fli1b

Summary

Gene Symbol: fli1b
Description: Fli-1 proto-oncogene, ETS transcription factor b
Alias: zgc:5777174, Fli-1 proto-oncogene, ETS transcription factor b, fli-1 proto-oncogene, ETS transcription factor b, fli-1 homolog, friend leukemia integration 1b
Species: zebrafish
Products:     fli1b

Top Publications

  1. Sumanas S, Lin S. Ets1-related protein is a key regulator of vasculogenesis in zebrafish. PLoS Biol. 2006;4:e10 pubmed
    ..These results demonstrate that Etsrp is necessary and sufficient for the initiation of vasculogenesis. ..
  2. Pham V, Lawson N, Mugford J, Dye L, Castranova D, Lo B, et al. Combinatorial function of ETS transcription factors in the developing vasculature. Dev Biol. 2007;303:772-83 pubmed
    ..in the zebrafish to analyze four ETS family members expressed together in the zebrafish vasculature; fli1, fli1b, ets1, and etsrp...
  3. Ren X, Gomez G, Zhang B, Lin S. Scl isoforms act downstream of etsrp to specify angioblasts and definitive hematopoietic stem cells. Blood. 2010;115:5338-46 pubmed publisher
  4. Aday A, Zhu L, Lakshmanan A, Wang J, Lawson N. Identification of cis regulatory features in the embryonic zebrafish genome through large-scale profiling of H3K4me1 and H3K4me3 binding sites. Dev Biol. 2011;357:450-62 pubmed publisher
  5. Villefranc J, Nicoli S, Bentley K, Jeltsch M, Zarkada G, Moore J, et al. A truncation allele in vascular endothelial growth factor c reveals distinct modes of signaling during lymphatic and vascular development. Development. 2013;140:1497-506 pubmed publisher
  6. Rey S, Boltaña S, Vargas R, Roher N, MacKenzie S. Combining animal personalities with transcriptomics resolves individual variation within a wild-type zebrafish population and identifies underpinning molecular differences in brain function. Mol Ecol. 2013;22:6100-15 pubmed publisher
    ..These differences can be mapped to distinct regions of the brain and provide a foundation towards understanding the coordination of underpinning adaptive molecular events within populations. ..
  7. Craig M, Grajevskaja V, Liao H, Balciuniene J, Ekker S, Park J, et al. Etv2 and fli1b function together as key regulators of vasculogenesis and angiogenesis. Arterioscler Thromb Vasc Biol. 2015;35:865-76 pubmed publisher
    ..we investigated in the zebrafish model a role for Etv2 and related E26 transformation-specific factors, Fli1a and Fli1b in developmental angiogenesis...
  8. Reischauer S, Stone O, Villasenor A, Chi N, Jin S, Martin M, et al. Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification. Nature. 2016;535:294-8 pubmed publisher
  9. Patterson L, Patient R. The "Ets" factor: vessel formation in zebrafish--the missing link?. PLoS Biol. 2006;4:e24 pubmed

More Information

Publications16

  1. Ellett F, Kile B, Lieschke G. The role of the ETS factor erg in zebrafish vasculogenesis. Mech Dev. 2009;126:220-9 pubmed publisher
  2. Law S, Sargent T. Maternal pak4 expression is required for primitive myelopoiesis in zebrafish. Mech Dev. 2013;130:181-94 pubmed publisher
  3. Wythe J, Dang L, Devine W, Boudreau E, Artap S, He D, et al. ETS factors regulate Vegf-dependent arterial specification. Dev Cell. 2013;26:45-58 pubmed publisher
  4. Moore J, Sheppard Tindell S, Shestopalov I, Yamazoe S, Chen J, Lawson N. Post-transcriptional mechanisms contribute to Etv2 repression during vascular development. Dev Biol. 2013;384:128-40 pubmed publisher
    ..Taken together, our results suggest that etv2 acts during early development to specify endothelial lineages and is then down-regulated, in part through post-transcriptional repression by microRNAs, to allow normal vascular development. ..
  5. Renz M, Otten C, Faurobert E, Rudolph F, Zhu Y, Boulday G, et al. Regulation of β1 integrin-Klf2-mediated angiogenesis by CCM proteins. Dev Cell. 2015;32:181-90 pubmed publisher
    ..Our work reveals a β1 integrin-Klf2-Egfl7-signaling pathway that is tightly regulated by CCM proteins. This regulation prevents angiogenic overgrowth and ensures the quiescence of endothelial cells. ..
  6. Missinato M, Tobita K, Romano N, Carroll J, Tsang M. Extracellular component hyaluronic acid and its receptor Hmmr are required for epicardial EMT during heart regeneration. Cardiovasc Res. 2015;107:487-98 pubmed publisher
    ..HA and Hmmr are required for activated epicardial cell EMT and migration involving the FAK/Src pathway for proper heart regeneration. ..
  7. Baltrunaite K, Craig M, Palencia Desai S, Chaturvedi P, Pandey R, Hegde R, et al. ETS transcription factors Etv2 and Fli1b are required for tumor angiogenesis. Angiogenesis. 2017;20:307-323 pubmed publisher
    ..B16 melanoma cells resulted in a significant increase in expression of the ETS transcription factors etv2 and fli1b expression throughout the embryonic vasculature...