Gene Symbol: drd4b
Description: dopamine receptor D4b
Alias: Drd4c, dopamine receptor D4b, dopamine D4c receptor
Boehmler W, Carr T, Thisse C, Thisse B, Canfield V, Levenson R. D4 Dopamine receptor genes of zebrafish and effects of the antipsychotic clozapine on larval swimming behaviour. Genes Brain Behav. 2007;6:155-66 pubmed
..By mining the zebrafish genomic database, we identified three distinct D4R genes, drd4a, drd4b and drd4c, and generated full-length open reading frames encoding each of the three D4Rs by reverse transcription-..
Reimer M, Norris A, Ohnmacht J, Patani R, Zhong Z, Dias T, et al
. Dopamine from the brain promotes spinal motor neuron generation during development and adult regeneration. Dev Cell. 2013;25:478-91 pubmed publisher
..Hence, we describe a supraspinal control mechanism for the development and regeneration of specific spinal cell types that uses dopamine as a signal. ..
Toro C, Trapani J, Pacentine I, Maeda R, SHEETS L, Mo W, et al
. Dopamine Modulates the Activity of Sensory Hair Cells. J Neurosci. 2015;35:16494-503 pubmed publisher
..The mechanism of dopamine activation requires voltage-gated calcium channels that are also present at hair-cell synapses. ..
Ek F, Malo M, Ã…berg Andersson M, Wedding C, Kronborg J, Svensson P, et al
. Behavioral Analysis of Dopaminergic Activation in Zebrafish and Rats Reveals Similar Phenotypes. ACS Chem Neurosci. 2016;7:633-46 pubmed publisher
..Molecular modeling of dopamine D2 and D4 receptors indicated that nonconserved amino acids have limited influence on important ligand-receptor interactions. ..
Sarty K, Cowie A, Martyniuk C. The legacy pesticide dieldrin acts as a teratogen and alters the expression of dopamine transporter and dopamine receptor 2a in zebrafish (Danio rerio) embryos. Comp Biochem Physiol C Toxicol Pharmacol. 2017;194:37-47 pubmed publisher
..This is an important consideration when incorporating transcriptomics into embryo testing as expression levels can change with removal of the chorion prior to exposure. ..
Liang X, Souders C, Zhang J, Martyniuk C. Tributyltin induces premature hatching and reduces locomotor activity in zebrafish (Danio rerio) embryos/larvae at environmentally relevant levels. Chemosphere. 2017;189:498-506 pubmed publisher
..e. timing of hatch and locomotor behavior) are more sensitive to environmentally-relevant concentrations of TBT compared to the molecular and metabolic endpoints examined here. ..