dlx3b

Summary

Gene Symbol: dlx3b
Description: distal-less homeobox gene 3b
Alias: dlx-3, dlx3, id:ibd3531, wu:fb83f11, zgc:91827, distal-less homeobox protein 3b, homeobox protein Dlx3b
Species: zebrafish

Top Publications

  1. ncbi Zebrafish hox clusters and vertebrate genome evolution
    A Amores
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Science 282:1711-4. 1998
  2. ncbi Genetic interactions underlying otic placode induction and formation
    Keely S Solomon
    Department of Biology, Emory University, Atlanta, Georgia, USA
    Dev Dyn 230:419-33. 2004
  3. ncbi Developmentally restricted actin-regulatory molecules control morphogenetic cell movements in the zebrafish gastrula
    David F Daggett
    Comparative and Developmental Genetics Section, Medical Research Council, Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
    Curr Biol 14:1632-8. 2004
  4. pmc Inhibition of Wnt/Axin/beta-catenin pathway activity promotes ventral CNS midline tissue to adopt hypothalamic rather than floorplate identity
    Marika Kapsimali
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 131:5923-33. 2004
  5. doi Distinct functions for ERK1 and ERK2 in cell migration processes during zebrafish gastrulation
    S F Gabby Krens
    Institute of Biology, Leiden University, Wassenaarseweg 64, 2333 AL Leiden, The Netherlands
    Dev Biol 319:370-83. 2008
  6. pmc Combinatorial roles for BMPs and Endothelin 1 in patterning the dorsal-ventral axis of the craniofacial skeleton
    Courtney Alexander
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA
    Development 138:5135-46. 2011
  7. pmc Gremlin 2 regulates distinct roles of BMP and Endothelin 1 signaling in dorsoventral patterning of the facial skeleton
    Elizabeth Zuniga
    Broad CIRM Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Development 138:5147-56. 2011
  8. ncbi sucker encodes a zebrafish Endothelin-1 required for ventral pharyngeal arch development
    C T Miller
    Institute of Neuroscience, Eugene, OR 97403 1254, USA
    Development 127:3815-28. 2000
  9. doi Negative regulation of wnt11 expression by Jnk signaling during zebrafish gastrulation
    Jungwon Seo
    Department of Developmental and Regenerative Biology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
    J Cell Biochem 110:1022-37. 2010
  10. pmc Noncanonical Wnt signaling regulates midline convergence of organ primordia during zebrafish development
    Takaaki Matsui
    Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Genes Dev 19:164-75. 2005

Scientific Experts

Detail Information

Publications104 found, 100 shown here

  1. ncbi Zebrafish hox clusters and vertebrate genome evolution
    A Amores
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Science 282:1711-4. 1998
    ..Thus, teleosts, the most species-rich group of vertebrates, appear to have more copies of these developmental regulatory genes than do mammals, despite less complexity in the anterior-posterior axis...
  2. ncbi Genetic interactions underlying otic placode induction and formation
    Keely S Solomon
    Department of Biology, Emory University, Atlanta, Georgia, USA
    Dev Dyn 230:419-33. 2004
    ..In zebrafish, fgf3 and fgf8, dlx3b and dlx4b, and foxi1 have been identified as the earliest-acting genes in this process...
  3. ncbi Developmentally restricted actin-regulatory molecules control morphogenetic cell movements in the zebrafish gastrula
    David F Daggett
    Comparative and Developmental Genetics Section, Medical Research Council, Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, United Kingdom
    Curr Biol 14:1632-8. 2004
    ..Our results provide direct evidence for the deployment of developmentally restricted actin-regulatory molecules in the control of morphogenetic cell movements during vertebrate development...
  4. pmc Inhibition of Wnt/Axin/beta-catenin pathway activity promotes ventral CNS midline tissue to adopt hypothalamic rather than floorplate identity
    Marika Kapsimali
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 131:5923-33. 2004
    ....
  5. doi Distinct functions for ERK1 and ERK2 in cell migration processes during zebrafish gastrulation
    S F Gabby Krens
    Institute of Biology, Leiden University, Wassenaarseweg 64, 2333 AL Leiden, The Netherlands
    Dev Biol 319:370-83. 2008
    ..Together, our data define distinct roles for ERK1 and ERK2 in developmental cell migration processes during zebrafish embryogenesis...
  6. pmc Combinatorial roles for BMPs and Endothelin 1 in patterning the dorsal-ventral axis of the craniofacial skeleton
    Courtney Alexander
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA
    Development 138:5135-46. 2011
    ....
  7. pmc Gremlin 2 regulates distinct roles of BMP and Endothelin 1 signaling in dorsoventral patterning of the facial skeleton
    Elizabeth Zuniga
    Broad CIRM Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Development 138:5147-56. 2011
    ..2 and three Dlx genes (dlx3b, dlx5a and dlx6a) in intermediate precursors...
  8. ncbi sucker encodes a zebrafish Endothelin-1 required for ventral pharyngeal arch development
    C T Miller
    Institute of Neuroscience, Eugene, OR 97403 1254, USA
    Development 127:3815-28. 2000
    ..suc/et-1 mutant embryos have severe defects in ventral arch neural crest expression of dHAND, dlx2, msxE, gsc, dlx3 and EphA3 in the anterior arches. Dorsal expression patterns are unaffected...
  9. doi Negative regulation of wnt11 expression by Jnk signaling during zebrafish gastrulation
    Jungwon Seo
    Department of Developmental and Regenerative Biology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
    J Cell Biochem 110:1022-37. 2010
    ..Furthermore, non-canonical Wnt signaling may coordinate vertebrate CE movements by triggering Jnk activation that represses the expression of the CE-triggering ligand wnt11...
  10. pmc Noncanonical Wnt signaling regulates midline convergence of organ primordia during zebrafish development
    Takaaki Matsui
    Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Genes Dev 19:164-75. 2005
    ..Overall, our results uncover a late, previously unexpected role of noncanonical Wnt signaling in the control of midline assembly of organ precursors during vertebrate embryo development...
  11. ncbi Understanding endothelin-1 function during craniofacial development in the mouse and zebrafish
    David E Clouthier
    Department of Molecular, Cellular and Craniofacial Biology, University of Louisville, Kentucky 40292, USA
    Birth Defects Res C Embryo Today 72:190-9. 2004
    ....
  12. pmc The BMP signaling gradient patterns dorsoventral tissues in a temporally progressive manner along the anteroposterior axis
    Jennifer A Tucker
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
    Dev Cell 14:108-19. 2008
    ..We propose that a temporal cue regulates a cell's competence to respond to BMP signaling, allowing the acquisition of a cell's DV and AP identity simultaneously...
  13. pmc The tumor suppressor PRDM5 regulates Wnt signaling at early stages of zebrafish development
    Natalia Meani
    Department on Experimental Oncology, European Institute of Oncology, Milan, Italy
    PLoS ONE 4:e4273. 2009
    ..Our data demonstrate that PRDM5 regulates the expression of components of both canonical and non canonical wnt pathways and negatively modulates wnt signaling in vivo...
  14. pmc Analysis of sphingosine-1-phosphate signaling mutants reveals endodermal requirements for the growth but not dorsoventral patterning of jaw skeletal precursors
    Bartosz Balczerski
    Eli and Edythe Broad Institute for Regenerative Medicine and Stem Cell Research, Department of Cell and Neurobiology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Dev Biol 362:230-41. 2012
    ..Hence, we propose that the S1P-dependent anterior foregut endoderm functions primarily through Shh to regulate the growth but not DV patterning of zebrafish jaw precursors...
  15. ncbi Expression of Dlx genes during the development of the zebrafish pharyngeal dentition: evolutionary implications
    V Borday-Birraux
    PGE UPR 9034, CNRS, Gif sur Yvette, France
    Evol Dev 8:130-41. 2006
    ....
  16. ncbi dlx3b and dlx4b function in the development of Rohon-Beard sensory neurons and trigeminal placode in the zebrafish neurula
    Takao Kaji
    Department of Craniofacial Biology, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Dev Biol 276:523-40. 2004
    ..In the present study, we extend these findings to zebrafish, where we unequivocally demonstrate that dlx3b and dlx4b function in a dose-dependent manner to specify cell fates such as Rohon-Beard sensory neurons and ..
  17. doi Low divergence in Dlx gene expression between dentitions of the medaka (Oryzias latipes) versus high level of expression shuffling in osteichtyans
    M Debiais-Thibaud
    Laboratoire Evolution, Génome et Spéciation, UPR9034 CNRS, Gif sur Yvette, and Université Paris Sud, Orsay, France
    Evol Dev 10:464-76. 2008
    ..Our results demonstrate a low constraint on dlx gene expression shuffling in the odontogenic cascade within osteichtyans but the non-individualization of oral and pharyngeal dentitions in the medaka...
  18. pmc Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements
    Jason R Jessen
    Department of Biological Sciences, Vanderbilt University, VU Station B 351634, Nashville, TN 37235, USA
    Nat Cell Biol 4:610-5. 2002
    ..We propose Trilobite/Stbm mediates cellular interactions that confer directionality on distinct movements during vertebrate embryogenesis...
  19. ncbi Ventral and lateral regions of the zebrafish gastrula, including the neural crest progenitors, are established by a bmp2b/swirl pathway of genes
    V H Nguyen
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, USA
    Dev Biol 199:93-110. 1998
    ..Based on the alterations in tissue-specific gene expression, we propose a model whereby swirl/bmp2b acts as a morphogen to specify different cell types along the dorsoventral axis...
  20. doi RPTPalpha and PTPepsilon signaling via Fyn/Yes and RhoA is essential for zebrafish convergence and extension cell movements during gastrulation
    Mark van Eekelen
    Hubrecht Institute KNAW and University Medical Center Utrecht, The Netherlands
    Dev Biol 340:626-39. 2010
    ..Our results demonstrate that RPTPalpha and PTPepsilon are essential for C&E movements in a signaling pathway parallel to non-canonical Wnts and upstream of Fyn, Yes and RhoA...
  21. ncbi Epibranchial and otic placodes are induced by a common Fgf signal, but their subsequent development is independent
    Shun Kuo Sun
    Children s Brain Tumour Research Centre, Institute of Genetics, Queen s Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK
    Dev Biol 303:675-86. 2007
    ..We further show that epibranchial sox3 expression is unaffected in mutants in which no otic placode forms, where dlx3b and dlx4b are knocked down, or deleted along with sox9a...
  22. ncbi The zebrafish eya1 gene and its expression pattern during embryogenesis
    I Sahly
    Unité de Génétique des Déficits Sensoriels, CNRS URA 1968, Institute Pasteur, 25 rue du Dr Roux, F 75724 Paris Cedex 15, France
    Dev Genes Evol 209:399-410. 1999
    ....
  23. pmc Cloning and characterization of two members of the vertebrate Dlx gene family
    A Simeone
    International Institute of Genetics and Biophysics, Consiglio Nazionale delle Ricerche, Naples, Italy
    Proc Natl Acad Sci U S A 91:2250-4. 1994
    ..The expression pattern of these genes, together with their chromosome localization, may provide useful cues for the study of congenital disorders in which there is a combination of craniofacial and limb defects...
  24. pmc Redundant activities of Tfap2a and Tfap2c are required for neural crest induction and development of other non-neural ectoderm derivatives in zebrafish embryos
    Wei Li
    Interdisciplinary Graduate Program in Genetics, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Dev Biol 304:338-54. 2007
    ....
  25. pmc Otoc1: a novel otoconin-90 ortholog required for otolith mineralization in zebrafish
    Jessica A Petko
    Department of Pharmacology, Penn State University College of Medicine, Hershey, PA 17033, USA
    Dev Neurobiol 68:209-22. 2008
    ..Knockdown of otoc1 mRNA translation with antisense morpholinos produced a variety of aberrant otolith phenotypes. Our results suggest that Otoc1 may serve to nucleate calcium carbonate mineralization of aragonitic otoliths...
  26. pmc Mesendodermal signals required for otic induction: Bmp-antagonists cooperate with Fgf and can facilitate formation of ectopic otic tissue
    Hye Joo Kwon
    Biology Department, Texas A and M University, College Station, Texas, USA
    Dev Dyn 238:1582-94. 2009
    ..Developmental Dynamics 238:1582-1594, 2009. (c) 2009 Wiley-Liss, Inc...
  27. ncbi The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation
    Beate Kilian
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerasse 108, 01307 Dresden, Germany
    Mech Dev 120:467-76. 2003
    ..The characterisation of the role of Ppt/Wnt5 provides insight into the functional diversity of Wnt genes in regulating vertebrate gastrulation movements...
  28. ncbi Combinatorial activity of Flamingo proteins directs convergence and extension within the early zebrafish embryo via the planar cell polarity pathway
    Caroline J Formstone
    MRC Centre for Developmental Neurobiology, New Hunts House, Kings College London, London SE1 1UL, UK
    Dev Biol 282:320-35. 2005
    ..However, while we show that control over axial extension is autonomous, we find that Fmi1a is not required within lateral cells undergoing dorsal convergence...
  29. ncbi The genetics of hearing and balance in zebrafish
    Teresa Nicolson
    Oregon Hearing Research Center and Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239, USA
    Annu Rev Genet 39:9-22. 2005
    ..This review addresses the most recent advances in our understanding of how the ear forms and discusses the molecules in hair cells that are essential for sensing sound and movement in the zebrafish...
  30. ncbi Wnt11 functions in gastrulation by controlling cell cohesion through Rab5c and E-cadherin
    Florian Ulrich
    Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany
    Dev Cell 9:555-64. 2005
    ..Together, our results suggest that Wnt11 controls tissue morphogenesis by modulating E-cadherin-mediated cell cohesion through Rab5c, a novel mechanism of Wnt signaling in gastrulation...
  31. ncbi Zebrafish msxB, msxC and msxE function together to refine the neural-nonneural border and regulate cranial placodes and neural crest development
    Bryan T Phillips
    Biology Department, Texas A and M University, College Station, TX 77843 3258, USA
    Dev Biol 294:376-90. 2006
    ..These effects appear to involve Distal-less (Dlx) protein activity, as loss of dlx3b and dlx4b suppresses ventralization in Msx-depleted embryos...
  32. pmc A zebrafish screen for craniofacial mutants identifies wdr68 as a highly conserved gene required for endothelin-1 expression
    Robert M Nissen
    Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    BMC Dev Biol 6:28. 2006
    ..However, many essential genes required for craniofacial development remain to be identified...
  33. ncbi N-cadherin is required for the polarized cell behaviors that drive neurulation in the zebrafish
    Elim Hong
    Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD 21250, USA
    Development 133:3895-905. 2006
    ....
  34. pmc Wnt11 controls cell contact persistence by local accumulation of Frizzled 7 at the plasma membrane
    Sabine Witzel
    Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany
    J Cell Biol 175:791-802. 2006
    ..We propose that Wnt11, by interacting with Frizzled 7 and Flamingo, modulates local cell contact persistence to coordinate cell movements during gastrulation...
  35. ncbi Zebrafish foxi1 mediates otic placode formation and jaw development
    Keely S Solomon
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Development 130:929-40. 2003
    ..In addition, foxi1 is expressed in the developing branchial arches, and jaw formation is disrupted in hearsay mutant embryos...
  36. pmc Fgf-dependent otic induction requires competence provided by Foxi1 and Dlx3b
    Stefan Hans
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    BMC Dev Biol 7:5. 2007
    ..We previously suggested that Foxi1 and Dlx3b may provide competence to form the ear because loss of both foxi1 and dlx3b results in ablation of all otic tissue ..
  37. ncbi Changes in retinoic acid signaling alter otic patterning
    Stefan Hans
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Development 134:2449-58. 2007
    ..Thus, excess RA expands otic competence, whereas the loss of RA impairs the expression of fgf3 and wnt8b in the hindbrain, compromising the induction and maintenance of otic fate...
  38. pmc Kinase-activating and kinase-impaired cardio-facio-cutaneous syndrome alleles have activity during zebrafish development and are sensitive to small molecule inhibitors
    Corina Anastasaki
    MRC Human Genetics Unit and The University of Edinburgh Institute for Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Hum Mol Genet 18:2543-54. 2009
    ..Importantly, we find a developmental window in which treatment with a MEK inhibitor can restore the normal early development of the embryo, without the additional, unwanted developmental effects of the drug...
  39. ncbi RhoA acts downstream of Wnt5 and Wnt11 to regulate convergence and extension movements by involving effectors Rho kinase and Diaphanous: use of zebrafish as an in vivo model for GTPase signaling
    Shizhen Zhu
    Cell Signaling and Developmental Biology Laboratory, National University of Singapore, 14 Science Drive 4, Singapore 117543, The Republic of Singapore
    Cell Signal 18:359-72. 2006
    ..These findings also support the versatility of the zebrafish as a model to further investigate the roles of various classes of small GTPases in regulating cell dynamics in vivo...
  40. ncbi Pax8 and Pax2a function synergistically in otic specification, downstream of the Foxi1 and Dlx3b transcription factors
    Stefan Hans
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Development 131:5091-102. 2004
    ..provide evidence that pax8 expression and pax2a expression are regulated by two independent factors, Foxi1 and Dlx3b, respectively. Combined loss of both factors eliminates all indications of otic specification...
  41. ncbi Phosphoinositide 3-kinase is required for process outgrowth and cell polarization of gastrulating mesendodermal cells
    Juan Antonio Montero
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307, Dresden, Germany
    Curr Biol 13:1279-89. 2003
    ..However, cell polarization and directed cell migration are reduced but not completely abolished in the absence of Wnt/PCP signals; this observation indicates that other signaling pathways must be involved...
  42. ncbi Fgf3 and Fgf8 dependent and independent transcription factors are required for otic placode specification
    Dong Liu
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA Gene Tools, LLC, 1 Summerton Way, Philomath, OR 97370, USA
    Development 130:2213-24. 2003
    ..Removal of dlx3b, dlx4b and sox9a genes together also blocks ear development, although a few residual cells form an otic epithelium...
  43. ncbi Prickle 1 regulates cell movements during gastrulation and neuronal migration in zebrafish
    Filipa Carreira-Barbosa
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 130:4037-46. 2003
    ..In addition, Pk1 interacts with Tri to mediate posterior migration of branchiomotor neurons, probably independent of the noncanonical Wnt pathway...
  44. ncbi Fgf3 signaling from the ventral diencephalon is required for early specification and subsequent survival of the zebrafish adenohypophysis
    Wiebke Herzog
    Max Planck Institute for Immunobiology, Stuebeweg 51, 79108 Freiburg, Germany
    Development 131:3681-92. 2004
    ..This early specification seems to be essential for the subsequent survival of pituitary cells, but not for pituitary morphogenesis or pituitary cell proliferation...
  45. ncbi Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio
    M Hammerschmidt
    Max Planck Institut fur Entwicklungsbiologie, Abteilung fur Genetik, Tubingen, Germany
    Development 123:143-51. 1996
    ..Mutants in kugelig (kgg) do not form the yolk tube at the posterior side of the yolk sac...
  46. ncbi Fgf3 and Fgf8 are required together for formation of the otic placode and vesicle
    Habib Maroon
    MRC Centre for Developmental Neurobiology, New Hunt s House, King s College London, Guy s Campus, London SE1 9RT, UK
    Development 129:2099-108. 2002
    ..1 and dlx3) but were not accompanied by effects on cell division or death...
  47. ncbi Combined haploid and insertional mutation screen in the zebrafish
    Elizabeth Wiellette
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA
    Genesis 40:231-40. 2004
    ....
  48. ncbi Concerted action of two dlx paralogs in sensory placode formation
    Keely S Solomon
    Department of Biology, Emory University, Atlanta, Georgia 30322, USA
    Development 129:3127-36. 2002
    ..The b380 deletion removes several known genes and expressed sequence tags, including dlx3 and dlx7, two transcription factors that share a homoeobox domain similar in sequence to the Drosophila Distal-less ..
  49. ncbi pitx3 defines an equivalence domain for lens and anterior pituitary placode
    Sunit Dutta
    Department of Developmental Biology, University Freiburg, Germany
    Development 132:1579-90. 2005
    ..We analyzed pituitary precursor cell lineages and find that pitx3 and distal-less3b (dlx3b) expression domains define lens and pituitary precursor positions...
  50. pmc Fyn/Yes and non-canonical Wnt signalling converge on RhoA in vertebrate gastrulation cell movements
    Chris Jopling
    Hubrecht Laboratory, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    EMBO Rep 6:426-31. 2005
    ..Our results show that Fyn and Yes act together with non-canonical Wnt signalling via RhoA in CE cell movements during gastrulation...
  51. pmc Essential roles of G{alpha}12/13 signaling in distinct cell behaviors driving zebrafish convergence and extension gastrulation movements
    Fang Lin
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Cell Biol 169:777-87. 2005
    ..These findings provide the first evidence that Galpha(12) and Galpha(13) have overlapping and essential roles in distinct cell behaviors that drive vertebrate gastrulation...
  52. ncbi Tip-1 induces filopodia growth and is important for gastrulation movements during zebrafish development
    Jaya Besser
    Department of Moleclar Cellular Biology, University of Leiden, 2333 AL Leiden, The Netherlands
    Dev Growth Differ 49:205-14. 2007
    ..Our observations indicate a role for TIP-1 in gastrulation movements and in filopodia growth induction...
  53. ncbi Expression of the dlx gene family during formation of the cranial bones in the zebrafish (Danio rerio): differential involvement in the visceral skeleton and braincase
    L Verreijdt
    Ghent University, Biology Department, Ghent, Belgium
    Dev Dyn 235:1371-89. 2006
    ..Whether dlx genes originally functioned in the visceral skeleton only, and whether their involvement in the formation of neurocranial bones (as in mammals) is secondary, awaits clarification...
  54. pmc dlx3b/4b are required for the formation of the preplacodal region and otic placode through local modulation of BMP activity
    Robert Esterberg
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Dev Biol 325:189-99. 2009
    ..The zebrafish dlx3b/4b transcription factors are expressed at the neural plate border where they play partially redundant roles in the ..
  55. pmc Dickkopf-1 regulates gastrulation movements by coordinated modulation of Wnt/beta catenin and Wnt/PCP activities, through interaction with the Dally-like homolog Knypek
    Luca Caneparo
    Medical Research Council Centre for Developmental Neurobiology, King s College London, SE1 1UL London, UK
    Genes Dev 21:465-80. 2007
    ..Our data therefore indicate that Dkk1 regulates gastrulation movement through interaction with LRP5/6 and Kny and coordinated modulations of Wnt/beta catenin and Wnt/PCP pathways...
  56. ncbi Role of the hindbrain in patterning the otic vesicle: a study of the zebrafish vhnf1 mutant
    Virginie Lecaudey
    Unite de Biologie du Developpement, CNRS UMR 7622, Universite Pierre et Marie Curie, Paris, France
    Dev Biol 303:134-43. 2007
    ..They suggest that, despite the evolution of inner ear structure and function, some of the mechanisms underlying the regionalisation of the otic vesicle in fish and amniotes have been conserved...
  57. pmc Genetic ablation of neural crest cell diversification
    Brigitte L Arduini
    Center for Molecular Neurobiology, Ohio State University, Columbus, OH 43210, USA
    Development 136:1987-94. 2009
    ..Our results identify a genetic regulatory pathway functionally discrete from the process of neural crest induction that is required for the initiation of neural crest cell diversification during embryonic development...
  58. pmc Transcriptional control of Rohon-Beard sensory neuron development at the neural plate border
    Christy Cortez Rossi
    Department of Craniofacial Biology, University of Colorado, Denver, Colorado 80010, USA
    Dev Dyn 238:931-43. 2009
    ..Here, we show that prior to RB differentiation, prdm1a overlaps extensively with the epidermal marker dlx3b but shows little overlap with the neuroectodermal markers sox3 and sox19a...
  59. pmc Cep70 and Cep131 contribute to ciliogenesis in zebrafish embryos
    Christopher J Wilkinson
    Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, CB2 3DY, UK
    BMC Cell Biol 10:17. 2009
    ..In a number of human diseases, such Bardet-Biedl syndrome, centrosome/cilium proteins are mutated, leading to polycystic kidney disease, situs inversus, and neurological problems, amongst other symptoms...
  60. pmc Flamingo regulates epiboly and convergence/extension movements through cell cohesive and signalling functions during zebrafish gastrulation
    Filipa Carreira-Barbosa
    Department of Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 136:383-92. 2009
    ..Fmi/Celsr therefore has a dual role in mediating two separate morphogenetic movements through its roles in mediating cell cohesion and Wnt/PCP signalling during zebrafish gastrulation...
  61. doi Hgf/c-met expression and functional analysis during zebrafish embryogenesis
    Andrew J Latimer
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Dev Dyn 237:3904-15. 2008
    ..Similar to mouse, knockdown of zebrafish Met reduces liver size. Our results suggest a role for Met during endoderm specification and indicate that mechanisms of liver development are conserved between mammals and bony fish...
  62. doi Lpp is involved in Wnt/PCP signaling and acts together with Scrib to mediate convergence and extension movements during zebrafish gastrulation
    Hilke B V K Vervenne
    Laboratory for Molecular Oncology, Department of Human Genetics, K U Leuven, Leuven, Belgium
    Dev Biol 320:267-77. 2008
    ..Finally, we demonstrate that Lpp interacts with the PCP protein Scrib in zebrafish, and that Lpp and Scrib cooperate for the mediation of C&E...
  63. pmc Selective neuronal requirement for huntingtin in the developing zebrafish
    Tanya L Henshall
    ARC Special Research Centre for the Molecular Genetics of Development and Discipline of Genetics, School of Molecular and Biomedical Sciences, The University of Adelaide, Adelaide, SA, Australia
    Hum Mol Genet 18:4830-42. 2009
    ..These investigations demonstrate a specific 'rate-limiting' role for huntingtin in formation of the telencephalon and the pre-placodal region, and differing levels of requirement for huntingtin function in specific nerve cell types...
  64. pmc A key role for poly(ADP-ribose) polymerase 3 in ectodermal specification and neural crest development
    Michele Rouleau
    Cancer Research Laboratory, CHUQ Research Center, Centre hospitalier de l Universite Laval, Quebec, Canada
    PLoS ONE 6:e15834. 2011
    ..In contrast to PARP1 and PARP2, the functions of PARP3 are undefined. Here, we reveal critical functions for PARP3 during vertebrate development...
  65. ncbi Coordinated cell-shape changes control epithelial movement in zebrafish and Drosophila
    Mathias Köppen
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, 01307 Dresden, Germany
    Development 133:2671-81. 2006
    ..Thus, this study has characterized a conserved mechanism underlying coordinated cell-shape changes during epithelial morphogenesis...
  66. pmc Sox2 and Fgf interact with Atoh1 to promote sensory competence throughout the zebrafish inner ear
    Elly M Sweet
    Biology Department, Texas A and M University, College Station, TX 77843 3258, USA
    Dev Biol 358:113-21. 2011
    ..Thus, expression of fgf3, fgf8 or sox2 strongly enhances competence to respond to Atoh1...
  67. ncbi A mutation in zebrafish affecting a localized cellular function required for normal ear development
    B B Riley
    Department of Biology, Texas A and M University, College Station 77843 3258, USA
    Dev Biol 179:427-35. 1996
    ..Expression patterns of several ear marker genes (msxC, msxD, and dlx3) also appear normal in the mutant...
  68. pmc Noonan syndrome gain-of-function mutations in NRAS cause zebrafish gastrulation defects
    Vincent Runtuwene
    Hubrecht Institute KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Dis Model Mech 4:393-9. 2011
    ..In conclusion, mutations in NRAS from individuals with Noonan syndrome activated N-Ras signaling and induced developmental defects in zebrafish embryos, indicating that activating mutations in NRAS cause Noonan syndrome...
  69. doi Stereotypical cell division orientation controls neural rod midline formation in zebrafish
    Elena Quesada-Hernández
    Institute of Science and Technology Austria, Am Campus 1, A 3400 Klosterneuburg, Austria
    Curr Biol 20:1966-72. 2010
    ..These findings suggest a novel function for Fz7-controlled cell division orientation in neural rod midline formation during neurulation...
  70. pmc The basic helix-loop-helix olig3 establishes the neural plate boundary of the trunk and is necessary for development of the dorsal spinal cord
    Alida Filippi
    Dipartimento di Biologia and Facolta di Psicologia, Universita degli Studi di Padova, Via Ugo Bassi 58 B, I 35121 Padua, Italy
    Proc Natl Acad Sci U S A 102:4377-82. 2005
    ..Thus, a proper regulation of the olig gene family is essential for the formation of three cell types (oligodendrocytes, astrocytes, and neural crest) that are unique to vertebrates...
  71. pmc Kctd15 inhibits neural crest formation by attenuating Wnt/beta-catenin signaling output
    Sunit Dutta
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Development 137:3013-8. 2010
    ..We propose that Kctd15 inhibits NC formation by attenuating the output of the canonical Wnt pathway, thereby restricting expansion of the NC domain beyond its normal range...
  72. pmc MicroRNA-183 family members regulate sensorineural fates in the inner ear
    Haiqiong Li
    Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA
    J Neurosci 30:3254-63. 2010
    ..Our findings suggest both distinct and common roles for the three miRNAs in cell-fate determination in the inner ear, and these principles might apply to development of other sensory organs...
  73. pmc Six3 functions in anterior neural plate specification by promoting cell proliferation and inhibiting Bmp4 expression
    Gaia Gestri
    Sezione di Biologia Cellulare e dello Sviluppo, Dipartimento di Fisiologia, e Biochimica, Universita degli Studi di Pisa, Via Carducci 13, 56010 Ghezzano Pisa, Italy
    Development 132:2401-13. 2005
    ..These results suggest a very early role for Six3 in specification of the anterior neural plate, through the regulation of cell proliferation and the inhibition of BMP signalling...
  74. pmc The zebrafish homologue of mammalian chimerin Rac-GAPs is implicated in epiboly progression during development
    Federico Coluccio Leskow
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, USA
    Proc Natl Acad Sci U S A 103:5373-8. 2006
    ..Our results reveal a crucial role for chn1 in early development and implicate Rac as a key regulator of morphogenetic movements during zebrafish epiboly...
  75. ncbi Zebrafish furin mutants reveal intricacies in regulating Endothelin1 signaling in craniofacial patterning
    Macie B Walker
    Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403, USA
    Dev Biol 295:194-205. 2006
    ....
  76. pmc Stepwise maturation of apicobasal polarity of the neuroepithelium is essential for vertebrate neurulation
    Xiaojun Yang
    Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 29:11426-40. 2009
    ..Furthermore, precocious overexpression of Lin7c induces multiaxial mirror symmetry in zebrafish neurulation. Our data suggest that stepwise maturation of apicobasal polarity plays an essential role in vertebrate neurulation...
  77. doi Extracellular matrix assembly and organization during zebrafish gastrulation
    Andrew Latimer
    Department of Medicine Division of Genetic Medicine and the Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Matrix Biol 29:89-96. 2010
    ..These results provide a framework for uncovering the interrelationship between ECM structure and cellular processes regulating convergence and extension such as directed migration and mediolateral/radial intercalation...
  78. pmc Zebrafish eaf1 and eaf2/u19 mediate effective convergence and extension movements through the maintenance of wnt11 and wnt5 expression
    Jing Xia Liu
    Key Laboratory of Biodiversity and Conservation of Aquatic Organisms, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China
    J Biol Chem 284:16679-92. 2009
    ..However, the ectopic expression of wnt11 and wnt5 did not affect eaf1 and eaf2/u19 expression. These data indicate that eaf1 and eaf2/u19 act upstream of noncanonical Wnt signaling to mediate convergence and extension movements...
  79. pmc Cadherin-11 controls otolith assembly: evidence for extracellular cadherin activity
    Sherry G Clendenon
    Department of Medicine, Indiana University Medical Center, Indianapolis, Indiana 46202 5130, USA
    Dev Dyn 238:1909-22. 2009
    ....
  80. ncbi Isolation, characterization, and expression analysis of zebrafish large Mafs
    M Kajihara
    Institute of Basic Medical Sciences, University of Tsukuba, Tennodai, Tsukuba 305 8575, Japan
    J Biochem 129:139-46. 2001
    ..These data indicate that SMafs may play important roles in somitogenesis, and that Maf proteins may have overlapping and yet specific functions as to the determination and differentiation of cell lineages...
  81. pmc Chemokine signaling controls endodermal migration during zebrafish gastrulation
    Sreelaja Nair
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA
    Science 322:89-92. 2008
    ..This process may have relevance to human gastrointestinal bifurcations and other organ defects...
  82. ncbi Zebrafish chaperone protein GP96 is required for otolith formation during ear development
    Saulius Sumanas
    Discovery Genomics, Inc, 614 McKinley PI NE, Minneapolis, MN 55413, USA
    Dev Biol 261:443-55. 2003
    ..We conclude that the GP96 chaperone protein is involved in the otolith formation during normal ear development. This is the first report of a specific function during organism development being attributed to a chaperone class molecule...
  83. ncbi Amotl2 is essential for cell movements in zebrafish embryo and regulates c-Src translocation
    Huizhe Huang
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    Development 134:979-88. 2007
    ..These data provide the first evidence that amotl2 is essential for cell movements in vertebrate embryos...
  84. ncbi Skeletal and pigment cell defects in the lockjaw mutant reveal multiple roles for zebrafish tfap2a in neural crest development
    Robert D Knight
    Department of Developmental and Cell Biology, University of California, Irvine, California, USA
    Dev Dyn 229:87-98. 2004
    ..Developmental Dynamics 229:87-98, 2004...
  85. ncbi Cadherin-2 participates in the morphogenesis of the zebrafish inner ear
    Sherry Babb-Clendenon
    Department of Medicine, Indiana University Medical Center, 950 West Walnut Street, Indianapolis, IN 46202, USA
    J Cell Sci 119:5169-77. 2006
    ..These findings demonstrate that Cdh2 selectively affects epithelial morphogenetic cell movements, particularly semicircular canal formation, during normal ear mophogenesis...
  86. ncbi Twisted gastrulation promotes BMP signaling in zebrafish dorsal-ventral axial patterning
    Shawn C Little
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, 1211 BRBII III, 421 Curie Boulevard, Philadelphia, PA 19104 6058, USA
    Development 131:5825-35. 2004
    ..Our results support a model in which zebrafish Tsg1 promotes BMP signaling, and thus ventral cell fates, during DV axial patterning...
  87. pmc Tbx16 cooperates with Wnt11 in assembling the zebrafish organizer
    Jonathan B Muyskens
    Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403 1254, USA
    Mech Dev 124:35-42. 2007
    ..Our findings thus reveal that Tbx16, in combination with Wnt11, are critical components not only in morphogenesis but also in initial assembly of the organizer...
  88. ncbi Zebrafish pax5 regulates development of the utricular macula and vestibular function
    Su Jin Kwak
    Biology Department, Texas A and M University, College Station, Texas, USA
    Dev Dyn 235:3026-38. 2006
    ..Thus, pax5 works in conjunction with fgf3 and pax2a to establish and/or maintain the utricular macula and is essential for vestibular function...
  89. ncbi Development of the nervus terminalis: origin and migration
    Kathleen E Whitlock
    Department of Molecular Biology and Genetics, 445 Biotechnology Building, Cornell University, Ithaca, NY 14850, USA
    Microsc Res Tech 65:2-12. 2004
    ..In this review, the data surrounding this finding will be discussed in light of recent findings on neural crest and placode origins...
  90. pmc mef2ca is required in cranial neural crest to effect Endothelin1 signaling in zebrafish
    Craig T Miller
    Institute of Neuroscience, 1254 University of Oregon, Eugene, OR 97403, USA
    Dev Biol 308:144-57. 2007
    ..Surprisingly, dlx4b and dlx3b are oppositely affected in mef2ca mutants...
  91. ncbi Molecular changes associated with teratogen-induced cyclopia
    Evyn J Loucks
    Children s Memorial Research Center Program in Developmental Biology, Chicago, Illinois, USA
    Birth Defects Res A Clin Mol Teratol 79:642-51. 2007
    ..Exposure of zebrafish embryos to a number of teratogens results in cyclopia, but little is known about the underlying molecular changes...
  92. pmc A zebrafish LMO4 ortholog limits the size of the forebrain and eyes through negative regulation of six3b and rx3
    Catherine W McCollum
    Department of Biochemistry and Cell Biology, Rice University, Houston, TX 77005, USA
    Dev Biol 309:373-85. 2007
    ..We propose that lmo4b has an essential role in forebrain development as a modulator of six3 and rx3 expression, and thus indirectly influences neural cell fate commitment, cell proliferation and tissue growth in the anterior CNS...
  93. doi Sdf1/Cxcr4 signaling controls the dorsal migration of endodermal cells during zebrafish gastrulation
    Takamasa Mizoguchi
    Department of Biological Science, Graduate School of Science, Hiroshima University, Kagamiyama 1 3 1, Higashi Hiroshima, Hiroshima, Japan
    Development 135:2521-9. 2008
    ....
  94. doi Pnas4 is a novel regulator for convergence and extension during vertebrate gastrulation
    Shaohua Yao
    State Key Laboratory of Biotherapy, West China Hospital and Life Science College, Sichuan University, Chengdu, China
    FEBS Lett 582:2325-32. 2008
    ..In addition, genetic interaction assays indicate that Pnas4 might act in parallel with non-canonical Wnt signal in the regulation of cell movement. Our data suggest that Pnas4 is a key regulator of cell movement during gastrulation...
  95. doi Protocadherin-18a has a role in cell adhesion, behavior and migration in zebrafish development
    Emil Aamar
    Laboratory of Molecular Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Building 6B, Room 413, Bethesda, MD, USA
    Dev Biol 318:335-46. 2008
    ..These results suggest a role for Pcdh18a in cell adhesion, migration and behavior but not cell specification during gastrula and segmentation stages of development...
  96. pmc Sparc (Osteonectin) functions in morphogenesis of the pharyngeal skeleton and inner ear
    Josep Rotllant
    Center of Marine Biotechnology, University of Maryland Biotechnology Institute, Baltimore, MD 21202, USA
    Matrix Biol 27:561-72. 2008
    ..A comparison of the phenotypes of Sparc knockdown and known zebrafish mutants with similar defects places Sparc downstream of sox9 in the genetic network that regulates development of the pharyngeal skeleton and inner ear of vertebrates...
  97. ncbi Midkine-b regulates cell specification at the neural plate border in zebrafish
    Daniel Liedtke
    Department of Physiological Chemistry I, Biocenter, University of Wurzburg, Wurzburg, Germany
    Dev Dyn 237:62-74. 2008
    ..Our results imply that Mdkb is required for the earliest steps of cell specification at the neural plate border in zebrafish...
  98. pmc Cadherin-mediated adhesion regulates posterior body formation
    Michael J Harrington
    Department of Biological Sciences, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, Maryland 21250, USA
    BMC Dev Biol 7:130. 2007
    ..However the lengthening of the axis continues during post-gastrula stages in the tailbud region, and is thought to involve convergent extension movements as well as other cell behaviors specific to posterior regions...
  99. ncbi Snail1a and Snail1b cooperate in the anterior migration of the axial mesendoderm in the zebrafish embryo
    Maria J Blanco
    Instituto Cajal, CSIC, Doctor Arce 37, 28002 Madrid, Spain
    Development 134:4073-81. 2007
    ....
  100. ncbi Evolution of the neuropeptide Y family: new genes by chromosome duplications in early vertebrates and in teleost fishes
    Gorel Sundstrom
    Department of Neuroscience, Uppsala University, Box 593, 75124 Uppsala, Sweden
    Gen Comp Endocrinol 155:705-16. 2008
    ..Our study shows that when sequence comparisons give ambiguous results, chromosomal location can serve as a useful criterion to identify orthologs. This strategy may help to resolve relationships in several families of short peptides...

Research Grants35

  1. Intrinsic vs extrinsic defects in neural crest cell patterning
    Macie Walker; Fiscal Year: 2007
    ..The major goals of this project are to use zebrafish and mice as model organisms to determine mechanisms by which facial tissues are formed and to uncover avenues for rescue and repair of a specific congenital craniofacial birth defect. ..
  2. DORSAL-VENTRAL PATTERN FORMATION IN THE ZEBRAFISH EMBRYO
    Mary Mullins; Fiscal Year: 2006
    ..These studies are directly relevant to the study of human disease, since some of the genes in this pathway have been shown or are implicated in the cause of multiple human disease states and human inherited disorders. ..
  3. Genetic analysis of ovary development and oogenesis
    Mary Mullins; Fiscal Year: 2007
    ..Identification of the mutant zebrafish genes will provide candidate genes responsible for the human defects, which could ultimately lead to genetic testing or therapeutic intervention. ..
  4. DORSAL-VENTRAL PATTERN FORMATION IN THE ZEBRAFISH EMBRYO
    Mary Mullins; Fiscal Year: 2007
    ..Thus it is critical to identify and study all the genetic players in this process. ..
  5. Genetic and molecular dissection of hair-cell function
    Teresa Nicolson; Fiscal Year: 2009
    ..The data from these experiments will help to increase our understanding of the biology of deafness genes and may lead to potential therapies for deafness patients. ..
  6. Genetic analysis of ovary development and oogenesis
    Mary Mullins; Fiscal Year: 2009
    ..Identification of the mutant zebrafish genes will provide candidate genes responsible for the human defects, which could ultimately lead to genetic testing or therapeutic intervention. ..
  7. DORSAL-VENTRAL PATTERN FORMATION IN THE ZEBRAFISH EMBRYO
    Mary C Mullins; Fiscal Year: 2010
    ....
  8. Genetic analysis of male gonadal development
    Mary C Mullins; Fiscal Year: 2010
    ..Identification of the genes responsible for these defects in the zebrafish will provide candidate genes responsible for the human defects, which could ultimately lead to genetic testing or therapeutic intervention. ..
  9. Genetic Analysis of Maternal Factors in Embryonic Devel*
    Mary Mullins; Fiscal Year: 2005
    ..These studies will be relevant to the nature of human sterilities, birth defects, and human inherited disorders. ..
  10. DORSAL-VENTRAL PATTERN FORMATION IN THE ZEBRAFISH EMBRYO
    Mary Mullins; Fiscal Year: 2003
    ....
  11. DORSAL-VENTRAL PATTERN FORMATION IN THE ZEBRAFISH EMBRYO
    Mary C Mullins; Fiscal Year: 2010
    ....