eomesa

Summary

Gene Symbol: eomesa
Description: eomesodermin homolog a
Alias: eom, eomes, eomesodermin homolog, eom-a, eomes1, tbr2, tbr2a
Species: zebrafish

Top Publications

  1. Bruce A, Howley C, Zhou Y, Vickers S, Silver L, King M, et al. The maternally expressed zebrafish T-box gene eomesodermin regulates organizer formation. Development. 2003;130:5503-17 pubmed
    ..We have cloned and characterized a maternal T-box gene in the zebrafish, eomesodermin (eomes). During oogenesis, the eomes transcript becomes localized to the cortex of the oocyte...
  2. Du S, Draper B, Mione M, Moens C, Bruce A. Differential regulation of epiboly initiation and progression by zebrafish Eomesodermin A. Dev Biol. 2012;362:11-23 pubmed publisher
    ..In zebrafish, one of the two Eomes homologs, Eomesa, has been implicated in dorsal-ventral patterning, epiboly and endoderm specification in experiments employing ..
  3. Slagle C, Aoki T, Burdine R. Nodal-dependent mesendoderm specification requires the combinatorial activities of FoxH1 and Eomesodermin. PLoS Genet. 2011;7:e1002072 pubmed publisher
    ..Our findings also offer novel insights into the co-evolution of the Nodal signaling pathway, the notochord specification program, and the chordate branch of the deuterostome family of animals. ..
  4. Picozzi P, Wang F, Cronk K, Ryan K. Eomesodermin requires transforming growth factor-beta/activin signaling and binds Smad2 to activate mesodermal genes. J Biol Chem. 2009;284:2397-408 pubmed publisher
    The T-box gene Eomesodermin (Eomes) is required for early embryonic mesoderm differentiation in mouse, frog (Xenopus laevis), and zebrafish, is important in late cardiac development in Xenopus, and for CD8+ T effector cell function in ..
  5. Bjornson C, Griffin K, Farr G, Terashima A, Himeda C, Kikuchi Y, et al. Eomesodermin is a localized maternal determinant required for endoderm induction in zebrafish. Dev Cell. 2005;9:523-33 pubmed
    ..Here, we show that cas expression depends upon the T box transcription factor Eomesodermin (Eomes), a maternal determinant that is localized to marginal blastomeres...
  6. Ando H, Kobayashi M, Tsubokawa T, Uyemura K, Furuta T, Okamoto H. Lhx2 mediates the activity of Six3 in zebrafish forebrain growth. Dev Biol. 2005;287:456-68 pubmed
    ..Our results suggest that Lhx2 may mediate an alternative or parallel pathway for control of cellular proliferation in the developing forebrain via Six3. ..
  7. Takizawa F, Araki K, Kobayashi I, Moritomo T, Ototake M, Nakanishi T. Molecular cloning and expression analysis of T-bet in ginbuna crucian carp (Carassius auratus langsdorfii). Mol Immunol. 2008;45:127-36 pubmed
    ..These results suggest that ginbuna T-bet is involved in the immune system, especially in T-cell function, and is an important tool to analyze teleost cell-mediated immunity. ..
  8. Tallafuss A, Kelly M, Gay L, Gibson D, Batzel P, Karfilis K, et al. Transcriptomes of post-mitotic neurons identify the usage of alternative pathways during adult and embryonic neuronal differentiation. BMC Genomics. 2015;16:1100 pubmed publisher
    ..This important insight and the lists of enriched genes we have identified will now help pave the way to a better understanding of the mechanisms of embryonic and adult neuronal differentiation and how to manipulate these processes. ..
  9. Dean B, Erdoğan B, Gamse J, Wu S. Dbx1b defines the dorsal habenular progenitor domain in the zebrafish epithalamus. Neural Dev. 2014;9:20 pubmed publisher
    ..We provide clear evidence in support of dbx1b marking the progenitor populations that give rise to the dorsal habenulae. In addition, the expression of dbx1b in the dorsal diencephalon is tightly controlled by FGF signaling. ..

More Information

Publications31

  1. Schmidt R, Beil T, Strähle U, Rastegar S. Stab wound injury of the zebrafish adult telencephalon: a method to investigate vertebrate brain neurogenesis and regeneration. J Vis Exp. 2014;:e51753 pubmed publisher
    ..This method combined for example with RNA deep sequencing can help to screen for new genes with a role in zebrafish adult telencephalon neurogenesis, regeneration, and repair. ..
  2. Takizawa F, Araki K, Ohtani M, Toda H, Saito Y, Lampe V, et al. Transcription analysis of two Eomesodermin genes in lymphocyte subsets of two teleost species. Fish Shellfish Immunol. 2014;36:215-22 pubmed publisher
    Eomesodermin (Eomes), a T-box transcription factor, is a key molecule associated with function and differentiation of CD8(+) T cells and NK cells...
  3. Windner S, Bird N, PATTERSON S, Doris R, DEVOTO S. Fss/Tbx6 is required for central dermomyotome cell fate in zebrafish. Biol Open. 2012;1:806-14 pubmed publisher
  4. Walshe J, Mason I. Unique and combinatorial functions of Fgf3 and Fgf8 during zebrafish forebrain development. Development. 2003;130:4337-49 pubmed
    ..Analysis of embryos treated with an FGFR inhibitor suggests that continuous FGF signalling is required from gastrulation stages for normal forebrain patterning, and identifies additional requirements for FGFR activity. ..
  5. Muto A, Arai K, Watanabe S. Rab11-FIP4 is predominantly expressed in neural tissues and involved in proliferation as well as in differentiation during zebrafish retinal development. Dev Biol. 2006;292:90-102 pubmed
  6. Veil M, Schaechtle M, Gao M, Kirner V, Buryanova L, Grethen R, et al. Maternal Nanog is required for zebrafish embryo architecture and for cell viability during gastrulation. Development. 2018;145: pubmed publisher
    ..It is also required for the correctly timed activation of endoderm genes and for the degradation of maternal eomesa mRNA via miR-430...
  7. Carlin D, Sepich D, Grover V, Cooper M, Solnica Krezel L, Inbal A. Six3 cooperates with Hedgehog signaling to specify ventral telencephalon by promoting early expression of Foxg1a and repressing Wnt signaling. Development. 2012;139:2614-24 pubmed publisher
    ..We further find that Six3 promotes ventral telencephalic fates through transient regulation of foxg1a expression and repression of the Wnt/?-catenin pathway. ..
  8. Miyasaka N, Morimoto K, Tsubokawa T, Higashijima S, Okamoto H, Yoshihara Y. From the olfactory bulb to higher brain centers: genetic visualization of secondary olfactory pathways in zebrafish. J Neurosci. 2009;29:4756-67 pubmed publisher
    ..Moreover, our finding of asymmetric bulbo-habenular projection renders the olfactory system an attractive model for the studies of brain asymmetry and lateralized behaviors. ..
  9. Mueller T, Wullimann M, Guo S. Early teleostean basal ganglia development visualized by zebrafish Dlx2a, Lhx6, Lhx7, Tbr2 (eomesa), and GAD67 gene expression. J Comp Neurol. 2008;507:1245-57 pubmed publisher
    We examined the brain expression patterns of zebrafish genes Lhx6, Lhx7, Dlx2a, GAD67, and Tbr2/eomesa; except for GAD67, expression domains are restricted to the forebrain...
  10. Takizawa F, Araki K, Ito K, Moritomo T, Nakanishi T. Expression analysis of two Eomesodermin homologues in zebrafish lymphoid tissues and cells. Mol Immunol. 2007;44:2324-31 pubmed
    ..on the role of Eomes in the immune system of lower vertebrates to date, although developmental studies on Eomes (Eomes1) have been performed in zebrafish...
  11. März M, Schmidt R, Rastegar S, Strahle U. Regenerative response following stab injury in the adult zebrafish telencephalon. Dev Dyn. 2011;240:2221-31 pubmed publisher
    ..Remarkably, the proliferative response is almost completely restricted to the lesioned hemisphere indicating that signals inducing regeneration remain mainly confined within the lesioned half of the telencephalon. ..
  12. Volkmann K, Chen Y, Harris M, Wullimann M, Köster R. The zebrafish cerebellar upper rhombic lip generates tegmental hindbrain nuclei by long-distance migration in an evolutionary conserved manner. J Comp Neurol. 2010;518:2794-817 pubmed publisher
  13. Ganz J, Kroehne V, Freudenreich D, Machate A, Geffarth M, Braasch I, et al. Subdivisions of the adult zebrafish pallium based on molecular marker analysis. F1000Res. 2014;3:308 pubmed publisher
    ..Combinatorial expression analysis of ascl1a, eomesa, emx1, emx2, emx3, and Prox1 identifies four main divisions in the adult zebrafish pallium...
  14. Ganz J, Kaslin J, Freudenreich D, Machate A, Geffarth M, Brand M. Subdivisions of the adult zebrafish subpallium by molecular marker analysis. J Comp Neurol. 2012;520:633-55 pubmed publisher
    ..Furthermore, combinatorial expression of Isl, nkx2.1b, lhx1b, tbr1, eomesa, emx1, emx2, and emx3 identifies striatal-like, pallidal-like, and septal-like subdivisions within the subpallium...
  15. Bruce A, Howley C, Dixon Fox M, Ho R. T-box gene eomesodermin and the homeobox-containing Mix/Bix gene mtx2 regulate epiboly movements in the zebrafish. Dev Dyn. 2005;233:105-14 pubmed
    The T-box gene eomesodermin (eomes) has been implicated in mesoderm specification and patterning in both zebrafish and frog. Here, we describe an additional function for eomes in the control of morphogenesis...
  16. Chen L, Zheng J, Yang N, Li H, Guo S. Genomic selection identifies vertebrate transcription factor Fezf2 binding sites and target genes. J Biol Chem. 2011;286:18641-9 pubmed publisher
    ..Through loss of function, gain of function, and chromatin immunoprecipitation, we further identified and validated eomesa/tbr2 and lhx2b as biologically relevant target genes of Fezf2...
  17. Wang L, Shang N, Feng H, Guo Q, Dai H. Molecular cloning of grass carp (Ctenopharyngodon idellus) T-bet and GATA-3, and their expression profiles with IFN-? in response to grass carp reovirus (GCRV) infection. Fish Physiol Biochem. 2013;39:793-805 pubmed publisher
    ..From this finding, we realize that GCRV mainly induces a Th1 response, and Th1 cell-mediated recognition mechanisms play very important roles in anti-virus cellular immune of grass carp. ..
  18. Ohata S, Aoki R, Kinoshita S, Yamaguchi M, Tsuruoka Kinoshita S, Tanaka H, et al. Dual roles of Notch in regulation of apically restricted mitosis and apicobasal polarity of neuroepithelial cells. Neuron. 2011;69:215-30 pubmed publisher
  19. Kumari P, Gilligan P, Lim S, Tran L, Winkler S, Philp R, et al. An essential role for maternal control of Nodal signaling. elife. 2013;2:e00683 pubmed publisher
    ..Thus, Ybx1 prevents ectopic Nodal activity, revealing a new paradigm in the regulation of Nodal signaling, which is likely to be conserved. DOI:http://dx.doi.org/10.7554/eLife.00683.001. ..
  20. Bae Y, Kani S, Shimizu T, Tanabe K, Nojima H, Kimura Y, et al. Anatomy of zebrafish cerebellum and screen for mutations affecting its development. Dev Biol. 2009;330:406-26 pubmed publisher
    ..Our data provide a platform for future studies of zebrafish cerebellar development. ..
  21. Nelson A, Cutty S, Niini M, Stemple D, Flicek P, Houart C, et al. Global identification of Smad2 and Eomesodermin targets in zebrafish identifies a conserved transcriptional network in mesendoderm and a novel role for Eomesodermin in repression of ectodermal gene expression. BMC Biol. 2014;12:81 pubmed publisher
    ..We also show that Smad2 and zebrafish Eomesodermin a (Eomesa) bind common genomic regions proximal to genes involved in mesoderm and endoderm formation, suggesting Eomesa ..
  22. Sugimoto K, Hui S, Sheng D, Nakayama M, Kikuchi K. Zebrafish FOXP3 is required for the maintenance of immune tolerance. Dev Comp Immunol. 2017;73:156-162 pubmed publisher