Gene Symbol: eda
Description: ectodysplasin A
Alias: si:ch73-223d24.5, ectodysplasin-A, nackt, nkt
Harris M, Rohner N, Schwarz H, Perathoner S, Konstantinidis P, NUSSLEIN VOLHARD C. Zebrafish eda and edar mutants reveal conserved and ancestral roles of ectodysplasin signaling in vertebrates. PLoS Genet. 2008;4:e1000206 pubmed publisher
..The mutations represent adult-viable, loss of function alleles in the ectodysplasin (eda) and ectodysplasin receptor (edar) genes...
Poulton L, Nolan K, Anastasaki C, Waldmann H, Patton E. A novel role for Glucocorticoid-Induced TNF Receptor Ligand (Gitrl) in early embryonic zebrafish development. Int J Dev Biol. 2010;54:815-25 pubmed publisher
..25-10 hpf). We found Stat3 signalling to be altered in the gitrl-morphants, suggesting that one possible role for Gitrl during embryogenesis may be modulation of Jak/Stat signalling. ..
Yuan Q, Zhao M, Tandon B, Maili L, Liu X, Zhang A, et al
. Role of WNT10A in failure of tooth development in humans and zebrafish. Mol Genet Genomic Med. 2017;5:730-741 pubmed publisher
..of additional tooth development genes were directly correlated with wnt10a expression; expression of msx1, dlx2b, eda, and axin2 was decreased upon wnt10a knockdown, and increased upon wnt10a overexpression...
Aigler S, Jandzik D, Hatta K, Uesugi K, Stock D. Selection and constraint underlie irreversibility of tooth loss in cypriniform fishes. Proc Natl Acad Sci U S A. 2014;111:7707-12 pubmed publisher
..We identified regional loss of expression of the Ectodysplasin (Eda) signaling ligand as a likely cause of dentition reduction...
Sadier A, Lambert E, Chevret P, Decimo D, Semon M, Tohmé M, et al
. Tinkering signaling pathways by gain and loss of protein isoforms: the case of the EDA pathway regulator EDARADD. BMC Evol Biol. 2015;15:129 pubmed publisher
..These results suggest that the newly evolved A isoform enables modulating EDA signaling in specific conditions and with different dynamics...