dlx4b

Summary

Gene Symbol: dlx4b
Description: distal-less homeobox 4b
Alias: dlx7, fj03c01, wu:fj03c01, zgc:109858, homeobox protein Dlx4b, DLX-7, distal-less homeobox gene 4b, distal-less homeobox gene 7, distal-less homeobox protein 4b
Species: zebrafish

Top Publications

  1. Kaji T, Artinger K. dlx3b and dlx4b function in the development of Rohon-Beard sensory neurons and trigeminal placode in the zebrafish neurula. Dev Biol. 2004;276:523-40 pubmed
    ..In the present study, we extend these findings to zebrafish, where we unequivocally demonstrate that dlx3b and dlx4b function in a dose-dependent manner to specify cell fates such as Rohon-Beard sensory neurons and trigeminal ..
  2. Esterberg R, Fritz A. dlx3b/4b are required for the formation of the preplacodal region and otic placode through local modulation of BMP activity. Dev Biol. 2009;325:189-99 pubmed publisher
    ..Our results provide insight into the mechanisms of PPR specification as well as the role of dlx3b/4b function in PPR and otic placode induction. ..
  3. Borday Birraux V, Van der Heyden C, Debiais Thibaud M, Verreijdt L, Stock D, Huysseune A, et al. Expression of Dlx genes during the development of the zebrafish pharyngeal dentition: evolutionary implications. Evol Dev. 2006;8:130-41 pubmed
  4. Verreijdt L, Debiais Thibaud M, Borday Birraux V, Van der Heyden C, Sire J, Huysseune A. Expression of the dlx gene family during formation of the cranial bones in the zebrafish (Danio rerio): differential involvement in the visceral skeleton and braincase. Dev Dyn. 2006;235:1371-89 pubmed
    ..Whether dlx genes originally functioned in the visceral skeleton only, and whether their involvement in the formation of neurocranial bones (as in mammals) is secondary, awaits clarification. ..
  5. Talbot J, Johnson S, Kimmel C. hand2 and Dlx genes specify dorsal, intermediate and ventral domains within zebrafish pharyngeal arches. Development. 2010;137:2507-17 pubmed publisher
    ..in both dorsal and intermediate defects, whereas knockdown of three intermediate-domain restricted genes dlx3b, dlx4b and dlx5a results in intermediate-domain-specific defects...
  6. Debiais Thibaud M, Germon I, Laurenti P, Casane D, Borday Birraux V. Low divergence in Dlx gene expression between dentitions of the medaka (Oryzias latipes) versus high level of expression shuffling in osteichtyans. Evol Dev. 2008;10:464-76 pubmed publisher
    ..Our results demonstrate a low constraint on dlx gene expression shuffling in the odontogenic cascade within osteichtyans but the non-individualization of oral and pharyngeal dentitions in the medaka...
  7. Solomon K, Fritz A. Concerted action of two dlx paralogs in sensory placode formation. Development. 2002;129:3127-36 pubmed
    ..The b380 deletion removes several known genes and expressed sequence tags, including dlx3 and dlx7, two transcription factors that share a homoeobox domain similar in sequence to the Drosophila Distal-less gene...
  8. Hans S, Irmscher A, Brand M. Zebrafish Foxi1 provides a neuronal ground state during inner ear induction preceding the Dlx3b/4b-regulated sensory lineage. Development. 2013;140:1936-45 pubmed publisher
    ..Thus, in addition to otic fate Foxi1 provides neuronal competence during OEPD induction prior to and independently of the Dlx3b/4b-mediated sensory fate of the developing inner ear. ..
  9. Wang H, Zhou Q, Kesinger J, Norris C, Valdez C. Heme regulates exocrine peptidase precursor genes in zebrafish. Exp Biol Med (Maywood). 2007;232:1170-80 pubmed
    ..Our findings provide a better understanding of heme deficiency pathogenesis and enhance our ability to diagnose and treat patients with porphyria or pancreatic diseases. ..

More Information

Publications24

  1. Amores A, Force A, Yan Y, Joly L, Amemiya C, Fritz A, et al. Zebrafish hox clusters and vertebrate genome evolution. Science. 1998;282:1711-4 pubmed
    ..Thus, teleosts, the most species-rich group of vertebrates, appear to have more copies of these developmental regulatory genes than do mammals, despite less complexity in the anterior-posterior axis. ..
  2. Schwarzer S, Spieß S, Brand M, Hans S. Dlx3b/4b is required for early-born but not later-forming sensory hair cells during zebrafish inner ear development. Biol Open. 2017;6:1270-1278 pubmed publisher
    Morpholino-mediated knockdown has shown that the homeodomain transcription factors Dlx3b and Dlx4b are essential for proper induction of the otic-epibranchial progenitor domain (OEPD), as well as subsequent formation of sensory hair ..
  3. Dutta S, Dietrich J, Aspöck G, Burdine R, Schier A, Westerfield M, et al. pitx3 defines an equivalence domain for lens and anterior pituitary placode. Development. 2005;132:1579-90 pubmed
    ..We show that pitx3 is required for pituitary pre-placode formation and cell specification, whereas dlx3b and dlx4b are required to restrict pituitary placode size...
  4. Liu D, Chu H, Maves L, Yan Y, Morcos P, Postlethwait J, et al. Fgf3 and Fgf8 dependent and independent transcription factors are required for otic placode specification. Development. 2003;130:2213-24 pubmed
    ..Removal of dlx3b, dlx4b and sox9a genes together also blocks ear development, although a few residual cells form an otic epithelium...
  5. Solomon K, Kwak S, Fritz A. Genetic interactions underlying otic placode induction and formation. Dev Dyn. 2004;230:419-33 pubmed
    ..In zebrafish, fgf3 and fgf8, dlx3b and dlx4b, and foxi1 have been identified as the earliest-acting genes in this process...
  6. Rouleau M, Saxena V, Rodrigue A, Paquet E, Gagnon A, Hendzel M, et al. A key role for poly(ADP-ribose) polymerase 3 in ectodermal specification and neural crest development. PLoS ONE. 2011;6:e15834 pubmed publisher
    ..of parp3 expression in zebrafish impairs the expression of the neural crest cell specifier sox9a and of dlx3b/dlx4b, the formation of cranial sensory placodes, inner ears and pectoral fins...
  7. Solomon K, Kudoh T, Dawid I, Fritz A. Zebrafish foxi1 mediates otic placode formation and jaw development. Development. 2003;130:929-40 pubmed
    ..In addition, foxi1 is expressed in the developing branchial arches, and jaw formation is disrupted in hearsay mutant embryos. ..
  8. Nissen R, Amsterdam A, Hopkins N. A zebrafish screen for craniofacial mutants identifies wdr68 as a highly conserved gene required for endothelin-1 expression. BMC Dev Biol. 2006;6:28 pubmed
    ..The initial characterization of wdr68 suggests an important role in craniofacial development for the highly conserved Wdr68-Dyrk1 protein complexes. ..
  9. Nicolson T. The genetics of hearing and balance in zebrafish. Annu Rev Genet. 2005;39:9-22 pubmed
    ..This review addresses the most recent advances in our understanding of how the ear forms and discusses the molecules in hair cells that are essential for sensing sound and movement in the zebrafish. ..
  10. Miyasaka N, Wanner A, Li J, Mack Bucher J, Genoud C, Yoshihara Y, et al. Functional development of the olfactory system in zebrafish. Mech Dev. 2013;130:336-46 pubmed publisher
  11. Debiais Thibaud M, Metcalfe C, Pollack J, Germon I, Ekker M, Depew M, et al. Heterogeneous conservation of Dlx paralog co-expression in jawed vertebrates. PLoS ONE. 2013;8:e68182 pubmed publisher
    ..Regulatory constraints such as shared enhancers, and functional constraints including gene pleiotropy, may have contributed to the evolutionary inertia leading to high redundancy between gene expression patterns. ..
  12. Wu D, Mandal S, Choi A, Anderson A, Prochazkova M, Perry H, et al. DLX4 is associated with orofacial clefting and abnormal jaw development. Hum Mol Genet. 2015;24:4340-52 pubmed publisher
    ..We used antisense morpholino oligonucleotides to target the orthologous Danio rerio gene, dlx4b, and found reduced cranial size and abnormal cartilaginous elements...
  13. Phillips B, Kwon H, Melton C, Houghtaling P, Fritz A, Riley B. Zebrafish msxB, msxC and msxE function together to refine the neural-nonneural border and regulate cranial placodes and neural crest development. Dev Biol. 2006;294:376-90 pubmed
    ..These effects appear to involve Distal-less (Dlx) protein activity, as loss of dlx3b and dlx4b suppresses ventralization in Msx-depleted embryos...
  14. Rossi C, Kaji T, Artinger K. Transcriptional control of Rohon-Beard sensory neuron development at the neural plate border. Dev Dyn. 2009;238:931-43 pubmed publisher
    ..Expression analysis in prdm1a and neurogenin1 mutant and dlx3b/dlx4b morpholino-injected embryos suggests that prdm1a is upstream of dlx3b, dlx4b, and neurogenin1 at the NPB...
  15. Miller C, Swartz M, Khuu P, Walker M, Eberhart J, Kimmel C. mef2ca is required in cranial neural crest to effect Endothelin1 signaling in zebrafish. Dev Biol. 2007;308:144-57 pubmed
    ..dlx5a and dlx6a, known Edn1 targets, are downregulated in mef2ca mutant pharyngeal arch CNC. Surprisingly, dlx4b and dlx3b are oppositely affected in mef2ca mutants...