Gene Symbol: ern1
Description: endoplasmic reticulum to nucleus signaling 1
Alias: sb:eu1005, zgc:109932, endoplasmic reticulum to nucleus signaling 1
Hu M, Bai Y, Zhang C, Liu F, Cui Z, Chen J, et al
. Liver-Enriched Gene 1, a Glycosylated Secretory Protein, Binds to FGFR and Mediates an Anti-stress Pathway to Protect Liver Development in Zebrafish. PLoS Genet. 2016;12:e1005881 pubmed publisher
..Therefore, Leg1 plays a unique role in protecting liver development under different stress conditions by serving as a secreted signaling molecule/modulator. ..
Niu X, Gao C, Jan Lo L, Luo Y, Meng C, Hong J, et al
. Sec13 safeguards the integrity of the endoplasmic reticulum and organogenesis of the digestive system in zebrafish. Dev Biol. 2012;367:197-207 pubmed publisher
..Our data provide the first direct genetic evidence that COPII function is essential for the organogenesis of the digestive system...
Moussavi Nik S, Newman M, Wilson L, Ebrahimie E, Wells S, Musgrave I, et al
. Alzheimer's disease-related peptide PS2V plays ancient, conserved roles in suppression of the unfolded protein response under hypoxia and stimulation of Î³-secretase activity. Hum Mol Genet. 2015;24:3662-78 pubmed publisher
..Our data support a model in which chronic hypoxia in aged brains promotes excessive Notch signalling and accumulation of AÎ² that contribute to AD pathogenesis. ..
Chen L, Hu Y, He J, Chen J, Giesy J, Xie P. Responses of the Proteome and Metabolome in Livers of Zebrafish Exposed Chronically to Environmentally Relevant Concentrations of Microcystin-LR. Environ Sci Technol. 2017;51:596-607 pubmed publisher
..Identification of proteins and metabolites in liver of zebrafish responsive to MC-LR provides insights into mechanisms of chronic toxicity of MCs. ..
Murayama E, Sarris M, Redd M, Le Guyader D, Vivier C, Horsley W, et al
. NACA deficiency reveals the crucial role of somite-derived stromal cells in haematopoietic niche formation. Nat Commun. 2015;6:8375 pubmed publisher
Qi M, Dang Y, Xu Q, Yu L, Liu C, Yuan Y, et al
. Microcystin-LR induced developmental toxicity and apoptosis in zebrafish (Danio rerio) larvae by activation of ER stress response. Chemosphere. 2016;157:166-73 pubmed publisher
..Taken together, the results observed in this study suggested that ER stress plays a critical role in developmental toxicity and apoptosis in zebrafish embryos exposed to MC-LR. ..