fgfr1a

Summary

Gene Symbol: fgfr1a
Description: fibroblast growth factor receptor 1a
Alias: cb231, fgfr1, sb:cb231, FGFR-1-A, bFGF-R-1-A, basic fibroblast growth factor receptor 1-A, fibroblast growth factor receptor 1, fibroblast growth factor receptor 1-A
Species: zebrafish

Top Publications

  1. doi Wnt/beta-catenin and Fgf signaling control collective cell migration by restricting chemokine receptor expression
    Andy Aman
    Department of Neurobiology and Anatomy, University of Utah School of Medicine, 401 MREB, 20N Medical Drive, Salt Lake City, UT 84132, USA
    Dev Cell 15:749-61. 2008
  2. doi Smad2/3 activities are required for induction and patterning of the neuroectoderm in zebrafish
    Shunji Jia
    Protein Science Laboratory of Ministry of Education, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    Dev Biol 333:273-84. 2009
  3. ncbi Fgf signaling instructs position-dependent growth rate during zebrafish fin regeneration
    Yoonsung Lee
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 132:5173-83. 2005
  4. pmc Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function
    Avinash Persaud
    Programs in Cell Biology and Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    EMBO J 30:3259-73. 2011
  5. pmc Fgf signaling is required for photoreceptor maintenance in the adult zebrafish retina
    Sarah Hochmann
    DFG Center for Regenerative Therapies Dresden, Cluster of Excellence CRTD, Technische Universitat Dresden, Dresden, Germany
    PLoS ONE 7:e30365. 2012
  6. pmc Compensatory growth mechanisms regulated by BMP and FGF signaling mediate liver regeneration in zebrafish after partial hepatectomy
    Natalia G Kan
    Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA
    FASEB J 23:3516-25. 2009
  7. doi Duplication of fgfr1 permits Fgf signaling to serve as a target for selection during domestication
    Nicolas Rohner
    Max Planck Institute for Developmental Biology, Spemannstrasse 35, 72076 Tubingen, Germany
    Curr Biol 19:1642-7. 2009
  8. doi Fgf20b is required for the ectomesenchymal fate establishment of cranial neural crest cells in zebrafish
    Hajime Yamauchi
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    Biochem Biophys Res Commun 409:705-10. 2011
  9. ncbi Zebrafish fgfr1 is a member of the fgf8 synexpression group and is required for fgf8 signalling at the midbrain-hindbrain boundary
    Steffen Scholpp
    Max Planck Institute of Molecular Cell Biology and Genetics, Department of Genetics, University of Technology TU, 01307, Dresden, Germany
    Dev Genes Evol 214:285-95. 2004
  10. ncbi Bmp and Fgf signaling are essential for liver specification in zebrafish
    Donghun Shin
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Liver Center, University of California, San Francisco, CA 94158, USA
    Development 134:2041-50. 2007

Research Grants

  1. DEVELOPMENT OF THE OLFACTORY SYSTEM IN ZEBRAFISH
    KATHLEEN WHITLOCK; Fiscal Year: 2004
  2. Development of gonadotropin releasing hormone cells
    KATHLEEN WHITLOCK; Fiscal Year: 2009

Scientific Experts

  • KATHLEEN WHITLOCK
  • Alex Nechiporuk
  • William Norton
  • Ryan Thummel
  • Nicolas Rohner
  • Michael Brand
  • Jan Kaslin
  • Airon A Wills
  • Da Wei Liu
  • Su Mei Tsai
  • Kenneth D Poss
  • Sarah Hochmann
  • Laure Bally-Cuif
  • Julia Ganz
  • Virginie Lecaudey
  • Shuizi Rachel Yu
  • Jonas Ries
  • Steffen Scholpp
  • Wen Pin Wang
  • Robert J Duszynski
  • Adriana Bosco
  • M Priyadarshini
  • Wei Hao Liao
  • Ana Sofia Azevedo
  • Marie A Breau
  • Ankita Das
  • P K Umasankar
  • Sandra Ernst
  • Molly J Harding
  • Noriko Tonou-Fujimori
  • Avinash Persaud
  • Hajime Yamauchi
  • Ajay B Chitnis
  • Aaron W Aday
  • Michaela Geffarth
  • Stefan Hans
  • Miho Matsuda
  • Satoshi Ota
  • Troy Camarata
  • Nobuyuki Itoh
  • Ayumi Miyake
  • Judith M Neugebauer
  • Robert Esterberg
  • Natalia G Kan
  • Petra Schwille
  • Markus Burkhardt
  • Shunji Jia
  • Andy Aman
  • Yoshiaki Nakayama
  • Christoph Leucht
  • A Smith
  • Christian Stigloher
  • Stefanie Topp
  • Akinori Kawamura
  • Donghun Shin
  • Hayato Yokoi
  • Yoshikazu Hirate
  • Chris Hall
  • Morgane Poulain
  • Kyo Yamasu
  • Peter E Bayliss
  • Yoonsung Lee
  • Julie A Groves
  • Yuta Komoike
  • Hiroyuki Takeda
  • Yung Shu Kuan
  • Patricia Gaspar
  • Bih Fen Lin
  • Chia Hsiung Cheng
  • Charlotte Bureau
  • Yun Jin Jiang
  • Gen Der Chen
  • Pung Pung Hwang
  • Wen Ta Chiu
  • Y C Chen
  • J Tuimala
  • P Panula
  • Elizabeth E LeClair
  • Kuo Sheng Hung
  • Pierre Affaticati
  • Chang Jen Huang
  • Jacek Topczewski
  • Sheng Ping L Hwang
  • Christina Lillesaar
  • Mehmet Ender Avci
  • David G Wilkinson
  • James R Thieman
  • Anja Machate
  • Leonor Saude
  • Antonio Jacinto

Detail Information

Publications56

  1. doi Wnt/beta-catenin and Fgf signaling control collective cell migration by restricting chemokine receptor expression
    Andy Aman
    Department of Neurobiology and Anatomy, University of Utah School of Medicine, 401 MREB, 20N Medical Drive, Salt Lake City, UT 84132, USA
    Dev Cell 15:749-61. 2008
    ..Although the Fgf, Wnt/beta-catenin, and chemokine signaling pathways are well known to be involved in cancer progression, these studies provide in vivo evidence that these pathways are functionally linked...
  2. doi Smad2/3 activities are required for induction and patterning of the neuroectoderm in zebrafish
    Shunji Jia
    Protein Science Laboratory of Ministry of Education, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    Dev Biol 333:273-84. 2009
    ..Thus, Smad2/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis...
  3. ncbi Fgf signaling instructs position-dependent growth rate during zebrafish fin regeneration
    Yoonsung Lee
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 132:5173-83. 2005
    ..Our results demonstrate that Fgf signaling defines position-dependent blastemal properties and growth rates for the regenerating zebrafish appendage...
  4. pmc Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function
    Avinash Persaud
    Programs in Cell Biology and Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    EMBO J 30:3259-73. 2011
    b>Fibroblast growth factor receptor 1 (FGFR1) has critical roles in cellular proliferation and differentiation during animal development and adult homeostasis...
  5. pmc Fgf signaling is required for photoreceptor maintenance in the adult zebrafish retina
    Sarah Hochmann
    DFG Center for Regenerative Therapies Dresden, Cluster of Excellence CRTD, Technische Universitat Dresden, Dresden, Germany
    PLoS ONE 7:e30365. 2012
    ..Ultimately, rod and cone photoreceptors are regenerated completely. Our study reveals the requirement of Fgf signaling to maintain photoreceptors and for proliferation during regeneration in the adult zebrafish retina...
  6. pmc Compensatory growth mechanisms regulated by BMP and FGF signaling mediate liver regeneration in zebrafish after partial hepatectomy
    Natalia G Kan
    Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA
    FASEB J 23:3516-25. 2009
    ....
  7. doi Duplication of fgfr1 permits Fgf signaling to serve as a target for selection during domestication
    Nicolas Rohner
    Max Planck Institute for Developmental Biology, Spemannstrasse 35, 72076 Tubingen, Germany
    Curr Biol 19:1642-7. 2009
    ..The affected gene is fibroblast growth factor receptor 1 (fgfr1), which is known to have an essential embryonic function in vertebrate development...
  8. doi Fgf20b is required for the ectomesenchymal fate establishment of cranial neural crest cells in zebrafish
    Hajime Yamauchi
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    Biochem Biophys Res Commun 409:705-10. 2011
    ..However, the proliferation and apoptosis of cranial neural crest cells were essentially unchanged. Fgfr1 knockdown embryos also showed dysplastic neurocranial and pharyngeal cartilages...
  9. ncbi Zebrafish fgfr1 is a member of the fgf8 synexpression group and is required for fgf8 signalling at the midbrain-hindbrain boundary
    Steffen Scholpp
    Max Planck Institute of Molecular Cell Biology and Genetics, Department of Genetics, University of Technology TU, 01307, Dresden, Germany
    Dev Genes Evol 214:285-95. 2004
    ..Here, we describe cloning and expression analysis of the zebrafish fibroblast growth factor receptor 1 ( fgfr1)...
  10. ncbi Bmp and Fgf signaling are essential for liver specification in zebrafish
    Donghun Shin
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Liver Center, University of California, San Francisco, CA 94158, USA
    Development 134:2041-50. 2007
    ....
  11. ncbi Inhibition of zebrafish fin regeneration using in vivo electroporation of morpholinos against fgfr1 and msxb
    Ryan Thummel
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, USA
    Dev Dyn 235:336-46. 2006
    ..Morpholino oligonucleotides against fgfr1 and msxb were utilized and knock-down of both proteins resulted in reduced fin outgrowth...
  12. ncbi Roles for Fgf signaling during zebrafish fin regeneration
    K D Poss
    Howard Hughes Medical Institute, Eccles Institute of Human Genetics, University of Utah Health Sciences Center, 15N 2030E, Salt Lake City, Utah, 84112, USA
    Dev Biol 222:347-58. 2000
    ..We find that fibroblast growth factor receptor 1 (fgfr1) is expressed in mesenchymal cells underlying the wound epidermis during blastema formation ..
  13. ncbi Fgf19 is required for zebrafish lens and retina development
    Yoshiaki Nakayama
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto 606 8501, Japan
    Dev Biol 313:752-66. 2008
    ..Knockdown of Fgf19 also caused incorrect axon pathfinding. The present findings indicate that Fgf19 positively regulates the patterning and growth of the retina, and the differentiation and growth of the lens in zebrafish...
  14. doi Shroom3 is required downstream of FGF signalling to mediate proneuromast assembly in zebrafish
    Sandra Ernst
    Centre for Biological Signalling Studies, University of Freiburg, Schänzlestrasse 18, D 79104 Freiburg, Germany
    Development 139:4571-81. 2012
    ..In conclusion, we uncovered the first mechanistic link between patterning and morphogenesis during LL sensory organ formation...
  15. pmc Protein tyrosine phosphatase receptor type O (Ptpro) regulates cerebellar formation during zebrafish development through modulating Fgf signaling
    Wei Hao Liao
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 104, Taiwan
    Cell Mol Life Sci 70:2367-81. 2013
    ..Moreover, Ptpro physically interacted with the Fgf receptor 1a (Fgfr1a) and dephosphorylated Fgfr1a in a dose-dependant manner...
  16. pmc An amputation resets positional information to a proximal identity in the regenerating zebrafish caudal fin
    Ana Sofia Azevedo
    Instituto de Medicina Molecular e Instituto de Histologia e Biologia do Desenvolvimento, Faculdade de Medicina da Universidade de Lisboa, Lisbon, 1649 028, Portugal
    BMC Dev Biol 12:24. 2012
    ..We investigated the existence of positional information for bifurcation formation by performing repeated amputations at different proximal-distal places along the fin...
  17. pmc Divergent requirements for fibroblast growth factor signaling in zebrafish maxillary barbel and caudal fin regeneration
    Robert J Duszynski
    Department of Biological Sciences, DePaul University, Chicago, IL 60614, USA
    Dev Growth Differ 55:282-300. 2013
    ..Multiple FGF ligands (fgf20a, fgf24), receptors (fgfr1-4) and downstream targets (pea3, il17d) are expressed in normal and regenerating barbel tissue, confirming FGF ..
  18. pmc Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning
    P K Umasankar
    Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Nat Cell Biol 14:488-501. 2012
    ..Still, the fcho1 morphant phenotype is distinct from severe embryonic defects apparent when AP-2 is depleted. Our data thus challenge the primacy of FCHO1/2 in coat initiation...
  19. doi Development of hypothalamic serotoninergic neurons requires Fgf signalling via the ETS-domain transcription factor Etv5b
    Adriana Bosco
    Zebrafish Neurogenetics Group, Laboratory of Neurobiology and Development, CNRS UPR3294, Institute of Neurobiology Albert Fessard, 1 Avenue de Terrasse, 91198 Gif sur Yvette, France
    Development 140:372-84. 2013
    ..Our results highlight a novel role for Etv5b in neuronal development and provide support for the existence of a developmental heterogeneity among 5-HT neurons in their requirement for ETS-domain transcription factors...
  20. pmc Bmps and id2a act upstream of Twist1 to restrict ectomesenchyme potential of the cranial neural crest
    Ankita Das
    Broad CIRM Center, University of Southern California Keck School of Medicine, Los Angeles, California, United States of America
    PLoS Genet 8:e1002710. 2012
    ..Together our model shows how the integration of Bmp inhibition at its origin and Fgf activation along its migratory route would confer temporal and spatial specificity to the generation of ectomesenchyme from the neural crest...
  21. doi A zebrafish model of PINK1 deficiency reveals key pathway dysfunction including HIF signaling
    M Priyadarshini
    Neuroscience center and Institute of Biomedicine Anatomy, University of Helsinki, Haartmaninkatu 8, 00290 Helsinki, Finland
    Neurobiol Dis 54:127-38. 2013
    ..Our findings suggest that a lack of pink1 in zebrafish alters many vital and critical pathways in addition to the HIF signaling pathway...
  22. pmc Fgfr-Ras-MAPK signaling is required for apical constriction via apical positioning of Rho-associated kinase during mechanosensory organ formation
    Molly J Harding
    Department of Cell and Developmental Biology, Oregon Health and Science University, Portland, OR 97239, USA
    Development 139:3130-5. 2012
    ..This mechanism presents a novel cellular strategy for driving cell shape changes...
  23. doi Fibroblast growth factor (Fgf) signaling pathway regulates liver homeostasis in zebrafish
    Su Mei Tsai
    Institute of Medical Sciences, Tzu Chi University, No 701, Section 3, Chung Yang Road, Hualien, 970, Taiwan
    Transgenic Res 22:301-14. 2013
    ..Disruption of the Fgf signal-mediated metabolism might indirectly affect hepatocyte proliferation...
  24. pmc Chemokine and Fgf signalling act as opposing guidance cues in formation of the lateral line primordium
    Marie A Breau
    Division of Developmental Neurobiology, MRC National Institute for Medical Research, London NW7 1AA, UK
    Development 139:2246-53. 2012
    ..These findings reveal a novel chemotactic role for Fgf signalling in which it enables the coalescence of the lateral line primordium from an initial fuzzy pattern into a compact group of migrating cells...
  25. pmc Fibroblast growth factor receptor 2c signaling is required for intestinal cell differentiation in zebrafish
    Da Wei Liu
    Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan
    PLoS ONE 8:e58310. 2013
    ..Although fibroblast growth factor (Fgf) signaling is important for cell proliferation and differentiation in various tissues, its role in intestinal differentiation is less well understood...
  26. doi Modulation of Fgfr1a signaling in zebrafish reveals a genetic basis for the aggression-boldness syndrome
    William H J Norton
    Zebrafish Neurogenetics, Laboratory of Neurobiology and Development, Institut de Neurobiologie Alfred Fessard, Unité Propre de Recherche 3294, CNRS, Avenue de la Terrasse, Gif sur Yvette, 91190, France
    J Neurosci 31:13796-807. 2011
    ..Here we show that mutation of the gene encoding fibroblast growth factor receptor 1a (fgfr1a) simultaneously increases aggression, boldness, and exploration in adult zebrafish...
  27. doi Fgf8 morphogen gradient forms by a source-sink mechanism with freely diffusing molecules
    Shuizi Rachel Yu
    Developmental Genetics, Biotechnology Center, TUD, Tatzberg 47 49, 01307 Dresden, Germany
    Nature 461:533-6. 2009
    ..Our results demonstrate that a freely diffusing morphogen can set up concentration gradients in a complex multicellular tissue by a simple source-sink mechanism...
  28. ncbi Zebrafish Mesp family genes, mesp-a and mesp-b are segmentally expressed in the presomitic mesoderm, and Mesp-b confers the anterior identity to the developing somites
    A Sawada
    Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya 464 8602, Japan
    Development 127:1691-702. 2000
    ..a reduction in expression of the posterior genes, myoD and notch5, with uniform expression of the anterior genes, FGFR1, papc and notch6...
  29. doi Heterogeneity and Fgf dependence of adult neural progenitors in the zebrafish telencephalon
    Julia Ganz
    Biotechnology Center and Center for Regenerative Therapies Dresden, Dresden University of Technology, Tatzberg 47 49, 01307 Dresden, Germany
    Glia 58:1345-63. 2010
    ....
  30. pmc Atoh1a expression must be restricted by Notch signaling for effective morphogenesis of the posterior lateral line primordium in zebrafish
    Miho Matsuda
    Laboratory of Molecular Genetics, Section on Neural Developmental Dynamics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Development 137:3477-87. 2010
    ..in the central cell, it drives expression of fgf10 and of the Notch ligand deltaD, while it inhibits expression of fgfr1. As a source of Fgf10, the central cell activates the FGF pathway in neighboring cells, ensuring that they form ..
  31. pmc Pdlim7 is required for maintenance of the mesenchymal/epidermal Fgf signaling feedback loop during zebrafish pectoral fin development
    Troy Camarata
    Department of Pediatrics, Northwestern University, The Feinberg School of Medicine, Children s Memorial Research Center, Chicago, IL 60614, USA
    BMC Dev Biol 10:104. 2010
    ..This Tbx5 regulation is critical in heart formation, but the coexpression of both proteins in other developing tissues suggests a broader functional role...
  32. pmc Identification of cis regulatory features in the embryonic zebrafish genome through large-scale profiling of H3K4me1 and H3K4me3 binding sites
    Aaron W Aday
    Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01602, USA
    Dev Biol 357:450-62. 2011
    ....
  33. doi FGF receptor gene expression and its regulation by FGF signaling during early zebrafish development
    Satoshi Ota
    Division of Life Science, Graduate School of Science and Engineering, Saitama University, Shimo okubo, Sakura ku, Saitama, Japan
    Genesis 48:707-16. 2010
    ..b>fgfr1 alone was expressed maternally throughout the blastoderm, and then zygotically in the anterior neural plate and ..
  34. doi Modular scanning FCS quantifies receptor-ligand interactions in living multicellular organisms
    Jonas Ries
    Biotechnology Center, Technical University of Dresden, Dresden, Germany
    Nat Methods 6:643-5. 2009
    ..We quantified the mobility of fibroblast growth factor receptors Fgfr1 and Fgfr4 in cell membranes of living zebrafish embryos and determined their in vivo binding affinities to their ..
  35. ncbi Mutant analyses reveal different functions of fgfr1 in medaka and zebrafish despite conserved ligand-receptor relationships
    Hayato Yokoi
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Dev Biol 304:326-37. 2007
    ..Positional-candidate cloning revealed that the hdf mutation causes a functionally null form of Fgfr1. The fgfr1hdf is thus the first fgf receptor mutant in fish...
  36. ncbi Specification of epibranchial placodes in zebrafish
    Alexei Nechiporuk
    Department of Biological Structure, University of Washington, Seattle, WA 98195 7420, USA
    Development 134:611-23. 2007
    ..The coordinated interplay between craniofacial tissues would thus assure proper spatial and temporal interactions in the shaping of the vertebrate head...
  37. ncbi An essential role for zebrafish Fgfrl1 during gill cartilage development
    Chris Hall
    Department of Molecular Medicine and Pathology, School of Medical Sciences, The University of Auckland, P O 92019, Auckland, New Zealand
    Mech Dev 123:925-40. 2006
    ..A duplicate zebrafish gene, fgfrl1b, has now been identified. We show that Fgfrl1b is also required for proper formation of all ventral cartilage elements and acts cooperatively with Fgfrl1a during gill cartilage formation...
  38. ncbi Development of GnRH cells: Setting the stage for puberty
    K E Whitlock
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, United States
    Mol Cell Endocrinol 254:39-50. 2006
    ..Thus the signaling of the GnRH neuronal circuitry is set up early in development laying the foundation for the GnRH network that is activated at puberty leading to reproductive function in the mature animal...
  39. ncbi Zebrafish endoderm formation is regulated by combinatorial Nodal, FGF and BMP signalling
    Morgane Poulain
    National Institute for Medical Research, Division of Developmental Biology, The Ridgeway, Mill Hill, London, UK
    Development 133:2189-200. 2006
    ..These results identify a molecular mechanism whereby FGF attenuates Nodal-induced endodermal transcription factors and highlight a potential mechanism whereby mesoderm and endoderm fates could segregate from each other...
  40. pmc Chemical modulation of receptor signaling inhibits regenerative angiogenesis in adult zebrafish
    Peter E Bayliss
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nat Chem Biol 2:265-73. 2006
    ..This study illustrates the utility of the adult zebrafish as a new model system for receptor signaling and chemical biology...
  41. ncbi Canopy1, a novel regulator of FGF signaling around the midbrain-hindbrain boundary in zebrafish
    Yoshikazu Hirate
    Laboratory for Developmental Gene Regulation, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako, Saitama, 351 0198, Japan
    Curr Biol 16:421-7. 2006
    ..Cnpy1 is localized in the endoplasmic reticulum and interacts with FGFR1. This study highlights a positive-feedback loop between the FGFR pathway and Cnpy1 that may ensure the strength of ..
  42. ncbi Fgf8 drives myogenic progression of a novel lateral fast muscle fibre population in zebrafish
    Julie A Groves
    MRC Centre for Developmental Neurobiology and Randall Division for Cell and Molecular Biophysics, New Hunt s House, King s College London, London SE1 1UL, UK
    Development 132:4211-22. 2005
    ..We conclude that Fgf8 drives terminal differentiation of a specific population of lateral muscle precursor cells within the early somite...
  43. ncbi Endoderm-derived Fgf3 is necessary and sufficient for inducing neurogenesis in the epibranchial placodes in zebrafish
    Alexei Nechiporuk
    Department of Biological Structure, University of Washington, Seattle, WA 98195 7420, USA
    Development 132:3717-30. 2005
    ..Based on these findings, we propose a model for epibranchial placode development in which Fgf3 is a major endodermal determinant required for epibranchial placode neurogenesis...
  44. ncbi Zebrafish Polycomb group gene ph2alpha is required for epiboly and tailbud formation acting downstream of FGF signaling
    Yuta Komoike
    Department of Biology, School of Education and in Integrated Bioscience and Biomedical Engineering, Graduate School of Science and Engineering, Waseda University, 1 6 1 Nishi Waseda, Shinjuku, Tokyo 169 8050, Japan
    Biochem Biophys Res Commun 328:858-66. 2005
    ..Treatment with SU5402, an inhibitor of Fgfrs, or injection of dominant-negative Fgfr1 DNA markedly reduced ph2alpha expression in the tailbud...
  45. ncbi Regulated addition of new myocardial and epicardial cells fosters homeostatic cardiac growth and maintenance in adult zebrafish
    Airon A Wills
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 135:183-92. 2008
    ..Our results demonstrate that the adult zebrafish ventricle grows and is maintained by cardiomyocyte hyperplasia, and that epicardial cells are added to the ventricle in an Fgf-dependent fashion to support homeostasis...
  46. doi Gene expression analysis on sections of zebrafish regenerating fins reveals limitations in the whole-mount in situ hybridization method
    A Smith
    Ottawa Health Research Institute, Ottawa, ON, Canada
    Dev Dyn 237:417-25. 2008
    ....
  47. doi Stem cells in the adult zebrafish cerebellum: initiation and maintenance of a novel stem cell niche
    Jan Kaslin
    Biotechnology Center and Center for Regenerative Therapies Dresden, Dresden University of Technology, 01307 Dresden, Germany
    J Neurosci 29:6142-53. 2009
    ..Nevertheless, retained epithelial properties such as distinct polarization and ventricular contact are critical common determinants to maintain neural stem cell activity in vertebrates...
  48. pmc FGF signalling during embryo development regulates cilia length in diverse epithelia
    Judith M Neugebauer
    Department of Neurobiology and Anatomy, University of Utah School of Medicine, Eccles Institute of Human Genetics, Building 533, Room 3160, 15 North 2030 East, Salt Lake City, Utah 84112 5330, USA
    Nature 458:651-4. 2009
    ..Morpholino knockdown of FGF receptor 1 (Fgfr1) in zebrafish cell-autonomously reduces cilia length in Kupffer's vesicle and perturbs directional fluid flow ..
  49. pmc dlx3b/4b are required for the formation of the preplacodal region and otic placode through local modulation of BMP activity
    Robert Esterberg
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Dev Biol 325:189-99. 2009
    ..Our results provide insight into the mechanisms of PPR specification as well as the role of dlx3b/4b function in PPR and otic placode induction...
  50. pmc Fgfs control homeostatic regeneration in adult zebrafish fins
    Airon A Wills
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 135:3063-70. 2008
    ..Our experiments reveal that the facultative machinery that regenerates amputated teleost fins also has a surprisingly vigorous role in homeostatic regeneration...
  51. doi Fgf signaling in the zebrafish adult brain: association of Fgf activity with ventricular zones but not cell proliferation
    Stefanie Topp
    Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Department Zebrafish Neurogenetics, Institute of Developmental Genetics, D 85764 Neuherberg, Germany
    J Comp Neurol 510:422-39. 2008
    ..We report expression of Fgf signals (fgf3,4,8a,8b,17b), receptors (fgfr1-4), and targets (erm, pea3, dusp6, spry1,2,4, and P-ERK) and document that genes of the embryonic fgf8 ..
  52. doi Dynamic Fgf signaling couples morphogenesis and migration in the zebrafish lateral line primordium
    Virginie Lecaudey
    European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg, Germany
    Development 135:2695-705. 2008
    ..Furthermore, this work uncovers a surprising link between internal tissue organization and collective migration...
  53. doi FGF-dependent mechanosensory organ patterning in zebrafish
    Alex Nechiporuk
    University of Washington, School of Medicine, Department of Biological Structure, Seattle, WA 98195 7420, USA
    Science 320:1774-7. 2008
    ..This previously unrecognized mechanism may be applicable to understanding segmentation and morphogenesis in other organ systems...
  54. doi MicroRNA-9 directs late organizer activity of the midbrain-hindbrain boundary
    Christoph Leucht
    Department of Zebrafish Neurogenetics, Institute of Developmental Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
    Nat Neurosci 11:641-8. 2008
    ..Together, these findings highlight a previously unknown mechanism by which a single microRNA fine-tunes late MHB coherence via its co-regulation of patterning activities and neurogenesis...
  55. ncbi Expression of the FGF receptor 2 gene (fgfr2) during embryogenesis in the zebrafish Danio rerio
    Noriko Tonou-Fujimori
    Department of Regulation Biology, Faculty of Science, Saitama University, 255 Shimo okubo, Saitama City, Saitama 338 8570, Japan
    Mech Dev 119:S173-8. 2002
    ..We compared the expression of the four fgfr genes (fgfr1-4) in the CNS of zebrafish embryos and show that fgfr1 is the only fgfr gene that is expressed in the dorsal ..

Research Grants13

  1. DEVELOPMENT OF THE OLFACTORY SYSTEM IN ZEBRAFISH
    KATHLEEN WHITLOCK; Fiscal Year: 2004
    ..abstract_text> ..
  2. Development of gonadotropin releasing hormone cells
    KATHLEEN WHITLOCK; Fiscal Year: 2009
    ....