Gene Symbol: egr1
Description: early growth response 1
Alias: krox-24, krox24, wu:fj64b05, wu:fq25f01, early growth response protein 1, EGR-1, etID309970.14, zinc finger protein Krox-24
Species: zebrafish

Top Publications

  1. Hu C, Yang C, Chen W, Huang C, Huang H, Chen M, et al. Egr1 gene knockdown affects embryonic ocular development in zebrafish. Mol Vis. 2006;12:1250-8 pubmed
    To identify the changes in zebrafish embryonic ocular development after early growth response factor 1 (Egr1) gene knockdown by Egr1-specific translation inhibitor, morpholino oligonucleotides (MO)...
  2. Close R, Toro S, Martial J, Muller M. Expression of the zinc finger Egr1 gene during zebrafish embryonic development. Mech Dev. 2002;118:269-72 pubmed
    b>Egr1 is a highly conserved zinc finger protein which plays important roles in many aspects of vertebrate development and in the adult...
  3. Drummond I, Rohwer Nutter P, Sukhatme V. The zebrafish egr1 gene encodes a highly conserved, zinc-finger transcriptional regulator. DNA Cell Biol. 1994;13:1047-55 pubmed
    ..We have isolated a zebrafish egr1 homologue by screening a zebrafish genomic library with a mouse Egr1 zinc finger probe...
  4. Huang C, Huang C, Cheng Y, Yu J. Histamine metabolism influences blood vessel branching in zebrafish reg6 mutants. BMC Dev Biol. 2008;8:31 pubmed publisher
    ..Taken together, our results suggest that blood vessel branching is influenced by histamine metabolism, possibly through regulating the expression of the egr-1 transcription factor. ..
  5. Kobayashi I, Ono H, Moritomo T, Kano K, Nakanishi T, Suda T. Comparative gene expression analysis of zebrafish and mammals identifies common regulators in hematopoietic stem cells. Blood. 2010;115:e1-9 pubmed publisher
    ..Some of these genes, such as egr1, gata2, and id1, have been previously implicated in the regulation of HSCs...
  6. Larbuisson A, Dalcq J, Martial J, Muller M. Fgf receptors Fgfr1a and Fgfr2 control the function of pharyngeal endoderm in late cranial cartilage development. Differentiation. 2013;86:192-206 pubmed publisher
    ..endodermal pouches are correctly formed and patterned, receptor knock down leads to decreased expression of runx3, egr1 and sox9b in this tissue, while expression of fsta, coding for a secreted BMP/Tgfß inhibitor, is clearly increased...
  7. Zhang L, CHO J, Ptak D, Leung Y. The role of egr1 in early zebrafish retinogenesis. PLoS ONE. 2013;8:e56108 pubmed publisher
    ..The purpose of this study is to investigate the role of early growth response 1 (egr1), a transcription factor (TF) that has been reported to control eye development and function, on retinal ..
  8. Boyer B, Ernest S, Rosa F. Egr-1 induction provides a genetic response to food aversion in zebrafish. Front Behav Neurosci. 2013;7:51 pubmed publisher
    ..Altogether, our data indicate that egr-1 participates specifically in food aversion. The existence of reward-coupled changes in taste sensitivity in humans suggests that our results are relevant to situations in humans. ..
  9. Naderi M, Salahinejad A, Jamwal A, Chivers D, Niyogi S. Chronic Dietary Selenomethionine Exposure Induces Oxidative Stress, Dopaminergic Dysfunction, and Cognitive Impairment in Adult Zebrafish (Danio rerio). Environ Sci Technol. 2017;51:12879-12888 pubmed publisher
    ..Collectively, our results illustrate that cognitive impairment in zebrafish could be associated with Se-induced oxidative stress and altered dopaminergic neurotransmission in the brain. ..

More Information


  1. Lickwar C, Camp J, Weiser M, Cocchiaro J, Kingsley D, Furey T, et al. Genomic dissection of conserved transcriptional regulation in intestinal epithelial cells. PLoS Biol. 2017;15:e2002054 pubmed publisher
  2. Baker B, Yee J, Meyer D, Yang D, Baker T. Histological and Transcriptomic Changes in Male Zebrafish Testes Due to Early Life Exposure to Low Level 2,3,7,8-Tetrachlorodibenzo-p-Dioxin. Zebrafish. 2016;13:413-23 pubmed publisher
    ..These data will inform future investigations to elucidate the mechanism of adult-onset and transgenerational infertility due to TCDD exposure in zebrafish. ..
  3. Zhang L, Bonilla S, Zhang Y, Leung Y. p35 promotes the differentiation of amacrine cell subtype in the zebrafish retina under the regulation of egr1. Dev Dyn. 2014;243:315-23 pubmed publisher
    Early growth response 1 (egr1) is a transcription factor (TF) for controlling the differentiation of Parvalbumin (Parv) -expressing amacrine cells (ACs) in zebrafish...
  4. Jia H, King I, Chopra S, Wan H, Ni T, Jiang C, et al. Vertebrate heart growth is regulated by functional antagonism between Gridlock and Gata5. Proc Natl Acad Sci U S A. 2007;104:14008-13 pubmed
    ..Hence, our studies suggest that Grl regulates embryonic heart growth via opposing Gata5, at least in part through their protein interactions in modulating gene expression. ..
  5. Banjo T, Grajcarek J, Yoshino D, Osada H, Miyasaka K, Kida Y, et al. Haemodynamically dependent valvulogenesis of zebrafish heart is mediated by flow-dependent expression of miR-21. Nat Commun. 2013;4:1978 pubmed publisher
    ..We conclude that miR-21 is a central component of a flow-controlled mechanotransduction system in a physicogenetic regulatory loop. ..
  6. Anelli V, Villefranc J, Chhangawala S, Martinez McFaline R, Riva E, Nguyen A, et al. Oncogenic BRAF disrupts thyroid morphogenesis and function via twist expression. elife. 2017;6: pubmed publisher
    ..These data suggest that expression of TWIST2 plays a role in an early step of BRAFV600E-mediated transformation. ..
  7. Ruuskanen J, Xhaard H, Marjamäki A, Salaneck E, Salminen T, Yan Y, et al. Identification of duplicated fourth alpha2-adrenergic receptor subtype by cloning and mapping of five receptor genes in zebrafish. Mol Biol Evol. 2004;21:14-28 pubmed
  8. Dalcq J, Pasque V, Ghaye A, Larbuisson A, Motte P, Martial J, et al. RUNX3, EGR1 and SOX9B form a regulatory cascade required to modulate BMP-signaling during cranial cartilage development in zebrafish. PLoS ONE. 2012;7:e50140 pubmed publisher
    ..In this study, we show that the endodermal factors Runx3 and Sox9b form a regulatory cascade with Egr1 resulting in transcriptional repression of the fsta gene, encoding a BMP antagonist, in pharyngeal endoderm...
  9. deCarvalho T, Akitake C, Thisse C, Thisse B, Halpern M. Aversive cues fail to activate fos expression in the asymmetric olfactory-habenula pathway of zebrafish. Front Neural Circuits. 2013;7:98 pubmed publisher
    ..The results indicate that L-R asymmetry of the epithalamus sets the directionality of olfactory innervation, however, the lhx2a:YFP OB-Ha pathway does not appear to mediate fear responses to aversive odorants...
  10. Micale L, Loviglio M, Manzoni M, Fusco C, Augello B, Migliavacca E, et al. A fish-specific transposable element shapes the repertoire of p53 target genes in zebrafish. PLoS ONE. 2012;7:e46642 pubmed publisher
    ..Our data pinpoint a remarkable example of convergent evolution: the exaptation of lineage-specific transposons to shape p53-regulated neuronal morphogenesis-related pathways in both a hominid and a teleost fish. ..
  11. Kress S, Wullimann M. Correlated basal expression of immediate early gene egr1 and tyrosine hydroxylase in zebrafish brain and downregulation in olfactory bulb after transitory olfactory deprivation. J Chem Neuroanat. 2012;46:51-66 pubmed publisher
    ..In rodents, the immediate early gene egr1 is involved in maintaining the dopaminergic phenotype of periglomerular olfactory bulb cells in an activity ..
  12. Hortopan G, Dinday M, Baraban S. Spontaneous seizures and altered gene expression in GABA signaling pathways in a mind bomb mutant zebrafish. J Neurosci. 2010;30:13718-28 pubmed publisher
    ..This work may have important implications for neurological and neurodevelopmental disorders associated with mutations in ubiquitin ligase activity. ..
  13. Oosterhof N, Holtman I, Kuil L, van der Linde H, Boddeke E, Eggen B, et al. Identification of a conserved and acute neurodegeneration-specific microglial transcriptome in the zebrafish. Glia. 2017;65:138-149 pubmed publisher
    ..glia 2016;65:138-149. ..
  14. Wu M, Liu S, Hu L, Qu H, Pan C, Lei P, et al. Global transcriptomic analysis of zebrafish in response to embryonic exposure to three antidepressants, amitriptyline, fluoxetine and mianserin. Aquat Toxicol. 2017;192:274-283 pubmed publisher
    ..subfamily 1, group D, member 1 (nr1d1) and period 2 (per2); and genes encoding early growth response factors (egr1 and egr4), in the antidepressant-treated fish larvae...
  15. Teles M, Almeida O, Lopes J, Oliveira R. Social interactions elicit rapid shifts in functional connectivity in the social decision-making network of zebrafish. Proc Biol Sci. 2015;282:20151099 pubmed publisher
    ..e. the state of its interconnected areas) is central to its functional relevance. ..