Gene Symbol: ezh2
Description: enhancer of zeste 2 polycomb repressive complex 2 subunit
Alias: eya2, im:7149338, zgc:136376, zgc:152758, histone-lysine N-methyltransferase EZH2, enhancer of zeste homolog 2, eyes absent homolog 2
Nica G, Herzog W, Sonntag C, Nowak M, Schwarz H, Zapata A, et al
. Eya1 is required for lineage-specific differentiation, but not for cell survival in the zebrafish adenohypophysis. Dev Biol. 2006;292:189-204 pubmed
..Eya1 is required for lineage-specific differentiation of adenohypophyseal cells, but not for their survival, thereby uncoupling the differentiation-promoting and anti-apoptotic effects of Eya proteins seen in other tissues. ..
McMahon C, Gestri G, Wilson S, Link B. Lmx1b is essential for survival of periocular mesenchymal cells and influences Fgf-mediated retinal patterning in zebrafish. Dev Biol. 2009;332:287-98 pubmed publisher
..Overall, we propose zebrafish lmx1b.1 and lmx1b.2 promote the survival of periocular mesenchymal cells that influence multiple signaling events required for proper ocular development. ..
Beauchemin M, Smith A, Yin V. Dynamic microRNA-101a and Fosab expression controls zebrafish heart regeneration. Development. 2015;142:4026-37 pubmed publisher
..In summation, our studies indicate that the precise temporal modulation of the miR-101a/fosab genetic axis is crucial for coordinating CM proliferation and scar tissue removal during zebrafish heart regeneration. ..
Saxena S, Purushothaman S, Meghah V, Bhatti B, Poruri A, Meena Lakshmi M, et al
. Role of annexin gene and its regulation during zebrafish caudal fin regeneration. Wound Repair Regen. 2016;24:551-9 pubmed publisher
Crippa S, Nemir M, Ounzain S, Ibberson M, Berthonneche C, Sarre A, et al
. Comparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways. Cardiovasc Res. 2016;110:73-84 pubmed publisher
..Targets of miR-26a involve activators of the cell cycle and Ezh2, a component of the polycomb repressive complex 2 (PRC2)...
Dupret B, Volkel P, Vennin C, Toillon R, Le Bourhis X, Angrand P. The histone lysine methyltransferase Ezh2 is required for maintenance of the intestine integrity and for caudal fin regeneration in zebrafish. Biochim Biophys Acta Gene Regul Mech. 2017;1860:1079-1093 pubmed publisher
The histone lysine methyltransferase EZH2, as part of the Polycomb Repressive Complex 2 (PRC2), mediates H3K27me3 methylation which is involved in gene expression program repression...
Stewart S, Tsun Z, Izpisua Belmonte J. A histone demethylase is necessary for regeneration in zebrafish. Proc Natl Acad Sci U S A. 2009;106:19889-94 pubmed publisher
..These results indicate that histone modifications at discreet genomic positions may serve as a crucial regulatory event in the initiation of fin regeneration. ..
Zhou T, Wang L, Zhu K, Dong M, Xu P, Chen Y, et al
. Dominant-negative C/ebp? and polycomb group protein Bmi1 extend short-lived hematopoietic stem/progenitor cell life span and induce lethal dyserythropoiesis. Blood. 2011;118:3842-52 pubmed publisher
..The results indicate that Bmi1 acts immediately downstream of C/ebp?DN to regulate the survival and self-renewal of HSPCs and contribute to the erythropoietic dysplasia. ..