Gene Symbol: dusp5
Description: dual specificity phosphatase 5
Alias: wu:fc03b11, wu:fc86e02, dual specificity protein phosphatase 5
Species: zebrafish
Products:     dusp5

Top Publications

  1. Sumanas S, Lin S. Ets1-related protein is a key regulator of vasculogenesis in zebrafish. PLoS Biol. 2006;4:e10 pubmed
    ..These results demonstrate that Etsrp is necessary and sufficient for the initiation of vasculogenesis. ..
  2. Pramanik K, Chun C, Garnaas M, Samant G, Li K, Horswill M, et al. Dusp-5 and Snrk-1 coordinately function during vascular development and disease. Blood. 2009;113:1184-91 pubmed publisher
    ..Importantly, mutations in dusp-5 and snrk-1 have been identified in affected tissues of patients with vascular anomalies, implicating the Snrk-1-Dusp-5 signaling pathway in human disease. ..
  3. Sumanas S, Jorniak T, Lin S. Identification of novel vascular endothelial-specific genes by the microarray analysis of the zebrafish cloche mutants. Blood. 2005;106:534-41 pubmed
    ..Dual specificity phosphatase 5 (dusp5), cadherin 5 (cdh5; VE-cadherin), aquaporin 8 (aqp8), adrenomedullin receptor (admr), complement receptor C1qR-..
  4. Qian F, Zhen F, Ong C, Jin S, Meng Soo H, Stainier D, et al. Microarray analysis of zebrafish cloche mutant using amplified cDNA and identification of potential downstream target genes. Dev Dyn. 2005;233:1163-72 pubmed
    ..znfl2), neutrophil cytosol factor 1 (ncf1), matrix metalloproteinase 13 (mmp13), dual specificity phosphatase 5 (dusp5), and a novel gene referred as zebrafish vessel-specific gene 1 (zvsg1) are predominantly expressed in ..
  5. Lorent K, Gong W, Koo K, Waisbourd Zinman O, Karjoo S, Zhao X, et al. Identification of a plant isoflavonoid that causes biliary atresia. Sci Transl Med. 2015;7:286ra67 pubmed publisher
    ..Together, these findings provide direct evidence that BA could be initiated by perinatal exposure to an environmental toxin. ..
  6. Faltermann S, Hutter S, Christen V, Hettich T, Fent K. Anti-Inflammatory Activity of Cyanobacterial Serine Protease Inhibitors Aeruginosin 828A and Cyanopeptolin 1020 in Human Hepatoma Cell Line Huh7 and Effects in Zebrafish (Danio rerio). Toxins (Basel). 2016;8: pubmed publisher
    ..The data further demonstrate that pathways that are influenced by microcystin-LR are not affected by aeruginosin 828A. ..
  7. Weber G, Choe S, Dooley K, Paffett Lugassy N, Zhou Y, Zon L. Mutant-specific gene programs in the zebrafish. Blood. 2005;106:521-30 pubmed
  8. Molina G, Vogt A, Bakan A, Dai W, Queiroz de Oliveira P, Znosko W, et al. Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages. Nat Chem Biol. 2009;5:680-7 pubmed publisher
    ..This study highlights the power of in vivo zebrafish chemical screens to identify new compounds targeting Dusp6, a component of the FGF signaling pathway that has eluded traditional high-throughput in vitro screens...
  9. Zhang N, Li H, Liu J, Yang W. Gene expression profiles in zebrafish (Danio rerio) liver after acute exposure to okadaic acid. Environ Toxicol Pharmacol. 2014;37:791-802 pubmed publisher
    ..Our findings may give some useful information on the pathways of OA-induced injury in fish. ..

More Information


  1. Faltermann S, Grundler V, Gademann K, Pernthaler J, Fent K. Comparative effects of nodularin and microcystin-LR in zebrafish: 2. Uptake and molecular effects in eleuthero-embryos and adult liver with focus on endoplasmic reticulum stress. Aquat Toxicol. 2016;171:77-87 pubmed publisher
    ..strong transcriptional changes occurred for tumor necrosis factor alpha (tnfa) and dual specificity phosphatase 5 (dusp5), associated with mitogen activated protein kinase (MAPK) pathway...
  2. Fish J, Cantu Gutierrez M, Dang L, Khyzha N, Chen Z, Veitch S, et al. Dynamic regulation of VEGF-inducible genes by an ERK/ERG/p300 transcriptional network. Development. 2017;144:2428-2444 pubmed publisher
    ..Collectively, these findings elucidate a novel transcriptional pathway contributing to VEGF-dependent angiogenesis. ..
  3. Quillien A, Abdalla M, Yu J, Ou J, Zhu L, Lawson N. Robust Identification of Developmentally Active Endothelial Enhancers in Zebrafish Using FANS-Assisted ATAC-Seq. Cell Rep. 2017;20:709-720 pubmed publisher
    ..Thus, FANS-assisted ATAC-seq using transgenic zebrafish embryos provides a robust approach for genome-wide identification of active tissue-specific enhancer elements. ..
  4. Wu M, Liu S, Hu L, Qu H, Pan C, Lei P, et al. Global transcriptomic analysis of zebrafish in response to embryonic exposure to three antidepressants, amitriptyline, fluoxetine and mianserin. Aquat Toxicol. 2017;192:274-283 pubmed publisher
    ..results revealed a significant concentration-dependent reduction in the levels of dual-specificity phosphatase 5 (dusp5) mRNA, as well as a non-concentration-dependent gene expression inhibition of prostaglandin D2 synthase b (ptgdsb);..