Gene Symbol: epcam
Description: epithelial cell adhesion molecule
Alias: sb:cb6, tacstd, wu:fj17g02, zgc:110304, zgc:77119, epithelial cell adhesion molecule, pan-epithelial glycoprotein, tumor-associated calcium signal transducer
Species: zebrafish

Top Publications

  1. Slanchev K, Carney T, Stemmler M, Koschorz B, Amsterdam A, Schwarz H, et al. The epithelial cell adhesion molecule EpCAM is required for epithelial morphogenesis and integrity during zebrafish epiboly and skin development. PLoS Genet. 2009;5:e1000563 pubmed publisher
    ..Here, we describe epcam (tacstd) null mutants in zebrafish...
  2. Villablanca E, Renucci A, Sapede D, Lec V, Soubiran F, Sandoval P, et al. Control of cell migration in the zebrafish lateral line: implication of the gene "tumour-associated calcium signal transducer," tacstd. Dev Dyn. 2006;235:1578-88 pubmed
    ..In this report, we describe another zebrafish gene that is heterogeneously expressed in the migrating cells, tacstd. This gene codes for a membrane protein that is homologous to the TACSTD1/2 mammalian proteins...
  3. Guan R, El Rass S, Spillane D, Lam S, Wang Y, Wu J, et al. rbm47, a novel RNA binding protein, regulates zebrafish head development. Dev Dyn. 2013;242:1395-404 pubmed publisher
    ..b>epcam and a2ml were identified as the most significantly up- and down-regulated genes, respectively...
  4. Yanicostas C, Ernest S, Dayraud C, Petit C, Soussi Yanicostas N. Essential requirement for zebrafish anosmin-1a in the migration of the posterior lateral line primordium. Dev Biol. 2008;320:469-79 pubmed publisher
  5. Balci T, Prykhozhij S, Teh E, Da as S, McBride E, Liwski R, et al. A transgenic zebrafish model expressing KIT-D816V recapitulates features of aggressive systemic mastocytosis. Br J Haematol. 2014;167:48-61 pubmed publisher
    ..In addition, epcam was consistently downregulated in both transgenic adults and embryos...
  6. Vannier C, Mock K, Brabletz T, Driever W. Zeb1 regulates E-cadherin and Epcam (epithelial cell adhesion molecule) expression to control cell behavior in early zebrafish development. J Biol Chem. 2013;288:18643-59 pubmed publisher
    ..Furthermore, Zeb1 acts as a repressor of epcam in the deep cells of the blastoderm and may contribute to control of epithelial integrity of enveloping layer ..
  7. Argout X, Fouet O, Wincker P, Gramacho K, Legavre T, Sabau X, et al. Towards the understanding of the cocoa transcriptome: Production and analysis of an exhaustive dataset of ESTs of Theobroma cacao L. generated from various tissues and under various conditions. BMC Genomics. 2008;9:512 pubmed publisher
    ..cacao. This EST collection represents a unique and important molecular resource for T. cacao study and improvement, facilitating the discovery of candidate genes for important T. cacao trait variation...
  8. Go W, Bessarab D, Korzh V. atp2b1a regulates Ca(2+) export during differentiation and regeneration of mechanosensory hair cells in zebrafish. Cell Calcium. 2010;48:302-13 pubmed publisher
  9. Gallardo V, Liang J, Behra M, Elkahloun A, Villablanca E, Russo V, et al. Molecular dissection of the migrating posterior lateral line primordium during early development in zebrafish. BMC Dev Biol. 2010;10:120 pubmed publisher

More Information


  1. Venkiteswaran G, Lewellis S, Wang J, Reynolds E, Nicholson C, Knaut H. Generation and dynamics of an endogenous, self-generated signaling gradient across a migrating tissue. Cell. 2013;155:674-87 pubmed publisher
    ..The rear of the primordium generates this gradient through continuous sequestration of Sdf1 protein by the alternate Sdf1-receptor Cxcr7. Modeling shows that this is a physically plausible scenario. ..
  2. Wang J, Leng X, Wang G, Wan X, Cao H. The construction of intrahepatic cholangiocarcinoma model in zebrafish. Sci Rep. 2017;7:13419 pubmed publisher
    ..This work indicates that our transgenic zebrafish could be a valuable model, not only for studying liver cancer, but also for exploring new therapeutic targets. ..
  3. Ma D, Wang L, Wang S, Gao Y, Wei Y, Liu F. Foxn1 maintains thymic epithelial cells to support T-cell development via mcm2 in zebrafish. Proc Natl Acad Sci U S A. 2012;109:21040-5 pubmed publisher
    ..Our results reveal that the foxn1-mcm2 axis plays a central role in the genetic regulatory network controlling thymus development in zebrafish...
  4. Han Y, Mu Y, Li X, Xu P, Tong J, Liu Z, et al. Grhl2 deficiency impairs otic development and hearing ability in a zebrafish model of the progressive dominant hearing loss DFNA28. Hum Mol Genet. 2011;20:3213-26 pubmed publisher
    ..We show that the expression of claudin b (cldnb) and epcam is abolished or dramatically reduced and apical junctional complexes are abnormal in otic epithelial cells of ..
  5. Hegedus Z, Zakrzewska A, Agoston V, Ordas A, Racz P, Mink M, et al. Deep sequencing of the zebrafish transcriptome response to mycobacterium infection. Mol Immunol. 2009;46:2918-30 pubmed publisher
  6. Lu H, Ma J, Yang Y, Shi W, Luo L. EpCAM is an endoderm-specific Wnt derepressor that licenses hepatic development. Dev Cell. 2013;24:543-53 pubmed publisher
    ..is achieved, we identify an endoderm-enriched, single transmembrane protein, epithelial-cell-adhesion-molecule (EpCAM), as an endoderm-specific Wnt derepressor in zebrafish...
  7. Ko S, Choi T, Russell J, So J, Monga S, Shin D. Bromodomain and extraterminal (BET) proteins regulate biliary-driven liver regeneration. J Hepatol. 2016;64:316-325 pubmed publisher
    ..BET proteins regulate BEC-driven liver regeneration at multiple steps: BEC dedifferentiation, HB-LC proliferation, the proliferation of newly generated hepatocytes, and hepatocyte maturation. ..
  8. Holzer G, Morishita Y, Fini J, Lorin T, Gillet B, Hughes S, et al. Thyroglobulin Represents a Novel Molecular Architecture of Vertebrates. J Biol Chem. 2016;291:16553-66 pubmed publisher
    ..By contrast, we have not been able to find any orthologs of Tg among non-vertebrate species. Thus, Tg appears to be a novel protein elaborated as a single event at the base of vertebrates and virtually unchanged thereafter. ..
  9. Dworkin S, Darido C, Georgy S, Wilanowski T, Srivastava S, Ellett F, et al. Midbrain-hindbrain boundary patterning and morphogenesis are regulated by diverse grainy head-like 2-dependent pathways. Development. 2012;139:525-36 pubmed publisher
    ..Collectively, these data show that MHB maintenance and morphogenesis are dissociable events regulated by grhl2b through diverse transcriptional targets. ..
  10. Kuechlin S, Schoels M, Slanchev K, Lassmann S, Walz G, Yakulov T. EpCAM controls morphogenetic programs during zebrafish pronephros development. Biochem Biophys Res Commun. 2017;487:209-215 pubmed publisher
    b>Epithelial cell adhesion molecule EpCAM is a transmembrane glycoprotein that is dynamically expressed in human and murine renal epithelia during development...