dnaaf4

Summary

Gene Symbol: dnaaf4
Description: dynein axonemal assembly factor 4
Alias: EKN1, dyx1c1, zgc:77853, dyslexia susceptibility 1 candidate gene 1 protein, dyslexia susceptibility 1 candidate 1
Species: zebrafish
Products:     dnaaf4

Top Publications

  1. Chen Y, Zhao M, Wang S, Chen J, Wang Y, Cao Q, et al. A novel role for DYX1C1, a chaperone protein for both Hsp70 and Hsp90, in breast cancer. J Cancer Res Clin Oncol. 2009;135:1265-76 pubmed publisher
    ..repeat (TPR) motifs at its C-terminus essential for neuronal migration, and a p23 domain at its N-terminus, DYX1C1 was the first gene proposed to have a role in developmental dyslexia...
  2. Tarkar A, Loges N, Slagle C, Francis R, Dougherty G, Tamayo J, et al. DYX1C1 is required for axonemal dynein assembly and ciliary motility. Nat Genet. 2013;45:995-1003 pubmed publisher
    ..Thus, we propose that DYX1C1 is a newly identified dynein axonemal assembly factor (DNAAF4).
  3. Chandrasekar G, Vesterlund L, Hultenby K, Tapia P ez I, Kere J. The zebrafish orthologue of the dyslexia candidate gene DYX1C1 is essential for cilia growth and function. PLoS ONE. 2013;8:e63123 pubmed publisher
    b>DYX1C1, a susceptibility gene for dyslexia, encodes a tetratricopeptide repeat domain containing protein that has been implicated in neuronal migration in rodent models. The developmental role of this gene remains unexplored...
  4. Grimes D, Boswell C, Morante N, Henkelman R, Burdine R, Ciruna B. Zebrafish models of idiopathic scoliosis link cerebrospinal fluid flow defects to spine curvature. Science. 2016;352:1341-4 pubmed publisher