ephb2a

Summary

Gene Symbol: ephb2a
Description: eph receptor B2a
Alias: ephb2, si:ch73-160e9.1, ephrin type-B receptor 2, EPH receptor B2
Species: zebrafish
Products:     ephb2a

Top Publications

  1. French C, Erickson T, French D, Pilgrim D, Waskiewicz A. Gdf6a is required for the initiation of dorsal-ventral retinal patterning and lens development. Dev Biol. 2009;333:37-47 pubmed publisher
    ..Taken together, these data indicate that Gdf6a initiates dorsal retinal patterning independent of Bmp4, and regulates lens differentiation. ..
  2. Erickson T, French C, Waskiewicz A. Meis1 specifies positional information in the retina and tectum to organize the zebrafish visual system. Neural Dev. 2010;5:22 pubmed publisher
    ..By patterning both the retina and tectum, Meis1 plays an important role in establishing the retinotectal map and organizing the visual system. ..
  3. Kida Y, Sato T, Miyasaka K, Suto A, Ogura T. Daam1 regulates the endocytosis of EphB during the convergent extension of the zebrafish notochord. Proc Natl Acad Sci U S A. 2007;104:6708-13 pubmed
    ..We elucidate the molecular mechanism underlying the CE movement of notochord cells with Daam1 as a dynamic coordinator of endocytosis and cytoskeletal remodeling. ..
  4. Jang I, Lu Y, Zhao L, Wenzel P, Kume T, Datta S, et al. Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium. Blood. 2015;125:1418-26 pubmed publisher
    ..These data establish a pathway linking Notch signaling to Foxc2 in hemogenic endothelial cells to promote definitive hematopoiesis. ..
  5. Goessling W, North T, Loewer S, Lord A, Lee S, Stoick Cooper C, et al. Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell. 2009;136:1136-47 pubmed publisher
    ..Our work provides in vivo evidence that Wnt activation in stem cells requires PGE2, and suggests the PGE2/Wnt interaction is a master regulator of vertebrate regeneration and recovery. ..
  6. Lee H, Tseng W, Lo F, Liu T, Tsai H. FoxD5 mediates anterior-posterior polarity through upstream modulator Fgf signaling during zebrafish somitogenesis. Dev Biol. 2009;336:232-45 pubmed publisher
    ..somites, including loss of the striped patterns of anterior-posterior polarity genes deltaC, notch2, notch3 and EphB2a, as well as the absence of mespa expression in S-I...
  7. Pi Roig A, Martin Blanco E, Minguillon C. Distinct tissue-specific requirements for the zebrafish tbx5 genes during heart, retina and pectoral fin development. Open Biol. 2014;4:140014 pubmed publisher
    ..Furthermore, we uncover a novel role for tbx5 genes in the establishment of correct heart asymmetry in zebrafish embryos. ..
  8. Coxam B, Neyt C, Grassini D, Le Guen L, Smith K, Schulte Merker S, et al. carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (cad) regulates Notch signaling and vascular development in zebrafish. Dev Dyn. 2015;244:1-9 pubmed publisher
    ..These findings suggest important posttranslational modifications requiring Cad as an unappreciated mechanism that regulates Notch/Vegf signaling during angiogenesis. ..
  9. Keung M, Chan L, Kwok H, Wong R, Yue P. Role of microRNA-520h in 20(R)-ginsenoside-Rg3-mediated angiosuppression. J Ginseng Res. 2016;40:151-9 pubmed publisher
    ..Rg3 treatment was validated by quantitative real-time polymerase chain reaction, while the protein expressions of EphB2 and EphB4 were found to decrease, respectively...

More Information

Publications14

  1. Zhang J, Jiang Z, Liu X, Meng A. Eph/ephrin signaling maintains the boundary of dorsal forerunner cell cluster during morphogenesis of the zebrafish embryonic left-right organizer. Development. 2016;143:2603-15 pubmed publisher
    ..Therefore, our data uncover an important role of Eph/ephrin signaling in maintaining DFC cluster boundary and KV boundary for normal left-right asymmetrical development. ..
  2. Geudens I, Herpers R, Hermans K, Segura I, Ruiz de Almodovar C, Bussmann J, et al. Role of delta-like-4/Notch in the formation and wiring of the lymphatic network in zebrafish. Arterioscler Thromb Vasc Biol. 2010;30:1695-702 pubmed publisher
    ..At a later phase, Notch silencing impaired navigation of lymphatic intersomitic vessels along their arterial templates. These studies imply critical roles for Notch signaling in the formation and wiring of the lymphatic network. ..
  3. Chou C, Hsu H, Quek S, Chan W, Liu Y. Arterial and venous vessels are required for modulating developmental relocalization and laterality of the interrenal tissue in zebrafish. Dev Dyn. 2010;239:1995-2004 pubmed publisher
  4. Cvejic A, Serbanovic Canic J, Stemple D, Ouwehand W. The role of meis1 in primitive and definitive hematopoiesis during zebrafish development. Haematologica. 2011;96:190-8 pubmed publisher
    ..These results imply that meis1, jointly with pbx1, regulates primitive hematopoiesis as well as vascular development. ..
  5. Kawasaki J, Aegerter S, Fevurly R, Mammoto A, Mammoto T, Sahin M, et al. RASA1 functions in EPHB4 signaling pathway to suppress endothelial mTORC1 activity. J Clin Invest. 2014;124:2774-84 pubmed publisher