Gene Symbol: evx1
Description: even-skipped homeobox 1
Alias: cb416, evx-1, homeobox even-skipped homolog protein 1
Species: zebrafish

Top Publications

  1. Pyati U, Cooper M, Davidson A, Nechiporuk A, Kimelman D. Sustained Bmp signaling is essential for cloaca development in zebrafish. Development. 2006;133:2275-84 pubmed
    ..Furthermore, our data suggest that alterations in Bmp signaling are one possible cause of anorectal malformations during human embryogenesis...
  2. Suster M, Kania A, Liao M, Asakawa K, Charron F, Kawakami K, et al. A novel conserved evx1 enhancer links spinal interneuron morphology and cis-regulation from fish to mammals. Dev Biol. 2009;325:422-33 pubmed publisher
    ..Here, we establish a link between cis-regulation and morphology of spinal interneurons that express the Evx1 homeodomain transcription factor from fish to mammals...
  3. Slanchev K, Pütz M, Schmitt A, Kramer Zucker A, Walz G. Nephrocystin-4 is required for pronephric duct-dependent cloaca formation in zebrafish. Hum Mol Genet. 2011;20:3119-28 pubmed publisher
  4. Schulte C, Allen C, England S, Juárez Morales J, Lewis K. Evx1 is required for joint formation in zebrafish fin dermoskeleton. Dev Dyn. 2011;240:1240-8 pubmed publisher
    The transcription factor Evx1 is expressed in the joints between individual lepidotrichia (bony ray) segments and at the distal tips of the lepidotrichia in developing zebrafish fins...
  5. Burckle C, Gaudé H, Vesque C, Silbermann F, Salomon R, Jeanpierre C, et al. Control of the Wnt pathways by nephrocystin-4 is required for morphogenesis of the zebrafish pronephros. Hum Mol Genet. 2011;20:2611-27 pubmed publisher
    ..Moreover, they highlight common signalling functions for inversin and nephrocystin-4, suggesting that these two nephrocystins are involved in common physiopathological mechanisms. ..
  6. Juárez Morales J, MARTINEZ DE LUNA R, Zuber M, Roberts A, Lewis K. Zebrafish transgenic constructs label specific neurons in Xenopus laevis spinal cord and identify frog V0v spinal neurons. Dev Neurobiol. 2017;77:1007-1020 pubmed publisher
    ..2017 Wiley Periodicals, Inc. Develop Neurobiol 77: 1007-1020, 2017. ..
  7. Juárez Morales J, Schulte C, Pezoa S, Vallejo G, Hilinski W, England S, et al. Evx1 and Evx2 specify excitatory neurotransmitter fates and suppress inhibitory fates through a Pax2-independent mechanism. Neural Dev. 2016;11:5 pubmed publisher
    ..In this paper we use single and double mutant zebrafish embryos to identify the spinal cord functions of Evx1 and Evx2...
  8. Debiais Thibaud M, Borday Birraux V, Germon I, Bourrat F, Metcalfe C, Casane D, et al. Development of oral and pharyngeal teeth in the medaka (Oryzias latipes): comparison of morphology and expression of eve1 gene. J Exp Zool B Mol Dev Evol. 2007;308:693-708 pubmed
    ..Because it permits direct comparisons between oral and pharyngeal teeth by molecular, development and functional studies, the medaka is an excellent model to develop further insights into the evolution of odontogenesis in gnathostomes. ..
  9. Avaron F, Thaëron Antono C, Beck C, Borday Birraux V, Géraudie J, Casane D, et al. Comparison of even-skipped related gene expression pattern in vertebrates shows an association between expression domain loss and modification of selective constraints on sequences. Evol Dev. 2003;5:145-56 pubmed
    ..evolution, two rounds of whole genome duplication followed by individual gene losses gave rise to three paralogs: evx1, evx2, and eve1. Then, eve1 was maintained in Actinopterygii lineage but not in Tetrapoda...

More Information


  1. Dardis G, Tryon R, Ton Q, Johnson S, Iovine M. Cx43 suppresses evx1 expression to regulate joint initiation in the regenerating fin. Dev Dyn. 2017;246:691-699 pubmed publisher
    ..we have evidence that the gap junction protein Cx43 suppresses joint formation by suppressing the expression of the evx1 transcription factor. Joint morphogenesis proceeds through at least two discrete stages...
  2. Hilinski W, Bostrom J, England S, Juárez Morales J, De Jager S, Armant O, et al. Lmx1b is required for the glutamatergic fates of a subset of spinal cord neurons. Neural Dev. 2016;11:16 pubmed publisher
    ..Finally, we also establish that Evx1 and Evx2, two transcription factors that are required for V0v cells to acquire their excitatory neurotransmitter ..
  3. Suster M, Sumiyama K, Kawakami K. Transposon-mediated BAC transgenesis in zebrafish and mice. BMC Genomics. 2009;10:477 pubmed publisher
  4. Hutchinson S, Cheesman S, Hale L, Boone J, Eisen J. Nkx6 proteins specify one zebrafish primary motoneuron subtype by regulating late islet1 expression. Development. 2007;134:1671-7 pubmed
    ..We suggest that Nkx6 proteins regulate MiP development at least in part by maintaining the islet1 expression that is required both to promote the MiP subtype and to suppress interneuron development. ..
  5. Song M, Brown N, Kuwada J. The cfy mutation disrupts cell divisions in a stage-dependent manner in zebrafish embryos. Dev Biol. 2004;276:194-206 pubmed
    ..These results suggest that the cfy gene regulates mitosis perhaps in a stage-dependent manner in vertebrate embryos. ..
  6. Parkin C, Allen C, Ingham P. Hedgehog signalling is required for cloacal development in the zebrafish embryo. Int J Dev Biol. 2009;53:45-57 pubmed publisher
    ..These studies establish the zebrafish as a model for ARMs, and for the elucidation of other pathways involved in hindgut developmental processes. ..
  7. Schroter C, Oates A. Segment number and axial identity in a segmentation clock period mutant. Curr Biol. 2010;20:1254-8 pubmed publisher
  8. Stickney H, Imai Y, Draper B, Moens C, Talbot W. Zebrafish bmp4 functions during late gastrulation to specify ventroposterior cell fates. Dev Biol. 2007;310:71-84 pubmed
    ..In addition, we present genetic evidence supporting a role for a morphogenetic BMP gradient in establishing mesodermal fates during the later phase of BMP signaling. ..
  9. Dong X, Li J, He L, Gu C, Jia W, Yue Y, et al. Zebrafish Znfl1 proteins control the expression of hoxb1b gene in the posterior neuroectoderm by acting upstream of pou5f3 and sall4 genes. J Biol Chem. 2017;292:13045-13055 pubmed publisher
  10. Lavoie H, Debeane F, Trinh Q, Turcotte J, Corbeil Girard L, Dicaire M, et al. Polymorphism, shared functions and convergent evolution of genes with sequences coding for polyalanine domains. Hum Mol Genet. 2003;12:2967-79 pubmed
  11. Ubuka T, Tsutsui K. Evolution of gonadotropin-inhibitory hormone receptor and its ligand. Gen Comp Endocrinol. 2014;209:148-61 pubmed publisher
  12. Bingham S, Chaudhari S, Vanderlaan G, Itoh M, Chitnis A, Chandrasekhar A. Neurogenic phenotype of mind bomb mutants leads to severe patterning defects in the zebrafish hindbrain. Dev Dyn. 2003;228:451-63 pubmed
  13. Phelps R, Chidester S, Dehghanizadeh S, Phelps J, Sandoval I, Rai K, et al. A two-step model for colon adenoma initiation and progression caused by APC loss. Cell. 2009;137:623-34 pubmed publisher
    ..Consistent with this model, human FAP adenomas showed robust upregulation of CtBP1 in the absence of detectable nuclear beta-catenin, whereas nuclear beta-catenin was detected in carcinomas. ..
  14. Gribble S, Kim H, Bonner J, Wang X, Dorsky R. Tcf3 inhibits spinal cord neurogenesis by regulating sox4a expression. Development. 2009;136:781-9 pubmed publisher
    ..Both of these functions are mediated by Tcf3 independently of canonical Wnt signaling. Together, our data indicate a novel mechanism for the regulation of neurogenesis by Tcf3-mediated repression. ..
  15. Bubenshchikova E, Ichimura K, Fukuyo Y, Powell R, Hsu C, Morrical S, et al. Wtip and Vangl2 are required for mitotic spindle orientation and cloaca morphogenesis. Biol Open. 2012;1:588-96 pubmed publisher
  16. Liao W, Cheng C, Hung K, Chiu W, Chen G, Hwang P, et al. Protein tyrosine phosphatase receptor type O (Ptpro) regulates cerebellar formation during zebrafish development through modulating Fgf signaling. Cell Mol Life Sci. 2013;70:2367-81 pubmed publisher
    ..Therefore, our findings demonstrate that Ptpro activity is required for patterning the zebrafish embryonic brain. Specifically, Ptpro regulates cerebellar formation during zebrafish development through modulating Fgf signaling. ..
  17. Tornini V, Thompson J, Allen R, Poss K. Live fate-mapping of joint-associated fibroblasts visualizes expansion of cell contributions during zebrafish fin regeneration. Development. 2017;144:2889-2895 pubmed publisher
    ..Our experiments visualize and quantify how incorporation into an appendage blastema broadens the progeny contributions of a cellular subpopulation that normally has proximodistal restrictions. ..
  18. Stil A, Drapeau P. Neuronal labeling patterns in the spinal cord of adult transgenic Zebrafish. Dev Neurobiol. 2016;76:642-60 pubmed publisher
    ..expression of green fluorescent protein (GFP) is driven by promoters to hb9 and isl1 in motoneurons, alx/chx10 and evx1 interneurons, ngn1 in sensory neurons and olig2 in oligodendrocytes, as well as antibodies for neurons (HuC/D, NF ..
  19. Zannino D, Downes G, SAGERSTROM C. prdm12b specifies the p1 progenitor domain and reveals a role for V1 interneurons in swim movements. Dev Biol. 2014;390:247-60 pubmed publisher
    ..We conclude that prdm12b is required for V1 interneuron specification and that these neurons control swimming movements in zebrafish. ..
  20. Braat A, Speksnijder J, Zivkovic D. Germ line development in fishes. Int J Dev Biol. 1999;43:745-60 pubmed
    ..Special emphasis is placed on vasa gene expression as a potential universal germ line marker and suggestions are made for novel, zebrafish specific approaches to investigate the vertebrate germ line. ..
  21. Ahn D, Ho R. Tri-phasic expression of posterior Hox genes during development of pectoral fins in zebrafish: implications for the evolution of vertebrate paired appendages. Dev Biol. 2008;322:220-33 pubmed publisher
    ..Our results suggest that, although simpler in organization, teleost fins do have a distal structure that might be considered comparable to the autopod region of limbs. ..
  22. Ton Q, Iovine M. Identification of an evx1-dependent joint-formation pathway during FIN regeneration. PLoS ONE. 2013;8:e81240 pubmed publisher
    ..First, we identify three genes that influence joint formation, evx1, dlx5a, and mmp9...
  23. He L, Xu W, Jing Y, Wu M, Song S, Cao Y, et al. Yes-associated protein (Yap) is necessary for ciliogenesis and morphogenesis during pronephros development in zebrafish (Danio Rerio). Int J Biol Sci. 2015;11:935-47 pubmed publisher
    ..Taken together, our data reveals that Yap is required for pronephric duct integrity, maintenance of baso-lateral cell polarity, and ciliogenesis during zebrafish kidney development. ..