dlx6a

Summary

Gene Symbol: dlx6a
Description: distal-less homeobox 6a
Alias: dlx6, homeobox protein Dlx6a, DLX-6, distal-less homeobox gene 6a, distal-less homeobox protein 6a
Species: zebrafish
Products:     dlx6a

Top Publications

  1. Alexander C, Zuniga E, Blitz I, Wada N, Le Pabic P, Javidan Y, et al. Combinatorial roles for BMPs and Endothelin 1 in patterning the dorsal-ventral axis of the craniofacial skeleton. Development. 2011;138:5135-46 pubmed publisher
    ..at these stages reduces expression of the ventral signal Edn1, as well as ventral-specific genes such as hand2 and dlx6a in the arches, and expands expression of the dorsal signal jag1b...
  2. Zerucha T, Stühmer T, Hatch G, Park B, Long Q, Yu G, et al. A highly conserved enhancer in the Dlx5/Dlx6 intergenic region is the site of cross-regulatory interactions between Dlx genes in the embryonic forebrain. J Neurosci. 2000;20:709-21 pubmed
    Four Dlx homeobox genes, Dlx1, Dlx2, Dlx5, and Dlx6 are expressed in the same primordia of the mouse forebrain with temporally overlapping patterns...
  3. Zuniga E, Rippen M, Alexander C, Schilling T, Crump J. Gremlin 2 regulates distinct roles of BMP and Endothelin 1 signaling in dorsoventral patterning of the facial skeleton. Development. 2011;138:5147-56 pubmed publisher
    ..2 and three Dlx genes (dlx3b, dlx5a and dlx6a) in intermediate precursors...
  4. Borday Birraux V, Van der Heyden C, Debiais Thibaud M, Verreijdt L, Stock D, Huysseune A, et al. Expression of Dlx genes during the development of the zebrafish pharyngeal dentition: evolutionary implications. Evol Dev. 2006;8:130-41 pubmed
    ..We found that (i) dlx1a and dlx6a are not expressed in teeth, in contrast to their murine orthologs, Dlx1 and Dlx6; (ii) the expression of the six ..
  5. MacDonald R, Debiais Thibaud M, Talbot J, Ekker M. The relationship between dlx and gad1 expression indicates highly conserved genetic pathways in the zebrafish forebrain. Dev Dyn. 2010;239:2298-306 pubmed publisher
    ..Our results indicate the dlx genes are regulated by an evolutionarily conserved genetic pathway and may play a role in GABAergic interneuron differentiation in the zebrafish forebrain...
  6. MacDonald R, Pollack J, Debiais Thibaud M, Heude E, Talbot J, Ekker M. The ascl1a and dlx genes have a regulatory role in the development of GABAergic interneurons in the zebrafish diencephalon. Dev Biol. 2013;381:276-85 pubmed publisher
    ..Loss of Dlx1a and Dlx2a function, and, to a lesser extent, of Dlx5a and Dlx6a, impairs gad1b expression in the prethalamus and hypothalamus...
  7. Debiais Thibaud M, Germon I, Laurenti P, Casane D, Borday Birraux V. Low divergence in Dlx gene expression between dentitions of the medaka (Oryzias latipes) versus high level of expression shuffling in osteichtyans. Evol Dev. 2008;10:464-76 pubmed publisher
    ..Our results demonstrate a low constraint on dlx gene expression shuffling in the odontogenic cascade within osteichtyans but the non-individualization of oral and pharyngeal dentitions in the medaka...
  8. Talbot J, Johnson S, Kimmel C. hand2 and Dlx genes specify dorsal, intermediate and ventral domains within zebrafish pharyngeal arches. Development. 2010;137:2507-17 pubmed publisher
    ..Collectively, our work indicates that the expression and function of hand2 and Dlx genes specify major patterning domains along the dorsoventral axis of zebrafish pharyngeal arches...
  9. Yu M, Xi Y, Pollack J, Debiais Thibaud M, MacDonald R, Ekker M. Activity of dlx5a/dlx6a regulatory elements during zebrafish GABAergic neuron development. Int J Dev Neurosci. 2011;29:681-91 pubmed publisher
    ..4kb dlx5a/dlx6a intergenic sequence (encompassing I56i and I56ii) and one with a ?1...

More Information

Publications32

  1. Zuniga E, Stellabotte F, Crump J. Jagged-Notch signaling ensures dorsal skeletal identity in the vertebrate face. Development. 2010;137:1843-52 pubmed publisher
    ..Together, these results indicate a novel function of Jagged-Notch signaling in ensuring dorsal identity within broad fields of facial skeletal precursors. ..
  2. Birnbaum R, Everman D, Murphy K, Gurrieri F, Schwartz C, Ahituv N. Functional characterization of tissue-specific enhancers in the DLX5/6 locus. Hum Mol Genet. 2012;21:4930-8 pubmed publisher
    ..In addition, they highlight specific enhancers in which mutations could lead to non-syndromic hearing loss, craniofacial defects or limb malformations. ..
  3. Verreijdt L, Debiais Thibaud M, Borday Birraux V, Van der Heyden C, Sire J, Huysseune A. Expression of the dlx gene family during formation of the cranial bones in the zebrafish (Danio rerio): differential involvement in the visceral skeleton and braincase. Dev Dyn. 2006;235:1371-89 pubmed
    ..Whether dlx genes originally functioned in the visceral skeleton only, and whether their involvement in the formation of neurocranial bones (as in mammals) is secondary, awaits clarification. ..
  4. Solek C, Feng S, Perin S, Weinschutz Mendes H, Ekker M. Lineage tracing of dlx1a/2a and dlx5a/6a expressing cells in the developing zebrafish brain. Dev Biol. 2017;427:131-147 pubmed publisher
  5. Mione M, Baldessari D, Deflorian G, Nappo G, Santoriello C. How neuronal migration contributes to the morphogenesis of the CNS: insights from the zebrafish. Dev Neurosci. 2008;30:65-81 pubmed
    ..These examples reinforce the concept that migratory events contribute to the distribution of cell types with diverse identities through the CNS and that zebrafish transgenic lines represent excellent tools to study these events. ..
  6. Debiais Thibaud M, Metcalfe C, Pollack J, Germon I, Ekker M, Depew M, et al. Heterogeneous conservation of Dlx paralog co-expression in jawed vertebrates. PLoS ONE. 2013;8:e68182 pubmed publisher
    ..Regulatory constraints such as shared enhancers, and functional constraints including gene pleiotropy, may have contributed to the evolutionary inertia leading to high redundancy between gene expression patterns. ..
  7. Miller C, Swartz M, Khuu P, Walker M, Eberhart J, Kimmel C. mef2ca is required in cranial neural crest to effect Endothelin1 signaling in zebrafish. Dev Biol. 2007;308:144-57 pubmed
    ..mef2ca plays a critical role in establishing the proper nested expression patterns of dlx genes. dlx5a and dlx6a, known Edn1 targets, are downregulated in mef2ca mutant pharyngeal arch CNC...
  8. Wang X, Lee J, Dorsky R. Identification of Wnt-responsive cells in the zebrafish hypothalamus. Zebrafish. 2009;6:49-58 pubmed publisher
    ..These data suggest that canonical Wnt signaling may be functionally required for maintenance of neural progenitor and precursor pools in the embryo, and for ongoing neurogenesis in the adult zebrafish. ..
  9. Alvarado E, Yousefelahiyeh M, Alvarado G, Shang R, Whitman T, MARTINEZ A, et al. Wdr68 Mediates Dorsal and Ventral Patterning Events for Craniofacial Development. PLoS ONE. 2016;11:e0166984 pubmed publisher
    ..While ISL treatment failed, SB431542 partially rescued dlx2a expression in wdr68 mutants. Together these findings reveal an indirect role for Wdr68 in the BMP-Edn1-Jag1b signaling hierarchy and dorso-anterior expression of dlx1a/2a. ..
  10. Levkowitz G, Zeller J, Sirotkin H, French D, Schilbach S, Hashimoto H, et al. Zinc finger protein too few controls the development of monoaminergic neurons. Nat Neurosci. 2003;6:28-33 pubmed
    ..Our results indicate that tof/fezl is a key component in regulating the development of monoaminergic neurons in the vertebrate brain. ..
  11. Wang X, Kopinke D, Lin J, McPherson A, Duncan R, Otsuna H, et al. Wnt signaling regulates postembryonic hypothalamic progenitor differentiation. Dev Cell. 2012;23:624-36 pubmed publisher
    ..This study establishes the vertebrate hypothalamus as a model for Wnt-regulated postembryonic neural progenitor differentiation and defines specific roles for Wnt signaling in neurogenesis. ..
  12. Walker M, Miller C, Coffin Talbot J, Stock D, Kimmel C. Zebrafish furin mutants reveal intricacies in regulating Endothelin1 signaling in craniofacial patterning. Dev Biol. 2006;295:194-205 pubmed
  13. Gallardo V, Liang J, Behra M, Elkahloun A, Villablanca E, Russo V, et al. Molecular dissection of the migrating posterior lateral line primordium during early development in zebrafish. BMC Dev Biol. 2010;10:120 pubmed publisher
  14. Choudhry P, Joshi D, Funke B, Trede N. Alcama mediates Edn1 signaling during zebrafish cartilage morphogenesis. Dev Biol. 2011;349:483-93 pubmed publisher
    ..1 during chondrogenesis. Collectively our results support a model by which Alcama on the endoderm interacts with Nadl1.1 on NC to mediate Edn1 signaling and NC differentiation during chondrogenesis. ..
  15. Amores A, Force A, Yan Y, Joly L, Amemiya C, Fritz A, et al. Zebrafish hox clusters and vertebrate genome evolution. Science. 1998;282:1711-4 pubmed
    ..Thus, teleosts, the most species-rich group of vertebrates, appear to have more copies of these developmental regulatory genes than do mammals, despite less complexity in the anterior-posterior axis. ..
  16. Zhu P, Narita Y, Bundschuh S, Fajardo O, Schärer Y, Chattopadhyaya B, et al. Optogenetic Dissection of Neuronal Circuits in Zebrafish using Viral Gene Transfer and the Tet System. Front Neural Circuits. 2009;3:21 pubmed publisher
    ..These approaches provide new opportunities for the optogenetic dissection of neuronal circuit structure and function. ..
  17. Walker M, Miller C, Swartz M, Eberhart J, Kimmel C. phospholipase C, beta 3 is required for Endothelin1 regulation of pharyngeal arch patterning in zebrafish. Dev Biol. 2007;304:194-207 pubmed
  18. Heude E, Shaikho S, Ekker M. The dlx5a/dlx6a genes play essential roles in the early development of zebrafish median fin and pectoral structures. PLoS ONE. 2014;9:e98505 pubmed publisher
    The Dlx5 and Dlx6 genes encode homeodomain transcription factors essential for the proper development of limbs in mammalian species. However, the role of their teleost counterparts in fin development has received little attention...
  19. Iklé J, Tavares A, King M, Ding H, Colombo S, Firulli B, et al. Nkx2.5 regulates endothelin converting enzyme-1 during pharyngeal arch patterning. Genesis. 2017;55: pubmed publisher
    ..5 functions through modulating Ece1 expression or function. These studies illustrate a new function for Nkx2.5 in embryonic development and provide new avenues with which to pursue potential mechanisms underlying human facial disorders. ..
  20. Alexander C, Piloto S, Le Pabic P, Schilling T. Wnt signaling interacts with bmp and edn1 to regulate dorsal-ventral patterning and growth of the craniofacial skeleton. PLoS Genet. 2014;10:e1004479 pubmed publisher
  21. Sundstrom G, Larsson T, Brenner S, Venkatesh B, Larhammar D. Evolution of the neuropeptide Y family: new genes by chromosome duplications in early vertebrates and in teleost fishes. Gen Comp Endocrinol. 2008;155:705-16 pubmed
    ..Our study shows that when sequence comparisons give ambiguous results, chromosomal location can serve as a useful criterion to identify orthologs. This strategy may help to resolve relationships in several families of short peptides. ..
  22. Fisher S, Jagadeeswaran P, Halpern M. Radiographic analysis of zebrafish skeletal defects. Dev Biol. 2003;264:64-76 pubmed
    ..Radiography is a practical screening tool to detect subtle skeletal abnormalities in the adult zebrafish. The identification of chihuahua demonstrates that mutant phenotypes analogous to human skeletal dysplasias will be discovered. ..
  23. Nissen R, Amsterdam A, Hopkins N. A zebrafish screen for craniofacial mutants identifies wdr68 as a highly conserved gene required for endothelin-1 expression. BMC Dev Biol. 2006;6:28 pubmed
    ..The initial characterization of wdr68 suggests an important role in craniofacial development for the highly conserved Wdr68-Dyrk1 protein complexes. ..