Gene Symbol: drgx
Description: dorsal root ganglia homeobox
Alias: prrxl1, dorsal root ganglia homeobox protein, drg11, paired related homeobox protein-like 1, paired-like homeodomain transcription factor DRG11
McCormick L, Hutt J, Hazan J, Houart C, Cohen J. The homeodomain transcription factor drg11 is expressed in primary sensory neurons and their putative CNS targets during embryonic development of the zebrafish. Gene Expr Patterns. 2007;7:289-96 pubmed
The drg11 gene is a member of the vertebrate aristaless-related gene family and encodes a paired homeodomain transcription factor...
Regadas I, Matos M, Monteiro F, Gomez Skarmeta J, Lima D, Bessa J, et al
. Several cis-regulatory elements control mRNA stability, translation efficiency, and expression pattern of Prrxl1 (paired related homeobox protein-like 1). J Biol Chem. 2013;288:36285-301 pubmed publisher
The homeodomain transcription factor Prrxl1/DRG11 has emerged as a crucial molecule in the establishment of the pain circuitry, in particular spinal cord targeting of dorsal root ganglia (DRG) axons and differentiation of nociceptive ..
Dyer C, Blanc E, Hanisch A, Roehl H, Otto G, Yu T, et al
. A bi-modal function of Wnt signalling directs an FGF activity gradient to spatially regulate neuronal differentiation in the midbrain. Development. 2014;141:63-72 pubmed publisher
..This controls a dynamic, posteriorly retracting expression of her5 that directs neuronal differentiation in a precise spatiotemporal manner in the midbrain...
Aoki M, Segawa H, Naito M, Okamoto H. Identification of possible downstream genes required for the extension of peripheral axons in primary sensory neurons. Biochem Biophys Res Commun. 2014;445:357-62 pubmed publisher
..They are not reported the involvement of axonal extension or their functions in neural cells. Finally, knockdown of these genes suggested their direct actual involvement in the extension of peripheral axons in sensory neurons. ..
Dyer C, Linker C, Graham A, Knight R. Specification of sensory neurons occurs through diverse developmental programs functioning in the brain and spinal cord. Dev Dyn. 2014;243:1429-39 pubmed publisher
..Our work reveals fundamental differences between the development of MTN and RB neurons and suggests that these populations are non-homologous and thus have distinct developmental and, probably, evolutionary origins. ..