eya1

Summary

Gene Symbol: eya1
Description: EYA transcriptional coactivator and phosphatase 1
Alias: wu:fc13c10, zgc:100770, eyes absent homolog 1, dog eared
Species: zebrafish
Products:     eya1

Top Publications

  1. Herzog W, Sonntag C, von der Hardt S, Roehl H, Varga Z, Hammerschmidt M. Fgf3 signaling from the ventral diencephalon is required for early specification and subsequent survival of the zebrafish adenohypophysis. Development. 2004;131:3681-92 pubmed
    ..This early specification seems to be essential for the subsequent survival of pituitary cells, but not for pituitary morphogenesis or pituitary cell proliferation...
  2. Nechiporuk A, Linbo T, Poss K, Raible D. Specification of epibranchial placodes in zebrafish. Development. 2007;134:611-23 pubmed
    ..The coordinated interplay between craniofacial tissues would thus assure proper spatial and temporal interactions in the shaping of the vertebrate head...
  3. Leger S, Brand M. Fgf8 and Fgf3 are required for zebrafish ear placode induction, maintenance and inner ear patterning. Mech Dev. 2002;119:91-108 pubmed
    ..We suggest a model of zebrafish inner ear development with several discrete steps that utilize sequential Fgf signals during otic placode induction and vesicle patterning. ..
  4. Nechiporuk A, Raible D. FGF-dependent mechanosensory organ patterning in zebrafish. Science. 2008;320:1774-7 pubmed publisher
    ..This previously unrecognized mechanism may be applicable to understanding segmentation and morphogenesis in other organ systems. ..
  5. Li W, Cornell R. Redundant activities of Tfap2a and Tfap2c are required for neural crest induction and development of other non-neural ectoderm derivatives in zebrafish embryos. Dev Biol. 2007;304:338-54 pubmed
  6. Nica G, Herzog W, Sonntag C, Nowak M, Schwarz H, Zapata A, et al. Eya1 is required for lineage-specific differentiation, but not for cell survival in the zebrafish adenohypophysis. Dev Biol. 2006;292:189-204 pubmed
    The homeodomain transcription factor Six1 and its modulator, the protein phosphatase Eya1, cooperate to promote cell differentiation and survival during mouse organ development...
  7. Kwon H, Riley B. Mesendodermal signals required for otic induction: Bmp-antagonists cooperate with Fgf and can facilitate formation of ectopic otic tissue. Dev Dyn. 2009;238:1582-94 pubmed publisher
    ..Developmental Dynamics 238:1582-1594, 2009. (c) 2009 Wiley-Liss, Inc. ..
  8. Esterberg R, Fritz A. dlx3b/4b are required for the formation of the preplacodal region and otic placode through local modulation of BMP activity. Dev Biol. 2009;325:189-99 pubmed publisher
    ..Our results provide insight into the mechanisms of PPR specification as well as the role of dlx3b/4b function in PPR and otic placode induction. ..
  9. Aman A, Piotrowski T. Wnt/beta-catenin and Fgf signaling control collective cell migration by restricting chemokine receptor expression. Dev Cell. 2008;15:749-61 pubmed publisher
    ..Although the Fgf, Wnt/beta-catenin, and chemokine signaling pathways are well known to be involved in cancer progression, these studies provide in vivo evidence that these pathways are functionally linked. ..

More Information

Publications60

  1. McGraw H, Drerup C, Culbertson M, Linbo T, Raible D, Nechiporuk A. Lef1 is required for progenitor cell identity in the zebrafish lateral line primordium. Development. 2011;138:3921-30 pubmed publisher
    ..These findings revealed a novel role for the Wnt signaling pathway during mechanosensory organ formation in zebrafish. ..
  2. Schlosser G. Evolutionary origins of vertebrate placodes: insights from developmental studies and from comparisons with other deuterostomes. J Exp Zool B Mol Dev Evol. 2005;304:347-99 pubmed
  3. Phillips B, Kwon H, Melton C, Houghtaling P, Fritz A, Riley B. Zebrafish msxB, msxC and msxE function together to refine the neural-nonneural border and regulate cranial placodes and neural crest development. Dev Biol. 2006;294:376-90 pubmed
    ..These data suggest that mutual antagonism between Msx and Dlx proteins achieves a balance of function required for normal preplacodal differentiation and placement of the neural-nonneural border. ..
  4. Feng Y, Xu Q. Pivotal role of hmx2 and hmx3 in zebrafish inner ear and lateral line development. Dev Biol. 2010;339:507-18 pubmed publisher
    ..Our data suggest that hmx2 and hmx3 act as cell autonomous factors required redundantly for cell fate specification and differentiation during inner ear and lateral line development. ..
  5. Kozlowski D, Whitfield T, Hukriede N, Lam W, Weinberg E. The zebrafish dog-eared mutation disrupts eya1, a gene required for cell survival and differentiation in the inner ear and lateral line. Dev Biol. 2005;277:27-41 pubmed
    ..The dog locus encodes the eyes absent-1 (eya1) gene and single point mutations were found in three independent dog alleles, each prematurely truncating the ..
  6. Dutta S, Dietrich J, Aspöck G, Burdine R, Schier A, Westerfield M, et al. pitx3 defines an equivalence domain for lens and anterior pituitary placode. Development. 2005;132:1579-90 pubmed
    ..During mid-somitogenesis, Hedgehog then acts on the established median placode as a necessary and sufficient signal to specify pituitary cell types. ..
  7. Lecaudey V, Ulloa E, Anselme I, Stedman A, Schneider Maunoury S, Pujades C. Role of the hindbrain in patterning the otic vesicle: a study of the zebrafish vhnf1 mutant. Dev Biol. 2007;303:134-43 pubmed
    ..They suggest that, despite the evolution of inner ear structure and function, some of the mechanisms underlying the regionalisation of the otic vesicle in fish and amniotes have been conserved. ..
  8. Dutta S, Dawid I. Kctd15 inhibits neural crest formation by attenuating Wnt/beta-catenin signaling output. Development. 2010;137:3013-8 pubmed publisher
    ..We propose that Kctd15 inhibits NC formation by attenuating the output of the canonical Wnt pathway, thereby restricting expansion of the NC domain beyond its normal range...
  9. Graf M, Teo Qi Wen E, Sarusie M, Rajaei F, Winkler C. Dmrt5 controls corticotrope and gonadotrope differentiation in the zebrafish pituitary. Mol Endocrinol. 2015;29:187-99 pubmed publisher
    ..Intriguingly, its effect on gonadotrope numbers defines a first nongonadal role for a dmrt family member that appears crucial for the activity of the reproductive system. ..
  10. Schibler A, Malicki J. A screen for genetic defects of the zebrafish ear. Mech Dev. 2007;124:592-604 pubmed
    ..As it proved to be the case in past screening efforts of this type, these mutant lines represent an asset in the studies of molecular mechanisms that regulate vertebrate ear development. ..
  11. Kwon H, Bhat N, Sweet E, Cornell R, Riley B. Identification of early requirements for preplacodal ectoderm and sensory organ development. PLoS Genet. 2010;6:e1001133 pubmed publisher
  12. Abbas L, Whitfield T. Nkcc1 (Slc12a2) is required for the regulation of endolymph volume in the otic vesicle and swim bladder volume in the zebrafish larva. Development. 2009;136:2837-48 pubmed publisher
    ..This exemplifies the use of morpholinos as potential therapeutic agents for genetic disease...
  13. Whitfield T, Granato M, van Eeden F, Schach U, Brand M, Furutani Seiki M, et al. Mutations affecting development of the zebrafish inner ear and lateral line. Development. 1996;123:241-54 pubmed
    ..At least one mutant, dog-eared, shows defects in both the ear and another placodally derived sensory system, the lateral line, while hypersensitive mutants have additional trunk lateral line organs...
  14. Algama M, Tasker E, Williams C, Parslow A, Bryson Richardson R, Keith J. Genome-wide identification of conserved intronic non-coding sequences using a Bayesian segmentation approach. BMC Genomics. 2017;18:259 pubmed publisher
    ..We attribute the higher sensitivity of the pathway-focussed analysis compared to the genome-wide analysis to improved alignment quality, suggesting that enhanced genomic alignments may reveal many more conserved intronic sequences. ..
  15. Breau M, Wilkinson D, Xu Q. A Hox gene controls lateral line cell migration by regulating chemokine receptor expression downstream of Wnt signaling. Proc Natl Acad Sci U S A. 2013;110:16892-7 pubmed publisher
  16. Hammond K, van Eeden F, Whitfield T. Repression of Hedgehog signalling is required for the acquisition of dorsolateral cell fates in the zebrafish otic vesicle. Development. 2010;137:1361-71 pubmed publisher
  17. Grant K, Raible D, Piotrowski T. Regulation of latent sensory hair cell precursors by glia in the zebrafish lateral line. Neuron. 2005;45:69-80 pubmed
    ..Transplantation of wt glia into mutants rescues the appropriate temporal differentiation of interneuromast cells. Our studies reveal a role for glia in regulating sensory hair cell precursors. ..
  18. Rotllant J, Liu D, Yan Y, Postlethwait J, Westerfield M, Du S. Sparc (Osteonectin) functions in morphogenesis of the pharyngeal skeleton and inner ear. Matrix Biol. 2008;27:561-72 pubmed publisher
    ..A comparison of the phenotypes of Sparc knockdown and known zebrafish mutants with similar defects places Sparc downstream of sox9 in the genetic network that regulates development of the pharyngeal skeleton and inner ear of vertebrates...
  19. Omata Y, Nojima Y, Nakayama S, Okamoto H, Nakamura H, Funahashi J. Role of Bone morphogenetic protein 4 in zebrafish semicircular canal development. Dev Growth Differ. 2007;49:711-9 pubmed
    ..Furthermore, the protrusions in gallery treated with Noggin were partially rescued. These data indicate that BMP4 plays an important role in the development of protrusions to form semicircular canals. ..
  20. Schüler S, Hauptmann J, Perner B, Kessels M, Englert C, Qualmann B. Ciliated sensory hair cell formation and function require the F-BAR protein syndapin I and the WH2 domain-based actin nucleator Cobl. J Cell Sci. 2013;126:196-208 pubmed publisher
  21. Wada H, Ghysen A, Satou C, Higashijima S, Kawakami K, Hamaguchi S, et al. Dermal morphogenesis controls lateral line patterning during postembryonic development of teleost fish. Dev Biol. 2010;340:583-94 pubmed publisher
    ..These results strongly suggest a control of postembryonic neuromast patterns by underlying dermal structures. This dermal control may explain some aspects of the evolution of lateral line patterns. ..
  22. Xing C, Gong B, Xue Y, Han Y, Wang Y, Meng A, et al. TGFβ1a regulates zebrafish posterior lateral line formation via Smad5 mediated pathway. J Mol Cell Biol. 2015;7:48-61 pubmed publisher
    ..Therefore, TGFβ/Smad5 signaling plays an important role in the zebrafish lateral line formation. ..
  23. McCarroll M, Nechiporuk A. Fgf3 and Fgf10a work in concert to promote maturation of the epibranchial placodes in zebrafish. PLoS ONE. 2013;8:e85087 pubmed publisher
    ..These findings highlight the importance and complexity of reiterated Fgf signaling during cranial placode formation and subsequent sensory organ development. ..
  24. Miyasaka N, Wanner A, Li J, Mack Bucher J, Genoud C, Yoshihara Y, et al. Functional development of the olfactory system in zebrafish. Mech Dev. 2013;130:336-46 pubmed publisher
  25. Nikaido M, Navajas Acedo J, Hatta K, Piotrowski T. Retinoic acid is required and Fgf, Wnt, and Bmp signaling inhibit posterior lateral line placode induction in zebrafish. Dev Biol. 2017;431:215-225 pubmed publisher
    ..This is the first report that the aLLp and pLLp depend on different inductive mechanisms and that pLLp induction requires the inhibition of Fgf, Wnt and Bmp signaling. ..
  26. Lin C, Chen W, Lee H, Yang P, Yang H, Tsai H. The transcription factor Six1a plays an essential role in the craniofacial myogenesis of zebrafish. Dev Biol. 2009;331:152-66 pubmed publisher
    ..Therefore, we proposed four putative regulatory pathways to understand how six1a distinctly interacts with either myf5 or myod during zebrafish craniofacial muscle development. ..
  27. Wada H, Hamaguchi S, Sakaizumi M. Development of diverse lateral line patterns on the teleost caudal fin. Dev Dyn. 2008;237:2889-902 pubmed publisher
    ..These results establish terminal neuromast patterning as a new model for the study of the developmental mechanisms underlying diverse lateral line patterns...
  28. Hernandez P, Olivari F, Sarrazin A, Sandoval P, Allende M. Regeneration in zebrafish lateral line neuromasts: expression of the neural progenitor cell marker sox2 and proliferation-dependent and-independent mechanisms of hair cell renewal. Dev Neurobiol. 2007;67:637-54 pubmed
    ..Thus, our results describe the dynamics of hair cell regeneration in zebrafish and suggest the existence of at least two mechanisms for recovery of these cells in neuromasts. ..
  29. He Y, Tang D, Li W, Chai R, Li H. Histone deacetylase 1 is required for the development of the zebrafish inner ear. Sci Rep. 2016;6:16535 pubmed publisher
    ..Taken together, our results indicate that HDAC1 plays an important role in otic vesicle formation. ..
  30. Landgraf K, Bollig F, Trowe M, Besenbeck B, Ebert C, Kruspe D, et al. Sipl1 and Rbck1 are novel Eya1-binding proteins with a role in craniofacial development. Mol Cell Biol. 2010;30:5764-75 pubmed publisher
    The eyes absent 1 protein (Eya1) plays an essential role in the development of various organs in both invertebrates and vertebrates...
  31. Hava D, Forster U, Matsuda M, Cui S, Link B, Eichhorst J, et al. Apical membrane maturation and cellular rosette formation during morphogenesis of the zebrafish lateral line. J Cell Sci. 2009;122:687-95 pubmed publisher
  32. Haffter P, Granato M, Brand M, Mullins M, Hammerschmidt M, Kane D, et al. The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development. 1996;123:1-36 pubmed
    ..Here we give an overview of the spectrum of mutant phenotypes obtained, and discuss the limits and the potentials of a genetic saturation screen in the zebrafish. ..
  33. Tang C, Lai Y, Chen Y, Li C, Lu Y, Chen H, et al. Expression of zebrafish anterior gradient 2 in the semicircular canals and supporting cells of otic vesicle sensory patches is regulated by Sox10. Biochim Biophys Acta. 2014;1839:425-37 pubmed publisher
    ..6 to -2.5 kbp region upstream of agr2. These results demonstrate that agr2 expression in the otic vesicles of zebrafish embryos is regulated by Sox10. ..
  34. Han H, Chou C, Chu C, Cheng C, Yang C, Hung C, et al. The Nogo-C2/Nogo receptor complex regulates the morphogenesis of zebrafish lateral line primordium through modulating the expression of dkk1b, a Wnt signal inhibitor. PLoS ONE. 2014;9:e86345 pubmed publisher
    ..We thus suggest that a novel Nogo-C2 complex, consisting of Nogo-C2, NgRH1a, p75, and TROY, regulates Fgf signaling and dkk1b expression, thereby ensuring stable organization of the PLL primordium. ..
  35. Solomon K, Fritz A. Concerted action of two dlx paralogs in sensory placode formation. Development. 2002;129:3127-36 pubmed
    ..Expression patterns of the otic marker pax2.1, olfactory marker anxV and eya1, a marker of both placodes, in morpholino-injected embryos recapitulate the reduced expression of these genes seen ..
  36. Hammond K, Whitfield T. Fgf and Hh signalling act on a symmetrical pre-pattern to specify anterior and posterior identity in the zebrafish otic placode and vesicle. Development. 2011;138:3977-87 pubmed publisher
    ..Each signalling pathway has instructive activity: neither acts simply to repress activity of the other, and, together, they appear to be key players in the specification of anteroposterior asymmetries in the zebrafish ear. ..
  37. Dickmeis T, Lahiri K, Nica G, Vallone D, Santoriello C, Neumann C, et al. Glucocorticoids play a key role in circadian cell cycle rhythms. PLoS Biol. 2007;5:e78 pubmed
    ..Instead, they act in concert with a systemic signaling environment of which glucocorticoids are an essential part. ..
  38. Hung I, Cherng B, Hsu W, Lee S. Calnexin is required for zebrafish posterior lateral line development. Int J Dev Biol. 2013;57:427-38 pubmed publisher
    ..These results suggest that calnexin is essential for neuromast formation during lateral line development in the zebrafish. ..
  39. Bricaud O, Collazo A. The transcription factor six1 inhibits neuronal and promotes hair cell fate in the developing zebrafish (Danio rerio) inner ear. J Neurosci. 2006;26:10438-51 pubmed
    ..Unlike in mouse, six1 does not appear to be dependent on eya1, although it seems to be important for the regulation of eya1 and pax2b expression in the ventral otic epithelium...
  40. Xu H, Ye D, Behra M, Burgess S, Chen S, Lin F. G?1 controls collective cell migration by regulating the protrusive activity of leader cells in the posterior lateral line primordium. Dev Biol. 2014;385:316-27 pubmed publisher
    ..Collectively, our data indicate that G?1 controls migration of the pLLP, likely by acting downstream of the Cxcl12a/Cxcr4b signaling. This study also provides compelling evidence for functional specificity among G? isoforms in vivo. ..
  41. Dufourcq P, Roussigne M, Blader P, Rosa F, Peyrieras N, Vriz S. Mechano-sensory organ regeneration in adults: the zebrafish lateral line as a model. Mol Cell Neurosci. 2006;33:180-7 pubmed
    ..Altogether, our observations indicate that caudal lateral line regeneration is not a mere recapitulation of the ontogenic process. ..
  42. Sarrazin A, Villablanca E, Nuñez V, Sandoval P, Ghysen A, Allende M. Proneural gene requirement for hair cell differentiation in the zebrafish lateral line. Dev Biol. 2006;295:534-45 pubmed
    ..We propose that the emergence of two atonal homologs, ath1 and ngn1, allowed the cellular segregation of mechanoreception and signal transmission that were originally performed by a single cell type as found in insects. ..
  43. Breau M, Wilson D, Wilkinson D, Xu Q. Chemokine and Fgf signalling act as opposing guidance cues in formation of the lateral line primordium. Development. 2012;139:2246-53 pubmed publisher
    ..These findings reveal a novel chemotactic role for Fgf signalling in which it enables the coalescence of the lateral line primordium from an initial fuzzy pattern into a compact group of migrating cells. ..
  44. He Y, Wang Z, Sun S, Tang D, Li W, Chai R, et al. HDAC3 Is Required for Posterior Lateral Line Development in Zebrafish. Mol Neurobiol. 2016;53:5103-17 pubmed publisher
    ..Our results indicate that HDAC3 plays a crucial role in regulating posterior lateral line (PLL) formation and provide evidence for epigenetic regulation in auditory organ development. ..
  45. Bricaud O, Collazo A. Balancing cell numbers during organogenesis: Six1a differentially affects neurons and sensory hair cells in the inner ear. Dev Biol. 2011;357:191-201 pubmed publisher
    ..The dual role of Six1a in the developing otocyst provides a mechanism for balancing the relative number of hair cells and neurons during organogenesis of the inner ear. ..
  46. Reichert S, Randall R, Hill C. A BMP regulatory network controls ectodermal cell fate decisions at the neural plate border. Development. 2013;140:4435-44 pubmed publisher
    ..Taken together, our data define a BMP regulatory network that controls cell fate decisions at the neural plate border. ..
  47. Wang L, Sewell W, Kim S, Shin J, Macrae C, Zon L, et al. Eya4 regulation of Na+/K+-ATPase is required for sensory system development in zebrafish. Development. 2008;135:3425-34 pubmed publisher
    ..We conclude that eya4 regulation of Na+/K+-ATPase is crucial for the development of mechanosensory cells and the maintenance of cardiac function in zebrafish. ..
  48. Aman A, Nguyen M, Piotrowski T. Wnt/β-catenin dependent cell proliferation underlies segmented lateral line morphogenesis. Dev Biol. 2011;349:470-82 pubmed publisher
  49. Nicolson T. The genetics of hearing and balance in zebrafish. Annu Rev Genet. 2005;39:9-22 pubmed
    ..This review addresses the most recent advances in our understanding of how the ear forms and discusses the molecules in hair cells that are essential for sensing sound and movement in the zebrafish. ..
  50. Feijóo C, Saldias M, De la Paz J, Gomez Skarmeta J, Allende M. Formation of posterior cranial placode derivatives requires the Iroquois transcription factor irx4a. Mol Cell Neurosci. 2009;40:328-37 pubmed publisher
    ..Our results point to irx4a as a critical gene for numerous developmental processes and highlight its role in the formation of placodal derivatives in vertebrates. ..
  51. Sarrazin A, Nuñez V, Sapede D, Tassin V, Dambly Chaudiere C, Ghysen A. Origin and early development of the posterior lateral line system of zebrafish. J Neurosci. 2010;30:8234-44 pubmed publisher
    ..The delayed formation of secondary afferent neurons accounts for the capability of the fish to form a new PLL ganglion after ablation of the embryonic ganglion at 24 hpf...