Gene Symbol: epoa
Description: erythropoietin a
Alias: epo, erythropoietin
Species: zebrafish
Products:     epoa

Top Publications

  1. Li M, Gao Z, Ji D, Zhang S. Functional characterization of GH-like homolog in amphioxus reveals an ancient origin of GH/GH receptor system. Endocrinology. 2014;155:4818-30 pubmed publisher
    ..These data collectively suggest that a vertebrate-like neuroendocrine axis setting has already emerged in amphioxus, which lays a foundation for subsequent formation of hypothalamic-pituitary system in vertebrates. ..
  2. Kopp R, Schwerte T, Egg M, Sandbichler A, Egger B, Pelster B. Chronic reduction in cardiac output induces hypoxic signaling in larval zebrafish even at a time when convective oxygen transport is not required. Physiol Genomics. 2010;42A:8-23 pubmed publisher
    ..The results showed that a chronic reduction in blood flow generated hypoxic molecular signals despite partial compensation by increased oxygen carrying capacity and transiently slowed the overall development of zebrafish bre larvae. ..
  3. Guan B, Ma H, Wang Y, Hu Y, Lin Z, Zhu Z, et al. Vitreoscilla hemoglobin (VHb) overexpression increases hypoxia tolerance in zebrafish (Danio rerio). Mar Biotechnol (NY). 2011;13:336-44 pubmed publisher
    ..levels of several marker genes (hypoxia-inducible factor alpha 1, heat shock cognate 70-kDa protein, erythropoietin, beta and alpha globin genes, lactate dehydrogenase, catalase, superoxide dismutase, and glutathione ..
  4. Robertson C, Wright P, Köblitz L, Bernier N. Hypoxia-inducible factor-1 mediates adaptive developmental plasticity of hypoxia tolerance in zebrafish, Danio rerio. Proc Biol Sci. 2014;281: pubmed publisher
    ..We conclude that mounting a HIF-1 response during embryogenesis is associated with long-term impacts on the phenotype of later stages which could influence both individual hypoxia tolerance and population dynamics. ..
  5. Lewis R, Noor S, Fraser F, Sertori R, Liongue C, Ward A. Regulation of embryonic hematopoiesis by a cytokine-inducible SH2 domain homolog in zebrafish. J Immunol. 2014;192:5739-48 pubmed publisher
    ..This occurred concomitantly with increased activation of STAT5. This study indicates that CISH functions as a conserved in vivo target and regulator of STAT5 in the control of embryonic hematopoiesis. ..
  6. Parente V, Balasso S, Pompilio G, Verduci L, Colombo G, Milano G, et al. Hypoxia/reoxygenation cardiac injury and regeneration in zebrafish adult heart. PLoS ONE. 2013;8:e53748 pubmed publisher
    ..The initial decrease in ventricular function is followed by full recovery. This model more closely mimics reperfusion injury in mammals than other cardiac injury models. ..
  7. Paffett Lugassy N, Hsia N, Fraenkel P, Paw B, Leshinsky I, Barut B, et al. Functional conservation of erythropoietin signaling in zebrafish. Blood. 2007;110:2718-26 pubmed
    b>Erythropoietin (Epo) and its cognate receptor (EpoR) are required for maintaining adequate levels of circulating erythrocytes during embryogenesis and adulthood...
  8. Folkerts E, Blewett T, He Y, Goss G. Alterations to Juvenile Zebrafish (Danio rerio) Swim Performance after Acute Embryonic Exposure to Sub-lethal Exposures of Hydraulic Fracturing Flowback and Produced Water. Aquat Toxicol. 2017;193:50-59 pubmed publisher
    ..After either 24 or 48h exposures, embryos were examined for expression of 3 hypoxia related genes. Erythropoietin (epoa) but not hypoxia inducible factor (hif1aa) nor hemoglobin -ß chain (hbbe1...
  9. Vettori A, Greenald D, Wilson G, Peron M, Facchinello N, Markham E, et al. Glucocorticoids promote Von Hippel Lindau degradation and Hif-1? stabilization. Proc Natl Acad Sci U S A. 2017;114:9948-9953 pubmed publisher
    ..Our data support a model for GCs to stabilize HIF through activation of c-src and subsequent destabilization of pVHL. ..

More Information


  1. de Bruin A, A Cornelissen P, Kirchmaier B, Mokry M, Iich E, Nirmala E, et al. Genome-wide analysis reveals NRP1 as a direct HIF1?-E2F7 target in the regulation of motorneuron guidance in vivo. Nucleic Acids Res. 2016;44:3549-66 pubmed publisher
    ..Therefore, we conclude that repression of NRP1 by the HIF1?-E2F7 complex regulates MN axon guidance in vivo. ..
  2. Rasighaemi P, Onnebo S, Liongue C, Ward A. ETV6 (TEL1) regulates embryonic hematopoiesis in zebrafish. Haematologica. 2015;100:23-31 pubmed publisher
    ..This study suggests that ETV6 plays a broader and more complex role in early hematopoiesis than previously thought, impacting on the development of multiple lineages. ..
  3. Svoboda O, Stachura D, Machonova O, Pajer P, Brynda J, Zon L, et al. Dissection of vertebrate hematopoiesis using zebrafish thrombopoietin. Blood. 2014;124:220-8 pubmed publisher
    ..Combinatorial use of zebrafish Tpo, erythropoietin, and granulocyte colony stimulating factor (Gcsf) allowed the investigation of HSPCs responsible for erythro-, ..
  4. Almeida D, Bianchini A, Marins L. Growth hormone overexpression generates an unfavorable phenotype in juvenile transgenic zebrafish under hypoxic conditions. Gen Comp Endocrinol. 2013;194:102-9 pubmed publisher
    ..Taken together, these findings indicate that GH-transgenesis impaired the ability of juvenile zebrafish to sustain an aerobic metabolism and induced anaerobic metabolism when the fish were challenged with low oxygen levels. ..
  5. Yaqoob N, Holotta M, Prem C, Kopp R, Schwerte T. Ontogenetic development of erythropoiesis can be studied non-invasively in GATA-1:DsRed transgenic zebrafish. Comp Biochem Physiol A Mol Integr Physiol. 2009;154:270-8 pubmed publisher
    ..effort was also made to correlate our luminance data (GATA-1 expression) and total blood cell concentrations with Epo mRNA production. Quantitative RT-PCR of 2-15 dpf old zebrafish was carried out for this purpose...
  6. Chu C, Cheng C, Chen G, Chen Y, Hung C, Huang K, et al. The zebrafish erythropoietin: functional identification and biochemical characterization. FEBS Lett. 2007;581:4265-71 pubmed
    In the present study, the zebrafish epo cDNA was cloned. The encoded protein displays 90%, 55% and 32% identity to the Epo from carp, fugu and human, respectively...
  7. van der Meulen T, Schipper H, van den Boogaart J, Huising M, Kranenbarg S, Van Leeuwen J. Endurance exercise differentially stimulates heart and axial muscle development in zebrafish (Danio rerio). Am J Physiol Regul Integr Comp Physiol. 2006;291:R1040-8 pubmed
    ..expression of the "slow" types of myosin and troponin C was increased, together with expression of erythropoietin and myoglobin, which enhance oxygen transport, indicating a shift toward a slow aerobic phenotype...
  8. Egg M, Köblitz L, Hirayama J, Schwerte T, Folterbauer C, Kurz A, et al. Linking oxygen to time: the bidirectional interaction between the hypoxic signaling pathway and the circadian clock. Chronobiol Int. 2013;30:510-29 pubmed publisher
    ..or an overstimulated circadian clock, modified gene transcription levels of oxygen-regulated genes such as erythropoietin and vascular endothelial growth factor 165 and altered the hypoxia-induced increase in Hif-1? protein ..
  9. Kulkarni R, Tohari S, Ho A, Brenner S, Venkatesh B. Characterization of a hypoxia-response element in the Epo locus of the pufferfish, Takifugu rubripes. Mar Genomics. 2010;3:63-70 pubmed publisher
    Animals respond to hypoxia by increasing synthesis of the glycoprotein hormone erythropoietin (Epo) which in turn stimulates the production of red blood cells...
  10. Egg M, Paulitsch M, Ennemoser Y, Wüstenhagen A, Schwerte T, Sandbichler A, et al. Chronodisruption increases cardiovascular risk in zebrafish via reduced clearance of senescent erythrocytes. Chronobiol Int. 2014;31:680-9 pubmed publisher
    ..as reflected by decreased expression levels of hypoxia inducible factor 1 and its down-stream target genes erythropoietin, responsible for the generation of red blood cells (RBC) and vascular endothelial growth factor, which is ..
  11. Stachura D, Svoboda O, Lau R, Balla K, Zon L, Bartunek P, et al. Clonal analysis of hematopoietic progenitor cells in the zebrafish. Blood. 2011;118:1274-82 pubmed publisher
    ..of myeloerythroid progenitor cells, we developed clonal methylcellulose assays by using recombinant zebrafish erythropoietin and granulocyte colony-stimulating factor...
  12. Kopp R, Köblitz L, Egg M, Pelster B. HIF signaling and overall gene expression changes during hypoxia and prolonged exercise differ considerably. Physiol Genomics. 2011;43:506-16 pubmed publisher
  13. Hyvärinen J, Parikka M, Sormunen R, Ramet M, Tryggvason K, Kivirikko K, et al. Deficiency of a transmembrane prolyl 4-hydroxylase in the zebrafish leads to basement membrane defects and compromised kidney function. J Biol Chem. 2010;285:42023-32 pubmed publisher
    ..Many HIF target genes were induced in the P4H-TM-deficient morphants, but the observed phenotype is not likely to be mediated at least solely via the HIF pathway, and thus P4H-TM probably has additional, as yet unknown, substrates. ..
  14. Kulkeaw K, Ishitani T, Kanemaru T, Fucharoen S, Sugiyama D. Cold exposure down-regulates zebrafish hematopoiesis. Biochem Biophys Res Commun. 2010;394:859-64 pubmed publisher
    ..factors (Runx1, scl, c-myb and GATA-2) and particularly erythropoiesis-related factors (klfd, hbaa1, ba1, GATA-1, EPO, and EPOr) was down-regulated, whereas myelopoiesis-related factors (csf1a and csf3) was up-regulated in low ..
  15. Ma A, Fan A, Ward A, Liongue C, Lewis R, Cheng S, et al. A novel zebrafish jak2a(V581F) model shared features of human JAK2(V617F) polycythemia vera. Exp Hematol. 2009;37:1379-1386.e4 pubmed publisher
    ..In this study, we generated a zebrafish ortholog of human JAK2(V617F) (referred herewith jak2a(V581F)) by site-directed mutagenesis and examined its relevance as a model of human PV...
  16. Metelo A, Noonan H, Li X, Jin Y, Baker R, Kamentsky L, et al. Pharmacological HIF2α inhibition improves VHL disease-associated phenotypes in zebrafish model. J Clin Invest. 2015;125:1987-97 pubmed publisher
    ..This study demonstrates that small-molecule targeting of HIF2α improves VHL-related phenotypes in a vertebrate animal model and supports further exploration of this strategy for treating VHL disease. ..
  17. Guarienti M, Giacopuzzi E, Gianoncelli A, Sigala S, Spano P, Pecorelli S, et al. Computational and functional analysis of biopharmaceutical drugs in zebrafish: Erythropoietin as a test model. Pharmacol Res. 2015;102:12-21 pubmed publisher
    ..This is mainly due to the zebrafish advantages when compared to other animal models. Erythropoietin is a glycoprotein hormone that acts principally on erythroid progenitors, stimulating their survival, ..
  18. Mahony C, Fish R, Pasche C, Bertrand J. tfec controls the hematopoietic stem cell vascular niche during zebrafish embryogenesis. Blood. 2016;128:1336-45 pubmed publisher
    ..The full comprehension of the mechanisms induced by tfec will represent an important milestone toward the expansion of HSCs for regenerative purposes. ..