Gene Symbol: defbl2
Description: defensin, beta-like 2
Alias: db-2, beta-defensin-like 2, BD-2, defensin-like protein 2, zfdb-2
Zou J, Mercier C, Koussounadis A, Secombes C. Discovery of multiple beta-defensin like homologues in teleost fish. Mol Immunol. 2007;44:638-47 pubmed
..In healthy zebrafish, constitutive expression of defensins was detected by RT-PCR in gill, gonad, gut, kidney, muscle, skin and spleen but the levels and patterns varied for individual defensin genes. ..
Liang T, Wang D, Zhang G, Wei K, Wang W, Zou G. Molecular cloning and expression analysis of two ?-defensin genes in the blunt snout bream (Megalobrama amblycephala). Comp Biochem Physiol B Biochem Mol Biol. 2013;166:91-8 pubmed publisher
..The results suggest that ma?D-1 and ma?D-2 may play important roles in protecting blunt snout bream embryos, fry and juveniles from pathogenic microbe invading. ..
Zhang H, Shen B, Wu H, Gao L, Liu Q, Wang Q, et al
. Th17-like immune response in fish mucosal tissues after administration of live attenuated Vibrio anguillarum via different vaccination routes. Fish Shellfish Immunol. 2014;37:229-38 pubmed publisher
..In turbot, effective immune protection against wild-type V. anguillarum was obtained by bath-vaccinated and the Th17-like responses were found in mucosal and systemic tissues. ..
Yang H, Zou S, Zhai L, Wang Y, Zhang F, An L, et al
. Pathogen invasion changes the intestinal microbiota composition and induces innate immune responses in the zebrafish intestine. Fish Shellfish Immunol. 2017;71:35-42 pubmed publisher
..These results suggested that the invasion of pathogen could change the intestinal microbiota composition and induce intestinal innate immune responses in zebrafish. ..
Oehlers S, Flores M, Chen T, Hall C, Crosier K, Crosier P. Topographical distribution of antimicrobial genes in the zebrafish intestine. Dev Comp Immunol. 2011;35:385-91 pubmed publisher
..Expression of the zebrafish ?-defensin family was examined in adult zebrafish tissues. Strong expression of defensin beta-like 1 was detected in the swim bladder of zebrafish from the larval stage of development through to adults. ..
Garcia Valtanen P, Martinez Lopez A, Ortega Villaizan M, Perez L, Coll J, Estepa A. In addition to its antiviral and immunomodulatory properties, the zebrafish ?-defensin 2 (zfBD2) is a potent viral DNA vaccine molecular adjuvant. Antiviral Res. 2014;101:136-47 pubmed publisher
..To note that psoriasis can be induced in zebrafish and the over-expression of ?-defensin 2 is implicated in the inflammatory response associated with this human skin disorder. ..
Liu X, Chang X, Wu H, Xiao J, Gao Y, Zhang Y. Role of intestinal inflammation in predisposition of Edwardsiella tarda infection in zebrafish (Danio rerio). Fish Shellfish Immunol. 2014;41:271-8 pubmed publisher
..tarda infection might inhibit the growth of intestinal microbiota. Our results suggest that maintaining good management to avoid intestinal inflammation is a feasible prevention measure against edwardsiellosis. ..
Jheng Y, Lee L, Ting C, Pan C, Hui C, Chen J. Zebrafish fed on recombinant Artemia expressing epinecidin-1 exhibit increased survival and altered expression of immunomodulatory genes upon Vibrio vulnificus infection. Fish Shellfish Immunol. 2015;42:1-15 pubmed publisher
..vulnificus (204) infection; expression of immune-responsive genes, including hepcidin and defbl2, was altered, as shown by qPCR...
Garcia Valtanen P, Martínez López A, López Muñoz A, Bello Perez M, Medina Gali R, Ortega Villaizan M, et al
. Zebra Fish Lacking Adaptive Immunity Acquire an Antiviral Alert State Characterized by Upregulated Gene Expression of Apoptosis, Multigene Families, and Interferon-Related Genes. Front Immunol. 2017;8:121 pubmed publisher
..From this and other studies, it might be concluded that some of the characteristics of mammalian trained immunity are present in lower vertebrates. ..