| eif4g2aGene Symbol: eif4g2a Description: eukaryotic translation initiation factor 4, gamma 2a Alias: NAT1A, im:7148615, wu:fb81f07, wu:fb82b06, wu:fb98h08, eukaryotic translation initiation factor 4, gamma 2a, eIF4G-related protein NAT1A Species: zebrafish Takahashi K, Maruyama M, Tokuzawa Y, Murakami M, Oda Y, Yoshikane N, et al. Evolutionarily conserved non-AUG translation initiation in NAT1/p97/DAP5 (EIF4G2). Genomics. 2005;85:360-71 pubmed publisher ..We found that NAT1 orthologs in Drosophila melanogaster and Halocynthia roretzi also use non-AUG start codons, demonstrating evolutionary conservation of the noncanonical translation initiation... Wardle F, Odom D, Bell G, Yuan B, Danford T, Wiellette E, et al. Zebrafish promoter microarrays identify actively transcribed embryonic genes. Genome Biol. 2006;7:R71 pubmed ..This approach will allow investigators to determine the genomic binding locations of DNA interacting proteins during development and expedite the assembly of the genetic networks that regulate embryogenesis. .. Nousch M, Reed V, Bryson Richardson R, Currie P, Preiss T. The eIF4G-homolog p97 can activate translation independent of caspase cleavage. RNA. 2007;13:374-84 pubmed ..These data indicate that full-length p97 is a translational activator with essential role(s) in unstressed cells, suggesting a reassessment of current models of p97 function. .. Stapel L, Lombardot B, Broaddus C, Kainmueller D, Jug F, Myers E, et al. Automated detection and quantification of single RNAs at cellular resolution in zebrafish embryos. Development. 2016;143:540-6 pubmed publisher Joseph S, Pálfy M, Hilbert L, Kumar M, Karschau J, Zaburdaev V, et al. Competition between histone and transcription factor binding regulates the onset of transcription in zebrafish embryos. elife. 2017;6: pubmed publisher ..Our results demonstrate that the relative levels of histones and transcription factors regulate the onset of transcription in the embryo. ..
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