Gene Symbol: dusp4
Description: dual specificity phosphatase 4
Alias: zgc:55423, dual specificity protein phosphatase 4
Species: zebrafish

Top Publications

  1. Brown J, Snir M, Noushmehr H, Kirby M, Hong S, Elkahloun A, et al. Transcriptional profiling of endogenous germ layer precursor cells identifies dusp4 as an essential gene in zebrafish endoderm specification. Proc Natl Acad Sci U S A. 2008;105:12337-42 pubmed publisher
    ..Loss-of-function studies revealed that one of these genes, the MAP kinase inhibitor dusp4, is essential for early development...
  2. Liu Z, Wei S, Wang Q. [The Nodal regulated dusp4 inhibits mesendoderm formation during zebrafish gastrulation]. Yi Chuan. 2012;34:1153-8 pubmed
    MAP kinase phosphatase-2 (MKP-2/DUSP4), a dual specificity protein phosphatase with tyrosine/serine/ threonine phosphatase activity, is associated with cellular proliferation and differentiation, but its functions during embryo ..
  3. Le X, Pugach E, Hettmer S, Storer N, Liu J, Wills A, et al. A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development. Development. 2013;140:2354-64 pubmed publisher
    ..Our work demonstrates that the activated pathways in RAS induction during embryogenesis are also important in oncogenesis and that inhibition of these pathways suppresses tumor growth. ..
  4. Tal T, Franzosa J, Tilton S, Philbrick K, Iwaniec U, Turner R, et al. MicroRNAs control neurobehavioral development and function in zebrafish. FASEB J. 2012;26:1452-61 pubmed publisher
    ..Together, these data support an integral role for miRNAs in the establishment of vertebrate neurobehavioral and skeletal systems. ..
  5. Stulberg M, Lin A, Zhao H, Holley S. Crosstalk between Fgf and Wnt signaling in the zebrafish tailbud. Dev Biol. 2012;369:298-307 pubmed publisher
  6. Ignatius M, Hayes M, Lobbardi R, Chen E, McCarthy K, Sreenivas P, et al. The NOTCH1/SNAIL1/MEF2C Pathway Regulates Growth and Self-Renewal in Embryonal Rhabdomyosarcoma. Cell Rep. 2017;19:2304-2318 pubmed publisher
    ..Our data implicate the NOTCH1/SNAI1/MEF2C signaling axis as a major determinant of TPC self-renewal and differentiation in ERMS, raising hope of therapeutically targeting this pathway in the future. ..