efna5a

Summary

Gene Symbol: efna5a
Description: ephrin-A5a
Alias: cb1080, fl02c06, wu:fl02c06, ephrin-A5a, ephrin-A5b
Species: zebrafish

Top Publications

  1. Picker A, Brennan C, Reifers F, Clarke J, Holder N, Brand M. Requirement for the zebrafish mid-hindbrain boundary in midbrain polarisation, mapping and confinement of the retinotectal projection. Development. 1999;126:2967-78 pubmed
    ..The MHB organizer, possibly via Fgf8 itself, is thus required for midbrain polarisation and for restricting axonal growth, but other cell populations may also influence midbrain polarity. ..
  2. Picker A, Brand M. Fgf signals from a novel signaling center determine axial patterning of the prospective neural retina. Development. 2005;132:4951-62 pubmed
  3. French C, Erickson T, Callander D, Berry K, Koss R, Hagey D, et al. Pbx homeodomain proteins pattern both the zebrafish retina and tectum. BMC Dev Biol. 2007;7:85 pubmed
    ..These data define a novel role for Pbx in patterning the vertebrate retina and tectum in a manner required for proper retinal ganglion cell axon outgrowth. ..
  4. Nakayama Y, Miyake A, Nakagawa Y, Mido T, Yoshikawa M, Konishi M, et al. Fgf19 is required for zebrafish lens and retina development. Dev Biol. 2008;313:752-66 pubmed
    ..Knockdown of Fgf19 also caused incorrect axon pathfinding. The present findings indicate that Fgf19 positively regulates the patterning and growth of the retina, and the differentiation and growth of the lens in zebrafish. ..
  5. Picker A, Cavodeassi F, Machate A, Bernauer S, Hans S, Abe G, et al. Dynamic coupling of pattern formation and morphogenesis in the developing vertebrate retina. PLoS Biol. 2009;7:e1000214 pubmed publisher
  6. Paulus J, Halloran M. Zebrafish bashful/laminin-alpha 1 mutants exhibit multiple axon guidance defects. Dev Dyn. 2006;235:213-24 pubmed
    ..In contrast to CNS axons, most peripheral axons appear normal in bal mutants. Our results, thus, reveal important and diverse functions for laminin-alpha1 in guiding developing axons in vivo. ..
  7. Kim M, Liu I, Song Y, Lee J, Halfter W, Balice Gordon R, et al. Agrin is required for posterior development and motor axon outgrowth and branching in embryonic zebrafish. Glycobiology. 2007;17:231-47 pubmed
    ..Together these results show that agrin plays an important role in both peripheral and CNS development and also modulates posterior development in zebrafish. ..
  8. Liu I, Zhang C, Kim M, Cole G. Retina development in zebrafish requires the heparan sulfate proteoglycan agrin. Dev Neurobiol. 2008;68:877-98 pubmed publisher
    ..Collectively, these agrin morphant phenotypes provide support for a crucial role of agrin in retina development and formation of an ordered retinotectal topographic map in the optic tectum of zebrafish. ..
  9. Sanek N, Taylor A, Nyholm M, Grinblat Y. Zebrafish zic2a patterns the forebrain through modulation of Hedgehog-activated gene expression. Development. 2009;136:3791-800 pubmed publisher
    ..These data uncover a novel, essential role for Zic2a as a modulator of Hh-activated gene expression in the developing forebrain and advance our understanding of a key gene regulatory network that, when disrupted, causes HPE. ..

More Information

Publications15

  1. Erickson T, French C, Waskiewicz A. Meis1 specifies positional information in the retina and tectum to organize the zebrafish visual system. Neural Dev. 2010;5:22 pubmed publisher
    ..By patterning both the retina and tectum, Meis1 plays an important role in establishing the retinotectal map and organizing the visual system. ..
  2. Liao W, Cheng C, Hung K, Chiu W, Chen G, Hwang P, et al. Protein tyrosine phosphatase receptor type O (Ptpro) regulates cerebellar formation during zebrafish development through modulating Fgf signaling. Cell Mol Life Sci. 2013;70:2367-81 pubmed publisher
    ..Therefore, our findings demonstrate that Ptpro activity is required for patterning the zebrafish embryonic brain. Specifically, Ptpro regulates cerebellar formation during zebrafish development through modulating Fgf signaling. ..
  3. Zhang J, Jiang Z, Liu X, Meng A. Eph/ephrin signaling maintains the boundary of dorsal forerunner cell cluster during morphogenesis of the zebrafish embryonic left-right organizer. Development. 2016;143:2603-15 pubmed publisher
    ..Therefore, our data uncover an important role of Eph/ephrin signaling in maintaining DFC cluster boundary and KV boundary for normal left-right asymmetrical development. ..
  4. McMahon C, Gestri G, Wilson S, Link B. Lmx1b is essential for survival of periocular mesenchymal cells and influences Fgf-mediated retinal patterning in zebrafish. Dev Biol. 2009;332:287-98 pubmed publisher
    ..Overall, we propose zebrafish lmx1b.1 and lmx1b.2 promote the survival of periocular mesenchymal cells that influence multiple signaling events required for proper ocular development. ..
  5. Liu Y, Berndt J, Su F, Tawarayama H, Shoji W, Kuwada J, et al. Semaphorin3D guides retinal axons along the dorsoventral axis of the tectum. J Neurosci. 2004;24:310-8 pubmed
    ..These results suggest that Sema3D in the ventral tectum normally acts to inhibit ventral RGCs from extending into ventral tectum, ensuring their correct innervation of dorsal tectum. ..
  6. Ye M, Berry Wynne K, Asai Coakwell M, Sundaresan P, Footz T, French C, et al. Mutation of the bone morphogenetic protein GDF3 causes ocular and skeletal anomalies. Hum Mol Genet. 2010;19:287-98 pubmed publisher
    ..By demonstrating the pleiotropic effects of GDF3 mutation, these results extend the contribution of perturbed BMP signaling to human disease and potentially implicate multi-allelic inheritance of BMP variants in developmental disorders. ..