en1b

Summary

Gene Symbol: en1b
Description: engrailed homeobox 1b
Alias: eng1b, eng4, wu:fc84e11, zgc:113499, homeobox protein engrailed-1, engrailed 1b, engrailed 4
Species: zebrafish
Products:     en1b

Top Publications

  1. Higashijima S, Masino M, Mandel G, Fetcho J. Engrailed-1 expression marks a primitive class of inhibitory spinal interneuron. J Neurosci. 2004;24:5827-39 pubmed
  2. Hatta K, BreMiller R, Westerfield M, Kimmel C. Diversity of expression of engrailed-like antigens in zebrafish. Development. 1991;112:821-32 pubmed
    ..Specific expression patterns are observed in taste buds, otic vesicles and teeth. Thus we propose that eng genes function in diverse cell types in zebrafish, but play selector roles that can be classified into a few basic types. ..
  3. Kimura Y, Hisano Y, Kawahara A, Higashijima S. Efficient generation of knock-in transgenic zebrafish carrying reporter/driver genes by CRISPR/Cas9-mediated genome engineering. Sci Rep. 2014;4:6545 pubmed publisher
    ..Due to its simplicity, design flexibility, and high efficiency, we propose that CRISPR/Cas9-mediated knock-in will become a standard method for the generation transgenic zebrafish. ..
  4. Hutchinson S, Cheesman S, Hale L, Boone J, Eisen J. Nkx6 proteins specify one zebrafish primary motoneuron subtype by regulating late islet1 expression. Development. 2007;134:1671-7 pubmed
    ..We suggest that Nkx6 proteins regulate MiP development at least in part by maintaining the islet1 expression that is required both to promote the MiP subtype and to suppress interneuron development. ..
  5. Cerda G, Hargrave M, Lewis K. RNA profiling of FAC-sorted neurons from the developing zebrafish spinal cord. Dev Dyn. 2009;238:150-61 pubmed publisher
    ..This protocol for dissociating, sorting and RNA-profiling neurons from organogenesis-stage zebrafish embryos should also be applicable to other developing organs and tissues and potentially other model organisms. ..
  6. Ikenaga T, Urban J, Gebhart N, Hatta K, Kawakami K, Ono F. Formation of the spinal network in zebrafish determined by domain-specific pax genes. J Comp Neurol. 2011;519:1562-79 pubmed publisher
    ..In contrast, the RFP(+) cells of pax2a/pax8 double mutants displayed altered cell fates. CoBLs were not observed. Instead, RFP(+) cells exhibited axons descending ipsilaterally, a morphology resembling that of V2a/V2b interneurons. ..
  7. Juárez Morales J, Schulte C, Pezoa S, Vallejo G, Hilinski W, England S, et al. Evx1 and Evx2 specify excitatory neurotransmitter fates and suppress inhibitory fates through a Pax2-independent mechanism. Neural Dev. 2016;11:5 pubmed publisher
    ..These results significantly increase our understanding of the mechanisms of neuronal specification and the genetic networks involved in these processes. ..
  8. Wilson C, Nguyen C, Chen M, Yang J, Gacayan R, Huang J, et al. Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis. Nature. 2009;459:98-102 pubmed publisher
    ..Our results delineate a new pathway for central pair apparatus assembly, identify common regulators of Hh signalling and motile ciliogenesis, and provide insights into the evolution of the Hh cascade. ..
  9. Van de Peer Y, Frickey T, Taylor J, Meyer A. Dealing with saturation at the amino acid level: a case study based on anciently duplicated zebrafish genes. Gene. 2002;295:205-11 pubmed
    ..When trees are computed by omitting the saturated fraction of sites, most fish duplicates are sister sequences. ..

More Information

Publications24

  1. Ahmed M, Maurya A, Cheng L, Jorge E, Schubert F, Maire P, et al. Engrailed controls epaxial-hypaxial muscle innervation and the establishment of vertebrate three-dimensional mobility. Dev Biol. 2017;430:90-104 pubmed publisher
  2. Batista M, Jacobstein J, Lewis K. Zebrafish V2 cells develop into excitatory CiD and Notch signalling dependent inhibitory VeLD interneurons. Dev Biol. 2008;322:263-75 pubmed publisher
    ..In addition, we demonstrate that Notch signalling is required for V2 cells to develop into V2b cells. In the absence of Notch signalling, all V2b cells develop as V2a cells. ..
  3. Gribble S, Nikolaus O, Dorsky R. Regulation and function of Dbx genes in the zebrafish spinal cord. Dev Dyn. 2007;236:3472-83 pubmed
    ..Our data confirm that the dbx1a/1b/2 domain in zebrafish spinal cord development behaves similarly to amniotes, while extending knowledge of Dbx1 function in spinal cord patterning. ..
  4. Dolez M, Nicolas J, Hirsinger E. Laminins, via heparan sulfate proteoglycans, participate in zebrafish myotome morphogenesis by modulating the pattern of Bmp responsiveness. Development. 2011;138:97-106 pubmed publisher
    ..This study underlines the importance of extracellular cues for the precise spatial modulation of cell response to morphogens. ..
  5. Kinkhabwala A, Riley M, Koyama M, Monen J, Satou C, Kimura Y, et al. A structural and functional ground plan for neurons in the hindbrain of zebrafish. Proc Natl Acad Sci U S A. 2011;108:1164-9 pubmed publisher
    ..This simple organization probably forms a foundation for the construction of the networks underlying the many behaviors produced by the hindbrain. ..
  6. Su C, Kemp H, Moens C. Cerebellar development in the absence of Gbx function in zebrafish. Dev Biol. 2014;386:181-90 pubmed publisher
    ..Based on our findings we propose a revised model for the role of Gbx in cerebellar development. ..
  7. Scholpp S, Brand M. Morpholino-induced knockdown of zebrafish engrailed genes eng2 and eng3 reveals redundant and unique functions in midbrain--hindbrain boundary development. Genesis. 2001;30:129-33 pubmed
  8. Force A, Lynch M, Pickett F, Amores A, Yan Y, Postlethwait J. Preservation of duplicate genes by complementary, degenerative mutations. Genetics. 1999;151:1531-45 pubmed
    ..Cooke et al. 1997 (p. 362) ..
  9. Batista M, Lewis K. Pax2/8 act redundantly to specify glycinergic and GABAergic fates of multiple spinal interneurons. Dev Biol. 2008;323:88-97 pubmed publisher
  10. Gribble S, Kim H, Bonner J, Wang X, Dorsky R. Tcf3 inhibits spinal cord neurogenesis by regulating sox4a expression. Development. 2009;136:781-9 pubmed publisher
    ..Both of these functions are mediated by Tcf3 independently of canonical Wnt signaling. Together, our data indicate a novel mechanism for the regulation of neurogenesis by Tcf3-mediated repression. ..
  11. Hammond K, Baxendale S, McCauley D, Ingham P, Whitfield T. Expression of patched, prdm1 and engrailed in the lamprey somite reveals conserved responses to Hedgehog signaling. Evol Dev. 2009;11:27-40 pubmed publisher
    ..These data suggest the presence of conserved responses to Hh signaling in lamprey somites, although the full range of effects elicited by Hh in the zebrafish somite is not recapitulated. ..
  12. Teh C, Sun G, Shen H, Korzh V, Wohland T. Modulating the expression level of secreted Wnt3 influences cerebellum development in zebrafish transgenics. Development. 2015;142:3721-33 pubmed publisher
    ..Our work, supported by quantitative analysis of protein dynamics in vivo, highlights the importance of membrane-localized and secreted Wnt3 during cerebellum development. ..
  13. Zannino D, Downes G, SAGERSTROM C. prdm12b specifies the p1 progenitor domain and reveals a role for V1 interneurons in swim movements. Dev Biol. 2014;390:247-60 pubmed publisher
    ..We find that disruption of prdm12b function leads to dorsal expansion of nkx6.1 expression and loss of p1-derived eng1b-expressing V1 interneurons, while the adjacent p0 and p2 domains are unaffected...
  14. Koyama M, Kinkhabwala A, Satou C, Higashijima S, FETCHO J. Mapping a sensory-motor network onto a structural and functional ground plan in the hindbrain. Proc Natl Acad Sci U S A. 2011;108:1170-5 pubmed publisher
    ..Many different specialized hindbrain networks may arise similarly from a simple early patterning. ..
  15. Amores A, Force A, Yan Y, Joly L, Amemiya C, Fritz A, et al. Zebrafish hox clusters and vertebrate genome evolution. Science. 1998;282:1711-4 pubmed
    ..Thus, teleosts, the most species-rich group of vertebrates, appear to have more copies of these developmental regulatory genes than do mammals, despite less complexity in the anterior-posterior axis. ..