Gene Symbol: duox
Description: dual oxidase
Alias: duox1, dual oxidase 2, dual oxidase 1
Species: zebrafish

Top Publications

  1. Niethammer P, Grabher C, Look A, Mitchison T. A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish. Nature. 2009;459:996-9 pubmed publisher
    ..Using pharmacological and genetic inhibition, we show that this gradient is created by dual oxidase (Duox), and that it is required for rapid recruitment of leukocytes to the wound...
  2. Flores M, Crawford K, Pullin L, Hall C, Crosier K, Crosier P. Dual oxidase in the intestinal epithelium of zebrafish larvae has anti-bacterial properties. Biochem Biophys Res Commun. 2010;400:164-8 pubmed publisher
    ..Recent research highlighted the requirement for ROS generated by dual oxidase (DUOX) in host-defence responses in innate immunity and inflammatory disorders such as inflammatory bowel disease (IBD), ..
  3. Oehlers S, Flores M, Chen T, Hall C, Crosier K, Crosier P. Topographical distribution of antimicrobial genes in the zebrafish intestine. Dev Comp Immunol. 2011;35:385-91 pubmed publisher
    ..Expression of the zebrafish ?-defensin family was examined in adult zebrafish tissues. Strong expression of defensin beta-like 1 was detected in the swim bladder of zebrafish from the larval stage of development through to adults. ..
  4. Yoo S, Starnes T, Deng Q, Huttenlocher A. Lyn is a redox sensor that mediates leukocyte wound attraction in vivo. Nature. 2011;480:109-12 pubmed publisher
    ..This is the first identification, to our knowledge, of a physiological redox sensor that mediates leukocyte wound attraction in multicellular organisms. ..
  5. Feng Y, Santoriello C, Mione M, Hurlstone A, Martin P. Live imaging of innate immune cell sensing of transformed cells in zebrafish larvae: parallels between tumor initiation and wound inflammation. PLoS Biol. 2010;8:e1000562 pubmed publisher
    ..These parallels between the inflammatory responses to transformed cells and to wounds reinforce the suggestion by others that cancers resemble non-healing wounds. ..
  6. Rieger S, Sagasti A. Hydrogen peroxide promotes injury-induced peripheral sensory axon regeneration in the zebrafish skin. PLoS Biol. 2011;9:e1000621 pubmed publisher
    ..Thus, H(2)O(2) signaling helps coordinate wound healing with peripheral sensory axon reinnervation of the skin. ..
  7. Yan B, Han P, Pan L, Lu W, Xiong J, Zhang M, et al. IL-1? and reactive oxygen species differentially regulate neutrophil directional migration and Basal random motility in a zebrafish injury-induced inflammation model. J Immunol. 2014;192:5998-6008 pubmed publisher
    ..In addition, Il-1? overexpressing Tg(hsp70:(m)il-1?_eGFP;lyz:DsRed2)hkz10t;nz50 transgenic zebrafish provides a useful animal model for the study of chronic inflammatory disorder and for anti-inflammatory drug discovery. ..
  8. Opitz R, Maquet E, Zoenen M, Dadhich R, Costagliola S. TSH receptor function is required for normal thyroid differentiation in zebrafish. Mol Endocrinol. 2011;25:1579-99 pubmed publisher
    ..In addition, we identified tpo, iyd, duox, and duoxa as novel thyroid differentiation markers in zebrafish...
  9. Tauzin S, Starnes T, Becker F, Lam P, Huttenlocher A. Redox and Src family kinase signaling control leukocyte wound attraction and neutrophil reverse migration. J Cell Biol. 2014;207:589-98 pubmed publisher
    ..Thus, redox-SFK signaling in adjacent tissues is essential for coordinated leukocyte wound attraction and repulsion through pathways that involve contact-mediated guidance. ..

More Information


  1. Yang H, Zou S, Zhai L, Wang Y, Zhang F, An L, et al. Pathogen invasion changes the intestinal microbiota composition and induces innate immune responses in the zebrafish intestine. Fish Shellfish Immunol. 2017;71:35-42 pubmed publisher
    ..These results suggested that the invasion of pathogen could change the intestinal microbiota composition and induce intestinal innate immune responses in zebrafish. ..
  2. Shi Y, Zhang Y, Zhao F, Ruan H, Huang H, Luo L, et al. Acetylcholine serves as a derepressor in Loperamide-induced Opioid-Induced Bowel Dysfunction (OIBD) in zebrafish. Sci Rep. 2014;4:5602 pubmed publisher
  3. de Oliveira S, López Muñoz A, Candel S, Pelegrin P, Calado A, Mulero V. ATP modulates acute inflammation in vivo through dual oxidase 1-derived H2O2 production and NF-?B activation. J Immunol. 2014;192:5710-9 pubmed publisher
    b>Dual oxidase 1 (Duox1) is the NADPH oxidase responsible for the H2O2 gradient formed in tissues after injury to trigger the early recruitment of leukocytes...
  4. Brothers K, Gratacap R, Barker S, Newman Z, Norum A, Wheeler R. NADPH oxidase-driven phagocyte recruitment controls Candida albicans filamentous growth and prevents mortality. PLoS Pathog. 2013;9:e1003634 pubmed publisher
    ..These novel links between ROS-driven chemotaxis and fungal dimorphism expand our view of a key host defense mechanism and have important implications for pathogenesis. ..
  5. Oehlers S, Flores M, Hall C, Swift S, Crosier K, Crosier P. The inflammatory bowel disease (IBD) susceptibility genes NOD1 and NOD2 have conserved anti-bacterial roles in zebrafish. Dis Model Mech. 2011;4:832-41 pubmed publisher
    ..This work highlights the potential use of zebrafish larvae in the study of components of IBD pathogenesis. ..
  6. Candel S, de Oliveira S, López Muñoz A, García Moreno D, Espin Palazon R, Tyrkalska S, et al. Tnfa signaling through tnfr2 protects skin against oxidative stress-induced inflammation. PLoS Biol. 2014;12:e1001855 pubmed publisher
    ..reporter transgenes, fluorescence microscopy, and flow cytometry, we identified the local production of dual oxidase 1 (Duox1)-derived H?O? by Tnfa- and Tnfr2-deficient keratinocytes as a trigger for the activation of the master ..
  7. Han P, Zhou X, Chang N, Xiao C, Yan S, Ren H, et al. Hydrogen peroxide primes heart regeneration with a derepression mechanism. Cell Res. 2014;24:1091-107 pubmed publisher
    ..Decreasing H2O2 formation with the Duox inhibitors diphenyleneiodonium (DPI) or apocynin, or scavenging H2O2 by catalase overexpression markedly impaired ..
  8. Weaver C, Leung Y, Suter D. Expression dynamics of NADPH oxidases during early zebrafish development. J Comp Neurol. 2016;524:2130-41 pubmed publisher
    ..Although the sequences of five NOX genes (nox1, nox2/cybb, nox4, nox5, and duox) have been identified in the zebrafish genome, nothing is known about their expression pattern...