fgfr3

Summary

Gene Symbol: fgfr3
Description: fibroblast growth factor receptor 3
Alias: fc27h01, sb:eu563, wu:fc27h01, fibroblast growth factor receptor 3
Species: zebrafish

Top Publications

  1. Scholpp S, Groth C, Lohs C, Lardelli M, Brand M. Zebrafish fgfr1 is a member of the fgf8 synexpression group and is required for fgf8 signalling at the midbrain-hindbrain boundary. Dev Genes Evol. 2004;214:285-95 pubmed
    ..The expression patterns of fgfr1 and fgf8 are strikingly similar and knock-down of fgfr1 phenocopies many aspects observed in the fgf8 mutant acerebellar, suggesting that Fgf8 exerts its function mainly by binding to FgfR1. ..
  2. Nechiporuk A, Linbo T, Raible D. Endoderm-derived Fgf3 is necessary and sufficient for inducing neurogenesis in the epibranchial placodes in zebrafish. Development. 2005;132:3717-30 pubmed
    ..Based on these findings, we propose a model for epibranchial placode development in which Fgf3 is a major endodermal determinant required for epibranchial placode neurogenesis. ..
  3. Bosco A, Bureau C, Affaticati P, Gaspar P, Bally Cuif L, Lillesaar C. Development of hypothalamic serotoninergic neurons requires Fgf signalling via the ETS-domain transcription factor Etv5b. Development. 2013;140:372-84 pubmed publisher
    ..Our results highlight a novel role for Etv5b in neuronal development and provide support for the existence of a developmental heterogeneity among 5-HT neurons in their requirement for ETS-domain transcription factors. ..
  4. Groves J, Hammond C, Hughes S. Fgf8 drives myogenic progression of a novel lateral fast muscle fibre population in zebrafish. Development. 2005;132:4211-22 pubmed
    ..We conclude that Fgf8 drives terminal differentiation of a specific population of lateral muscle precursor cells within the early somite...
  5. Lecaudey V, Cakan Akdogan G, Norton W, Gilmour D. Dynamic Fgf signaling couples morphogenesis and migration in the zebrafish lateral line primordium. Development. 2008;135:2695-705 pubmed publisher
    ..Furthermore, this work uncovers a surprising link between internal tissue organization and collective migration. ..
  6. Hochmann S, Kaslin J, Hans S, Weber A, Machate A, Geffarth M, et al. Fgf signaling is required for photoreceptor maintenance in the adult zebrafish retina. PLoS ONE. 2012;7:e30365 pubmed publisher
    ..Ultimately, rod and cone photoreceptors are regenerated completely. Our study reveals the requirement of Fgf signaling to maintain photoreceptors and for proliferation during regeneration in the adult zebrafish retina. ..
  7. Tonou Fujimori N, Takahashi M, Onodera H, Kikuta H, Koshida S, Takeda H, et al. Expression of the FGF receptor 2 gene (fgfr2) during embryogenesis in the zebrafish Danio rerio. Mech Dev. 2002;119 Suppl 1:S173-8 pubmed
  8. Nakayama Y, Miyake A, Nakagawa Y, Mido T, Yoshikawa M, Konishi M, et al. Fgf19 is required for zebrafish lens and retina development. Dev Biol. 2008;313:752-66 pubmed
    ..Knockdown of Fgf19 also caused incorrect axon pathfinding. The present findings indicate that Fgf19 positively regulates the patterning and growth of the retina, and the differentiation and growth of the lens in zebrafish. ..
  9. Takezaki N, Figueroa F, Zaleska Rutczynska Z, Klein J. Molecular phylogeny of early vertebrates: monophyly of the agnathans as revealed by sequences of 35 genes. Mol Biol Evol. 2003;20:287-92 pubmed
    ..Our analyses also give a strong support for the separation of Chondrichthyes (cartilaginous fishes) before the divergence of Osteichthyes (bony fishes) from the other gnathostomes...

More Information

Publications40

  1. Rohs P, Ebert A, Zuba A, McFarlane S. Neuronal expression of fibroblast growth factor receptors in zebrafish. Gene Expr Patterns. 2013;13:354-61 pubmed publisher
    ..In many cases, the expression patterns are similar to those of homologous FGFRs in mouse, chicken, amphibians, and other teleosts. ..
  2. Yokoi H, Shimada A, Carl M, Takashima S, Kobayashi D, Narita T, et al. Mutant analyses reveal different functions of fgfr1 in medaka and zebrafish despite conserved ligand-receptor relationships. Dev Biol. 2007;304:326-37 pubmed
    ..Comparative analysis using different fish is thus invaluable for shedding light on evolutionary diversification of gene function. ..
  3. McCarthy N, Sidik A, Bertrand J, Eberhart J. An Fgf-Shh signaling hierarchy regulates early specification of the zebrafish skull. Dev Biol. 2016;415:261-277 pubmed publisher
    ..Collectively, our results provide a mechanistic understanding of early postchordal neurocranial development and demonstrate a hierarchy of signaling between Fgf and Hh in the development of this structure. ..
  4. Tiso N, Filippi A, Benato F, Negrisolo E, Modena N, Vaccari E, et al. Differential expression and regulation of olig genes in zebrafish. J Comp Neurol. 2009;515:378-96 pubmed publisher
    ..Our findings suggest a role for olig genes in CNS patterning as well as in multiple cell fate decisions during neural differentiation. ..
  5. Breau M, Wilkinson D, Xu Q. A Hox gene controls lateral line cell migration by regulating chemokine receptor expression downstream of Wnt signaling. Proc Natl Acad Sci U S A. 2013;110:16892-7 pubmed publisher
  6. Pouget C, Peterkin T, Simões F, Lee Y, Traver D, Patient R. FGF signalling restricts haematopoietic stem cell specification via modulation of the BMP pathway. Nat Commun. 2014;5:5588 pubmed publisher
    ..These results should help inform strategies to recapitulate the development of HSCs in vitro from pluripotent precursors. ..
  7. Kague E, Roy P, Asselin G, Hu G, Simonet J, Stanley A, et al. Osterix/Sp7 limits cranial bone initiation sites and is required for formation of sutures. Dev Biol. 2016;413:160-72 pubmed publisher
    ..The delay in bone maturation caused by loss of Sp7 leads to unregulated bone formation, revealing a new mechanism for patterning the skull and sutures. ..
  8. Yao D, Zhao F, Wu Y, Wang J, Dong W, Zhao J, et al. Dissecting the differentiation process of the preplacodal ectoderm in zebrafish. Dev Dyn. 2014;243:1338-51 pubmed publisher
  9. De Smet F, Tembuyser B, Lenard A, Claes F, Zhang J, Michielsen C, et al. Fibroblast growth factor signaling affects vascular outgrowth and is required for the maintenance of blood vessel integrity. Chem Biol. 2014;21:1310-1317 pubmed publisher
    ..In conclusion, our work illustrates the power of a small molecule probe to reveal insights into blood vessel formation and stabilization and thus of broad interest to the vascular biology community. ..
  10. Hirate Y, Okamoto H. Canopy1, a novel regulator of FGF signaling around the midbrain-hindbrain boundary in zebrafish. Curr Biol. 2006;16:421-7 pubmed
    ..This study highlights a positive-feedback loop between the FGFR pathway and Cnpy1 that may ensure the strength of FGF signaling in the MHB, leading to correct development of the tectum and cerebellum. ..
  11. Lovely C, Swartz M, McCarthy N, Norrie J, Eberhart J. Bmp signaling mediates endoderm pouch morphogenesis by regulating Fgf signaling in zebrafish. Development. 2016;143:2000-11 pubmed publisher
    ..Collectively, our analyses shed light on the tissue and signaling interactions that regulate development of the vertebrate face. ..
  12. Topczewska J, Shoela R, Tomaszewski J, Mirmira R, Gosain A. The Morphogenesis of Cranial Sutures in Zebrafish. PLoS ONE. 2016;11:e0165775 pubmed publisher
    ..Here we show RNA in situ hybridization for col1a1a, col2a1a, col10a1, bglap/osteocalcin, fgfr1a, fgfr1b, fgfr2, fgfr3, foxq1, twist2, twist3, runx2a, runx2b, sp7/osterix, and spp1/ osteopontin, indicating that the expression of ..
  13. Ota S, Tonou Fujimori N, Nakayama Y, Ito Y, Kawamura A, Yamasu K. FGF receptor gene expression and its regulation by FGF signaling during early zebrafish development. Genesis. 2010;48:707-16 pubmed publisher
    ..fgfr4 expression was first detected in late blastulae and was gradually restricted to the brain. fgfr2 and fgfr3 expression were initiated in early and late gastrulae, respectively; fgfr2 was expressed in the anterior neural ..
  14. Tsai S, Liu D, Wang W. Fibroblast growth factor (Fgf) signaling pathway regulates liver homeostasis in zebrafish. Transgenic Res. 2013;22:301-14 pubmed publisher
    ..Disruption of the Fgf signal-mediated metabolism might indirectly affect hepatocyte proliferation. ..
  15. Kaslin J, Ganz J, Geffarth M, Grandel H, Hans S, Brand M. Stem cells in the adult zebrafish cerebellum: initiation and maintenance of a novel stem cell niche. J Neurosci. 2009;29:6142-53 pubmed publisher
    ..Nevertheless, retained epithelial properties such as distinct polarization and ventricular contact are critical common determinants to maintain neural stem cell activity in vertebrates. ..
  16. Li M, Page McCaw P, Chen W. FGF1 Mediates Overnutrition-Induced Compensatory β-Cell Differentiation. Diabetes. 2016;65:96-109 pubmed publisher
    ..Thus, the recently discovered antidiabetes function of FGF1 may act partially through increasing β-cell differentiation. ..
  17. Lindy A, Basehore M, Munisha M, Williams A, Friez M, Writzl K, et al. Identification of a novel insertion mutation in FGFR3 that causes thanatophoric dysplasia type 1. Am J Med Genet A. 2016;170:1573-9 pubmed publisher
    ..These malformations result from autosomal dominant mutations in the fibroblast growth factor receptor 3 (FGFR3) gene...
  18. Hu M, Bai Y, Zhang C, Liu F, Cui Z, Chen J, et al. Liver-Enriched Gene 1, a Glycosylated Secretory Protein, Binds to FGFR and Mediates an Anti-stress Pathway to Protect Liver Development in Zebrafish. PLoS Genet. 2016;12:e1005881 pubmed publisher
    ..Further studies reveal that Leg1a binds to FGFR3 and mediates a novel anti-stress pathway to protect liver development through enhancing Erk activity...
  19. Waskiewicz A, Rikhof H, Moens C. Eliminating zebrafish pbx proteins reveals a hindbrain ground state. Dev Cell. 2002;3:723-33 pubmed
  20. Utami K, Winata C, Hillmer A, Aksoy I, Long H, Liany H, et al. Impaired development of neural-crest cell-derived organs and intellectual disability caused by MED13L haploinsufficiency. Hum Mutat. 2014;35:1311-20 pubmed publisher
  21. Hall C, Flores M, Murison G, Crosier K, Crosier P. An essential role for zebrafish Fgfrl1 during gill cartilage development. Mech Dev. 2006;123:925-40 pubmed
    ..A duplicate zebrafish gene, fgfrl1b, has now been identified. We show that Fgfrl1b is also required for proper formation of all ventral cartilage elements and acts cooperatively with Fgfrl1a during gill cartilage formation. ..
  22. Tallafuss A, Bally Cuif L. Tracing of her5 progeny in zebrafish transgenics reveals the dynamics of midbrain-hindbrain neurogenesis and maintenance. Development. 2003;130:4307-23 pubmed
    ..Together, our results suggest a model where an ordered MH pro-domain is identified at gastrulation, and where cell identity choices within this domain are subsequently differentially controlled by Fgf8 and Pax2.1 functions. ..
  23. Liu D, Tsai S, Lin B, Jiang Y, Wang W. Fibroblast growth factor receptor 2c signaling is required for intestinal cell differentiation in zebrafish. PLoS ONE. 2013;8:e58310 pubmed publisher
    ..These findings provide new evidences that Fgf signaling is required for the differentiation of intestinal cells in the zebrafish developing gut. ..
  24. Duszynski R, Topczewski J, LeClair E. Divergent requirements for fibroblast growth factor signaling in zebrafish maxillary barbel and caudal fin regeneration. Dev Growth Differ. 2013;55:282-300 pubmed publisher
  25. Sleptsova Friedrich I, Li Y, Emelyanov A, Ekker M, Korzh V, Ge R. fgfr3 and regionalization of anterior neural tube in zebrafish. Mech Dev. 2001;102:213-7 pubmed
    Here we describe the isolation of the zebrafish fgfr3 gene, its structure and chromosomal location. Expression in wild type embryos occurs in the axial mesoderm, the diencephalon, the anterior hindbrain and the anterior spinal cord...
  26. Garcia G, Goodale B, Wiley M, La Du J, Hendrix D, Tanguay R. In Vivo Characterization of an AHR-Dependent Long Noncoding RNA Required for Proper Sox9b Expression. Mol Pharmacol. 2017;91:609-619 pubmed publisher
    ..Our results place slincR as an intermediate between AHR2 activation and the reduction of sox9b mRNA in the AHR2 signaling pathway. ..
  27. Maier E, Whitfield T. RA and FGF signalling are required in the zebrafish otic vesicle to pattern and maintain ventral otic identities. PLoS Genet. 2014;10:e1004858 pubmed publisher
    ..In addition, our results indicate that FGF and RA signalling act in a feedback loop in the anterior OV, crucial for pattern refinement. ..
  28. Koch P, Löhr H, Driever W. A mutation in cnot8, component of the Ccr4-not complex regulating transcript stability, affects expression levels of developmental regulators and reveals a role of Fgf3 in development of caudal hypothalamic dopaminergic neurons. PLoS ONE. 2014;9:e113829 pubmed publisher
    ..Our data indicate that attenuation of Cnot8 activity differentially affects mRNA levels of developmental control genes. ..
  29. Esterberg R, Fritz A. dlx3b/4b are required for the formation of the preplacodal region and otic placode through local modulation of BMP activity. Dev Biol. 2009;325:189-99 pubmed publisher
    ..Our results provide insight into the mechanisms of PPR specification as well as the role of dlx3b/4b function in PPR and otic placode induction. ..
  30. Topp S, Stigloher C, Komisarczuk A, Adolf B, Becker T, Bally Cuif L. Fgf signaling in the zebrafish adult brain: association of Fgf activity with ventricular zones but not cell proliferation. J Comp Neurol. 2008;510:422-39 pubmed publisher
    ..Together these results stress the importance of Fgf signaling in the adult brain and establish the basis to study its function in zebrafish, in particular in relation to adult neurogenesis. ..
  31. Aksoy I, Utami K, Winata C, Hillmer A, Rouam S, Briault S, et al. Personalized genome sequencing coupled with iPSC technology identifies GTDC1 as a gene involved in neurodevelopmental disorders. Hum Mol Genet. 2017;26:367-382 pubmed publisher
    ..Our findings highlight the importance of combining sequencing technologies with the iPSC technology for NDDs modelling that could be applied for personalized medicine. ..