Gene Symbol: fgf1a
Description: fibroblast growth factor 1a
Alias: HBGF-1, aFGF, fgf1, zgc:73249, FGF-1, acidic fibroblast growth factor, fibroblast growth factor 1, heparin-binding growth factor 1
Species: zebrafish

Top Publications

  1. Goldshmit Y, Sztal T, Jusuf P, Hall T, Nguyen Chi M, Currie P. Fgf-dependent glial cell bridges facilitate spinal cord regeneration in zebrafish. J Neurosci. 2012;32:7477-92 pubmed publisher
    ..This suggests that differential Fgf regulation, rather than intrinsic cell differences, underlie the distinct responses of mammalian and zebrafish glia to injury. ..
  2. Schall K, Holoyda K, Isani M, Lien C, Al Alam D, Grikscheit T. Inhibition of Fgf signaling in short bowel syndrome increases weight loss and epithelial proliferation. Surgery. 2017;161:694-703 pubmed publisher
    ..Heat shock in hsp70:dnfgfr1-GFP fish decreases fgf 1 expression...
  3. Shi W, Chen X, Wang F, Gao M, Yang Y, Du Z, et al. ZDHHC16 modulates FGF/ERK dependent proliferation of neural stem/progenitor cells in the zebrafish telencephalon. Dev Neurobiol. 2016;76:1014-28 pubmed publisher
    ..2016 Wiley Periodicals, Inc. Develop Neurobiol 76: 1014-1028, 2016. ..
  4. Bosco A, Bureau C, Affaticati P, Gaspar P, Bally Cuif L, Lillesaar C. Development of hypothalamic serotoninergic neurons requires Fgf signalling via the ETS-domain transcription factor Etv5b. Development. 2013;140:372-84 pubmed publisher
    ..Our results highlight a novel role for Etv5b in neuronal development and provide support for the existence of a developmental heterogeneity among 5-HT neurons in their requirement for ETS-domain transcription factors. ..
  5. Songhet P, Adzic D, Reibe S, Rohr K. fgf1 is required for normal differentiation of erythrocytes in zebrafish primitive hematopoiesis. Dev Dyn. 2007;236:633-43 pubmed
    ..We here show that zebrafish fgf1 is involved in vivo in primitive hematopoiesis...
  6. Tse H, Hui M, Li L, Lee S, Leung A, Cheng S. Angiogenic efficacy of simplified 2-herb formula (NF3) in zebrafish embryos in vivo and rat aortic ring in vitro. J Ethnopharmacol. 2012;139:447-53 pubmed publisher
    ..NF3 exposure significantly induced up-regulation of VEGF-A, Flk-1, fgf1 and bRaf expression in zebrafish embryos...
  7. Li S, Lou S, Lei B, Chan T, Kwan Y, Chan S, et al. Transcriptional profiling of angiogenesis activities of calycosin in zebrafish. Mol Biosyst. 2011;7:3112-21 pubmed publisher
    ..The data have elucidated the connection between morphological observations and genomic evidence, indicating the potential roles of several key signaling pathways in angiogenesis. ..
  8. Jurynec M, Grunwald D. SHIP2, a factor associated with diet-induced obesity and insulin sensitivity, attenuates FGF signaling in vivo. Dis Model Mech. 2010;3:733-42 pubmed publisher
    ..We suggest that modulation of FGF signaling may be a principal function of SHIP2 in mammals. ..
  9. Itoh N, Konishi M. The zebrafish fgf family. Zebrafish. 2007;4:179-86 pubmed
    ..As the zebrafish system has proved useful for studying gene functions and genetic diseases, the present findings will be useful for elucidation of roles of FGFs in zebrafish and humans. ..

More Information


  1. Bhat N, Riley B. Integrin-?5 coordinates assembly of posterior cranial placodes in zebrafish and enhances Fgf-dependent regulation of otic/epibranchial cells. PLoS ONE. 2011;6:e27778 pubmed publisher
    ..These findings support a model in which itga5 coordinates cell migration into posterior placodes and augments Fgf signaling required for patterning of these tissues and cell survival in otic/epibranchial placodes. ..
  2. Simões F, Peterkin T, Patient R. Fgf differentially controls cross-antagonism between cardiac and haemangioblast regulators. Development. 2011;138:3235-45 pubmed publisher
    ..We propose that elevation of Fgf signalling in the anterior haemangioblast territory could have led to its recruitment into the heart field during evolution, increasing the size of the heart. ..
  3. Qian M, Yao S, Jing L, He J, Xiao C, Zhang T, et al. ENC1-like integrates the retinoic acid/FGF signaling pathways to modulate ciliogenesis of Kupffer's Vesicle during zebrafish embryonic development. Dev Biol. 2013;374:85-95 pubmed publisher
    ..Taken together, these data indicate thatEnc1l is a direct downstream effector of RA and FGF signaling pathways and modulates KV ciliogenesis in the zebrafish embryo. ..
  4. Jackman W, Davies S, Lyons D, Stauder C, Denton Schneider B, Jowdry A, et al. Manipulation of Fgf and Bmp signaling in teleost fishes suggests potential pathways for the evolutionary origin of multicuspid teeth. Evol Dev. 2013;15:107-18 pubmed publisher
  5. Li M, Page McCaw P, Chen W. FGF1 Mediates Overnutrition-Induced Compensatory β-Cell Differentiation. Diabetes. 2016;65:96-109 pubmed publisher
    ..We identified Fgf1 signaling as a key component of the overnutrition-induced β-cell differentiation signal in a small molecule ..
  6. Hernández Bejarano M, Gestri G, Spawls L, Nieto López F, Picker A, Tada M, et al. Opposing Shh and Fgf signals initiate nasotemporal patterning of the zebrafish retina. Development. 2015;142:3933-42 pubmed publisher
    ..Once the spatially complementary expression of foxd1 and foxg1 is established, the boundary between expression domains is maintained by mutual repression between Foxd1 and Foxg1. ..
  7. Bouzaffour M, Dufourcq P, Lecaudey V, Haas P, Vriz S. Fgf and Sdf-1 pathways interact during zebrafish fin regeneration. PLoS ONE. 2009;4:e5824 pubmed publisher
    ..This observation supports the idea that the regeneration process involves a delicate balance between multiple pathways. ..
  8. Zhao Y, Huang X, Ding T, Gong Z. Enhanced angiogenesis, hypoxia and neutrophil recruitment during Myc-induced liver tumorigenesis in zebrafish. Sci Rep. 2016;6:31952 pubmed publisher
    ..In sum, the current study demonstrated that the Myc-induced liver tumor model in zebrafish provides an excellent platform for study of tumor microenvironment. ..