Gene Symbol: fas
Description: Fas cell surface death receptor
Alias: tumor necrosis factor receptor superfamily member 6, tumor necrosis factor receptor superfamily member 26, Fas (TNF receptor superfamily, member 6)
Choi W, Giraldez A, Schier A. Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430. Science. 2007;318:271-4 pubmed
..These findings establish an approach to analyze the in vivo roles of specific miRNA-mRNA pairs and reveal a requirement for miRNAs in dampening and balancing agonist/antagonist pairs. ..
Ferrari L, Pistocchi A, Libera L, Boari N, Mortini P, Bellipanni G, et al
. FAS/FASL are dysregulated in chordoma and their loss-of-function impairs zebrafish notochord formation. Oncotarget. 2014;5:5712-24 pubmed publisher
..Apoptosis is necessary for the proper notochord development in vertebrates, and the apoptotic pathway mediated by Fas and Fasl has been demonstrated to be involved in notochord cells regression...
Luzio A, Matos M, Santos D, Fontaínhas Fernandes A, Monteiro S, Coimbra A. Disruption of apoptosis pathways involved in zebrafish gonad differentiation by 17?-ethinylestradiol and fadrozole exposures. Aquat Toxicol. 2016;177:269-84 pubmed publisher
..The death receptors (FAS; TRADD), anti-apoptotic (BCL-2; MDM2), pro-apoptotic (CASP-2 and -6) and cell proliferation (BIRC5/survivin; JUN) ..
Poulton L, Nolan K, Anastasaki C, Waldmann H, Patton E. A novel role for Glucocorticoid-Induced TNF Receptor Ligand (Gitrl) in early embryonic zebrafish development. Int J Dev Biol. 2010;54:815-25 pubmed publisher
..25-10 hpf). We found Stat3 signalling to be altered in the gitrl-morphants, suggesting that one possible role for Gitrl during embryogenesis may be modulation of Jak/Stat signalling. ..
Wiens G, Glenney G. Origin and evolution of TNF and TNF receptor superfamilies. Dev Comp Immunol. 2011;35:1324-35 pubmed publisher
..The increasing interest and use of TNFSF and TNFRSF modulators in human and animal medicine underscores the need to understand the evolutionary origins as well as conserved and novel functions of these biologically important molecules. ..
Estepa A, Coll J. Innate Multigene Family Memories Are Implicated in the Viral-Survivor Zebrafish Phenotype. PLoS ONE. 2015;10:e0135483 pubmed publisher
..The implications of the so-called "trained immunity" for future research in this field are also discussed. ..
Lu X, Wei Y, Liu F. Direct regulation of p53 by miR-142a-3p mediates the survival of hematopoietic stem and progenitor cells in zebrafish. Cell Discov. 2015;1:15027 pubmed publisher
..Therefore, our work reveals the significance of the miR-142a-3p-p53 pathway in controlling hematopoietic stem and progenitor cell survival, and thus advances our understanding of the role of p53 in vertebrate hematopoiesis. ..