that at least two forms of the protein exist in fish...
  14. Wong K, Rehn K, Palencia Desai S, Kohli V, Hunter W, Uhl J, et al. Hedgehog signaling is required for differentiation of endocardial progenitors in zebrafish. Dev Biol. 2012;361:377-91 pubmed publisher
    ..Inhibition of Hh signaling resulted in the loss of fibronectin (fn1) expression in the presumptive endocardial progenitors as early as the 10-somite stage which suggests that ..
  15. Pauli A, Norris M, Valen E, Chew G, Gagnon J, Zimmerman S, et al. Toddler: an embryonic signal that promotes cell movement via Apelin receptors. Science. 2014;343:1248636 pubmed publisher
    ..These results indicate that Toddler is an activator of APJ/Apelin receptor signaling, promotes gastrulation movements, and might be the first in a series of uncharacterized developmental signals...
  16. Hisano Y, Ota S, Takada S, Kawahara A. Functional cooperation of spns2 and fibronectin in cardiac and lower jaw development. Biol Open. 2013;2:789-94 pubmed publisher
    ..To examine the genetic interaction of S1P signaling and the cell adhesion molecule fibronectin, we have established a fn;spns2 double mutant...
  17. Palencia Desai S, Rost M, Schumacher J, Ton Q, Craig M, Baltrunaite K, et al. Myocardium and BMP signaling are required for endocardial differentiation. Development. 2015;142:2304-15 pubmed publisher
    ..Our results indicate that the myocardium is crucial for endocardial morphogenesis and differentiation, and identify BMP as a signal involved in endocardial differentiation. ..
  18. McCurley A, Callard G. Time Course Analysis of Gene Expression Patterns in Zebrafish Eye During Optic Nerve Regeneration. J Exp Neurosci. 2010;2010:17-33 pubmed
  19. Jülich D, Cobb G, Melo A, McMillen P, Lawton A, Mochrie S, et al. Cross-Scale Integrin Regulation Organizes ECM and Tissue Topology. Dev Cell. 2015;34:33-44 pubmed publisher
    ..elucidate a cross-scale mechanism for tissue assembly and ECM remodeling involving Cadherin 2, the ECM protein Fibronectin, and its receptor Integrin α5...
  20. Mana G, Clapero F, Panieri E, Panero V, Böttcher R, Tseng H, et al. PPFIA1 drives active ?5?1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis. Nat Commun. 2016;7:13546 pubmed publisher
    Basolateral polymerization of cellular fibronectin (FN) into a meshwork drives endothelial cell (EC) polarity and vascular remodelling...
  21. Stratman A, Pezoa S, Farrelly O, Castranova D, Dye L, Butler M, et al. Interactions between mural cells and endothelial cells stabilize the developing zebrafish dorsal aorta. Development. 2017;144:115-127 pubmed publisher
  22. Wehner D, Tsarouchas T, Michael A, Haase C, Weidinger G, Reimer M, et al. Wnt signaling controls pro-regenerative Collagen XII in functional spinal cord regeneration in zebrafish. Nat Commun. 2017;8:126 pubmed publisher
    ..Here, the authors show that Wnt/?-catenin signaling in fibroblast-like cells at a lesion activates axon re-growth via deposition of Collagen XII. ..
  23. Minchin J, Dahlman I, Harvey C, Mejhert N, Singh M, Epstein J, et al. Plexin D1 determines body fat distribution by regulating the type V collagen microenvironment in visceral adipose tissue. Proc Natl Acad Sci U S A. 2015;112:4363-8 pubmed publisher
    ..Together, our findings identify Plxnd1 as a novel regulator of VAT growth, body fat distribution, and insulin sensitivity in both zebrafish and humans. ..
  24. Wang J, Wu Y, Zhao F, Wu Y, Dong W, Zhao J, et al. Fgf-signaling-dependent Sox9a and Atoh1a regulate otic neural development in zebrafish. J Neurosci. 2015;35:234-44 pubmed publisher
    ..These newly uncovered roles for Atoh1and Sox9 in zebrafish otic development may be relevant to study in other species. ..
  25. Qiao L, Gao H, Zhang T, Jing L, Xiao C, Xiao Y, et al. Snail modulates the assembly of fibronectin via ?5 integrin for myocardial migration in zebrafish embryos. Sci Rep. 2014;4:4470 pubmed publisher
    ..Depletion of Snai1b function dramatically reduced expression of ?5 integrin, disrupted Fibronectin layer in the heart region, especially at the midline, and prevented migration of cardiac precursors, resulting ..
  26. Wang J, Karra R, Dickson A, Poss K. Fibronectin is deposited by injury-activated epicardial cells and is necessary for zebrafish heart regeneration. Dev Biol. 2013;382:427-35 pubmed publisher
    ..We found that Fibronectin, a main component of the extracellular matrix, is induced and deposited after cardiac damage...
  27. Cheng P, Andersen P, Hassel D, Kaynak B, Limphong P, Juergensen L, et al. Fibronectin mediates mesendodermal cell fate decisions. Development. 2013;140:2587-96 pubmed publisher
    ..promoted precardiac mesoderm formation in mouse embryonic stem cells and involved endodermal production of fibronectin. In vivo, fibronectin deficiency resulted in a dramatic reduction of mesoderm accompanied by endodermal ..
  28. Hayes J, Hartsock A, Clark B, Napier H, Link B, Gross J. Integrin ?5/fibronectin1 and focal adhesion kinase are required for lens fiber morphogenesis in zebrafish. Mol Biol Cell. 2012;23:4725-38 pubmed publisher
    ..cell-ECM interactions that mediate these processes are largely unknown, and here we demonstrate that fibronectin1 (Fn1), an ECM component, and integrin ?5, its cellular binding partner, are required in the zebrafish lens for fiber ..
  29. Palencia Desai S, Kohli V, Kang J, Chi N, Black B, Sumanas S. Vascular endothelial and endocardial progenitors differentiate as cardiomyocytes in the absence of Etsrp/Etv2 function. Development. 2011;138:4721-32 pubmed publisher
  30. Yamakoshi K, Shishido Y, Shimoda N. Generation of aberrant transcripts of and free DNA ends in zebrafish no tail gene. Mar Biotechnol (NY). 2005;7:163-72 pubmed
    ..DSEs were also generated in another zebrafish gene, noggin2 (nog2). DSEs in ntl and nog2 had common characteristics, which suggested that the AT repeats in these genes elicited DSEs by blocking progression of the replication. ..
  31. Liu D, Chu H, Maves L, Yan Y, Morcos P, Postlethwait J, et al. Fgf3 and Fgf8 dependent and independent transcription factors are required for otic placode specification. Development. 2003;130:2213-24 pubmed
  32. Liu X, Collodi P. Novel form of fibronectin from zebrafish mediates infectious hematopoietic necrosis virus infection. J Virol. 2002;76:492-8 pubmed
    The presence of a novel form of zebrafish fibronectin (FN2) on the cell surface increased the cell's susceptibility to infection by infectious hematopoietic necrosis virus (IHNV)...
  33. Slaats G, Ghosh A, Falke L, Le Corre S, Shaltiël I, van de Hoek G, et al. Nephronophthisis-associated CEP164 regulates cell cycle progression, apoptosis and epithelial-to-mesenchymal transition. PLoS Genet. 2014;10:e1004594 pubmed publisher
  34. Chiu C, Chou C, Takada S, Liu Y. Development and fibronectin signaling requirements of the zebrafish interrenal vessel. PLoS ONE. 2012;7:e43040 pubmed publisher
    ..vessel (IRV); which develops from the axial artery through angiogenesis and is associated with highly enriched Fibronectin (Fn) accumulation at its microenvironment...
  35. Kwon H, Riley B. Mesendodermal signals required for otic induction: Bmp-antagonists cooperate with Fgf and can facilitate formation of ectopic otic tissue. Dev Dyn. 2009;238:1582-94 pubmed publisher
    ..Developmental Dynamics 238:1582-1594, 2009. (c) 2009 Wiley-Liss, Inc. ..
  36. Hans S, Liu D, Westerfield M. Pax8 and Pax2a function synergistically in otic specification, downstream of the Foxi1 and Dlx3b transcription factors. Development. 2004;131:5091-102 pubmed
    ..Combined loss of both factors eliminates all indications of otic specification. We suggest that the Foxi1-Pax8 pathway provides an early 'jumpstart' of otic specification that is maintained by the Dlx3b-Pax2a pathway. ..
  37. Jiang Y, Brand M, Heisenberg C, Beuchle D, Furutani Seiki M, Kelsh R, et al. Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio. Development. 1996;123:205-16 pubmed
    ..Mutants in a group of 6 genes, snakehead(snk), natter (nat), otter (ott), fullbrain (ful), viper (vip) and white snake (wis) develop collapsed brain ventricles, before ..
  38. Norris M, Pauli A, Gagnon J, Lord N, Rogers K, Mosimann C, et al. Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling. elife. 2017;6: pubmed publisher
    ..These results suggest that Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling and indirectly affects endodermal cell migration via Cxcr4a-signaling. ..