Genomes and Genes
Gene Symbol: egr2b
Description: early growth response 2b
Alias: KRX-20, cb427, egr2, id:ibd5073, krox20, krx20, wu:fb71h10, zgc:92210, early growth response protein 2b, EGR-2b, krox-20, protein krx-20, zinc finger protein Krox-20
Publications178 found, 100 shown here
- Modulation of embryonic intracellular Ca2+ signaling by Wnt-5AD C Slusarski
Howard Hughes Medical Institute, University of Washington School of Medicine, Seattle 98195, USA
Dev Biol 182:114-20. 1997..These results suggest that intercellular signaling by a subset of vertebrate Wnts involves modulation of a intracellular Ca2+ signaling pathway, which may arise from phosphatidylinositol cycle activity...
- Ectopic expression of hoxb2 after retinoic acid treatment or mRNA injection: disruption of hindbrain and craniofacial morphogenesis in zebrafish embryosY L Yan
Institute of Neuroscience, University of Oregon, Eugene 97403 1254, USA
Dev Dyn 213:370-85. 1998..patterning in r4, fusion of cartilage elements arising from pharyngeal arches 1 and 2, and ectopic expression of krx20 and valentino (but not pax2, rtk1, or hoxb1) in the rostral hindbrain, midbrain, and, surprisingly, the eye...
- Interplay of pu.1 and gata1 determines myelo-erythroid progenitor cell fate in zebrafishJennifer Rhodes
Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
Dev Cell 8:97-108. 2005..1 in the bloodless mutant cloche resulted in myelopoietic rescue, providing intriguing evidence that this gene can function in the absence of some stem cell genes, such as scl, in governing myelopoiesis...
- Neuronal Neuregulin 1 type III directs Schwann cell migrationJulie R Perlin
Department of Developmental Biology, 279 Campus Dr, Beckman Center B300, Stanford University, Stanford, CA 94305, USA
Development 138:4639-48. 2011..These results demonstrate that Nrg1 type III is an essential signal that controls Schwann cell migration to ensure that these glia are present in the correct numbers and positions in developing nerves...
- A role for FGF-8 in the dorsoventral patterning of the zebrafish gastrulaM Fürthauer
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, ULP, Illkirch, France
Development 124:4253-64. 1997..We conclude that FGF-8 is involved in defining dorsoventral identity and is an important organizing factor responsible for specification of mesodermal and ectodermal dorsolateral territories of the zebrafish gastrula...
- Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and functionAvinash Persaud
Programs in Cell Biology and Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
EMBO J 30:3259-73. 2011..These results identify Nedd4-1 as a key regulator of FGFR1 endocytosis and signalling during neuronal differentiation and embryonic development...
- Perturbation of rRNA synthesis in the bap28 mutation leads to apoptosis mediated by p53 in the zebrafish central nervous systemMizuki Azuma
Laboratory of Molecular Genetics, NICHD, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 281:13309-16. 2006..The bap28 mutation provides a genetic approach to study the role of ribosome biogenesis in the development of a vertebrate embryo...
- Zic1 and Zic4 regulate zebrafish roof plate specification and hindbrain ventricle morphogenesisGina E Elsen
The Committee on Neurobiology, University of Chicago, 947 East 58th Street, Chicago, IL 60637, USA
Dev Biol 314:376-92. 2008..In summary, we conclude that Zic1 and Zic4 control zebrafish 4th ventricle morphogenesis by regulating multiple mechanisms including cell proliferation and fate specification in the dorsal hindbrain...
- The Hox cofactors Meis1 and Pbx act upstream of gata1 to regulate primitive hematopoiesisLaura M Pillay
Department of Biological Sciences, University of Alberta, Edmonton, Canada
Dev Biol 340:306-17. 2010..Our study conclusively demonstrates that Meis1 and Pbx act to specify the erythropoietic cell lineage and inhibit myelopoiesis...
- Distinct roles for Fgf, Wnt and retinoic acid in posteriorizing the neural ectodermTetsuhiro Kudoh
Department of Anatomy and Developmental Biology, University College London, Gower St, London WC1E 6BT, UK
Development 129:4335-46. 2002..Thus, cyp26 has an important role in linking the Fgf, Wnt and RA signals to regulate AP patterning of the neural ectoderm in the late blastula to gastrula embryo in zebrafish...
- Zebrafish Foxd3 is required for development of a subset of neural crest derivativesJames A Lister
Department of Biological Structure and Center for Developmental Biology, University of Washington, HSB G514, Box 357420, Seattle, 98195 7420, USA
Dev Biol 290:92-104. 2006....
- The mother superior mutation ablates foxd3 activity in neural crest progenitor cells and depletes neural crest derivatives in zebrafishMercedes Montero-Balaguer
Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
Dev Dyn 235:3199-212. 2006..Further analysis of mosm188 mutants and foxd3 morphants revealed that NC cells are initially formed, suggesting that foxd3 function is required to maintain the pool of NC progenitors...
- Frizzled3a and Celsr2 function in the neuroepithelium to regulate migration of facial motor neurons in the developing zebrafish hindbrainHironori Wada
Laboratory for Developmental Gene Regulation, Brain Science Institute, The Institute of Physical and Chemical Research RIKEN Saitama 351 0198, Japan
Development 133:4749-59. 2006..e. preventing integration of differentiated neurons into the neuroepithelial layer). This contrasts markedly with their reported role in reintegration of neuroepithelial daughter cells into the neuroepithelial layer after cell division...
- Negative regulation of wnt11 expression by Jnk signaling during zebrafish gastrulationJungwon Seo
Department of Developmental and Regenerative Biology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
J Cell Biochem 110:1022-37. 2010..Furthermore, non-canonical Wnt signaling may coordinate vertebrate CE movements by triggering Jnk activation that represses the expression of the CE-triggering ligand wnt11...
- Essential and opposing roles of zebrafish beta-catenins in the formation of dorsal axial structures and neurectodermGianfranco Bellipanni
Department of Biology, University of Pennsylvania, Philadelphia, 19104, USA
Development 133:1299-309. 2006..We propose that the early, dorsal-promoting function of beta-catenin-2 is essential to counteract a later, dorsal- and neurectoderm-repressing function that is shared by both beta-catenin genes...
- A subunit of the mediator complex regulates vertebrate neuronal developmentXiaoqun Wang
Program in Genetics, Neuroscience, and Developmental Biology, Department of Biopharmaceutical Sciences, and Center for Human Genetics, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 103:17284-9. 2006..Together, our analyses reveal a regulatory role of Mot/Med12 in vertebrate neuronal development...
- Expression of truncated Sek-1 receptor tyrosine kinase disrupts the segmental restriction of gene expression in the Xenopus and zebrafish hindbrainQ Xu
Developmental Biology Research Centre, Randall Institute, Kings College, London, UK
Development 121:4005-16. 1995..These data suggest that Sek-1, perhaps with other Eph-related receptors, is required for interactions that regulate the segmental identity or movement of cells...
- The BMP signaling gradient patterns dorsoventral tissues in a temporally progressive manner along the anteroposterior axisJennifer A Tucker
Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
Dev Cell 14:108-19. 2008..We propose that a temporal cue regulates a cell's competence to respond to BMP signaling, allowing the acquisition of a cell's DV and AP identity simultaneously...
- Membrane-type 1 matrix metalloproteinase regulates cell migration during zebrafish gastrulation: evidence for an interaction with non-canonical Wnt signalingRebecca C Coyle
Department of Medicine Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Exp Cell Res 314:2150-62. 2008..Together, our results support the notion that pathways regulating pericellular proteolysis and cell polarity converge to promote efficient cell migration...
- Combinatorial expression of zebrafish Brn-1- and Brn-2-related POU genes in the embryonic brain, pronephric primordium, and pharyngeal archesG Hauptmann
Biozentrum der Universitat Basel, Switzerland
Dev Dyn 218:345-58. 2000..We propose that coordinate expression of particular combinations of class III POU genes contribute to pattern formation or cell fate determination in the developing CNS and other structures...
- Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesisF Reifers
Department of Neurobiology, University of Heidelberg, Im Neuenheimer Feld 364, D 69120 Heidelberg, Germany
Development 125:2381-95. 1998..Fgf8 is therefore required in development of several important signaling centers in the zebrafish embryo, but may be redundant or dispensable for others...
- Cyp26 enzymes generate the retinoic acid response pattern necessary for hindbrain developmentRafael E Hernandez
HHMI and Division of Basic Science, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, Seattle, WA 98109 1024, USA
Development 134:177-87. 2007..We present a ;gradient-free' model for hindbrain patterning in which differential RA responsiveness along the hindbrain anterior-posterior axis is shaped primarily by the dynamic expression of RA-degrading enzymes...
- Cystein-serine-rich nuclear protein 1, Axud1/Csrnp1, is essential for cephalic neural progenitor proliferation and survival in zebrafishCarmen G Feijóo
Center for Genomics of the Cell, Facultad de Ciencias, Universidad Chile, Santiago, Chile
Dev Dyn 238:2034-43. 2009..Thus, we provide evidence as to the role of axud1 in brain growth in vertebrates...
- High mobility group box-1 (HMGB1; amphoterin) is required for zebrafish brain developmentXiang Zhao
Neuroscience Center, University of Helsinki, Helsinki FIN 00014, Finland
J Biol Chem 286:23200-13. 2011..Our data demonstrate that HMGB1 is a critical factor for brain development, enabling survival and proliferation of neural progenitors that will form the forebrain structures...
- The nieuwkoid gene characterizes and mediates a Nieuwkoop-center-like activity in the zebrafishD S Koos
Department of Molecular Biology, Princeton University, New Jersey 08544, USA
Curr Biol 8:1199-206. 1998....
- Role of BMP signaling and the homeoprotein Iroquois in the specification of the cranial placodal fieldAlvaro Glavic
Millennium Nucleus in Developmental Biology, Laboratory of Developmental Biology, Facultad de Ciencias, Universidad de Chile, Santiago
Dev Biol 272:89-103. 2004....
- Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movementsJason R Jessen
Department of Biological Sciences, Vanderbilt University, VU Station B 351634, Nashville, TN 37235, USA
Nat Cell Biol 4:610-5. 2002..We propose Trilobite/Stbm mediates cellular interactions that confer directionality on distinct movements during vertebrate embryogenesis...
- A role for MKP3 in axial patterning of the zebrafish embryoMichael Tsang
Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Development 131:2769-79. 2004..Thus, mkp3 encodes a feedback attenuator of the FGF pathway, the expression of which is initiated at an early stage so as to ensure correct FGF signaling levels at the time of axial patterning...
- vhnf1 integrates global RA patterning and local FGF signals to direct posterior hindbrain development in zebrafishRafael E Hernandez
Howard Hughes Medical Institute and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, PO Box 19024, Seattle, WA 98109, USA
Development 131:4511-20. 2004..The different requirements for vhnf1 and val to repress hoxb1a and ephrin-B2a, respectively, demonstrate that not all aspects of an individual rhombomere's identity are regulated coordinately...
- dlx3b and dlx4b function in the development of Rohon-Beard sensory neurons and trigeminal placode in the zebrafish neurulaTakao Kaji
Department of Craniofacial Biology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
Dev Biol 276:523-40. 2004..These data suggest that the contribution of dlx3b and dlx4b to neural plate border formation is partially non-cell-autonomous acting via BMP activity...
- Dual roles of zygotic and maternal Scribble1 in neural migration and convergent extension movements in zebrafish embryosHironori Wada
Laboratory for Developmental Gene Regulation, Brain Science Institute, The Institute of Physical and Chemical Research RIKEN Saitama 351 0198, Japan
Development 132:2273-85. 2005..The dual roles of the scrb1 gene in both neuronal migration and CE provide a novel insight into the underlying mechanisms of cell movement in vertebrate development...
- Zebrafish nodal-related 2 encodes an early mesendodermal inducer signaling from the extraembryonic yolk syncytial layerC E Erter
Department of Molecular Biology, Vanderbilt University, 1161 21st Avenue South, Nashville, Tennessee, 37232 2175, USA
Dev Biol 204:361-72. 1998..Our results suggest that znr2 encodes a robust mesendodermal inducer that signals nonautonomously during the earliest stages of embryonic patterning, and that part of this activity arises from within the YSL...
- EphA4 is required for cell adhesion and rhombomere-boundary formation in the zebrafishJulie E Cooke
Howard Hughes Medical Institute and Division of Basic Science, Fred Hutchinson Cancer Research Center B2 152, 1100 Fairview Avenue N, P O Box 19024, Seattle, Washington 98109, USA
Curr Biol 15:536-42. 2005....
- Differential regulation of the zebrafish orthopedia 1 gene during fate determination of diencephalic neuronsLuca Del Giacco
Department of Biology, Universita degli Studi di Milano, Via Celoria 26, Milano, 20133, Italy
BMC Dev Biol 6:50. 2006..However, there is little information on the intercellular factors that regulate Otp expression during development...
- Epibranchial and otic placodes are induced by a common Fgf signal, but their subsequent development is independentShun Kuo Sun
Children s Brain Tumour Research Centre, Institute of Genetics, Queen s Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK
Dev Biol 303:675-86. 2007....
- Initial anteroposterior pattern of the zebrafish central nervous system is determined by differential competence of the epiblastS Koshida
Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa ku, Nagoya, Japan
Development 125:1957-66. 1998..However, the requirement for FGF signalling is indirect in that cells with compromised ability to respond to FGF can still respond to anteroposterior positional information...
- The zebrafish spiel-ohne-grenzen (spg) gene encodes the POU domain protein Pou2 related to mammalian Oct4 and is essential for formation of the midbrain and hindbrain, and for pre-gastrula morphogenesisShawn Burgess
Massachusetts Institute of Technology, Center for Cancer Research, E17 340, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Development 129:905-16. 2002..1, wnt1, krox20) are severely reduced, correlating with the neuroectoderm-specific expression phase of pou2...
- Essential role for Csk upstream of Fyn and Yes in zebrafish gastrulationChris Jopling
Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
Mech Dev 124:129-36. 2007..The Csk knock down phenotype was rescued by simultaneous partial knock down of Fyn and Yes. We conclude that Csk acts upstream of Fyn and Yes to control vertebrate gastrulation cell movements...
- Zebrafish wnt8 and wnt8b share a common activity but are involved in distinct developmental pathwaysG M Kelly
Howard Hughes Medical Institute, Department of Pharmacology, Seattle, Washington, USA
Development 121:1787-99. 1995....
- valentino: a zebrafish gene required for normal hindbrain segmentationC B Moens
Institute of Neuroscience, University of Oregon, Eugene 97403 1254, USA
Development 122:3981-90. 1996..These results provide genetic evidence for a two-segment periodicity in the hindbrain and suggest that this periodicity arises sequentially, through the specification and later subdivision of a two-rhombomere unit, or 'protosegment'...
- Specification of the zebrafish nervous system by nonaxial signalsK Woo
Division of Biology and Biological Imaging Center, Beckman Institute, California Institute of Technology, Pasadena, CA 91125, USA
Science 277:254-7. 1997..Thus, the zebrafish gastrula may integrate spatially distinct signals from the organizer and the germring to pattern the neural axis...
- Equivalence in the genetic control of hindbrain segmentation in fish and mouseC B Moens
Institute of Neuroscience, University of Oregon, Eugene 97403 1254, USA
Development 125:381-91. 1998....
- In vivo cell sorting in complementary segmental domains mediated by Eph receptors and ephrinsQ Xu
Division of Developmental Neurobiology, National Institute for Medical Research, London, UK
Nature 399:267-71. 1999..These data implicate Eph receptors and ephrins in the segmental restriction of cell intermingling...
- Maternal and zygotic activity of the zebrafish ogon locus antagonizes BMP signalingV Miller-Bertoglio
Department of Embryology, Carnegie Institution of Washington, Johns Hopkins University, Baltimore, MD, USA
Dev Biol 214:72-86. 1999..The results suggest that ogo encodes an as yet unidentified dorsalizing factor that mediates dorsoventral patterning by directly or indirectly antagonizing BMP activity...
- Activin- and Nodal-related factors control antero-posterior patterning of the zebrafish embryoB Thisse
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, Illkirch, CU de Strasbourg, France
Nature 403:425-8. 2000..We propose that modulation of intercellular signalling by Antivin/Activin and Nodal-related factors provides a mechanism for the graded establishment of cell fates along the antero-posterior axis of the zebrafish embryo...
- Fgf3 and Fgf8 are required together for formation of the otic placode and vesicleHabib Maroon
MRC Centre for Developmental Neurobiology, New Hunt s House, King s College London, Guy s Campus, London SE1 9RT, UK
Development 129:2099-108. 2002..We propose that Fgf3 and Fgf8 are required together for formation of the otic placode and act during the earliest stages of its induction...
- Fgf3 and Fgf8 dependent and independent transcription factors are required for otic placode specificationDong Liu
Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA Gene Tools, LLC, 1 Summerton Way, Philomath, OR 97370, USA
Development 130:2213-24. 2003....
- nlz gene family is required for hindbrain patterning in the zebrafishJacqueline Hoyle
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts, USA
Dev Dyn 229:835-46. 2004..These data indicate that one function of the nlz gene family is to specify or maintain r4 identity, and to limit r3 and r5 during hindbrain formation...
- Paralog group 1 hox genes regulate rhombomere 5/6 expression of vhnf1, a repressor of rostral hindbrain fates, in a meis-dependent mannerSeong Kyu Choe
Program in Neuroscience, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605 2324, USA
Dev Biol 271:350-61. 2004..Notably, reductions in the function of another Hox cofactor, pbx, have not been reported to transform the caudal hindbrain, suggesting that Meis and Pbx proteins may also function differently in their roles as Hox cofactors...
- Rhombomere boundaries are Wnt signaling centers that regulate metameric patterning in the zebrafish hindbrainBruce B Riley
Biology Department, Texas A and M University, College Station, Texas 77843 3258, USA
Dev Dyn 231:278-91. 2004..Similar feedback mechanisms operate in the Drosophila wing disc and vertebrate limb bud, suggesting coaptation of a conserved signaling module that spatially organizes cells in complex organ systems...
- A reporter-assisted mutagenesis screen using alpha 1-tubulin-GFP transgenic zebrafish uncovers missteps during neuronal development and axonogenesisAbhilasha Gulati-Leekha
Molecular and Behavioral Neuroscience Institute, Department of Biological Chemistry, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109 070, USA
Dev Biol 296:29-47. 2006..Molecular identification of these loci and analysis of the remaining mutational repertoire will offer unique insights into the genetic inputs that go on to make a mature, differentiated neuron...
- Repression of the hindbrain developmental program by Cdx factors is required for the specification of the vertebrate spinal cordIsaac Skromne
Department of Organismal Biology and Anatomy, The University of Chicago, 1027 E 57th Street R107, Chicago, IL 60637, USA
Development 134:2147-58. 2007..We propose that by preventing the posterior-most region of the neural plate from following a hindbrain developmental program, Cdx factors help determine the size of the prospective hindbrain and spinal cord territories...
- Zebrafish Hoxb1a regulates multiple downstream genes including prickle1bMonica R Rohrschneider
The Committee on Developmental Biology, The University of Chicago, 1027 East 57th Street, Chicago, IL 60637, USA
Dev Biol 309:358-72. 2007..Using morpholino knock-down and cell transplantation, we demonstrate that the Hoxb1a target Prickle1b functions cell-autonomously to control facial neuron migration, a single aspect of r4 identity...
- Shp2 knockdown and Noonan/LEOPARD mutant Shp2-induced gastrulation defectsChris Jopling
Hubrecht Institute, Utrecht, The Netherlands
PLoS Genet 3:e225. 2007..The finding that defective Shp2 signaling induced cell movement defects as early as gastrulation may have implications for the monitoring and diagnosis of Noonan and LEOPARD syndrome...
- EphA4 and EfnB2a maintain rhombomere coherence by independently regulating intercalation of progenitor cells in the zebrafish neural keelHilary A Kemp
Howard Hughes Medical Institute and Division of Basic Science, Fred Hutchinson Cancer Research Center, B2 152, 1100 Fairview Ave N, Seattle, WA 98109, P O Box 19024, USA
Dev Biol 327:313-26. 2009..We propose a model in which Eph and Efn-dependent cell affinity within rhombomeres serve to maintain rhombomere organization during the potentially disruptive process of teleost neurulation...
- Increased Hox activity mimics the teratogenic effects of excess retinoic acid signalingJoshua S Waxman
Developmental Genetics Program and Department of Cell Biology, Kimmel Center for Biology and Medicine at the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
Dev Dyn 238:1207-13. 2009..These results suggest that Hox activity mediates the differential effects of ectopic RA on atrial and ventricular cardiomyocytes and may underlie the teratogenic effects of RA on the heart...
- Pbx acts with Hand2 in early myocardial differentiationLisa Maves
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Dev Biol 333:409-18. 2009..Our findings demonstrate new roles for Pbx proteins in vertebrate cardiac development and also provide new insight into connections between the transcriptional regulation of skeletal and cardiac muscle differentiation programs...
- Protocadherin-19 is essential for early steps in brain morphogenesisMichelle R Emond
Center for Molecular Neurobiology and Department of Neuroscience, 115 Rightmire Hall, Ohio State University, Columbus, OH 43210, USA
Dev Biol 334:72-83. 2009..1 and krox20. Characterization of embryos early in development by in vivo 2-photon timelapse microscopy reveals that the ..
- Axial, a zebrafish gene expressed along the developing body axis, shows altered expression in cyclops mutant embryosU Strahle
Department of Zoology, Molecular Embryology Laboratory and Developmental Genetics Laboratory, University of Oxford, UK
Genes Dev 7:1436-46. 1993..Taken together, our data suggest that Axial plays a crucial role in specification of both the axial mesendoderm and the ventral central nervous system...
- Ectopic expression of Hoxa-1 in the zebrafish alters the fate of the mandibular arch neural crest and phenocopies a retinoic acid-induced phenotypeD Alexandre
Developmental Biology Research Centre, Randall Institute, King s College, London, UK
Development 122:735-46. 1996..These results are discussed in terms of the role of Hoxa-1 in controlling anterior hindbrain patterning and the relationship between expression of Hoxa-1 and retinoic acid...
- Differential regulation of chordin expression domains in mutant zebrafishV E Miller-Bertoglio
Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
Dev Biol 192:537-50. 1997..1989), while axial mesodermal expression was affected. This finding reveals an unexpected function for spadetail in midline mesoderm and in differential regulation of chordin expression during gastrulation...
- Specification of the hindbrain fate in the zebrafishK Woo
Biological Imaging Center, Beckman Institute, California Institute of Technology, Pasadena 91125, USA
Dev Biol 197:283-96. 1998..they are able to maintain regional fate, as is evident by the expression of the hindbrain-specific marker, Krox20. In addition, we observe that committed hindbrain tissues are able to induce presumptive ventral epidermis to form ..
- Ventral and lateral regions of the zebrafish gastrula, including the neural crest progenitors, are established by a bmp2b/swirl pathway of genesV H Nguyen
Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, USA
Dev Biol 199:93-110. 1998..Based on the alterations in tissue-specific gene expression, we propose a model whereby swirl/bmp2b acts as a morphogen to specify different cell types along the dorsoventral axis...
- Mutations in the zebrafish unmask shared regulatory pathways controlling the development of catecholaminergic neuronsS Guo
Department of Neuroscience, Genentech, Inc, 1 DNA Way, South San Francisco, California, 94080, USA
Dev Biol 208:473-87. 1999..They further reveal an underlying universal mechanism for the control of CA cell fates, which involve combinatorial usage of regulatory genes...
- Expression of the Ets transcription factors erm and pea3 in early zebrafish developmentS R Münchberg
Department of Cell Biology, Max Planck Institute for Developmental Biology, Spemannstrasse 35, 72076, Tubingen, Germany
Mech Dev 88:233-6. 1999..In contrast, pea3 is not expressed in the rhombomeres but in the Rohon-Beard neurons, the sensory lateral line placodes and the heart...
- Signals from the yolk cell induce mesoderm, neuroectoderm, the trunk organizer, and the notochord in zebrafishE A Ober
Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Spemannstrasse 35, Tubingen, 72076, Germany
Dev Biol 215:167-81. 1999..In addition, these experiments show that the establishment of the anteroposterior axis is independent of the dorsoventral axis...
- The type I serine/threonine kinase receptor Alk8/Lost-a-fin is required for Bmp2b/7 signal transduction during dorsoventral patterning of the zebrafish embryoH Bauer
Hans Spemann Laboratory, Max Planck Institut fur Immunbiologie, Stuebeweg 51, D 79108 Freiburg, Germany
Development 128:849-58. 2001..Altogether, the data suggest that Alk8 acts as a Bmp2b/7 receptor upstream of Smad5...
- Morpholino phenocopies of the swirl, snailhouse, somitabun, minifin, silberblick, and pipetail mutationsZ Lele
Hans Spemann Laboratory, Max Planck Institut fur Immunbiologie, Freiburg, Germany
Genesis 30:190-4. 2001
- The zebrafish neckless mutation reveals a requirement for raldh2 in mesodermal signals that pattern the hindbrainG Begemann
MRC Intercellular Signalling Group, Centre for Developmental Genetics, University of Sheffield School of Medicine and Biomedical Science, Western Bank, UK
Development 128:3081-94. 2001....
- parachute/n-cadherin is required for morphogenesis and maintained integrity of the zebrafish neural tubeZsolt Lele
Max Planck Institute for Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
Development 129:3281-94. 2002..Our results thus highlight novel and crucial in vivo roles for Ncad in the control of cell convergence, maintenance of neuronal positioning and dorsal cell proliferation during vertebrate neural tube development...
- Establishment of hindbrain segmental identity requires signaling by FGF3 and FGF8Jennifer Walshe
MRC Centre for Developmental Neurobiology, New Hunt s House, King s College London, Guy s Campus, United Kingdom
Curr Biol 12:1117-23. 2002..being established through differential expression of a hierarchy of transcription factors, including Hox genes, Krox20, and Kreisler/Valentino...
- Cloning, expression and relationship of zebrafish gbx1 and gbx2 genes to Fgf signalingMuriel Rhinn
Department of Genetics, Max Planck Institute for Molecular Cell Biology and Genetics, University of Dresden, Pfotenhauer Strasse 108, 01307 Dresden, Germany
Mech Dev 120:919-36. 2003..Moreover, our results provide an example for switching of a specific gene function of gbx1 versus gbx2 between orthologous genes in zebrafish and mammals...
- Nlz belongs to a family of zinc-finger-containing repressors and controls segmental gene expression in the zebrafish hindbrainAlexander P Runko
Department of Biochemistry and Molecular Pharmacology, and Program in Neuroscience, University of Massachusetts Medical School, Worcester, MA 01605, USA
Dev Biol 262:254-67. 2003..We conclude that Nlz is a transcriptional repressor that controls segmental gene expression in the hindbrain. Lastly, we identify additional nlz-related genes, suggesting that Nlz belongs to a family of zinc-finger proteins...
- gbx2 Homeobox gene is required for the maintenance of the isthmic region in the zebrafish embryonic brainHiroshi Kikuta
Department of Regulation Biology, Faculty of Science, Saitama University, Saitama, Japan
Dev Dyn 228:433-50. 2003..Comparisons with the expression of otx2, wnt1, and krox20 showed that gbx2 is expressed in the anterior hindbrain...
- Isolation of nlz2 and characterization of essential domains in Nlz family proteinsAlexander P Runko
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
J Biol Chem 279:11917-25. 2004..Our data demonstrate that nlz2 functions similarly to nlz1 and define conserved domains essential for nuclear localization, self-association, and corepressor binding in this novel family of zinc-finger genes...
- An early Fgf signal required for gene expression in the zebrafish hindbrain primordiumNicole M Roy
Department of Biochemistry and Molecular Pharmacology, and Program in Neuroscience, University of Massachusetts Medical School, 364 Plantation Street LRB 822, Worcester, MA 01605, USA
Brain Res Dev Brain Res 148:27-42. 2004..Our results demonstrate an early role for Fgf signaling and reveal a dynamic relationship between the RA and Fgf signaling pathways during hindbrain development...
- The zebrafish Iroquois gene iro7 positions the r4/r5 boundary and controls neurogenesis in the rostral hindbrainVirginie Lecaudey
Unité de Biologie moléculaire du Développement, Unité INSERM 368, Ecole Normale Superieure, 46, rue d Ulm, 75005 Paris, France
Development 131:3121-31. 2004..We propose that iro7 has a dual function in the hindbrain of the zebrafish embryo: it is required for the proper positioning of the prospective r4/r5 boundary and it promotes neurogenesis in the anterior hindbrain...
- Beyond the neckless phenotype: influence of reduced retinoic acid signaling on motor neuron development in the zebrafish hindbrainG Begemann
Department of Biology, University of Konstanz, 78464 Constance, Germany
Dev Biol 271:119-29. 2004..In addition, blockage of RA-mediated signaling not only interferes with the differentiation of branchiomotor neurons and their axons in the hindbrain, but also affects the development of the posterior lateral line nerve...
- atoh1.2 and beta3.1 are two new bHLH-encoding genes expressed in selective precursor cells of the zebrafish anterior hindbrainBirgit Adolf
Zebrafish Neurogenetics Junior Research Group, Institute of Virology, Technical University Munich, Trogerstrasse 4b, D 81675 Munich, Germany
Gene Expr Patterns 5:35-41. 2004..In this territory we demonstrate that atoh1.2 and beta3.1 are transcribed in distinct precursors, further highlighting the subdivision of anterior zebrafish hindbrain into subdomains of bHLH expression...
- Genetic locus half baked is necessary for morphogenesis of the ectodermKaren N McFarland
University of Virginia Health Systems, Department of Pathology, Charlottesville, Virginia, USA
Dev Dyn 233:390-406. 2005....
- erbb3 and erbb2 are essential for schwann cell migration and myelination in zebrafishDavid A Lyons
Department of Developmental Biology, Stanford University, California 94305, USA
Curr Biol 15:513-24. 2005..Previous studies have not determined whether Nrg-ErbB signaling is essential in vivo for Schwann cell fate specification, proliferation, survival, migration, or the onset of myelination...
- Dynamic and sequential patterning of the zebrafish posterior hindbrain by retinoic acidLisa Maves
Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403 1254, USA
Dev Biol 285:593-605. 2005..Our results support a new model of dynamic RA action in the hindbrain, in which a temporally increasing source of RA is required to sequentially initiate progressively more posterior rhombomere identities...
- Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebratesAlison J Ross
Molecular Medicine Unit, Institute of Child Health, University College London, WC1N 1EH, UK
Nat Genet 37:1135-40. 2005..We also show that Vangl2 localizes to the basal body and axoneme of ciliated cells, a pattern reminiscent of that of the BBS proteins. These data suggest that cilia are intrinsically involved in PCP processes...
- Temporal and spatial action of tolloid (mini fin) and chordin to pattern tail tissuesStephanie A Connors
Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, 1211 BRBII, 421 Curie Blvd, Philadelphia, PA 19104 6058, USA
Dev Biol 293:191-202. 2006..Thus, fine modulation of BMP signaling levels through the negative and positive actions of Chordin and Tolloid, respectively, patterns tail tissues...
- Zebrafish msxB, msxC and msxE function together to refine the neural-nonneural border and regulate cranial placodes and neural crest developmentBryan T Phillips
Biology Department, Texas A and M University, College Station, TX 77843 3258, USA
Dev Biol 294:376-90. 2006..These data suggest that mutual antagonism between Msx and Dlx proteins achieves a balance of function required for normal preplacodal differentiation and placement of the neural-nonneural border...
- Lhx5 promotes forebrain development and activates transcription of secreted Wnt antagonistsGang Peng
Institute of Neuroscience, University of Oregon, Eugene, OR 97403 1254, USA
Development 133:3191-200. 2006..Our results demonstrate that Lhx5 is a required factor that promotes forebrain development and inhibits Wnt signaling by activating the transcription of secreted Wnt antagonists...
- Critical role of Brg1 member of the SWI/SNF chromatin remodeling complex during neurogenesis and neural crest induction in zebrafishBinnur Eroglu
Center for Molecular Chaperone Radiobiology and Cancer Virology, Medical College of Georgia, Augusta, Georgia, USA
Dev Dyn 235:2722-35. 2006..six3, and marked reduction in expression of the mid/hind-brain boundary and hind-brain genes, engrailed2 and krox20, respectively...
- Pbx proteins cooperate with Engrailed to pattern the midbrain-hindbrain and diencephalic-mesencephalic boundariesTimothy Erickson
Department of Biological Sciences, CW405, Biological Sciences Building, University of Alberta, Edmonton AB, Canada T6G2E9
Dev Biol 301:504-17. 2007..Our data support a novel model of midbrain development in which Pbx and Engrailed proteins cooperatively pattern the mesencephalic region of the neural tube...
- The zebrafish zic2a-zic5 gene pair acts downstream of canonical Wnt signaling to control cell proliferation in the developing tectumMolly K Nyholm
Department of Zoology, University of Wisconsin, Madison, WI 53706, USA
Development 134:735-46. 2007..Collectively these findings suggest that Wnts control midbrain proliferation, at least in part, through regulation of two novel target genes, the zic2a-zic5 gene pair...
- Pbx homeodomain proteins pattern both the zebrafish retina and tectumCurtis R French
Department of Biological Sciences, University of Alberta, Edmonton, Canada
BMC Dev Biol 7:85. 2007..Although previous results have demonstrated that Pbx is required for proper eye size, functions in regulating retinal cell identity and patterning have not yet been examined...
- Chordin expression, mediated by Nodal and FGF signaling, is restricted by redundant function of two beta-catenins in the zebrafish embryoMáté Varga
Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
Mech Dev 124:775-91. 2007....
- Pbx homeodomain proteins direct Myod activity to promote fast-muscle differentiationLisa Maves
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Development 134:3371-82. 2007..Our results reveal that Pbx proteins modulate Myod activity to drive fast-muscle gene expression, thus showing that homeodomain proteins can direct bHLH proteins to establish a specific cell-type identity...
- Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt responseJantje M Gerdes
McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Nat Genet 39:1350-60. 2007....
- Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolismPaul B Yu
Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, USA
Nat Chem Biol 4:33-41. 2008..These findings suggest an essential physiological role for hepatic BMP signaling in iron-hepcidin homeostasis...
- meis1 regulates cyclin D1 and c-myc expression, and controls the proliferation of the multipotent cells in the early developing zebrafish eyeJose Bessa
CABD, Consejo Superior de Investigaciones Cientificas Universidad Pablo de Olavide, Seville, Spain
Development 135:799-803. 2008....
- Hypomorphic mutations in syndromic encephalocele genes are associated with Bardet-Biedl syndromeCarmen C Leitch
McKusick Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, Maryland 21205, USA
Nat Genet 40:443-8. 2008..These data extend the genetic stratification of ciliopathies and suggest that BBS and MKS, although distinct clinically, are allelic forms of the same molecular spectrum...
- Cadmium inhibits neurogenesis in zebrafish embryonic brain developmentElly Suk Hen Chow
Division of Biology, California Institute of Technology, 1200 California Boulevard, Pasadena, CA 91125, USA
Aquat Toxicol 87:157-69. 2008..Our data suggest that cadmium-induced neurotoxicity can be caused by impaired neurogenesis, resulting in markedly reduced neuronal differentiation and axonogenesis...
- An essential role for DYF-11/MIP-T3 in assembling functional intraflagellar transport complexesChunmei Li
Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada
PLoS Genet 4:e1000044. 2008..Our findings therefore implicate MIP-T3 in a previously unknown but critical role in cilium biogenesis and further highlight the emerging role of this organelle in vertebrate development...
- Identification of a novel retinoid by small molecule screening with zebrafish embryosChetana Sachidanandan
Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America
PLoS ONE 3:e1947. 2008....
- Rostral hindbrain patterning involves the direct activation of a Krox20 transcriptional enhancer by Hox/Pbx and Meis factorsMichel A Wassef
INSERM, U784, Laboratoire de Génétique Moléculaire du Développement and 46 rue d Ulm, 75230 Paris, France
Development 135:3369-78. 2008..The morphogenesis of the vertebrate hindbrain involves the generation of metameric units called rhombomeres (r), and Krox20 encodes a transcription factor that is expressed in r3 and r5 and plays a major role in this segmentation process...
- Combinatorial roles for zebrafish retinoic acid receptors in the hindbrain, limbs and pharyngeal archesAngela Linville
Department of Developmental and Cell Biology, Developmental Biology Center, University of California, Irvine, CA 92697, USA
Dev Biol 325:60-70. 2009..These studies reveal novel tissue-specific roles for RARs in controlling the competence and sensitivity of cells to respond to RA...
- Specification and Positioning of the PancreasCHARLES SAGERSTROM; Fiscal Year: 2005..abstract_text> ..
- MOLECULAR ANALYSIS OF HINDBRAIN FORMATIONCHARLES SAGERSTROM; Fiscal Year: 2007..hox, meis and pbx genes are also protooncogenes involved in leukemia. A better understanding of Hox function will therefore be applicable to a broad set of biological processes and human disease conditions. ..
- GENETIC MECHANISMS OF HINDBRAIN SEGMENTATIONCecilia Moens; Fiscal Year: 2009..Aim 2 addresses the mechanism of plasticity. Finally, in Aim 3, we consider the mechanism by which long-range signals interact to specify the positions of specific hindbrain boundaries. ..
- Tilling the Zebrafish Genome: A Reverse Genetic ApproachLilianna Solnica Krezel; Fiscal Year: 2010..We now propose to use TILLING to identify mutations in 120 genes that are of importance to biomedical research, and to make these mutants available to the zebrafish community as rapidly as possible. ..
- BIOLOGY OF BAMACAN IN TUMORIGENESISGiancarlo Ghiselli; Fiscal Year: 2006..3) The contribution of bamacan in vivo to colon tumorigenesis by generating transgenic mice over-expressing bamacan in the intestinal epithelium. ..
- Bacterial regulation of GI tract cell proliferationSarah Cheeseman; Fiscal Year: 2007..The details of this interaction are relevant to human health, as the activities of the Gl microbiota are implicated in several hyperproliferative diseases of the Gl tract, including irritable bowel syndrome and colorectal cancer. ..
- Role of cdx genes and RA in regionalizing the endodermMARY KINKEL; Fiscal Year: 2007..Finally, I will investigate the role of RA signaling in regulating Cdx genes utilizing loss-of-function approaches as well as treatment with exogenous RA. ..
- Site-specific transgenesis in zebrafishJAMES LISTER; Fiscal Year: 2008..These tools will advance the usefulness of this model organism as a model for human development and disease. [unreadable] [unreadable] [unreadable]..
- Development of Cranial Motor NeuronsAnand Chandrasekhar; Fiscal Year: 2007..Together, these experiments will generate novel insight into neuronal migration mechanisms in the vertebrate hindbrain. ..