Gene Symbol: edar
Description: ectodysplasin A receptor
Alias: fls, tumor necrosis factor receptor superfamily member EDAR, ectodysplasin receptor, finless
Harris M, Rohner N, Schwarz H, Perathoner S, Konstantinidis P, NUSSLEIN VOLHARD C. Zebrafish eda and edar mutants reveal conserved and ancestral roles of ectodysplasin signaling in vertebrates. PLoS Genet. 2008;4:e1000206 pubmed publisher
..The mutations represent adult-viable, loss of function alleles in the ectodysplasin (eda) and ectodysplasin receptor (edar) genes...
Sadier A, Lambert E, Chevret P, Decimo D, Semon M, Tohmé M, et al
. Tinkering signaling pathways by gain and loss of protein isoforms: the case of the EDA pathway regulator EDARADD. BMC Evol Biol. 2015;15:129 pubmed publisher
..This study makes the case to pay greater attention to mosaic loss of evolutionarily speaking "young" isoforms as an important mechanism underlying phenotypic diversity and not simply as a manifestation of neutral evolution. ..
Choi J, Kim R, Yoon S, Kim W. Developmental Toxicity of Zinc Oxide Nanoparticles to Zebrafish (Danio rerio): A Transcriptomic Analysis. PLoS ONE. 2016;11:e0160763 pubmed publisher
..exposure shared similar biological pathways with those observed with ZnSO4 exposure, but six genes (aicda, cyb5d1, edar, intl2, ogfrl2 and tnfsf13b) associated with inflammation and the immune system responded specifically to ZnO NPs (..
Haffter P, Odenthal J, Mullins M, Lin S, Farrell M, Vogelsang E, et al
. Mutations affecting pigmentation and shape of the adult zebrafish. Dev Genes Evol. 1996;206:260-76 pubmed publisher
..Mutations in sandy produced embryos that failed to express tyrosinase activity. These are potentially useful for using tyrosinase as a marker for the generation of transgenic lines of zebrafish. ..
Aigler S, Jandzik D, Hatta K, Uesugi K, Stock D. Selection and constraint underlie irreversibility of tooth loss in cypriniform fishes. Proc Natl Acad Sci U S A. 2014;111:7707-12 pubmed publisher
Henke K, Daane J, Hawkins M, Dooley C, Busch Nentwich E, Stemple D, et al
. Genetic Screen for Postembryonic Development in the Zebrafish (Danio rerio): Dominant Mutations Affecting Adult Form. Genetics. 2017;207:609-623 pubmed publisher
..Taken together, these results show that dominant screens are a feasible and productive means to identify mutations that can further our understanding of gene function during postembryonic development and in disease. ..