Gene Symbol: fbxo32
Description: F-box protein 32
Alias: zgc:56479, F-box only protein 32, atrogin-1
Species: zebrafish
Products:     fbxo32

Top Publications

  1. Hanai J, Cao P, Tanksale P, Imamura S, Koshimizu E, Zhao J, et al. The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity. J Clin Invest. 2007;117:3940-51 pubmed
    ..Collectively, our human, animal, and in vitro findings shed light on the molecular mechanism of statin-induced myopathy and suggest that atrogin-1 may be a critical mediator of the muscle damage induced by statins. ..
  2. Seiliez I, Médale F, Aguirre P, Larquier M, Lanneretonne L, Alami Durante H, et al. Postprandial regulation of growth- and metabolism-related factors in zebrafish. Zebrafish. 2013;10:237-48 pubmed publisher
    ..Together, these results highlight some specificity of the zebrafish metabolism and demonstrate the interest and the limits of this species as a model organism for nutritional physiology studies. ..
  3. Cao P, Hanai J, Tanksale P, Imamura S, Sukhatme V, Lecker S. Statin-induced muscle damage and atrogin-1 induction is the result of a geranylgeranylation defect. FASEB J. 2009;23:2844-54 pubmed publisher
    ..Collectively, our animal and in vitro findings shed light on the molecular mechanism of statin-induced myopathy and suggest that atrogin-1 may be regulated by novel signaling pathways. ..
  4. Cleveland B, Evenhuis J. Molecular characterization of atrogin-1/F-box protein-32 (FBXO32) and F-box protein-25 (FBXO25) in rainbow trout (Oncorhynchus mykiss): Expression across tissues in response to feed deprivation. Comp Biochem Physiol B Biochem Mol Biol. 2010;157:248-57 pubmed publisher
    ..atrophy is largely the result of an increase in E3 ubiquitin ligase expression, specifically that of atrogin-1, or FBXO32, which functions to polyubiquitinate proteins...
  5. Al Habsi A, Massarsky A, Moon T. Exposure to gemfibrozil and atorvastatin affects cholesterol metabolism and steroid production in zebrafish (Danio rerio). Comp Biochem Physiol B Biochem Mol Biol. 2016;199:87-96 pubmed publisher
    ..We conclude that the reduction in cortisol may impair the ability of these fish to mount a suitable stress response, whereas the reduction of sex steroids may negatively affect reproduction. ..
  6. Bühler A, Kustermann M, Bummer T, Rottbauer W, Sandri M, Just S. Atrogin-1 Deficiency Leads to Myopathy and Heart Failure in Zebrafish. Int J Mol Sci. 2016;17: pubmed publisher
  7. Hasumura T, Meguro S. Exercise quantity-dependent muscle hypertrophy in adult zebrafish (Danio rerio). J Comp Physiol B. 2016;186:603-14 pubmed publisher
    ..These results open up the possibility for further investigations on the effects of exercise on skeletal muscle in adult zebrafish. ..
  8. Chen Q, Li C, Gong Z, Chan E, Snyder S, Lam S. Common deregulated gene expression profiles and morphological changes in developing zebrafish larvae exposed to environmental-relevant high to low concentrations of glucocorticoids. Chemosphere. 2017;172:429-439 pubmed publisher
    ..Three genes (cry2b, fbxo32, and klhl38b) responded robustly to all glucocorticoid concentrations tested...
  9. Pasha R, Moon T. Coenzyme Q10 protects against statin-induced myotoxicity in zebrafish larvae (Danio rerio). Environ Toxicol Pharmacol. 2017;52:150-160 pubmed publisher
    ..Together, the implication of our results contributes to the understanding of the mechanisms of action of the statin-induced damage in this model fish species. ..

More Information


  1. Yogev O, Williams V, Hinits Y, Hughes S. eIF4EBP3L acts as a gatekeeper of TORC1 in activity-dependent muscle growth by specifically regulating Mef2ca translational initiation. PLoS Biol. 2013;11:e1001679 pubmed publisher
    ..We suggest that by selectively inhibiting translational initiation of mef2ca and other mRNAs, eIF4EBP3L reprograms the translational profile of muscle, enabling it to adjust to new environmental conditions. ..