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Genomes and GenesSpecies | fgfr1aSummaryGene Symbol: fgfr1a Description: fibroblast growth factor receptor 1a Alias: cb231, fgfr1, sb:cb231, FGFR-1-A, bFGF-R-1-A, basic fibroblast growth factor receptor 1-A, fibroblast growth factor receptor 1, fibroblast growth factor receptor 1-A Species: zebrafish Top Publications
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Publications
Wnt/beta-catenin and Fgf signaling control collective cell migration by restricting chemokine receptor expressionAndy Aman
Department of Neurobiology and Anatomy, University of Utah School of Medicine, 401 MREB, 20N Medical Drive, Salt Lake City, UT 84132, USA
Dev Cell 15:749-61. 2008..Although the Fgf, Wnt/beta-catenin, and chemokine signaling pathways are well known to be involved in cancer progression, these studies provide in vivo evidence that these pathways are functionally linked...- Smad2/3 activities are required for induction and patterning of the neuroectoderm in zebrafishShunji Jia
Protein Science Laboratory of Ministry of Education, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
Dev Biol 333:273-84. 2009..Thus, Smad2/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis... 
Roles for Fgf signaling during zebrafish fin regenerationK D Poss
Howard Hughes Medical Institute, Eccles Institute of Human Genetics, University of Utah Health Sciences Center, 15N 2030E, Salt Lake City, Utah, 84112, USA
Dev Biol 222:347-58. 2000..We find that fibroblast growth factor receptor 1 (fgfr1) is expressed in mesenchymal cells underlying the wound epidermis during blastema formation ..- Modulation of Fgfr1a signaling in zebrafish reveals a genetic basis for the aggression-boldness syndromeWilliam H J Norton
Zebrafish Neurogenetics, Laboratory of Neurobiology and Development, Institut de Neurobiologie Alfred Fessard, Unité Propre de Recherche 3294, CNRS, Avenue de la Terrasse, Gif sur Yvette, 91190, France
J Neurosci 31:13796-807. 2011..Here we show that mutation of the gene encoding fibroblast growth factor receptor 1a (fgfr1a) simultaneously increases aggression, boldness, and exploration in adult zebrafish... 
Compensatory growth mechanisms regulated by BMP and FGF signaling mediate liver regeneration in zebrafish after partial hepatectomyNatalia G Kan
Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA
FASEB J 23:3516-25. 2009....- Stem cells in the adult zebrafish cerebellum: initiation and maintenance of a novel stem cell nicheJan Kaslin
Biotechnology Center and Center for Regenerative Therapies Dresden, Dresden University of Technology, 01307 Dresden, Germany
J Neurosci 29:6142-53. 2009..Nevertheless, retained epithelial properties such as distinct polarization and ventricular contact are critical common determinants to maintain neural stem cell activity in vertebrates... - FGF signalling during embryo development regulates cilia length in diverse epitheliaJudith M Neugebauer
Department of Neurobiology and Anatomy, University of Utah School of Medicine, Eccles Institute of Human Genetics, Building 533, Room 3160, 15 North 2030 East, Salt Lake City, Utah 84112 5330, USA
Nature 458:651-4. 2009..Morpholino knockdown of FGF receptor 1 (Fgfr1) in zebrafish cell-autonomously reduces cilia length in Kupffer's vesicle and perturbs directional fluid flow .. - dlx3b/4b are required for the formation of the preplacodal region and otic placode through local modulation of BMP activityRobert Esterberg
Department of Biology, Emory University, Atlanta, GA 30322, USA
Dev Biol 325:189-99. 2009..Our results provide insight into the mechanisms of PPR specification as well as the role of dlx3b/4b function in PPR and otic placode induction... - Fgfs control homeostatic regeneration in adult zebrafish finsAiron A Wills
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Development 135:3063-70. 2008..Our experiments reveal that the facultative machinery that regenerates amputated teleost fins also has a surprisingly vigorous role in homeostatic regeneration... - Fgf signaling in the zebrafish adult brain: association of Fgf activity with ventricular zones but not cell proliferationStefanie Topp
Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Department Zebrafish Neurogenetics, Institute of Developmental Genetics, D 85764 Neuherberg, Germany
J Comp Neurol 510:422-39. 2008..We report expression of Fgf signals (fgf3,4,8a,8b,17b), receptors (fgfr1-4), and targets (erm, pea3, dusp6, spry1,2,4, and P-ERK) and document that genes of the embryonic fgf8 .. - Modular scanning FCS quantifies receptor-ligand interactions in living multicellular organismsJonas Ries
Biotechnology Center, Technical University of Dresden, Dresden, Germany
Nat Methods 6:643-5. 2009..We quantified the mobility of fibroblast growth factor receptors Fgfr1 and Fgfr4 in cell membranes of living zebrafish embryos and determined their in vivo binding affinities to their .. - Duplication of fgfr1 permits Fgf signaling to serve as a target for selection during domesticationNicolas Rohner
Max Planck Institute for Developmental Biology, Spemannstrasse 35, 72076 Tubingen, Germany
Curr Biol 19:1642-7. 2009..The affected gene is fibroblast growth factor receptor 1 (fgfr1), which is known to have an essential embryonic function in vertebrate development... - Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and functionAvinash Persaud
Programs in Cell Biology and Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
EMBO J 30:3259-73. 2011b>Fibroblast growth factor receptor 1 (FGFR1) has critical roles in cellular proliferation and differentiation during animal development and adult homeostasis... - Fgf20b is required for the ectomesenchymal fate establishment of cranial neural crest cells in zebrafishHajime Yamauchi
Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
Biochem Biophys Res Commun 409:705-10. 2011..However, the proliferation and apoptosis of cranial neural crest cells were essentially unchanged. Fgfr1 knockdown embryos also showed dysplastic neurocranial and pharyngeal cartilages... - Identification of cis regulatory features in the embryonic zebrafish genome through large-scale profiling of H3K4me1 and H3K4me3 binding sitesAaron W Aday
Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01602, USA
Dev Biol 357:450-62. 2011.... - FGF receptor gene expression and its regulation by FGF signaling during early zebrafish developmentSatoshi Ota
Division of Life Science, Graduate School of Science and Engineering, Saitama University, Shimo okubo, Sakura ku, Saitama, Japan
Genesis 48:707-16. 2010..b>fgfr1 alone was expressed maternally throughout the blastoderm, and then zygotically in the anterior neural plate and .. - Pdlim7 is required for maintenance of the mesenchymal/epidermal Fgf signaling feedback loop during zebrafish pectoral fin developmentTroy Camarata
Department of Pediatrics, Northwestern University, The Feinberg School of Medicine, Children s Memorial Research Center, Chicago, IL 60614, USA
BMC Dev Biol 10:104. 2010..This Tbx5 regulation is critical in heart formation, but the coexpression of both proteins in other developing tissues suggests a broader functional role... - Atoh1a expression must be restricted by Notch signaling for effective morphogenesis of the posterior lateral line primordium in zebrafishMiho Matsuda
Laboratory of Molecular Genetics, Section on Neural Developmental Dynamics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Development 137:3477-87. 2010..in the central cell, it drives expression of fgf10 and of the Notch ligand deltaD, while it inhibits expression of fgfr1. As a source of Fgf10, the central cell activates the FGF pathway in neighboring cells, ensuring that they form .. - Heterogeneity and Fgf dependence of adult neural progenitors in the zebrafish telencephalonJulia Ganz
Biotechnology Center and Center for Regenerative Therapies Dresden, Dresden University of Technology, Tatzberg 47 49, 01307 Dresden, Germany
Glia 58:1345-63. 2010.... - Fgf8 morphogen gradient forms by a source-sink mechanism with freely diffusing moleculesShuizi Rachel Yu
Developmental Genetics, Biotechnology Center, TUD, Tatzberg 47 49, 01307 Dresden, Germany
Nature 461:533-6. 2009..Our results demonstrate that a freely diffusing morphogen can set up concentration gradients in a complex multicellular tissue by a simple source-sink mechanism... - Dynamic Fgf signaling couples morphogenesis and migration in the zebrafish lateral line primordiumVirginie Lecaudey
European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg, Germany
Development 135:2695-705. 2008..Furthermore, this work uncovers a surprising link between internal tissue organization and collective migration... - FGF-dependent mechanosensory organ patterning in zebrafishAlex Nechiporuk
University of Washington, School of Medicine, Department of Biological Structure, Seattle, WA 98195 7420, USA
Science 320:1774-7. 2008..This previously unrecognized mechanism may be applicable to understanding segmentation and morphogenesis in other organ systems... - MicroRNA-9 directs late organizer activity of the midbrain-hindbrain boundaryChristoph Leucht
Department of Zebrafish Neurogenetics, Institute of Developmental Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
Nat Neurosci 11:641-8. 2008..Together, these findings highlight a previously unknown mechanism by which a single microRNA fine-tunes late MHB coherence via its co-regulation of patterning activities and neurogenesis... - Canopy1, a novel regulator of FGF signaling around the midbrain-hindbrain boundary in zebrafishYoshikazu Hirate
Laboratory for Developmental Gene Regulation, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama, 351 0198, Japan
Curr Biol 16:421-7. 2006..Cnpy1 is localized in the endoplasmic reticulum and interacts with FGFR1. This study highlights a positive-feedback loop between the FGFR pathway and Cnpy1 that may ensure the strength of .. - Inhibition of zebrafish fin regeneration using in vivo electroporation of morpholinos against fgfr1 and msxbRyan Thummel
Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, USA
Dev Dyn 235:336-46. 2006..Morpholino oligonucleotides against fgfr1 and msxb were utilized and knock-down of both proteins resulted in reduced fin outgrowth... - Fgf signaling instructs position-dependent growth rate during zebrafish fin regenerationYoonsung Lee
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Development 132:5173-83. 2005..Our results demonstrate that Fgf signaling defines position-dependent blastemal properties and growth rates for the regenerating zebrafish appendage... - Fgf8 drives myogenic progression of a novel lateral fast muscle fibre population in zebrafishJulie A Groves
MRC Centre for Developmental Neurobiology and Randall Division for Cell and Molecular Biophysics, New Hunt s House, King s College London, London SE1 1UL, UK
Development 132:4211-22. 2005..We conclude that Fgf8 drives terminal differentiation of a specific population of lateral muscle precursor cells within the early somite... - Endoderm-derived Fgf3 is necessary and sufficient for inducing neurogenesis in the epibranchial placodes in zebrafishAlexei Nechiporuk
Department of Biological Structure, University of Washington, Seattle, WA 98195 7420, USA
Development 132:3717-30. 2005..Based on these findings, we propose a model for epibranchial placode development in which Fgf3 is a major endodermal determinant required for epibranchial placode neurogenesis... - Zebrafish Polycomb group gene ph2alpha is required for epiboly and tailbud formation acting downstream of FGF signalingYuta Komoike
Department of Biology, School of Education and in Integrated Bioscience and Biomedical Engineering, Graduate School of Science and Engineering, Waseda University, 1 6 1 Nishi Waseda, Shinjuku, Tokyo 169 8050, Japan
Biochem Biophys Res Commun 328:858-66. 2005..Treatment with SU5402, an inhibitor of Fgfrs, or injection of dominant-negative Fgfr1 DNA markedly reduced ph2alpha expression in the tailbud... - Zebrafish fgfr1 is a member of the fgf8 synexpression group and is required for fgf8 signalling at the midbrain-hindbrain boundarySteffen Scholpp
Max Planck Institute of Molecular Cell Biology and Genetics, Department of Genetics, University of Technology TU, 01307, Dresden, Germany
Dev Genes Evol 214:285-95. 2004..Here, we describe cloning and expression analysis of the zebrafish fibroblast growth factor receptor 1 ( fgfr1)... - Expression of the FGF receptor 2 gene (fgfr2) during embryogenesis in the zebrafish Danio rerioNoriko Tonou-Fujimori
Department of Regulation Biology, Faculty of Science, Saitama University, 255 Shimo okubo, Saitama City, Saitama 338 8570, Japan
Mech Dev 119:S173-8. 2002..We compared the expression of the four fgfr genes (fgfr1-4) in the CNS of zebrafish embryos and show that fgfr1 is the only fgfr gene that is expressed in the dorsal .. - Chemical modulation of receptor signaling inhibits regenerative angiogenesis in adult zebrafishPeter E Bayliss
Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
Nat Chem Biol 2:265-73. 2006..This study illustrates the utility of the adult zebrafish as a new model system for receptor signaling and chemical biology... - Zebrafish endoderm formation is regulated by combinatorial Nodal, FGF and BMP signallingMorgane Poulain
National Institute for Medical Research, Division of Developmental Biology, The Ridgeway, Mill Hill, London, UK
Development 133:2189-200. 2006..These results identify a molecular mechanism whereby FGF attenuates Nodal-induced endodermal transcription factors and highlight a potential mechanism whereby mesoderm and endoderm fates could segregate from each other... - Gene expression analysis on sections of zebrafish regenerating fins reveals limitations in the whole-mount in situ hybridization methodA Smith
Ottawa Health Research Institute, Ottawa, ON, Canada
Dev Dyn 237:417-25. 2008.... - Fgf19 is required for zebrafish lens and retina developmentYoshiaki Nakayama
Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
Dev Biol 313:752-66. 2008..Knockdown of Fgf19 also caused incorrect axon pathfinding. The present findings indicate that Fgf19 positively regulates the patterning and growth of the retina, and the differentiation and growth of the lens in zebrafish... - Regulated addition of new myocardial and epicardial cells fosters homeostatic cardiac growth and maintenance in adult zebrafishAiron A Wills
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Development 135:183-92. 2008..Our results demonstrate that the adult zebrafish ventricle grows and is maintained by cardiomyocyte hyperplasia, and that epicardial cells are added to the ventricle in an Fgf-dependent fashion to support homeostasis... - Bmp and Fgf signaling are essential for liver specification in zebrafishDonghun Shin
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Liver Center, University of California, San Francisco, CA 94158, USA
Development 134:2041-50. 2007.... - Mutant analyses reveal different functions of fgfr1 in medaka and zebrafish despite conserved ligand-receptor relationshipsHayato Yokoi
Department of Biological Sciences, Graduate School of Science, University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
Dev Biol 304:326-37. 2007..Positional-candidate cloning revealed that the hdf mutation causes a functionally null form of Fgfr1. The fgfr1hdf is thus the first fgf receptor mutant in fish... - Specification of epibranchial placodes in zebrafishAlexei Nechiporuk
Department of Biological Structure, University of Washington, Seattle, WA 98195 7420, USA
Development 134:611-23. 2007..The coordinated interplay between craniofacial tissues would thus assure proper spatial and temporal interactions in the shaping of the vertebrate head... - An essential role for zebrafish Fgfrl1 during gill cartilage developmentChris Hall
Department of Molecular Medicine and Pathology, School of Medical Sciences, The University of Auckland, P O 92019, Auckland, New Zealand
Mech Dev 123:925-40. 2006..A duplicate zebrafish gene, fgfrl1b, has now been identified. We show that Fgfrl1b is also required for proper formation of all ventral cartilage elements and acts cooperatively with Fgfrl1a during gill cartilage formation... - Development of GnRH cells: Setting the stage for pubertyK E Whitlock
Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, United States
Mol Cell Endocrinol 254:39-50. 2006..Thus the signaling of the GnRH neuronal circuitry is set up early in development laying the foundation for the GnRH network that is activated at puberty leading to reproductive function in the mature animal... - Zebrafish Mesp family genes, mesp-a and mesp-b are segmentally expressed in the presomitic mesoderm, and Mesp-b confers the anterior identity to the developing somitesA Sawada
Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
Development 127:1691-702. 2000..a reduction in expression of the posterior genes, myoD and notch5, with uniform expression of the anterior genes, FGFR1, papc and notch6...
Research Grants
- DEVELOPMENT OF THE OLFACTORY SYSTEM IN ZEBRAFISHKATHLEEN WHITLOCK; Fiscal Year: 2004..abstract_text> ..
- Development of gonadotropin releasing hormone cellsKATHLEEN WHITLOCK; Fiscal Year: 2009....