Gene Symbol: fhl2a
Description: four and a half LIM domains 2a
Alias: zgc:92428, four and a half LIM domains 2a, DKEYP-118H3.4, four and half LIM domains protein 2
Species: zebrafish
Products:     fhl2a

Top Publications

  1. Rafael M, Laizé V, Bensimon Brito A, Leite R, Schüle R, Cancela M. Four-and-a-half LIM domains protein 2 (FHL2) is associated with the development of craniofacial musculature in the teleost fish Sparus aurata. Cell Mol Life Sci. 2012;69:423-34 pubmed publisher
    ..Our data confirmed the key role of FHL2 protein during vertebrate development and gave new insights into its particular involvement in craniofacial muscle development and specificity for slow fibers. ..
  2. Musso G, Tasan M, Mosimann C, Beaver J, Plovie E, Carr L, et al. Novel cardiovascular gene functions revealed via systematic phenotype prediction in zebrafish. Development. 2014;141:224-35 pubmed publisher
    ..Thus, we show that systematic prioritization in zebrafish can accelerate the pace of developmental gene function discovery. ..
  3. Santos M, Braasch I, Boileau N, Meyer B, Sauteur L, Böhne A, et al. The evolution of cichlid fish egg-spots is linked with a cis-regulatory change. Nat Commun. 2014;5:5149 pubmed publisher
    ..combination of RNAseq, comparative genomics and functional experiments, we identify two novel pigmentation genes, fhl2a and fhl2b, and show that especially the more rapidly evolving b-paralog is associated with egg-spot formation...
  4. Etard C, Armant O, Roostalu U, Gourain V, Ferg M, Strähle U. Loss of function of myosin chaperones triggers Hsf1-mediated transcriptional response in skeletal muscle cells. Genome Biol. 2015;16:267 pubmed publisher
    ..Taken together, our data show that skeletal muscle cells respond to defective myosin chaperones with a complex gene program and suggest that this response is mediated by Hsf1 activation. ..

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