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Genomes and GenesSpecies | efnb2aSummaryGene Symbol: efnb2a Description: ephrin B2a Alias: efnb2, ephrin-B2a, id:ibd5072, ephrin-B2a Species: zebrafish Top Publications
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Publications
sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiationNathan D Lawson
Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, MD 20892, USA
Dev Cell 3:127-36. 2002..These studies reveal a complex signaling cascade responsible for establishing arterial cell fate and suggest differential effects of Vegf on developing endothelial cells...- Semaphorin-plexin signaling guides patterning of the developing vasculatureJesus Torres-Vazquez
Laboratory of Molecular Genetics, NICHD, National Institutes of Health, Bethesda, MD 20892, USA
Dev Cell 7:117-23. 2004..These results reveal the fundamental conservation of repulsive patterning mechanisms between axonal migration in the central nervous system and vascular endothelium during angiogenesis... 
Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formationShane P Herbert
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Cardiovascular Research Institute, University of California, San Francisco, CA 94158, USA
Science 326:294-8. 2009..Thus, directional control of progenitor migration drives arterial-venous segregation and generation of separate parallel vessels from a single precursor vessel, a process essential for vascular development...- A genetic screen for vascular mutants in zebrafish reveals dynamic roles for Vegf/Plcg1 signaling during artery developmentL D Covassin
Program in Gene Function and Expression, University of Massachusetts Medical School, Lazare Research Building, Room 617, 364 Plantation Street, Worcester, MA 01605, USA
Dev Biol 329:212-26. 2009..Together our genetic analyses suggest that Vegf/Plcg1 signaling acts at multiple time points and in different signaling contexts to mediate distinct aspects of artery development... - Snrk-1 is involved in multiple steps of angioblast development and acts via notch signaling pathway in artery-vein specification in vertebratesChang Z Chun
Department of Pediatrics, CRI Developmental Vascular Biology Program, Translational and Biomedical Research Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Blood 113:1192-9. 2009..The snrk-1 gene acts downstream or parallel to notch and upstream of gridlock during artery-vein specification, and the human gene compensates for zebrafish snrk-1 knockdown, suggesting evolutionary conservation of function... - Distinct genetic interactions between multiple Vegf receptors are required for development of different blood vessel types in zebrafishL D Covassin
Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA
Proc Natl Acad Sci U S A 103:6554-9. 2006.... - phospholipase C gamma-1 is required downstream of vascular endothelial growth factor during arterial developmentNathan D Lawson
Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
Genes Dev 17:1346-51. 2003..Our results indicate that Plcg1 functions specifically downstream of the Vegf receptor during embryonic development to govern formation of the arterial system... - Dissection of angiogenic signaling in zebrafish using a chemical genetic approachJoanne Chan
Department of Cancer Biology, Dana Farber Cancer Institute and the Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA
Cancer Cell 1:257-67. 2002..This approach allowed us to examine the effects of blood flow and the role of endothelial signals in organogenesis... - Artery/vein specification is governed by opposing phosphatidylinositol-3 kinase and MAP kinase/ERK signalingCharles C Hong
Developmental Biology Laboratory, Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
Curr Biol 16:1366-72. 2006..In summary, chemical genetic analysis has uncovered unanticipated opposing roles of PI3K and ERK in artery/vein specification... - Endothelial signalling by the Notch ligand Delta-like 4 restricts angiogenesisJonathan D Leslie
Vertebrate Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Development 134:839-44. 2007..Thus, Dll4-Notch signalling acts as an angiogenic ;off' switch by making endothelial cells unresponsive to Vegf... 
meis1 regulates the development of endothelial cells in zebrafishKen ichi Minehata
Horizontal Medical Research Organization, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
Biochem Biophys Res Commun 374:647-52. 2008..Thus, these results implicate that meis1 is a novel regulator involved in endothelial cell development, presumably affecting the vegf signaling pathway...- Expression screening and annotation of a zebrafish myoblast cDNA librarySarah Baxendale
MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield S10 2TN, UK
Gene Expr Patterns 9:73-82. 2009.... - ccm1 cell autonomously regulates endothelial cellular morphogenesis and vascular tubulogenesis in zebrafishBenjamin M Hogan
Hubrecht Institute KNAW and University Medical Centre Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
Hum Mol Genet 17:2424-32. 2008..Finally, we show that ccm1 function is cell autonomous, suggesting that it is endothelial cellular morphogenesis that is regulated by CCM proteins during development and pathogenesis... - The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate developmentAnnette Schenck
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
Cell 133:486-97. 2008..We propose that partitioning of Akt and selected effectors onto endosomal compartments represents a key mechanism contributing to the specificity of signal transduction in vertebrate development... - Zebrafish Sox7 and Sox18 function together to control arterial-venous identityHelene Pendeville
GIGA Research Unité de Biologie Moleculaire et Génie Génétique, Tour B34, Universite de Liege, B 4000 Sart Tilman, Belgium
Dev Biol 317:405-16. 2008..The striking similarities between the phenotype of Sox7/Sox18 morphants and Gridlock mutants strongly suggest that Sox7 and Sox18 control arterial-venous identity by regulating Gridlock expression... - Calcitonin receptor-like receptor guides arterial differentiation in zebrafishStefania Nicoli
Unit of General Pathology and Immunology, Department of Biomedical Sciences and Biotechnology, University of Brescia, Brescia, Italy
Blood 111:4965-72. 2008..These data demonstrate that crlr plays a nonredundant role in arterial differentiation, representing a novel element of the sonic hedgehog-vegf-notch signaling cascade that controls arterial/venous fate... - Sox18 and Sox7 play redundant roles in vascular developmentSolei Cermenati
Dipartimento di Scienze Biomolecolari e Biotecnologie, Universita degli Studi di Milano, Via Celoria 26, Milan, Italy
Blood 111:2657-66. 2008..Our data suggest that a defect in arteriovenous identity could be responsible for the formation of telangiectases in patients with HLT... - Redundant roles for sox7 and sox18 in arteriovenous specification in zebrafishRobert Herpers
Hubrecht Institute, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
Circ Res 102:12-5. 2008..Our study identifies members of the Sox family as key factors in specifying arteriovenous identity and will help to better understand hypotrichosis-lymphedema-telangiectasia and other diseases... - The role of the SPT6 chromatin remodeling factor in zebrafish embryogenesisFatma O Kok
Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, New York 11794, USA
Dev Biol 307:214-26. 2007..However, additional Spt6 mutant phenotypes are likely caused by vital functions of Spt6 in other pathways... - A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryosSuk Won Jin
Department of Biochemistry and Biophysics, Genetics and Human Genetics, and Cardiovascular Research Institute, University of California San Francisco, CA 94158, USA
Dev Biol 307:29-42. 2007..The analysis of the newly defined loci should lead to a greater understanding of vascular development and possibly provide new drug targets to treat the numerous pathologies associated with dysregulated blood vessel growth... - Mutation in utp15 disrupts vascular patterning in a p53-dependent manner in zebrafish embryosKevin Mouillesseaux
Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, California, United States of America
PLoS ONE 6:e25013. 2011..Using the zebrafish as a model organism, we sought to identify genes that influence normal vascular patterning... - An essential role for Radar (Gdf6a) in inducing dorsal fate in the zebrafish retinaNathan J Gosse
Department of Physiology, Program in Developmental Biology, Genetics, University of California, 1550 Fourth Street, San Francisco, CA 94158 2722, USA
Proc Natl Acad Sci U S A 106:2236-41. 2009..We conclude that Radar is near the top of a signaling cascade that establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map... - A genetic screen in zebrafish defines a hierarchical network of pathways required for hematopoietic stem cell emergenceCAROLINE E BURNS
Stem Cell Program and Division of Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
Blood 113:5776-82. 2009..Together, our results establish a hierarchy of signaling programs required and sufficient for HSC emergence in the AGM... - Evaluation and application of modularly assembled zinc-finger nucleases in zebrafishCong Zhu
Program in Gene Function and Expression, University of Massachusetts Medical School, Worcester, MA 01605, USA
Development 138:4555-64. 2011..This work provides a resource to allow targeted germline gene inactivation in zebrafish and highlights the benefit of a definitive reverse genetic strategy to reveal gene function... - Semaphorin-PlexinD1 signaling limits angiogenic potential via the VEGF decoy receptor sFlt1Tomasz Zygmunt
Department of Cell Biology, Helen L and Martin S Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA
Dev Cell 21:301-14. 2011..Hence, Sema-PlxnD1 signaling regulates distinct but related aspects of angiogenesis: the spatial allocation of angiogenic capacity within a primary vessel and sprout guidance... - Zebrafish mll gene is essential for hematopoiesisXiaoyang Wan
Key Laboratory of Aquatic Biodiversity and Conservation, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China
J Biol Chem 286:33345-57. 2011..Taken together, these findings demonstrate that zebrafish mll plays essential roles in hematopoiesis and that gadd45αa may serve as a potential downstream target for mediating the function of mll in hematopoiesis... - Zebrafish notch signalling pathway mutants exhibit trunk vessel patterning anomalies that are secondary to somite misregulationChristina Therapontos
NHLI, Faculty of Medicine, Imperial College London, London, United Kingdom
Dev Dyn 239:2761-8. 2010..Ectopic filopodia are not due to loss of dll4. Somite expression of known vascular guidance cues, efnb2, sema3a2, and plexinD1 are disrupted, suggesting that the ISV vascular phenotype is due to disruption of these cues... - Mtmr8 is essential for vasculature development in zebrafish embryosJie Mei
State Key Laboratory of Freshwater Ecology and Biotechnology, Center for Developmental Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Wuhan 430072, China
BMC Dev Biol 10:96. 2010..Here, we attempt to explore the function of Mtmr8 in vasculature development parallel to its function in muscle development... - nev (cyfip2) is required for retinal lamination and axon guidance in the zebrafish retinotectal systemAndrew J Pittman
Program in Neuroscience, Department of Neurobiology and Anatomy, and Brain Institute, University of Utah Medical Center, Salt Lake City, UT 84132, USA
Dev Biol 344:784-94. 2010.... - Hey2 acts upstream of Notch in hematopoietic stem cell specification in zebrafish embryosJonathan M Rowlinson
Institute of Genetics, School of Biology, University of Nottingham, Queen s Medical Centre, Nottingham, UK
Blood 116:2046-56. 2010..These results establish an essential role for Hey2 upstream of Notch in HSC formation... - Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesisYingdi Wang
Vascular Development Laboratory, Cancer Research UK London Research Institute, London WC2A 3PX, UK
Nature 465:483-6. 2010..Our results show that full VEGFR3 signalling is coupled to receptor internalization. Ephrin-B2 is a key regulator of this process and thereby controls angiogenic and lymphangiogenic growth... - Hedgehog signaling induces arterial endothelial cell formation by repressing venous cell fateCharles Williams
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203, USA
Dev Biol 341:196-204. 2010..Collectively, these studies suggest that arterial endothelial cells are specified and formed via repressing venous cell fate at the lateral plate mesoderm by Hh signaling during vasculogenesis... - TRPC1 is essential for in vivo angiogenesis in zebrafishPeng chun Yu
Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Circ Res 106:1221-32. 2010..Activation of transient receptor potential type C channels (TRPCs) has recently been shown to underlie chemotropic guidance of neural axons. It is thus of interest to examine whether TRPCs are also involved in vascular development... - Hedgehog signaling via angiopoietin1 is required for developmental vascular stabilityRyan E Lamont
Biochemistry and Molecular Biology, University of Calgary, 3330 Hospital Dr NW, Calgary, AB, Canada T2N 4N1
Mech Dev 127:159-68. 2010..This is the first direct in vivo link between hedgehog signaling and the induction of vascular stability by recruitment of perivascular mural cells through angiopoietin signaling... - Control of extracellular matrix assembly along tissue boundaries via Integrin and Eph/Ephrin signalingDörthe Jülich
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA
Development 136:2913-21. 2009..Within the tissue, interplay between Eph/Ephrin signaling, ligand-independent Integrin clustering and reciprocal Integrin inhibition restricts de novo ECM production to somite boundaries... - Gdf6a is required for the initiation of dorsal-ventral retinal patterning and lens developmentCurtis R French
Department of Biological Sciences, University of Alberta, CW405, Biological Sciences Bldg, Edmonton T6G 2E9, Canada
Dev Biol 333:37-47. 2009..Taken together, these data indicate that Gdf6a initiates dorsal retinal patterning independent of Bmp4, and regulates lens differentiation... - Genetic single-cell mosaic analysis implicates ephrinB2 reverse signaling in projections from the posterior tectum to the hindbrain in zebrafishTomomi Sato
Laboratory for Developmental Gene Regulation, Brain Science Institute, RIKEN, Wako, Saitama 351 0198, Japan
J Neurosci 27:5271-9. 2007..These results may provide a neuroanatomical and molecular basis for the motor command map in the tectum... - Ethanol disrupts the formation of hypochord and dorsal aorta during the development of embryonic zebrafishLinxi Qian
Key Laboratory of Molecular Medicine, Ministry of Education, Shanghai Medical School of Fudan University, Shanghai 200032, China
Sci China C Life Sci 48:608-15. 2005..These results provide important clues to the study of adverse effects of ethanol on the cardiovascular development in human fetus... - In vivo cell sorting in complementary segmental domains mediated by Eph receptors and ephrinsQ Xu
Division of Developmental Neurobiology, National Institute for Medical Research, London, UK
Nature 399:267-71. 1999..These data implicate Eph receptors and ephrins in the segmental restriction of cell intermingling... - Cooperative function of deltaC and her7 in anterior segment formationAndrew C Oates
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
Dev Biol 280:133-49. 2005..Thus, anterior segmentation requires the functions of both her and delta family members in a parallel manner, suggesting that the segmentation oscillator operates in paraxial mesoderm along the entire vertebrate axis... - Tbx2b is essential for neuronal differentiation along the dorsal/ventral axis of the zebrafish retinaJeffrey M Gross
Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 102:4371-6. 2005..Combined, these observations suggest that the cellular mechanisms regulating neuronal differentiation within the retina are asymmetric about the dorsal/ventral axis and that Tbx2b mediates this process within the dorsal retina... - Hedgehog signaling is required for adult blood stem cell formation in zebrafish embryosMartin Gering
Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham, NG7 2UH, United Kingdom
Dev Cell 8:389-400. 2005..Furthermore, HSC and DA formation also share Vegf and Notch requirements, which further distinguishes them from primitive hematopoiesis and underlines their close relationship during vertebrate development... - Chemokine signaling guides axons within the retina in zebrafishQin Li
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109 1048, USA
J Neurosci 25:1711-7. 2005..These data suggest that chemokine signaling is both necessary and sufficient for directing retinal growth cones within the retina... - Retinoic acid-metabolizing enzyme Cyp26a1 is essential for determining territories of hindbrain and spinal cord in zebrafishYumi Emoto
Department of Biological Information, Tokyo Institute of Technology, Yokohama 226 8501, Japan
Dev Biol 278:415-27. 2005..We propose a model in which Cyp26a1 attenuates RA signaling in the prospective rostral spinal cord to limit the expression of hox genes and to determine the hindbrain-spinal cord boundary... - Formation of the retinotectal projection requires Esrom, an ortholog of PAM (protein associated with Myc)Jasmine D'Souza
Developmental Neurobiology Group, Temasek Life Sciences Laboratory, 1 Research Link, Singapore 117604, Rep of Singapore
Development 132:247-56. 2005..These data identify a mediator of signal transduction in retinal growth cones, which is required for topographic map formation... - vhnf1 integrates global RA patterning and local FGF signals to direct posterior hindbrain development in zebrafishRafael E Hernandez
Howard Hughes Medical Institute and Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, PO Box 19024, Seattle, WA 98109, USA
Development 131:4511-20. 2004..The different requirements for vhnf1 and val to repress hoxb1a and ephrin-B2a, respectively, demonstrate that not all aspects of an individual rhombomere's identity are regulated coordinately... - Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctationRandall T Peterson
Nat Biotechnol 22:595-9. 2004..Thus, organism-based screens allow the discovery of small molecules that ameliorate complex dysmorphic syndromes even without targeting the affected gene directly... - EphrinB2a in the zebrafish retinotectal systemMahendra Wagle
Developmental Neurobiology, Temasek Life Sciences Laboratory, 1 Research Link, Singapore 117604
J Neurobiol 59:57-65. 2004..In vitro, zebrafish RGC axons are repelled by stripes of purified ephrinB2a. It is proposed that ephrinB2a may signal a subpopulation of RGC axons that they have reached their target neurons in the tectum... - Semaphorin3D guides retinal axons along the dorsoventral axis of the tectumYan Liu
Department of Zoology and Anatomy, University of Wisconsin, Madison, Wisconsin 53706, USA
J Neurosci 24:310-8. 2004..These results suggest that Sema3D in the ventral tectum normally acts to inhibit ventral RGCs from extending into ventral tectum, ensuring their correct innervation of dorsal tectum... - Eph/Ephrin signaling regulates the mesenchymal-to-epithelial transition of the paraxial mesoderm during somite morphogenesisArantza Barrios
Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
Curr Biol 13:1571-82. 2003..These observations suggest a role for Eph/Ephrin signaling in the regulation of somite epithelialization... - Boundary formation in the hindbrain: Eph only it were simpleJulie E Cooke
Howard Hughes Medical Institute, Division of Basic Sciences, Fred Hutchinson Cancer Research Center B2 152, 1100 Fairview Avenue N, Seattle, WA 98109, USA
Trends Neurosci 25:260-7. 2002..We discuss the contributions of two mechanisms -- cell sorting and plasticity -- to the formation of rhombomere boundaries... - Anteroposterior patterning is required within segments for somite boundary formation in developing zebrafishL Durbin
Department of Anatomy and Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK
Development 127:1703-13. 2000.... - Eph receptors and ephrins restrict cell intermingling and communicationG Mellitzer
Division of Developmental Neurobiology, National Institute for Medical Research, London, UK
Nature 400:77-81. 1999..These results reveal that Eph receptors and ephrins regulate two aspects of cell behaviour that can stabilize a distinct identity of adjacent cell populations... - EphA4 is required for cell adhesion and rhombomere-boundary formation in the zebrafishJulie E Cooke
Howard Hughes Medical Institute and Division of Basic Science, Fred Hutchinson Cancer Research Center B2 152, 1100 Fairview Avenue N, P O Box 19024, Seattle, Washington 98109, USA
Curr Biol 15:536-42. 2005.... - Cyclooxygenase-1 signaling is required for vascular tube formation during developmentYong I Cha
Department of Medicine, Cell and Developmental Biology and Cancer Biology, Vanderbilt University Medical Center and Vanderbilt Ingram Cancer Center, Vanderbilt University, 694 Preston Research Building, 2300 Pierce Ave, Nashville, TN 37232, USA
Dev Biol 282:274-83. 2005..Together, we provide the first evidence that COX-1 signaling is required for development of posterior mesoderm organs, specifically in the vascular tube formation and posterior nephric duct development... - Cellular and molecular analyses of vascular tube and lumen formation in zebrafishSuk Won Jin
Department of Biochemistry and Biophysics and Cardiovascular Research Institute, Program in Developmental Biology, University of California San Francisco, 1550 Fourth Street, San Francisco, CA 94143, USA
Development 132:5199-209. 2005..These studies provide the tools and a cellular framework for the investigation of mutations affecting vasculogenesis in zebrafish... - Hematopoietic stem cell fate is established by the Notch-Runx pathwayCaroline Erter Burns
Stem Cell Program and Division of Hematology Oncology Children s Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Genes Dev 19:2331-42. 2005..These data define the Notch-Runx pathway as critical for the developmental specification of HSC fate and the subsequent homeostasis of HSC number, thus providing a mechanism for amplifying stem cells in vivo... - Chemical modulation of receptor signaling inhibits regenerative angiogenesis in adult zebrafishPeter E Bayliss
Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
Nat Chem Biol 2:265-73. 2006..This study illustrates the utility of the adult zebrafish as a new model system for receptor signaling and chemical biology... - fused-somites-like mutants exhibit defects in trunk vessel patterningKenna M Shaw
Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
Dev Dyn 235:1753-60. 2006..Somitic expression of known vascular guidance factors efnb2a, sema3a1, and sema3a2 is aberrantly patterned in fss and bea mutants, suggesting that the vascular phenotype is .. - belladonna/(Ihx2) is required for neural patterning and midline axon guidance in the zebrafish forebrainAnandita Seth
Biology Department, University of Massachusetts, Amherst, MA 01003 9297, USA
Development 133:725-35. 2006..Our analysis reveals new roles for Ihx2 in midline axon guidance, forebrain patterning and eye morphogenesis... - Hedgehog regulated Slit expression determines commissure and glial cell position in the zebrafish forebrainMichael J F Barresi
Department of Biology, University of Massachusetts, Amherst, MA 01003, USA
Development 132:3643-56. 2005..This analysis shows that Hh signaling helps to pattern the expression of Slit guidance molecules that then help to regulate glial cell position and axon guidance across the midline of the forebrain... - Differentiation of arterial and venous endothelial cells and vascular morphogenesisMasanori Hirashima
The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, Tokyo, Japan
Endothelium 13:137-45. 2006..These insights indicate that the balance of these genetic factors and modification by epigenetic factors such as hemodynamics and oxygen tension are important for proper endothelial cell identities in vascular morphogenesis... - Selective regulation of arterial branching morphogenesis by synectinThomas W Chittenden
Angiogenesis Research Center, Section of Cardiology, Department of Medicine, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
Dev Cell 10:783-95. 2006..We conclude that synectin is involved in selective regulation of arterial, but not venous, growth and branching morphogenesis and that Rac1 plays an important role in this process... - Combinatorial function of ETS transcription factors in the developing vasculatureVan N Pham
Laboratory of Molecular Genetics, National Institute of Child Health and Human Development NIH, Building 6B, Room 309, 6 Center Drive, Bethesda, MD 20892, USA
Dev Biol 303:772-83. 2007..Our results demonstrate that combinatorial ETS factor function is essential for early endothelial specification and differentiation... - Differentiation of cerebellar cell identities in absence of Fgf signalling in zebrafish Otx morphantsIsabelle Foucher
MRC Centre for Developmental Neurobiology, New Hunt s House, King s College London, London SE1 9RT, UK
Development 133:1891-900. 2006..This maintenance is enough to allow cerebellar differentiation... - Essential and overlapping roles for laminin alpha chains in notochord and blood vessel formationSteven M Pollard
Division of Developmental Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK
Dev Biol 289:64-76. 2006.... - Integrinalpha5-dependent fibronectin accumulation for maintenance of somite boundaries in zebrafish embryosSumito Koshida
Okazaki Institute for Integrative Bioscience, National Institutes of Natural Sciences, Okazaki 444 8787, Japan
Dev Cell 8:587-98. 2005.... - Dynamic and sequential patterning of the zebrafish posterior hindbrain by retinoic acidLisa Maves
Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403 1254, USA
Dev Biol 285:593-605. 2005..Our results support a new model of dynamic RA action in the hindbrain, in which a temporally increasing source of RA is required to sequentially initiate progressively more posterior rhombomere identities... - Churchill and Sip1a repress fibroblast growth factor signaling during zebrafish somitogenesisFatma O Kok
Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, New York, USA
Dev Dyn 239:548-58. 2010..Finally, we found that blocking FGF8 restores somite morphology in ChCh and Sip1a compromised embryos. These results demonstrate a novel role for ChCh and Sip1a in repression of FGF activity... - The receptor protein-tyrosine phosphatase, Dep1, acts in arterial/venous cell fate decisions in zebrafish developmentFiona Rodriguez
Hubrecht Institute KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
Dev Biol 324:122-30. 2008..Our results suggest a model in which Dep1 acts upstream in a signaling pathway inhibiting PI3K, resulting in expression of Notch and Grl, thus regulating arterial specification in development... - EphA4 and EfnB2a maintain rhombomere coherence by independently regulating intercalation of progenitor cells in the zebrafish neural keelHilary A Kemp
Howard Hughes Medical Institute and Division of Basic Science, Fred Hutchinson Cancer Research Center, B2 152, 1100 Fairview Ave N, Seattle, WA 98109, P O Box 19024, USA
Dev Biol 327:313-26. 2009..The Eph receptor tyrosine kinase EphA4 and the membrane-bound Ephrin (Efn) ligand EfnB2a, which are expressed in complementary segments in the early hindbrain, are required for rhombomere boundary .. - Hematopoietic stem cell development is dependent on blood flowTrista E North
Stem Cell Program and Hematology Oncology, Children s Hospital, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA
Cell 137:736-48. 2009..This work links blood flow to AGM hematopoiesis and identifies NO as a conserved downstream regulator of HSC development... - A functional interaction between Irx and Meis patterns the anterior hindbrain and activates krox20 expression in rhombomere 3Aline Stedman
CNRS UMR7622, Laboratoire de Biologie du Developpement, Universite Pierre et Marie Curie, Bâtiment C 7ème étage, Boite 24, 9 quai Saint Bernard, 75005 Paris, France
Dev Biol 327:566-77. 2009..Together, our data point to an essential function of Iroquois transcription factors in krox20 activation and, more generally, in anterior hindbrain specification... - Notch signalling limits angiogenic cell behaviour in developing zebrafish arteriesArndt F Siekmann
Program in Gene Function and Expression, University of Massachusetts Medical School, Lazare Research Building, 364 Plantation Street, Worcester, Massachusetts 01605, USA
Nature 445:781-4. 2007..Together, these studies indicate that proper specification of cell identity, position and behaviour in a developing blood-vessel sprout is required for normal angiogenesis, and implicate the Notch signalling pathway in this process...
Research Grants
- Role of Plcg1 in Vegf signalingNathan Lawson; Fiscal Year: 2009..Since these signaling mechanisms are evolutionary conserved, the molecules we identify in this proposal represent possible targets for clinical manipulation of pathological blood vessel formation. ..
- Role of Notch in artery developmentNathan D Lawson; Fiscal Year: 2010..The studies in this proposal will address how blood vessel identities are determined during development. ..
- Endothelial lineage specification and differentiation in vertebrate embryosSuk Won Jin; Fiscal Year: 2009..Furthermore, it will also help us to understand the etiology of many vascular diseases and design a better way of using pluripotent progenitors for the therapeutic purposes. ..
- Using zinc finger nucleases to manipulate the zebrafish genomeScot A Wolfe; Fiscal Year: 2010..We will apply this technology in zebrafish to better understand the processes involved in heart regeneration and blood vessel formation. ..
- Endothelial lineage specification and differentiation in vertebrate embryosSuk Won Jin; Fiscal Year: 2010..Furthermore, it will also help us to understand the etiology of many vascular diseases and design a better way of using pluripotent progenitors for the therapeutic purposes. ..
- Reverse Genetic Screening for Vascular Mutants Using Zinc Finger NucleasesNathan D Lawson; Fiscal Year: 2010..In this proposal, we will apply new technology to generate zebrafish knockouts in more than 30 genes to investigate their function during vascular development. ..
- Identifying Vegf target genes during artery developmentNathan Lawson; Fiscal Year: 2005....
- Transgenic screen for artery development mutantsNathan Lawson; Fiscal Year: 2007..Together, these studies will allow identification of genes that are required for proper artery and vein development and will represent putative targets for therapeutic manipulation. ..
- Transcriptional Control of Endothelial DifferentiationNathan D Lawson; Fiscal Year: 2010..However, little is known about how these differences arise. In this proposal, we will utilize the zebra fish as a model system to identify gene programs that govern blood vessel identity in the developing embryo. ..