Gene Symbol: ednrba
Description: endothelin receptor Ba
Alias: ednrb1, ednrb1a, endothelin B receptor, endothelin receptor B, endothelin receptor B1a, ros, rose, rse
Species: zebrafish

Top Publications

  1. Arduini B, Henion P. Melanophore sublineage-specific requirement for zebrafish touchtone during neural crest development. Mech Dev. 2004;121:1353-64 pubmed
    ..Further, our results suggest that, like other neural crest-derived sublineages, melanogenic precursors constitute a heterogeneous population with respect to genetic requirements for development...
  2. Choudhry P, Joshi D, Funke B, Trede N. Alcama mediates Edn1 signaling during zebrafish cartilage morphogenesis. Dev Biol. 2011;349:483-93 pubmed publisher
    ..1 during chondrogenesis. Collectively our results support a model by which Alcama on the endoderm interacts with Nadl1.1 on NC to mediate Edn1 signaling and NC differentiation during chondrogenesis. ..
  3. Engeszer R, Wang G, Ryan M, Parichy D. Sex-specific perceptual spaces for a vertebrate basal social aggregative behavior. Proc Natl Acad Sci U S A. 2008;105:929-33 pubmed publisher
  4. Lopes S, Yang X, Müller J, Carney T, McAdow A, Rauch G, et al. Leukocyte tyrosine kinase functions in pigment cell development. PLoS Genet. 2008;4:e1000026 pubmed publisher
    ..In summary, we have discovered a novel signalling pathway in NCC development and demonstrate fate specification of iridophores as the first identified role for Ltk. ..
  5. Lang M, Patterson L, Gordon T, Johnson S, Parichy D. Basonuclin-2 requirements for zebrafish adult pigment pattern development and female fertility. PLoS Genet. 2009;5:e1000744 pubmed publisher
    ..These findings identify bnc2 as an important mediator of adult pigment pattern formation and identify bonaparte mutants as an animal model for dissecting bnc2 functions...
  6. Parichy D, Ransom D, Paw B, Zon L, Johnson S. An orthologue of the kit-related gene fms is required for development of neural crest-derived xanthophores and a subpopulation of adult melanocytes in the zebrafish, Danio rerio. Development. 2000;127:3031-44 pubmed
    ..These findings reveal an unexpected role for fms in pigment pattern development and demonstrate that parallel neural crest-derived pigment cell populations depend on the activities of two essentially paralogous genes, kit and fms. ..
  7. Cornell R, Yemm E, Bonde G, Li W, d Alençon C, Wegman L, et al. Touchtone promotes survival of embryonic melanophores in zebrafish. Mech Dev. 2004;121:1365-76 pubmed
    ..Thus, we have identified a zebrafish gene that when mutated produces semi-viable offspring and that may serve as a model of human diseases that have both pigmentation and neurological symptoms...
  8. Guh Y, Tseng Y, Yang C, Hwang P. Endothelin-1 regulates H?-ATPase-dependent transepithelial H? secretion in zebrafish. Endocrinology. 2014;155:1728-37 pubmed publisher
    ..These findings provide evidence that EDN1 signaling is involved in acid-base regulation in zebrafish and enhance our understanding of EDN1 regulation of transepithelial H? secretion in vertebrates. ..
  9. Stewart R, Arduini B, Berghmans S, George R, Kanki J, Henion P, et al. Zebrafish foxd3 is selectively required for neural crest specification, migration and survival. Dev Biol. 2006;292:174-88 pubmed

More Information


  1. Colanesi S, Taylor K, Temperley N, Lundegaard P, Liu D, North T, et al. Small molecule screening identifies targetable zebrafish pigmentation pathways. Pigment Cell Melanoma Res. 2012;25:131-43 pubmed publisher
  2. White R, Cech J, Ratanasirintrawoot S, Lin C, Rahl P, Burke C, et al. DHODH modulates transcriptional elongation in the neural crest and melanoma. Nature. 2011;471:518-22 pubmed publisher
    ..Taken together, these studies highlight developmental pathways in neural crest cells that have a direct bearing on melanoma formation. ..
  3. Frohnhöfer H, Krauss J, Maischein H, NUSSLEIN VOLHARD C. Iridophores and their interactions with other chromatophores are required for stripe formation in zebrafish. Development. 2013;140:2997-3007 pubmed publisher
    ..Mutations in rose (rse) or shady (shd) cause a lack or strong reduction of iridophores in adult fish; in addition, the melanophore ..
  4. Arduini B, Gallagher G, Henion P. Zebrafish endzone regulates neural crest-derived chromatophore differentiation and morphology. PLoS ONE. 2008;3:e2845 pubmed publisher
  5. Arduini B, Bosse K, Henion P. Genetic ablation of neural crest cell diversification. Development. 2009;136:1987-94 pubmed publisher
    ..Our results identify a genetic regulatory pathway functionally discrete from the process of neural crest induction that is required for the initiation of neural crest cell diversification during embryonic development. ..
  6. Bink R, Habuchi H, Lele Z, Dolk E, Joore J, Rauch G, et al. Heparan sulfate 6-o-sulfotransferase is essential for muscle development in zebrafish. J Biol Chem. 2003;278:31118-27 pubmed
    ..In conclusion, our results show that transfer of sulfate to specific positions on glycosaminoglycans is essential for muscle development. ..
  7. Lister J, Cooper C, Nguyen K, Modrell M, Grant K, Raible D. Zebrafish Foxd3 is required for development of a subset of neural crest derivatives. Dev Biol. 2006;290:92-104 pubmed
  8. Braasch I, Volff J, Schartl M. The endothelin system: evolution of vertebrate-specific ligand-receptor interactions by three rounds of genome duplication. Mol Biol Evol. 2009;26:783-99 pubmed publisher
    ..Bony vertebrates generally possess three receptor genes, EdnrA, EdnrB1, and EdnrB2...
  9. Nair S, Li W, Cornell R, Schilling T. Requirements for Endothelin type-A receptors and Endothelin-1 signaling in the facial ectoderm for the patterning of skeletogenic neural crest cells in zebrafish. Development. 2007;134:335-45 pubmed
    ..Collectively, our results indicate that Edn1 from the pharyngeal ectoderm signals through Ednra proteins to direct early dorsoventral patterning of the skeletogenic neural crest. ..
  10. Krauss J, Astrinidis P, Astrinides P, Frohnhöfer H, Walderich B, NUSSLEIN VOLHARD C. transparent, a gene affecting stripe formation in Zebrafish, encodes the mitochondrial protein Mpv17 that is required for iridophore survival. Biol Open. 2013;2:703-10 pubmed publisher
    ..The specificity of the tra phenotype is most likely due to redundancy after gene multiplication, making this mutant a valuable model to understand the molecular function of Mpv17 in mitochondria. ..
  11. Patterson L, Parichy D. Interactions with iridophores and the tissue environment required for patterning melanophores and xanthophores during zebrafish adult pigment stripe formation. PLoS Genet. 2013;9:e1003561 pubmed publisher
  12. Higdon C, Mitra R, Johnson S. Gene expression analysis of zebrafish melanocytes, iridophores, and retinal pigmented epithelium reveals indicators of biological function and developmental origin. PLoS ONE. 2013;8:e67801 pubmed publisher