dharma

Summary

Gene Symbol: dharma
Description: dharma
Alias: boz, dha, nwk, dharma, bozozok, momo, nieuwkoid
Species: zebrafish
Products:     dharma

Top Publications

  1. Solnica Krezel L, Stemple D, Mountcastle Shah E, Rangini Z, Neuhauss S, Malicki J, et al. Mutations affecting cell fates and cellular rearrangements during gastrulation in zebrafish. Development. 1996;123:67-80 pubmed
    ..These mutations provide an approach to understanding the genetic control of gastrulation in vertebrates. ..
  2. Belting H, Wendik B, Lunde K, Leichsenring M, Mössner R, Driever W, et al. Pou5f1 contributes to dorsoventral patterning by positive regulation of vox and modulation of fgf8a expression. Dev Biol. 2011;356:323-36 pubmed publisher
    ..Our data reveals a set of direct and indirect interactions of Pou5f1 with the BMP dorsoventral patterning network that serve to fine-tune dorsoventral patterning mechanisms and coordinate patterning with developmental timing. ..
  3. Leung T, Bischof J, Söll I, Niessing D, Zhang D, Ma J, et al. bozozok directly represses bmp2b transcription and mediates the earliest dorsoventral asymmetry of bmp2b expression in zebrafish. Development. 2003;130:3639-49 pubmed
    ..Mutations in zebrafish bozozok (boz) cause severe defects in axial mesoderm and anterior neurectoderm and affect organizer formation...
  4. Shimizu T, Yamanaka Y, Nojima H, Yabe T, Hibi M, Hirano T. A novel repressor-type homeobox gene, ved, is involved in dharma/bozozok-mediated dorsal organizer formation in zebrafish. Mech Dev. 2002;118:125-38 pubmed
    Dharma/Bozozok (Dha/Boz) is a homeodomain protein containing an Engrailed homology (Eh) 1 repressor motif. It is important in zebrafish dorsal organizer formation. Dha/Boz interacted with a co-repressor Groucho through the Eh1 motif...
  5. Melby A, Beach C, Mullins M, Kimelman D. Patterning the early zebrafish by the opposing actions of bozozok and vox/vent. Dev Biol. 2000;224:275-85 pubmed
    ..We show that ectopic vox or vent negatively regulates expression of the early dorsal gene bozozok (boz) and that ectopic boz eliminates vox and vent expression...
  6. Shimizu T, Yamanaka Y, Ryu S, Hashimoto H, Yabe T, Hirata T, et al. Cooperative roles of Bozozok/Dharma and Nodal-related proteins in the formation of the dorsal organizer in zebrafish. Mech Dev. 2000;91:293-303 pubmed
    ..Zebrafish bozozok/dharma (boz) and squint (sqt), which encode a homeodomain protein and a Nodal-related protein, respectively, are ..
  7. Fekany K, Yamanaka Y, Leung T, Sirotkin H, Topczewski J, Gates M, et al. The zebrafish bozozok locus encodes Dharma, a homeodomain protein essential for induction of gastrula organizer and dorsoanterior embryonic structures. Development. 1999;126:1427-38 pubmed
    ..We demonstrate that the zebrafish bozozok (boz) locus is required at the blastula stages for formation of the embryonic shield, the equivalent of the ..
  8. Lyman Gingerich J, Westfall T, Slusarski D, Pelegri F. hecate, a zebrafish maternal effect gene, affects dorsal organizer induction and intracellular calcium transient frequency. Dev Biol. 2005;286:427-39 pubmed
  9. Ramel M, Lekven A. Repression of the vertebrate organizer by Wnt8 is mediated by Vent and Vox. Development. 2004;131:3991-4000 pubmed
    ..Thus, whereas both Wnt8 and zygotic BMP are ventralizing agents that regulate common target genes, their temporally different modes of action are necessary to pattern the embryo harmoniously along its DV axis. ..

More Information

Publications80

  1. Howley C, Ho R. mRNA localization patterns in zebrafish oocytes. Mech Dev. 2000;92:305-9 pubmed
    ..Unique patterns of localization are seen in mature eggs as well. Some mRNAs maintain their oocyte localization patterns, while others localize upon egg activation (fertilization). ..
  2. Westfall T, Hjertos B, Slusarski D. Requirement for intracellular calcium modulation in zebrafish dorsal-ventral patterning. Dev Biol. 2003;259:380-91 pubmed
    ..These results provide evidence that modulation of calcium release is critical for early embryonic patterning and acts by influencing the stabilization of beta-catenin protein. ..
  3. Gore A, Maegawa S, Cheong A, Gilligan P, Weinberg E, Sampath K. The zebrafish dorsal axis is apparent at the four-cell stage. Nature. 2005;438:1030-5 pubmed
    ..Because the 3' untranslated region of the human nodal gene can also localize exogenous sequences to dorsal cells, this mechanism may be evolutionarily conserved. ..
  4. Maegawa S, Varga M, Weinberg E. FGF signaling is required for {beta}-catenin-mediated induction of the zebrafish organizer. Development. 2006;133:3265-76 pubmed
    ..beta-catenin signaling, to test for the epistatic relationship between beta-catenin activation, FGF signaling and bozozok, squint and chordin expression...
  5. Imai Y, Gates M, Melby A, Kimelman D, Schier A, Talbot W. The homeobox genes vox and vent are redundant repressors of dorsal fates in zebrafish. Development. 2001;128:2407-20 pubmed
    ..Expression of dorsal mesodermal genes, including chordin, goosecoid and bozozok, is strongly expanded in embryos that lack vox and vent function, indicating that the redundant action of vox and ..
  6. Bellipanni G, Varga M, Maegawa S, Imai Y, Kelly C, Myers A, et al. Essential and opposing roles of zebrafish beta-catenins in the formation of dorsal axial structures and neurectoderm. Development. 2006;133:1299-309 pubmed
    ..We propose that the early, dorsal-promoting function of beta-catenin-2 is essential to counteract a later, dorsal- and neurectoderm-repressing function that is shared by both beta-catenin genes...
  7. Shih Y, Kuo C, Hirst C, Dee C, Liu Y, Laghari Z, et al. SoxB1 transcription factors restrict organizer gene expression by repressing multiple events downstream of Wnt signalling. Development. 2010;137:2671-81 pubmed publisher
    ..Although beta-catenin, Bozozok and Squint are known to play major roles in establishing the dorsal organizer in vertebrate embryos, ..
  8. Nojima H, Shimizu T, Kim C, Yabe T, Bae Y, Muraoka O, et al. Genetic evidence for involvement of maternally derived Wnt canonical signaling in dorsal determination in zebrafish. Mech Dev. 2004;121:371-86 pubmed
    ..phenotypes and/or dorsalized the embryos, and restored or induced an ectopic and expanded expression of bozozok/dharma and goosecoid. However, dorsalization by wnt RNAs was affected in the tkk embryos...
  9. Westfall T, Brimeyer R, Twedt J, Gladon J, Olberding A, Furutani Seiki M, et al. Wnt-5/pipetail functions in vertebrate axis formation as a negative regulator of Wnt/beta-catenin activity. J Cell Biol. 2003;162:889-98 pubmed
    ..The Wnt-5 loss-of-function defect is consistent with Ca2+ modulation having an antagonistic interaction with Wnt/beta-catenin signaling. ..
  10. Feng Q, Zou X, Lu L, Li Y, Liu Y, Zhou J, et al. The stress-response gene redd1 regulates dorsoventral patterning by antagonizing Wnt/?-catenin activity in zebrafish. PLoS ONE. 2012;7:e52674 pubmed publisher
    ..These findings have unraveled a novel role of Redd1 in early development by antagonizing Wnt/?-catenin signaling. ..
  11. Nojima H, Rothhämel S, Shimizu T, Kim C, Yonemura S, Marlow F, et al. Syntabulin, a motor protein linker, controls dorsal determination. Development. 2010;137:923-33 pubmed publisher
    ..Our findings suggest that Syntabulin regulates the microtubule-dependent transport of the DDs, and provide evidence for the link between AV and dorsoventral axis formation. ..
  12. Ro H, Dawid I. Organizer restriction through modulation of Bozozok stability by the E3 ubiquitin ligase Lnx-like. Nat Cell Biol. 2009;11:1121-7 pubmed publisher
    ..We identified Bozozok (Boz, also known as Dharma or Nieuwkoid) as a binding partner and substrate of Lnx-l...
  13. Ober E, Schulte Merker S. Signals from the yolk cell induce mesoderm, neuroectoderm, the trunk organizer, and the notochord in zebrafish. Dev Biol. 1999;215:167-81 pubmed
    ..In addition, these experiments show that the establishment of the anteroposterior axis is independent of the dorsoventral axis. ..
  14. Flores M, Lam E, Crosier K, Crosier P. Osteogenic transcription factor Runx2 is a maternal determinant of dorsoventral patterning in zebrafish. Nat Cell Biol. 2008;10:346-52 pubmed publisher
  15. Wu S, Shin J, Sepich D, Solnica Krezel L. Chemokine GPCR signaling inhibits ?-catenin during zebrafish axis formation. PLoS Biol. 2012;10:e1001403 pubmed publisher
    ..Our study delineates a novel negative, Gsk3?-independent control mechanism of ?-catenin and implicates Ccr7 as a long-hypothesized GPCR regulating vertebrate axis formation. ..
  16. Sirotkin H, Dougan S, Schier A, Talbot W. bozozok and squint act in parallel to specify dorsal mesoderm and anterior neuroectoderm in zebrafish. Development. 2000;127:2583-92 pubmed
    ..the zygotically acting genes with key roles in the specification of dorsal axial structures are the homeobox gene bozozok (boz) and the nodal-related (TGF-(beta) family) gene squint (sqt)...
  17. Lim S, Kumari P, Gilligan P, Quach H, Mathavan S, Sampath K. Dorsal activity of maternal squint is mediated by a non-coding function of the RNA. Development. 2012;139:2903-15 pubmed publisher
    ..Our findings identify new non-coding functions for the Nodal genes and support a model wherein sqt RNA acts as a scaffold to bind and deliver/sequester maternal factors to future embryonic dorsal. ..
  18. Leung T, Söll I, Arnold S, Kemler R, Driever W. Direct binding of Lef1 to sites in the boz promoter may mediate pre-midblastula-transition activation of boz expression. Dev Dyn. 2003;228:424-32 pubmed
    ..Zebrafish bozozok (boz) mutant embryos have severe defects in axial mesoderm and anterior neuroectoderm...
  19. Ramel M, Buckles G, Baker K, Lekven A. WNT8 and BMP2B co-regulate non-axial mesoderm patterning during zebrafish gastrulation. Dev Biol. 2005;287:237-48 pubmed
  20. Ro H, Dawid I. Lnx-2b restricts gsc expression to the dorsal mesoderm by limiting Nodal and Bozozok activity. Biochem Biophys Res Commun. 2010;402:626-30 pubmed publisher
    Coordinated Nodal-related signals and Bozozok (Boz) activity are critical for the initial specification of dorsal mesoderm and anterior neuroectoderm during zebrafish embryogenesis...
  21. Gritsman K, Zhang J, Cheng S, Heckscher E, Talbot W, Schier A. The EGF-CFC protein one-eyed pinhead is essential for nodal signaling. Cell. 1999;97:121-32 pubmed
    ..Expression of the murine EGF-CFC gene cripto rescues oep mutants. These results suggest a conserved role for EGF-CFC proteins as essential extracellular cofactors for Nodal signaling during vertebrate development. ..
  22. Zhang Y, Li X, Qi J, Wang J, Liu X, Zhang H, et al. Rock2 controls TGFbeta signaling and inhibits mesoderm induction in zebrafish embryos. J Cell Sci. 2009;122:2197-207 pubmed publisher
    ..Thus, our data have unraveled previously unidentified functions of Rock2, in controlling TGFbeta signaling as well as in regulating embryonic patterning. ..
  23. Ramel M, Hill C. The ventral to dorsal BMP activity gradient in the early zebrafish embryo is determined by graded expression of BMP ligands. Dev Biol. 2013;378:170-82 pubmed publisher
    ..Both Dharma and FGF signalling contribute to graded bmp transcription during these early stages and it is subsequently ..
  24. Rong X, Zhou Y, Liu Y, Zhao B, Wang B, Wang C, et al. Glutathione peroxidase 4 inhibits Wnt/?-catenin signaling and regulates dorsal organizer formation in zebrafish embryos. Development. 2017;144:1687-1697 pubmed publisher
    ..Our findings unravel GPX4 as a suppressor of Wnt/?-catenin signals, suggesting a possible relationship between the Wnt/?-catenin pathway and selenium via the association of Tcf/Lef family proteins with GPX4. ..
  25. Long S, Ahmad N, Rebagliati M. The zebrafish nodal-related gene southpaw is required for visceral and diencephalic left-right asymmetry. Development. 2003;130:2303-16 pubmed
    ..These observations lead to a model of how visceral organ and brain left-right asymmetry are coordinated during embryogenesis...
  26. Feng L, Jiang H, Wu P, Marlow F. Negative feedback regulation of Wnt signaling via N-linked fucosylation in zebrafish. Dev Biol. 2014;395:268-86 pubmed publisher
    ..These results suggest that Wnt limits its own signaling activity in part via up-regulation of a transporter, slc35c1 that promotes terminal fucosylation and thereby limits Wnt activity. ..
  27. Lu Z, Liu W, Huang H, He Y, Han Y, Rui Y, et al. Protein encoded by the Axin(Fu) allele effectively down-regulates Wnt signaling but exerts a dominant negative effect on c-Jun N-terminal kinase signaling. J Biol Chem. 2008;283:13132-9 pubmed publisher
  28. Sharma D, Holets L, Zhang X, Kinsey W. Role of Fyn kinase in signaling associated with epiboly during zebrafish development. Dev Biol. 2005;285:462-76 pubmed
    ..determination such as beta-catenin, activin, and nodal appeared to function normally as evidenced by expression of boz, goosecoid, and mezzo...
  29. Gao R, Ma L, Du X, Zhang T, Zhao L, Liu L, et al. Rnf25/AO7 positively regulates wnt signaling via disrupting Nkd1-Axin inhibitory complex independent of its ubiquitin ligase activity. Oncotarget. 2016;7:23850-9 pubmed publisher
    ..Our results indicated that Rnf25 might serve as a molecular device, controlling the different antagonizing functions against canonical Wnt signaling between Nkd1 and Nkd2 cooperated with Axin. ..
  30. Schier A, Neuhauss S, Harvey M, Malicki J, Solnica Krezel L, Stainier D, et al. Mutations affecting the development of the embryonic zebrafish brain. Development. 1996;123:165-78 pubmed
    ..The identified loci establish the genetic foundation for a further analysis of the development of the zebrafish embryonic brain. ..
  31. Kuo C, Lam C, Hewitt J, Scotting P. Formation of the embryonic organizer is restricted by the competitive influences of Fgf signaling and the SoxB1 transcription factors. PLoS ONE. 2013;8:e57698 pubmed publisher
    ..The organizer therefore forms only where Nodal-induced Fgf signaling overlaps with Wnt signaling and the SoxB1 proteins are absent. ..
  32. Hino H, Nakanishi A, Seki R, Aoki T, Yamaha E, Kawahara A, et al. Roles of maternal wnt8a transcripts in axis formation in zebrafish. Dev Biol. 2018;434:96-107 pubmed publisher
    ..Finally, we re-examined the maternal wnt genes and found that Wnt6a is an alternative candidate DD. ..
  33. Simons M, Gloy J, Ganner A, Bullerkotte A, Bashkurov M, Krönig C, et al. Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways. Nat Genet. 2005;37:537-43 pubmed
    ..Fluid flow increases inversin levels in ciliated tubular epithelial cells and seems to regulate this crucial switch between Wnt signaling pathways during renal development. ..
  34. Gu Q, Yang X, He X, Li Q, Cui Z. Generation and characterization of a transgenic zebrafish expressing the reverse tetracycline transactivator. J Genet Genomics. 2013;40:523-31 pubmed publisher
    ..Thus, this rtTA-transgenic zebrafish can be utilized to dissect functions of genes in a temporal manner. ..
  35. Rui Y, Xu Z, Xiong B, Cao Y, Lin S, Zhang M, et al. A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida. Dev Cell. 2007;13:268-82 pubmed
    ..We have thus identified a dorsalization pathway that is exerted by Axin/JNK signaling and its inhibitor Aida during vertebrate embryogenesis. ..
  36. Ye Z, Zhang C, Tu T, Sun M, Liu D, Lu D, et al. Wnt5a uses CD146 as a receptor to regulate cell motility and convergent extension. Nat Commun. 2013;4:2803 pubmed publisher
    ..Our results suggest a model in which CD146 acts as a functional Wnt5a receptor in regulating cell migration and convergent extension, turning off the canonical Wnt signalling branch. ..
  37. Hartnett L, Glynn C, Nolan C, Grealy M, Byrnes L. Insulin-like growth factor-2 regulates early neural and cardiovascular system development in zebrafish embryos. Int J Dev Biol. 2010;54:573-83 pubmed publisher
    ..The finding that igf-2a and igf-2b do not act exclusively in a redundant manner may explain why both genes have been stably maintained in the genome. ..
  38. Hayes M, Naito M, Daulat A, Angers S, Ciruna B. Ptk7 promotes non-canonical Wnt/PCP-mediated morphogenesis and inhibits Wnt/?-catenin-dependent cell fate decisions during vertebrate development. Development. 2013;140:1807-18 pubmed publisher
  39. Jurynec M, Grunwald D. SHIP2, a factor associated with diet-induced obesity and insulin sensitivity, attenuates FGF signaling in vivo. Dis Model Mech. 2010;3:733-42 pubmed publisher
    ..We suggest that modulation of FGF signaling may be a principal function of SHIP2 in mammals. ..
  40. Shinya M, Eschbach C, Clark M, Lehrach H, Furutani Seiki M. Zebrafish Dkk1, induced by the pre-MBT Wnt signaling, is secreted from the prechordal plate and patterns the anterior neural plate. Mech Dev. 2000;98:3-17 pubmed
    ..Furthermore, dkk1 acts in parallel to the homeobox gene bozozok and bozozok is required for the maintenance of dkk1 expression...
  41. Tsai W, Zhang X, Sharma D, Wu W, Kinsey W. Role of Yes kinase during early zebrafish development. Dev Biol. 2005;277:129-41 pubmed
    ..These results demonstrate that Yes kinase plays an important role in epiboly and indicate that Yes kinase participates in signaling by focal adhesion kinase during early development. ..
  42. Angonin D, Van Raay T. Nkd1 functions as a passive antagonist of Wnt signaling. PLoS ONE. 2013;8:e74666 pubmed publisher
    ..These results suggest that Nkd1 functions as a passive antagonist of Wnt signaling, functioning only when homeostatic levels of Wnt signaling have been breached or when Wnt signaling becomes destabilized. ..
  43. Shao M, Wang M, Liu Y, Ge Y, Zhang Y, Shi D. Vegetally localised Vrtn functions as a novel repressor to modulate bmp2b transcription during dorsoventral patterning in zebrafish. Development. 2017;144:3361-3374 pubmed publisher
    ..Our work unveils a novel maternal mechanism regulating zygotic BMP gradient in dorsoventral patterning. ..
  44. Wei S, Shang H, Cao Y, Wang Q. The coiled-coil domain containing protein Ccdc136b antagonizes maternal Wnt/?-catenin activity during zebrafish dorsoventral axial patterning. J Genet Genomics. 2016;43:431-8 pubmed publisher
  45. Liu Q, Wu Z, Lv W, Yan Y, Li Y. Developmental expression of cyclin H and Cdk7 in zebrafish: the essential role of cyclin H during early embryo development. Cell Res. 2007;17:163-73 pubmed
    ..These results implicate Cyclin H in the regulation of the transcriptional machinery during midblastula transition and suggest that it is an essential gene in early zebrafish larval development. ..
  46. Mei W, Lee K, Marlow F, Miller A, Mullins M. hnRNP I is required to generate the Ca2+ signal that causes egg activation in zebrafish. Development. 2009;136:3007-17 pubmed publisher
    ..Our studies therefore reveal an important new role of hnrnp I in regulating the fundamental process of IP(3)-mediated Ca(2+) release at egg activation. ..
  47. Hashiguchi M, Shinya M, Tokumoto M, Sakai N. Nodal/Bozozok-independent induction of the dorsal organizer by zebrafish cell lines. Dev Biol. 2008;321:387-96 pubmed publisher
    ..In zebrafish, two molecular cascades--Bozozok/Dharma (Boz) and Nodal signaling--act in parallel to induce the dorsal organizer...
  48. Shimizu N, Ishitani S, Sato A, Shibuya H, Ishitani T. Hipk2 and PP1c cooperate to maintain Dvl protein levels required for Wnt signal transduction. Cell Rep. 2014;8:1391-404 pubmed publisher
    ..This regulation may be a negative feedback mechanism that fine-tunes Wnt/β-catenin signaling. ..
  49. Umasankar P, Sanker S, Thieman J, Chakraborty S, Wendland B, Tsang M, et al. Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning. Nat Cell Biol. 2012;14:488-501 pubmed publisher
    ..Still, the fcho1 morphant phenotype is distinct from severe embryonic defects apparent when AP-2 is depleted. Our data thus challenge the primacy of FCHO1/2 in coat initiation. ..
  50. Bruce A, Howley C, Zhou Y, Vickers S, Silver L, King M, et al. The maternally expressed zebrafish T-box gene eomesodermin regulates organizer formation. Development. 2003;130:5503-17 pubmed
    ..Overexpression of eomes results in Nodal-dependent and nieuwkoid/dharma (nwk/dhm) independent ectopic expression of the organizer markers goosecoid (gsc), chordin (chd) and ..
  51. Chen J, van Eeden F, Warren K, Chin A, Nusslein Volhard C, Haffter P, et al. Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish. Development. 1997;124:4373-82 pubmed
    ..Thus, the pattern of cardiac BMP4 appears to be in the pathway by which the heart interprets lateralizing signals from the midline. ..
  52. Hu S, Wu Z, Yan Y, Li Y. Sox31 is involved in central nervous system anteroposterior regionalization through regulating the organizer activity in zebrafish. Acta Biochim Biophys Sin (Shanghai). 2011;43:387-99 pubmed publisher
    ..The expression of Bozozok (Dharma), a direct target gene of pre-MBT Wnt/?-catenin signal, is suppressed by Sox31...
  53. Lu Y, Xie S, Zhang W, Zhang C, Gao C, Sun Q, et al. Twa1/Gid8 is a ?-catenin nuclear retention factor in Wnt signaling and colorectal tumorigenesis. Cell Res. 2017;27:1422-1440 pubmed publisher
    ..Thus, our results identify Twa1 as a previously undescribed regulator of the Wnt pathway for promoting colorectal tumorigenesis by facilitating ?-catenin nuclear retention. ..
  54. Li Z, Wang Y, Zhang M, Xu P, Huang H, Wu D, et al. The Amotl2 gene inhibits Wnt/?-catenin signaling and regulates embryonic development in zebrafish. J Biol Chem. 2012;287:13005-15 pubmed publisher
    ..Thus, our findings provide novel insights into functions of Motin family members and regulation of Wnt/?-catenin signaling. ..
  55. Moreno Ayala R, Schnabel D, Salas Vidal E, Lomelí H. PIAS-like protein Zimp7 is required for the restriction of the zebrafish organizer and mesoderm development. Dev Biol. 2015;403:89-100 pubmed publisher
    ..of zygotic Zimp7 produced axial mesodermal defects that were preceded by up-regulation of organizer genes such as bozozok, goosecoid and floating head at the onset of gastrulation and by down-regulation of the ventral markers vox, vent ..
  56. Stemple D, Solnica Krezel L, Zwartkruis F, Neuhauss S, Schier A, Malicki J, et al. Mutations affecting development of the notochord in zebrafish. Development. 1996;123:117-28 pubmed
  57. Odenthal J, Haffter P, Vogelsang E, Brand M, van Eeden F, Furutani Seiki M, et al. Mutations affecting the formation of the notochord in the zebrafish, Danio rerio. Development. 1996;123:103-15 pubmed
    ..defects in the embryonic development of the zebrafish we identified mutations in four genes,floating head (flh), momo (mom), no tail (ntl), and doc, that are required for early notochord formation...
  58. Kapp L, Abrams E, Marlow F, Mullins M. The integrator complex subunit 6 (Ints6) confines the dorsal organizer in vertebrate embryogenesis. PLoS Genet. 2013;9:e1003822 pubmed publisher
    ..Our results are consistent with a novel role for Ints6 in restricting the vertebrate organizer to a dorsal domain in embryonic patterning...
  59. Martin E, Moriarty M, Byrnes L, Grealy M. Plakoglobin has both structural and signalling roles in zebrafish development. Dev Biol. 2009;327:83-96 pubmed publisher
    ..These results establish the zebrafish as a model for ARVC caused by loss of plakoglobin function and indicate that there are signalling as well as structural consequences of this loss. ..
  60. Jia S, Dai F, Wu D, Lin X, Xing C, Xue Y, et al. Protein phosphatase 4 cooperates with Smads to promote BMP signaling in dorsoventral patterning of zebrafish embryos. Dev Cell. 2012;22:1065-78 pubmed publisher
    ..We conclude that Ppp4c is a critical positive regulator of BMP/Smad signaling during embryonic dorsoventral pattern formation in zebrafish. ..
  61. Varga M, Maegawa S, Weinberg E. Correct anteroposterior patterning of the zebrafish neurectoderm in the absence of the early dorsal organizer. BMC Dev Biol. 2011;11:26 pubmed publisher
    ..We also show that the zebrafish embryo can form a radial diffuse neural sheath in the absence of both BMP signaling and the early organizer. ..
  62. Kelsh R, Brand M, Jiang Y, Heisenberg C, Lin S, Haffter P, et al. Zebrafish pigmentation mutations and the processes of neural crest development. Development. 1996;123:369-89 pubmed
    ..In combination with the embryological advantages of zebrafish, these mutations should permit cellular and molecular dissection of many aspects of neural crest development...
  63. Putiri E, Pelegri F. The zebrafish maternal-effect gene mission impossible encodes the DEAH-box helicase Dhx16 and is essential for the expression of downstream endodermal genes. Dev Biol. 2011;353:275-89 pubmed publisher
    ..Maternal RNA helicases have long been known to be involved in the development of the animal germ line, but our findings add to growing evidence that these factors may also control specific gene expression programs in somatic tissues. ..
  64. Kim H, Lee M, Jeong Y, Ro H, Kim D, Shin Y, et al. Ottogi Inhibits Wnt/?-catenin Signaling by Regulating Cell Membrane Trafficking of Frizzled8. Sci Rep. 2017;7:13278 pubmed publisher
    ..Taken together, our data indicate that OTG functions as a novel negative regulator of Wnt signaling during development by the modulation of cell surface expression of Fz receptor. ..
  65. Diz Muñoz A, Krieg M, Bergert M, Ibarlucea Benitez I, Muller D, Paluch E, et al. Control of directed cell migration in vivo by membrane-to-cortex attachment. PLoS Biol. 2010;8:e1000544 pubmed publisher
    ..We propose that MCA is a key parameter controlling the relative proportions of different cell protrusion types in mesendoderm progenitors, and thus is key in controlling directed migration during gastrulation. ..
  66. Yimlamai D, Konnikova L, Moss L, Jay D. The zebrafish down syndrome cell adhesion molecule is involved in cell movement during embryogenesis. Dev Biol. 2005;279:44-57 pubmed
    ..Its loss results in early morphogenetic defects. dscam knockdown results in impaired cell movement during epiboly as well as in subsequent stages. We propose that migrating cells utilize dscam to remodel the developing embryo. ..
  67. El Messaoudi S, Renucci A. Expression pattern of the frizzled 7 gene during zebrafish embryonic development. Mech Dev. 2001;102:231-4 pubmed
    ..The strong sequence conservation of fz7 to the mouse, chick and Xenopus counterparts is also true for their expression pattern. ..
  68. Rong X, Chen C, Zhou P, Zhou Y, Li Y, Lu L, et al. R-spondin 3 regulates dorsoventral and anteroposterior patterning by antagonizing Wnt/?-catenin signaling in zebrafish embryos. PLoS ONE. 2014;9:e99514 pubmed publisher
    ..Human RSPO3 has similar action when tested in zebrafish embryos. These results suggest that Rspo3 regulates dorsoventral and anteroposterior patterning by negatively regulating the zygotic Wnt/?-catenin signaling in zebrafish embryos. ..
  69. Blagden C, Currie P, Ingham P, Hughes S. Notochord induction of zebrafish slow muscle mediated by Sonic hedgehog. Genes Dev. 1997;11:2163-75 pubmed
    ..We suggest that Shh acts to induce myoblasts committed to slow muscle differentiation from uncommitted presomitic mesoderm. ..
  70. Zacharia E, Bondesson M, Riu A, Ducharme N, Gustafsson J, Kakadiaris I. Automatic segmentation of time-lapse microscopy images depicting a live Dharma embryo. Conf Proc IEEE Eng Med Biol Soc. 2011;2011:8082-5 pubmed publisher
    Biological inferences about the toxicity of chemicals reached during experiments on the zebrafish Dharma embryo can be greatly affected by the analysis of the time-lapse microscopy images depicting the embryo...
  71. Driever W, Solnica Krezel L, Schier A, Neuhauss S, Malicki J, Stemple D, et al. A genetic screen for mutations affecting embryogenesis in zebrafish. Development. 1996;123:37-46 pubmed
    ..This screen demonstrates that mutations affecting a variety of developmental processes can be efficiently recovered from zebrafish. ..