Evx 2


Gene Symbol: Evx 2
Description: even-skipped homeobox 2
Alias: Evx-2, homeobox even-skipped homolog protein 2
Species: zebrafish
Products:     Evx 2

Top Publications

  1. Lavoie H, Debeane F, Trinh Q, Turcotte J, Corbeil Girard L, Dicaire M, et al. Polymorphism, shared functions and convergent evolution of genes with sequences coding for polyalanine domains. Hum Mol Genet. 2003;12:2967-79 pubmed
  2. Brulfert A, Monnot M, Geraudie J. Expression of two even-skipped genes eve1 and evx2 during zebrafish fin morphogenesis and their regulation by retinoic acid. Int J Dev Biol. 1998;42:1117-24 pubmed
    ..RA might alter growth and morphogenesis of the regenerating fins by a fine regulation of these genes among others. ..
  3. Debiais Thibaud M, Borday Birraux V, Germon I, Bourrat F, Metcalfe C, Casane D, et al. Development of oral and pharyngeal teeth in the medaka (Oryzias latipes): comparison of morphology and expression of eve1 gene. J Exp Zool B Mol Dev Evol. 2007;308:693-708 pubmed
    ..Because it permits direct comparisons between oral and pharyngeal teeth by molecular, development and functional studies, the medaka is an excellent model to develop further insights into the evolution of odontogenesis in gnathostomes. ..
  4. Juárez Morales J, MARTINEZ DE LUNA R, Zuber M, Roberts A, Lewis K. Zebrafish transgenic constructs label specific neurons in Xenopus laevis spinal cord and identify frog V0v spinal neurons. Dev Neurobiol. 2017;77:1007-1020 pubmed publisher
    ..2017 Wiley Periodicals, Inc. Develop Neurobiol 77: 1007-1020, 2017. ..
  5. Herault Y, Hraba Renevey S, van der Hoeven F, Duboule D. Function of the Evx-2 gene in the morphogenesis of vertebrate limbs. EMBO J. 1996;15:6727-38 pubmed
    ..These results show that, in limbs, Evx-2 functions like a Hoxd gene. A potential evolutionary scenario is discussed, in which Evx-2 was recruited by the HoxD complex in conjunction with the emergence of digits in an ancestral tetrapod. ..
  6. Becker K, Hart N. Reorganization of filamentous actin and myosin-II in zebrafish eggs correlates temporally and spatially with cortical granule exocytosis. J Cell Sci. 1999;112 ( Pt 1):97-110 pubmed
    ..We propose that closure of cortical crypts is driven by a contractile ring whose forces depend upon dynamic actin filaments and perhaps actomyosin interactions. ..
  7. Avaron F, Thaëron Antono C, Beck C, Borday Birraux V, Géraudie J, Casane D, et al. Comparison of even-skipped related gene expression pattern in vertebrates shows an association between expression domain loss and modification of selective constraints on sequences. Evol Dev. 2003;5:145-56 pubmed
  8. Marquart G, Tabor K, Brown M, Strykowski J, Varshney G, LaFave M, et al. A 3D Searchable Database of Transgenic Zebrafish Gal4 and Cre Lines for Functional Neuroanatomy Studies. Front Neural Circuits. 2015;9:78 pubmed publisher
    ..Cumulatively, this library of enhancer trap lines provides genetic access to 70% of the larval brain and is therefore a powerful and broadly accessible tool for the dissection of neural circuits in larval zebrafish. ..
  9. Juárez Morales J, Schulte C, Pezoa S, Vallejo G, Hilinski W, England S, et al. Evx1 and Evx2 specify excitatory neurotransmitter fates and suppress inhibitory fates through a Pax2-independent mechanism. Neural Dev. 2016;11:5 pubmed publisher
    ..These results significantly increase our understanding of the mechanisms of neuronal specification and the genetic networks involved in these processes. ..

More Information


  1. Hilinski W, Bostrom J, England S, Juárez Morales J, De Jager S, Armant O, et al. Lmx1b is required for the glutamatergic fates of a subset of spinal cord neurons. Neural Dev. 2016;11:16 pubmed publisher
    ..Taken together, our data significantly enhance our understanding of how spinal cord neurotransmitter fates are regulated. ..
  2. Ahn D, Ho R. Tri-phasic expression of posterior Hox genes during development of pectoral fins in zebrafish: implications for the evolution of vertebrate paired appendages. Dev Biol. 2008;322:220-33 pubmed publisher
    ..Our results suggest that, although simpler in organization, teleost fins do have a distal structure that might be considered comparable to the autopod region of limbs. ..
  3. Kimura Y, Hisano Y, Kawahara A, Higashijima S. Efficient generation of knock-in transgenic zebrafish carrying reporter/driver genes by CRISPR/Cas9-mediated genome engineering. Sci Rep. 2014;4:6545 pubmed publisher
    ..Due to its simplicity, design flexibility, and high efficiency, we propose that CRISPR/Cas9-mediated knock-in will become a standard method for the generation transgenic zebrafish. ..