Gene Symbol: dvl2
Description: dishevelled segment polarity protein 2
Alias: sb:eu471, wu:fc05d12, wu:fo71e09, wu:fp54a02, zgc:55372, segment polarity protein dishevelled homolog DVL-2, dishevelled 2, dsh homolog, dishevelled, dsh homolog 2
Species: zebrafish
Products:     dvl2

Top Publications

  1. Waxman J, Hocking A, Stoick C, Moon R. Zebrafish Dapper1 and Dapper2 play distinct roles in Wnt-mediated developmental processes. Development. 2004;131:5909-21 pubmed
    ..Dpr1 synergizes with zebrafish Dvl2, and with the Dvl-interacting kinases CK1epsilon, Par1 and CK2, in activating target genes...
  2. Angers S, Thorpe C, Biechele T, Goldenberg S, Zheng N, MacCoss M, et al. The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation. Nat Cell Biol. 2006;8:348-57 pubmed
  3. Matsui T, Raya A, Kawakami Y, Callol Massot C, Capdevila J, Rodriguez Esteban C, et al. Noncanonical Wnt signaling regulates midline convergence of organ primordia during zebrafish development. Genes Dev. 2005;19:164-75 pubmed
    ..Overall, our results uncover a late, previously unexpected role of noncanonical Wnt signaling in the control of midline assembly of organ precursors during vertebrate embryo development. ..
  4. Tawk M, Araya C, Lyons D, Reugels A, Girdler G, Bayley P, et al. A mirror-symmetric cell division that orchestrates neuroepithelial morphogenesis. Nature. 2007;446:797-800 pubmed
  5. Freisinger C, Fisher R, Slusarski D. Regulator of g protein signaling 3 modulates wnt5b calcium dynamics and somite patterning. PLoS Genet. 2010;6:e1001020 pubmed publisher
    ..These results provide the first evidence for an essential developmental role of RGS proteins in modulating the duration of non-canonical Wnt signaling. ..
  6. Schneider I, Schneider P, Derry S, Lin S, Barton L, Westfall T, et al. Zebrafish Nkd1 promotes Dvl degradation and is required for left-right patterning. Dev Biol. 2010;348:22-33 pubmed publisher
    ..Our findings show that Nkd1 acts as a ?-catenin antagonist in the DFCs necessary for LR patterning. ..
  7. Carreira Barbosa F, Kajita M, Kajita M, Morel V, Wada H, Okamoto H, et al. Flamingo regulates epiboly and convergence/extension movements through cell cohesive and signalling functions during zebrafish gastrulation. Development. 2009;136:383-92 pubmed publisher
    ..Fmi/Celsr therefore has a dual role in mediating two separate morphogenetic movements through its roles in mediating cell cohesion and Wnt/PCP signalling during zebrafish gastrulation. ..
  8. Richardson R, Metzger M, Knyphausen P, Ramezani T, Slanchev K, Kraus C, et al. Re-epithelialization of cutaneous wounds in adult zebrafish combines mechanisms of wound closure in embryonic and adult mammals. Development. 2016;143:2077-88 pubmed publisher
  9. Shimizu N, Ishitani S, Sato A, Shibuya H, Ishitani T. Hipk2 and PP1c cooperate to maintain Dvl protein levels required for Wnt signal transduction. Cell Rep. 2014;8:1391-404 pubmed publisher
    ..This regulation may be a negative feedback mechanism that fine-tunes Wnt/β-catenin signaling. ..

More Information


  1. Shiomi K, Uchida H, Keino Masu K, Masu M. Ccd1, a novel protein with a DIX domain, is a positive regulator in the Wnt signaling during zebrafish neural patterning. Curr Biol. 2003;13:73-7 pubmed
    ..These results indicate that Ccd1 is a novel positive regulator in this Wnt signaling pathway during zebrafish neural patterning. ..
  2. Stuckenholz C, Lu L, Thakur P, Choi T, Shin D, Bahary N. Sfrp5 modulates both Wnt and BMP signaling and regulates gastrointestinal organogenesis [corrected] in the zebrafish, Danio rerio. PLoS ONE. 2013;8:e62470 pubmed publisher
    ..We show that Sfrp5 inhibits both canonical and non-canonical Wnt signaling during embryonic and endodermal development, resulting in endodermal abnormalities...
  3. Lum W, Robertson J, Van Raay T. Dishevelled2 is a stable protein during early zebrafish development. Zebrafish. 2011;8:65-71 pubmed publisher
    ..we demonstrate that during early zebrafish development Nkd1 does not alter either endogenous or exogenous levels of Dvl2. Furthermore, Dvl2 does not affect the levels of Nkd1...
  4. Cui S, Capecci L, Matthews R. Disruption of planar cell polarity activity leads to developmental biliary defects. Dev Biol. 2011;351:229-41 pubmed publisher
    ..Our results demonstrate that PCP plays an important role in vertebrate biliary development, interacting with other factors known to be involved in biliary morphogenesis. ..
  5. Carvalho C, Vasanth S, Shinawi M, Russell C, Ramocki M, Brown C, et al. Dosage changes of a segment at 17p13.1 lead to intellectual disability and microcephaly as a result of complex genetic interaction of multiple genes. Am J Hum Genet. 2014;95:565-78 pubmed publisher
    ..in zebrafish embryos revealed a complex genetic architecture: dosage perturbation of four genes (ASGR1, ACADVL, DVL2, and GABARAP) impeded neurodevelopment and decreased dosage of the same loci caused a reduced mitotic index in ..
  6. Choe C, Collazo A, Trinh L, Pan L, Moens C, Crump J. Wnt-dependent epithelial transitions drive pharyngeal pouch formation. Dev Cell. 2013;24:296-309 pubmed publisher
    ..We propose that this dynamic control of epithelial morphology by Wnt signaling may be a common theme for the budding of organ anlagen from the endoderm. ..
  7. Yang Y, Thorpe C. BMP and non-canonical Wnt signaling are required for inhibition of secondary tail formation in zebrafish. Development. 2011;138:2601-11 pubmed publisher
    ..We propose a model in which BMP and the non-canonical Wnt pathway regulate tail morphogenesis by controlling cell migration and cell adhesion within the tailbud...
  8. Van Raay T, Fortino N, Miller B, Ma H, Lau G, Li C, et al. Naked1 antagonizes Wnt signaling by preventing nuclear accumulation of ?-catenin. PLoS ONE. 2011;6:e18650 pubmed publisher
    ..Given the conserved nature of Nkd1, our results shed light on the negative feedback regulation of Wnt signaling through the Nkd1-mediated negative control of nuclear accumulation of ?-catenin. ..
  9. Segalen M, Johnston C, Martin C, Dumortier J, Prehoda K, David N, et al. The Fz-Dsh planar cell polarity pathway induces oriented cell division via Mud/NuMA in Drosophila and zebrafish. Dev Cell. 2010;19:740-52 pubmed publisher
    ..Overall, we describe a Frizzled-Dishevelled-NuMA pathway that orients division from Drosophila to vertebrates. ..
  10. Hagemann A, Kurz J, Kauffeld S, Chen Q, Reeves P, Weber S, et al. In vivo analysis of formation and endocytosis of the Wnt/?-catenin signaling complex in zebrafish embryos. J Cell Sci. 2014;127:3970-82 pubmed publisher
    ..It is continuously assembled by Dvl2-mediated recruitment of the transducer complex to the activated receptors and partially disassembled by endocytosis...
  11. Serluca F, Xu B, Okabe N, Baker K, Lin S, Sullivan Brown J, et al. Mutations in zebrafish leucine-rich repeat-containing six-like affect cilia motility and result in pronephric cysts, but have variable effects on left-right patterning. Development. 2009;136:1621-31 pubmed publisher
    ..Combined with recently published results, our alleles suggest that the function of seahorse in cilia motility is separable from its function in other cilia-related phenotypes. ..
  12. Larraguibel J, Weiss A, Pasula D, Dhaliwal R, Kondra R, Van Raay T. Wnt ligand-dependent activation of the negative feedback regulator Nkd1. Mol Biol Cell. 2015;26:2375-84 pubmed publisher
    ..Furthermore, our results support the hypothesis that Nkd1 is recruited to the Wnt signalosome with Dvl2, where it becomes activated to move into the cytoplasm to interact with β-catenin, inhibiting its nuclear ..
  13. Jing L, Lefebvre J, Gordon L, Granato M. Wnt signals organize synaptic prepattern and axon guidance through the zebrafish unplugged/MuSK receptor. Neuron. 2009;61:721-33 pubmed publisher
    ..We propose that Wnt ligands activate unplugged/MuSK signaling in muscle fibers to restrict growth cone guidance and AChR prepatterns to the muscle center through a mechanism reminiscent of the planar cell polarity pathway. ..
  14. Cheng X, Shao M, Li J, Wang Y, Qi J, Xu Z, et al. Leucine repeat adaptor protein 1 interacts with Dishevelled to regulate gastrulation cell movements in zebrafish. Nat Commun. 2017;8:1353 pubmed publisher
    ..These findings demonstrate that Lurap1 functions to regulate cellular polarisation and motile behaviours during gastrulation movements. ..