dlx1a

Summary

Gene Symbol: dlx1a
Description: distal-less homeobox 1a
Alias: dlx1, zgc:111939, homeobox protein Dlx1a, DLX-1, distal-less homeobox gene 1a
Species: zebrafish
Products:     dlx1a

Top Publications

  1. Talbot J, Johnson S, Kimmel C. hand2 and Dlx genes specify dorsal, intermediate and ventral domains within zebrafish pharyngeal arches. Development. 2010;137:2507-17 pubmed publisher
    ..Knockdown of the broadly expressed genes dlx1a and dlx2a results in both dorsal and intermediate defects, whereas knockdown of three intermediate-domain ..
  2. Debiais Thibaud M, Germon I, Laurenti P, Casane D, Borday Birraux V. Low divergence in Dlx gene expression between dentitions of the medaka (Oryzias latipes) versus high level of expression shuffling in osteichtyans. Evol Dev. 2008;10:464-76 pubmed publisher
    ..Our results demonstrate a low constraint on dlx gene expression shuffling in the odontogenic cascade within osteichtyans but the non-individualization of oral and pharyngeal dentitions in the medaka...
  3. Zerucha T, Stühmer T, Hatch G, Park B, Long Q, Yu G, et al. A highly conserved enhancer in the Dlx5/Dlx6 intergenic region is the site of cross-regulatory interactions between Dlx genes in the embryonic forebrain. J Neurosci. 2000;20:709-21 pubmed
    Four Dlx homeobox genes, Dlx1, Dlx2, Dlx5, and Dlx6 are expressed in the same primordia of the mouse forebrain with temporally overlapping patterns...
  4. MacDonald R, Debiais Thibaud M, Talbot J, Ekker M. The relationship between dlx and gad1 expression indicates highly conserved genetic pathways in the zebrafish forebrain. Dev Dyn. 2010;239:2298-306 pubmed publisher
    ..We also generated transgenic zebrafish with regulatory elements from the zebrafish dlx1a/2a locus...
  5. Verreijdt L, Debiais Thibaud M, Borday Birraux V, Van der Heyden C, Sire J, Huysseune A. Expression of the dlx gene family during formation of the cranial bones in the zebrafish (Danio rerio): differential involvement in the visceral skeleton and braincase. Dev Dyn. 2006;235:1371-89 pubmed
    ..Whether dlx genes originally functioned in the visceral skeleton only, and whether their involvement in the formation of neurocranial bones (as in mammals) is secondary, awaits clarification. ..
  6. Borday Birraux V, Van der Heyden C, Debiais Thibaud M, Verreijdt L, Stock D, Huysseune A, et al. Expression of Dlx genes during the development of the zebrafish pharyngeal dentition: evolutionary implications. Evol Dev. 2006;8:130-41 pubmed
    ..We found that (i) dlx1a and dlx6a are not expressed in teeth, in contrast to their murine orthologs, Dlx1 and Dlx6; (ii) the expression of ..
  7. Debiais Thibaud M, Metcalfe C, Pollack J, Germon I, Ekker M, Depew M, et al. Heterogeneous conservation of Dlx paralog co-expression in jawed vertebrates. PLoS ONE. 2013;8:e68182 pubmed publisher
    ..Regulatory constraints such as shared enhancers, and functional constraints including gene pleiotropy, may have contributed to the evolutionary inertia leading to high redundancy between gene expression patterns. ..
  8. Solek C, Feng S, Perin S, Weinschutz Mendes H, Ekker M. Lineage tracing of dlx1a/2a and dlx5a/6a expressing cells in the developing zebrafish brain. Dev Biol. 2017;427:131-147 pubmed publisher
    ..We have found that dlx1a/2a and dlx5a/6a expressing progenitors give rise, for the most part, to small populations of cells which ..
  9. O Quin K, Yoshizawa M, Doshi P, Jeffery W. Quantitative genetic analysis of retinal degeneration in the blind cavefish Astyanax mexicanus. PLoS ONE. 2013;8:e57281 pubmed publisher
    ..The regions we identify serve as a starting point for future studies on the genetics of retinal degeneration and eye disease using the evolutionary mutant model Astyanax. ..

More Information

Publications18

  1. MacDonald R, Pollack J, Debiais Thibaud M, Heude E, Talbot J, Ekker M. The ascl1a and dlx genes have a regulatory role in the development of GABAergic interneurons in the zebrafish diencephalon. Dev Biol. 2013;381:276-85 pubmed publisher
    ..Expression of ascl1a overlaps with dlx1a in the telencephalon and diencephalon during early forebrain development...
  2. Alvarado E, Yousefelahiyeh M, Alvarado G, Shang R, Whitman T, MARTINEZ A, et al. Wdr68 Mediates Dorsal and Ventral Patterning Events for Craniofacial Development. PLoS ONE. 2016;11:e0166984 pubmed publisher
    ..Expression of dlx1a and dlx2a was also severely reduced in anterior dorsal and ventral 1st arch CNCC territory in wdr68 mutants...
  3. Amores A, Force A, Yan Y, Joly L, Amemiya C, Fritz A, et al. Zebrafish hox clusters and vertebrate genome evolution. Science. 1998;282:1711-4 pubmed
    ..Thus, teleosts, the most species-rich group of vertebrates, appear to have more copies of these developmental regulatory genes than do mammals, despite less complexity in the anterior-posterior axis. ..
  4. Klarić T, Lardelli M, Key B, Koblar S, Lewis M. Activity-dependent expression of neuronal PAS domain-containing protein 4 (npas4a) in the developing zebrafish brain. Front Neuroanat. 2014;8:148 pubmed publisher
    ..number of forebrain-specific defects including increased apoptosis and misexpression of the forebrain marker genes dlx1a and shha...
  5. Sundstrom G, Larsson T, Brenner S, Venkatesh B, Larhammar D. Evolution of the neuropeptide Y family: new genes by chromosome duplications in early vertebrates and in teleost fishes. Gen Comp Endocrinol. 2008;155:705-16 pubmed
    ..Our study shows that when sequence comparisons give ambiguous results, chromosomal location can serve as a useful criterion to identify orthologs. This strategy may help to resolve relationships in several families of short peptides. ..
  6. Sperber S, Saxena V, Hatch G, Ekker M. Zebrafish dlx2a contributes to hindbrain neural crest survival, is necessary for differentiation of sensory ganglia and functions with dlx1a in maturation of the arch cartilage elements. Dev Biol. 2008;314:59-70 pubmed
    ..Expression of dlx2a in the arches is subsequently followed by overlapping expression of the physically linked dlx1a gene, and of other paralogues that include dlx5a/dlx6a and dlx3b/dlx4b...
  7. Plessy C, Dickmeis T, Chalmel F, Strahle U. Enhancer sequence conservation between vertebrates is favoured in developmental regulator genes. Trends Genet. 2005;21:207-10 pubmed
  8. Turner K, Hawkins T, Yáñez J, Anadón R, Wilson S, Folgueira M. Afferent Connectivity of the Zebrafish Habenulae. Front Neural Circuits. 2016;10:30 pubmed publisher
    ..2014). ..
  9. Muthu V, Eachus H, Ellis P, Brown S, Placzek M. Rx3 and Shh direct anisotropic growth and specification in the zebrafish tuberal/anterior hypothalamus. Development. 2016;143:2651-63 pubmed publisher