Genomes and Genes
Gene Symbol: exorh
Description: extra-ocular rhodopsin
Alias: ExR, exo-rod, rhodopsin, exo-rhodopsin, exorhodopsin, zfExR
- Morrow J, Lazic S, Dixon Fox M, Kuo C, Schott R, de A Gutierrez E, et al. A second visual rhodopsin gene, rh1-2, is expressed in zebrafish photoreceptors and found in other ray-finned fishes. J Exp Biol. 2017;220:294-303 pubmed publisherb>Rhodopsin (rh1) is the visual pigment expressed in rod photoreceptors of vertebrates that is responsible for initiating the critical first step of dim-light vision...
- Lu P, Lund C, Khuansuwan S, Schumann A, Harney Tolo M, Gamse J, et al. Failure in closure of the anterior neural tube causes left isomerization of the zebrafish epithalamus. Dev Biol. 2013;374:333-44 pubmed publisher..This mechanism fails when the two sides of the epithalamus are widely separated from one another, suggesting that it is dependent upon a signaling protein with limited range. ..
- Sukeena J, Galicia C, Wilson J, McGinn T, Boughman J, Robison B, et al. Characterization and Evolution of the Spotted Gar Retina. J Exp Zool B Mol Dev Evol. 2016;326:403-421 pubmed publisher..Of note the spotted gar expresses both exo-rhodopsin (RH1-1) and rhodopsin (RH1-2) in rods...
- Kokel D, Dunn T, Ahrens M, Alshut R, Cheung C, Saint Amant L, et al. Identification of nonvisual photomotor response cells in the vertebrate hindbrain. J Neurosci. 2013;33:3834-43 pubmed publisher..Pharmacological inhibition of the visual cycle blocks PMR behaviors, suggesting that opsin-based photoreceptors control this behavior. These data represent the first known light-sensing circuit in the vertebrate hindbrain. ..
- Morrow J, Lazic S, Chang B. A novel rhodopsin-like gene expressed in zebrafish retina. Vis Neurosci. 2011;28:325-35 pubmed publisherThe visual pigment rhodopsin (rh1) constitutes the first step in the sensory transduction cascade in the rod photoreceptors of the vertebrate eye, forming the basis of vision at low light levels...
- Noche R, Lu P, Goldstein Kral L, Glasgow E, Liang J. Circadian rhythms in the pineal organ persist in zebrafish larvae that lack ventral brain. BMC Neurosci. 2011;12:7 pubmed publisher..Expression of two pineal rhythmic genes, exo-rhodopsin (exorh) and serotonin-N-acetyltransferase (aanat2), involved in photoreception and melatonin synthesis, ..
- Chen H, Leung T, Giger K, Stauffer A, Humbert J, Sinha S, et al. Expression of the G protein gammaT1 subunit during zebrafish development. Gene Expr Patterns. 2007;7:574-83 pubmed..in the developing retina, where its transcription overlaps with the photoreceptor cell-specific marker, rhodopsin (rho)...
- Bellingham J, Whitmore D, Philp A, Wells D, Foster R. Zebrafish melanopsin: isolation, tissue localisation and phylogenetic position. Brain Res Mol Brain Res. 2002;107:128-36 pubmed..They might represent a separate branch of photopigment evolution in the vertebrates or they may have a non-direct photosensory function, perhaps as a photoisomerase, in non-rod, non-cone light detection. ..