Gene Symbol: efna5b
Description: ephrin-A5b
Alias: EPLG7, ZfEphL4, al1, efna5, lerk7, tkral1, ephrin-A5b, AL-1, EPH-related receptor tyrosine kinase ligand 7, LERK-7, tyrosine kinase ligand AL-1
Species: zebrafish
Products:     efna5b

Top Publications

  1. Oates A, Lackmann M, Power M, Brennan C, Down L, Do C, et al. An early developmental role for eph-ephrin interaction during vertebrate gastrulation. Mech Dev. 1999;83:77-94 pubmed
  2. Kim M, Liu I, Song Y, Lee J, Halfter W, Balice Gordon R, et al. Agrin is required for posterior development and motor axon outgrowth and branching in embryonic zebrafish. Glycobiology. 2007;17:231-47 pubmed
    ..Together these results show that agrin plays an important role in both peripheral and CNS development and also modulates posterior development in zebrafish. ..
  3. Jelen N, Ule J, Zivin M, Darnell R. Evolution of Nova-dependent splicing regulation in the brain. PLoS Genet. 2007;3:1838-47 pubmed
  4. Gosse N, Nevin L, Baier H. Retinotopic order in the absence of axon competition. Nature. 2008;452:892-5 pubmed publisher
    ..We conclude that dense innervation is not required for targeting of retinal axons within the zebrafish tectum but serves to restrict arbor size and shape. ..
  5. Bernhardt R. Cellular and molecular bases of axonal pathfinding during embryogenesis of the fish central nervous system. J Neurobiol. 1999;38:137-60 pubmed
    ..Experimental evidence for the functions of these molecules in the zebrafish nervous system is accumulating. In the future, this analysis is expected to profit greatly from genetic screens that have recently been initiated. ..
  6. Becker T, Ostendorff H, Bossenz M, Schl├╝ter A, Becker C, Peirano R, et al. Multiple functions of LIM domain-binding CLIM/NLI/Ldb cofactors during zebrafish development. Mech Dev. 2002;117:75-85 pubmed
    ..Our results demonstrate multiple roles of the CLIM cofactor family for the development of entire organs, axonal outgrowth of specific neurons and protein expression levels. ..
  7. Paulus J, Halloran M. Zebrafish bashful/laminin-alpha 1 mutants exhibit multiple axon guidance defects. Dev Dyn. 2006;235:213-24 pubmed
    ..In contrast to CNS axons, most peripheral axons appear normal in bal mutants. Our results, thus, reveal important and diverse functions for laminin-alpha1 in guiding developing axons in vivo. ..
  8. Liu I, Zhang C, Kim M, Cole G. Retina development in zebrafish requires the heparan sulfate proteoglycan agrin. Dev Neurobiol. 2008;68:877-98 pubmed publisher
    ..Collectively, these agrin morphant phenotypes provide support for a crucial role of agrin in retina development and formation of an ordered retinotectal topographic map in the optic tectum of zebrafish. ..
  9. Liao W, Cheng C, Hung K, Chiu W, Chen G, Hwang P, et al. Protein tyrosine phosphatase receptor type O (Ptpro) regulates cerebellar formation during zebrafish development through modulating Fgf signaling. Cell Mol Life Sci. 2013;70:2367-81 pubmed publisher
    ..further investigated the function of ptpro in cerebellar development and found that the expression of ephrin-A5b (efnA5b), a Fgf signaling induced cerebellum patterning factor, was decreased while the expression of dusp6, a negative-..

More Information


  1. Zhang J, Jiang Z, Liu X, Meng A. Eph/ephrin signaling maintains the boundary of dorsal forerunner cell cluster during morphogenesis of the zebrafish embryonic left-right organizer. Development. 2016;143:2603-15 pubmed publisher
    ..Therefore, our data uncover an important role of Eph/ephrin signaling in maintaining DFC cluster boundary and KV boundary for normal left-right asymmetrical development. ..