dhrs3a

Summary

Gene Symbol: dhrs3a
Description: dehydrogenase/reductase (SDR family) member 3a
Alias: dhrs3, fc04h12, zgc:91839, dehydrogenase/reductase (SDR family) member 3a, dehydrogenase/reductase (SDR family) member 3, retd
Species: zebrafish

Top Publications

  1. Waxman J, Keegan B, Roberts R, Poss K, Yelon D. Hoxb5b acts downstream of retinoic acid signaling in the forelimb field to restrict heart field potential in zebrafish. Dev Cell. 2008;15:923-34 pubmed publisher
    ..Therefore, our results offer new perspectives on the mechanisms regulating organ size and the possible causes of congenital syndromes affecting both the heart and forelimb. ..
  2. Waxman J, Yelon D. Zebrafish retinoic acid receptors function as context-dependent transcriptional activators. Dev Biol. 2011;352:128-40 pubmed publisher
    ..Taking into account studies of RA signaling in tunicates and tetrapods, we propose a parsimonious model of the evolution of RAR function during chordate anterior-posterior patterning. ..
  3. Lupo G, Gestri G, O Brien M, Denton R, Chandraratna R, Ley S, et al. Retinoic acid receptor signaling regulates choroid fissure closure through independent mechanisms in the ventral optic cup and periocular mesenchyme. Proc Natl Acad Sci U S A. 2011;108:8698-703 pubmed publisher
    ..Furthermore, the identification of two cohorts of genes implicated in ventral eye morphogenesis may help to elucidate the genetic basis of ocular coloboma in humans. ..
  4. D Aniello E, Ravisankar P, Waxman J. Rdh10a Provides a Conserved Critical Step in the Synthesis of Retinoic Acid during Zebrafish Embryogenesis. PLoS ONE. 2015;10:e0138588 pubmed publisher
    ..Altogether, our results demonstrate that Rdh10a has a conserved requirement in the first step of RA production within vertebrate embryos. ..
  5. Shi Y, Obert E, Rahman B, Rohrer B, Lobo G. The Retinol Binding Protein Receptor 2 (Rbpr2) is required for Photoreceptor Outer Segment Morphogenesis and Visual Function in Zebrafish. Sci Rep. 2017;7:16207 pubmed publisher
  6. Chen J, Carney S, Peterson R, Heideman W. Comparative genomics identifies genes mediating cardiotoxicity in the embryonic zebrafish heart. Physiol Genomics. 2008;33:148-58 pubmed publisher
    ..Among the genes rapidly induced by RA was Nr2F5, a member of the COUP-TF family of transcriptional repressors. We found that induction of Nr2F5 was both necessary and sufficient for the cardiotoxic response to RA. ..
  7. Feng L, Hernandez R, Waxman J, Yelon D, Moens C. Dhrs3a regulates retinoic acid biosynthesis through a feedback inhibition mechanism. Dev Biol. 2010;338:1-14 pubmed publisher
    ..Focusing on genes known to be involved in RA metabolism, we determined that dhrs3a, which encodes a member of the short-chain dehydrogenase/reductase protein family, is both RA dependent and ..
  8. Oliveira E, Casado M, Raldua D, Soares A, Barata C, Pina B. Retinoic acid receptors' expression and function during zebrafish early development. J Steroid Biochem Mol Biol. 2013;138:143-51 pubmed publisher
    ..These changes did not affect the response to exogenous RA of the known RAR-responsive genes cyp26a1, dhrs3a, hoxb1b, hoxb5a, and hoxb5b...
  9. D Aniello E, Rydeen A, Anderson J, Mandal A, Waxman J. Depletion of retinoic acid receptors initiates a novel positive feedback mechanism that promotes teratogenic increases in retinoic acid. PLoS Genet. 2013;9:e1003689 pubmed publisher
    ..Our results support an intriguing novel mechanism by which depletion of RARs elicits a previously unrecognized positive feedback loop that can result in developmental defects due to teratogenic increases in embryonic RA...

More Information

Publications11

  1. Rydeen A, Waxman J. Cyp26 enzymes are required to balance the cardiac and vascular lineages within the anterior lateral plate mesoderm. Development. 2014;141:1638-48 pubmed publisher
    ..Our study provides novel insight into the earliest consequences of Cyp26 deficiency that underlie cardiovascular malformations in vertebrate embryos. ..
  2. Pelayo S, Oliveira E, Thienpont B, Babin P, Raldua D, André M, et al. Triiodothyronine-induced changes in the zebrafish transcriptome during the eleutheroembryonic stage: implications for bisphenol A developmental toxicity. Aquat Toxicol. 2012;110-111:114-22 pubmed publisher