Gene Symbol: drd4a
Description: dopamine receptor D4a
Alias: zgc:158147, D(4) dopamine receptor, dopamine D4a receptor
Toro C, Trapani J, Pacentine I, Maeda R, SHEETS L, Mo W, et al
. Dopamine Modulates the Activity of Sensory Hair Cells. J Neurosci. 2015;35:16494-503 pubmed publisher
..The mechanism of dopamine activation requires voltage-gated calcium channels that are also present at hair-cell synapses. ..
Liang X, Souders C, Zhang J, Martyniuk C. Tributyltin induces premature hatching and reduces locomotor activity in zebrafish (Danio rerio) embryos/larvae at environmentally relevant levels. Chemosphere. 2017;189:498-506 pubmed publisher
..e. timing of hatch and locomotor behavior) are more sensitive to environmentally-relevant concentrations of TBT compared to the molecular and metabolic endpoints examined here. ..
Boehmler W, Carr T, Thisse C, Thisse B, Canfield V, Levenson R. D4 Dopamine receptor genes of zebrafish and effects of the antipsychotic clozapine on larval swimming behaviour. Genes Brain Behav. 2007;6:155-66 pubmed
..By mining the zebrafish genomic database, we identified three distinct D4R genes, drd4a, drd4b and drd4c, and generated full-length open reading frames encoding each of the three D4Rs by reverse ..
Pan Y, Chatterjee D, Gerlai R. Strain dependent gene expression and neurochemical levels in the brain of zebrafish: focus on a few alcohol related targets. Physiol Behav. 2012;107:773-80 pubmed publisher
..They now also allow formulation of working hypotheses about possible mechanisms underlying the differential effects of acute and chronic alcohol treatment on these two zebrafish strains. ..
Reimer M, Norris A, Ohnmacht J, Patani R, Zhong Z, Dias T, et al
. Dopamine from the brain promotes spinal motor neuron generation during development and adult regeneration. Dev Cell. 2013;25:478-91 pubmed publisher
..Hence, we describe a supraspinal control mechanism for the development and regeneration of specific spinal cell types that uses dopamine as a signal. ..
Tallafuss A, Kelly M, Gay L, Gibson D, Batzel P, Karfilis K, et al
. Transcriptomes of post-mitotic neurons identify the usage of alternative pathways during adult and embryonic neuronal differentiation. BMC Genomics. 2015;16:1100 pubmed publisher
..This important insight and the lists of enriched genes we have identified will now help pave the way to a better understanding of the mechanisms of embryonic and adult neuronal differentiation and how to manipulate these processes. ..
Ek F, Malo M, Ã…berg Andersson M, Wedding C, Kronborg J, Svensson P, et al
. Behavioral Analysis of Dopaminergic Activation in Zebrafish and Rats Reveals Similar Phenotypes. ACS Chem Neurosci. 2016;7:633-46 pubmed publisher
..Molecular modeling of dopamine D2 and D4 receptors indicated that nonconserved amino acids have limited influence on important ligand-receptor interactions. ..
Sarty K, Cowie A, Martyniuk C. The legacy pesticide dieldrin acts as a teratogen and alters the expression of dopamine transporter and dopamine receptor 2a in zebrafish (Danio rerio) embryos. Comp Biochem Physiol C Toxicol Pharmacol. 2017;194:37-47 pubmed publisher
..This is an important consideration when incorporating transcriptomics into embryo testing as expression levels can change with removal of the chorion prior to exposure. ..
Naderi M, Salahinejad A, Jamwal A, Chivers D, Niyogi S. Chronic Dietary Selenomethionine Exposure Induces Oxidative Stress, Dopaminergic Dysfunction, and Cognitive Impairment in Adult Zebrafish (Danio rerio). Environ Sci Technol. 2017;51:12879-12888 pubmed publisher
..Collectively, our results illustrate that cognitive impairment in zebrafish could be associated with Se-induced oxidative stress and altered dopaminergic neurotransmission in the brain. ..