Gene Symbol: elnb
Description: elastin b
Alias: eln2, elastin b, tropoelastin
Species: zebrafish

Top Publications

  1. Miao M, Bruce A, Bhanji T, Davis E, Keeley F. Differential expression of two tropoelastin genes in zebrafish. Matrix Biol. 2007;26:115-24 pubmed
    ..Elastin is synthesized as a monomer, tropoelastin, but is rapidly transformed into its final polymeric form in the extracellular matrix...
  2. Zhou Y, Cashman T, Nevis K, Obregon P, Carney S, Liu Y, et al. Latent TGF-? binding protein 3 identifies a second heart field in zebrafish. Nature. 2011;474:645-8 pubmed publisher
    ..Taken together, our findings uncover a requirement for ltbp3-TGF-? signalling during zebrafish SHF development, a process that serves to enlarge the single ventricular chamber in this species. ..
  3. He D, Chung M, Chan E, Alleyne T, Ha K, Miao M, et al. Comparative genomics of elastin: Sequence analysis of a highly repetitive protein. Matrix Biol. 2007;26:524-40 pubmed
    ..The success of this approach for elastin offers a promising route to the elucidation of sequence, structure, function and evolutionary relationships for many other proteins with sequences of low complexity. ..
  4. Singh A, Sivadas A, Sabharwal A, Vellarikal S, Jayarajan R, Verma A, et al. Chamber Specific Gene Expression Landscape of the Zebrafish Heart. PLoS ONE. 2016;11:e0147823 pubmed publisher
    ..It is also postulated that this transcriptome atlas will help utilize zebrafish in a better way as a model for studying cardiac development and to explore functional role of gene networks in cardiac disease pathogenesis. ..
  5. Rydeen A, Waxman J. Cyp26 Enzymes Facilitate Second Heart Field Progenitor Addition and Maintenance of Ventricular Integrity. PLoS Biol. 2016;14:e2000504 pubmed publisher
    ..These novel findings indicate a primary effect of RA-induced OFT defects is disruption of the extracellular environment, which compromises both SHF recruitment and FHF ventricular integrity. ..
  6. Rambeau P, Faure E, Théron A, Avierinos J, Jopling C, Zaffran S, et al. Reduced aggrecan expression affects cardiac outflow tract development in zebrafish and is associated with bicuspid aortic valve disease in humans. Int J Cardiol. 2017;249:340-343 pubmed publisher
    ..We found that in type 0 BAV there was a significant reduction in the expression of AGGRECAN. Our data indicate that aggrecan is required for OFT development and when its expression is reduced this is associated with BAV in humans. ..
  7. Choudhry P, Trede N. DiGeorge syndrome gene tbx1 functions through wnt11r to regulate heart looping and differentiation. PLoS ONE. 2013;8:e58145 pubmed publisher
    ..This is the first study linking tbx1 and non-canonical Wnt signaling and extends our understanding of DGS and heart development. ..
  8. Kao R, Rurik J, Farr G, Dong X, Majesky M, Maves L. Pbx4 is Required for the Temporal Onset of Zebrafish Myocardial Differentiation. J Dev Biol. 2015;3:93-111 pubmed
    ..In summary, our data show that Pbx4 is required for the proper temporal activation of myocardial differentiation and establish a basis for studying additional roles of Pbx factors in heart development. ..
  9. Chung M, Miao M, Stahl R, Chan E, Parkinson J, Keeley F. Sequences and domain structures of mammalian, avian, amphibian and teleost tropoelastins: Clues to the evolutionary history of elastins. Matrix Biol. 2006;25:492-504 pubmed publisher
    b>Tropoelastin is the monomeric form of elastin, a polymeric extracellular matrix protein responsible for properties of extensibility and elastic recoil in connective tissues of most vertebrates...

More Information


  1. Hartnett L, Glynn C, Nolan C, Grealy M, Byrnes L. Insulin-like growth factor-2 regulates early neural and cardiovascular system development in zebrafish embryos. Int J Dev Biol. 2010;54:573-83 pubmed publisher
    ..The finding that igf-2a and igf-2b do not act exclusively in a redundant manner may explain why both genes have been stably maintained in the genome. ..
  2. Mandal A, Holowiecki A, Song Y, Waxman J. Wnt signaling balances specification of the cardiac and pharyngeal muscle fields. Mech Dev. 2017;143:32-41 pubmed publisher
    ..Our study provides insight into an antagonistic developmental mechanism that balances the sizes of the adjacent cardiac and PM progenitor fields in early vertebrate embryos. ..