Gene Symbol: defbl1
Description: defensin, beta-like 1
Alias: db-1, beta-defensin-like 1, BD-1, defensin-like protein 1, zfdb-1
Species: zebrafish

Top Publications

  1. Zou J, Mercier C, Koussounadis A, Secombes C. Discovery of multiple beta-defensin like homologues in teleost fish. Mol Immunol. 2007;44:638-47 pubmed
    ..In healthy zebrafish, constitutive expression of defensins was detected by RT-PCR in gill, gonad, gut, kidney, muscle, skin and spleen but the levels and patterns varied for individual defensin genes. ..
  2. Chang M, Nie P. RNAi suppression of zebrafish peptidoglycan recognition protein 6 (zfPGRP6) mediated differentially expressed genes involved in Toll-like receptor signaling pathway and caused increased susceptibility to Flavobacterium columnare. Vet Immunol Immunopathol. 2008;124:295-301 pubmed publisher
    ..In challenge experiments to determine the anti-bacterial response to Gram-negative bacteria, RNAi knock-down of zfPGRP6 markedly increased susceptibility to Flavobacterium columnare...
  3. Oehlers S, Flores M, Chen T, Hall C, Crosier K, Crosier P. Topographical distribution of antimicrobial genes in the zebrafish intestine. Dev Comp Immunol. 2011;35:385-91 pubmed publisher
    ..Expression of the zebrafish ?-defensin family was examined in adult zebrafish tissues. Strong expression of defensin beta-like 1 was detected in the swim bladder of zebrafish from the larval stage of development through to adults. ..
  4. Yang L, Zou M, Fu B, He S. Genome-wide identification, characterization, and expression analysis of lineage-specific genes within zebrafish. BMC Genomics. 2013;14:65 pubmed publisher
  5. Jheng Y, Lee L, Ting C, Pan C, Hui C, Chen J. Zebrafish fed on recombinant Artemia expressing epinecidin-1 exhibit increased survival and altered expression of immunomodulatory genes upon Vibrio vulnificus infection. Fish Shellfish Immunol. 2015;42:1-15 pubmed publisher
    ..These findings suggest that feeding transgenic Artemia expressing CMV-gfp-epi to larval fish has antimicrobial effects, without the drawbacks of introducing drug residues or inducing bacterial drug resistance. ..
  6. Galindo Villegas J, Montalban Arques A, Liarte S, de Oliveira S, Pardo Pastor C, Rubio Moscardo F, et al. TRPV4-Mediated Detection of Hyposmotic Stress by Skin Keratinocytes Activates Developmental Immunity. J Immunol. 2016;196:738-49 pubmed publisher
  7. Ulloa P, Solís C, De la Paz J, Alaurent T, Caruffo M, Hernández A, et al. Lactoferrin Decreases the Intestinal Inflammation Triggered by a Soybean Meal-Based Diet in Zebrafish. J Immunol Res. 2016;2016:1639720 pubmed publisher
    ..5 larvae had a mortality rate lower than control larvae. These results demonstrate that LF displays a dual effect in zebrafish, acting as an intestinal anti-inflammatory agent and improving performance against bacterial infection. ..
  8. Udayangani R, Dananjaya S, Nikapitiya C, Heo G, Lee J, De Zoysa M. Metagenomics analysis of gut microbiota and immune modulation in zebrafish (Danio rerio) fed chitosan silver nanocomposites. Fish Shellfish Immunol. 2017;66:173-184 pubmed publisher
    ..2-fold), IL-10 (5.0-fold), IL-12 (9.2-fold), IRF-1 (5.2-fold), Defbl1 (3-fold), Lyz (5...
  9. Yang H, Zou S, Zhai L, Wang Y, Zhang F, An L, et al. Pathogen invasion changes the intestinal microbiota composition and induces innate immune responses in the zebrafish intestine. Fish Shellfish Immunol. 2017;71:35-42 pubmed publisher
    ..These results suggested that the invasion of pathogen could change the intestinal microbiota composition and induce intestinal innate immune responses in zebrafish. ..

More Information


  1. Wang C, Chen Y, Bian W, Xie S, Qi G, Liu L, et al. Deletion of mstna and mstnb impairs the immune system and affects growth performance in zebrafish. Fish Shellfish Immunol. 2018;72:572-580 pubmed publisher
    ..While each paralogue contributes to the response to bacterial insult, mstnb affects the immune system through activation of the NF-?B pathway, and mstna is likely to act upstream of NF-?B at some as yet unidentified target. ..
  2. Galindo Villegas J, García Moreno D, de Oliveira S, Meseguer J, Mulero V. Regulation of immunity and disease resistance by commensal microbes and chromatin modifications during zebrafish development. Proc Natl Acad Sci U S A. 2012;109:E2605-14 pubmed
  3. Liang T, Wang D, Zhang G, Wei K, Wang W, Zou G. Molecular cloning and expression analysis of two ?-defensin genes in the blunt snout bream (Megalobrama amblycephala). Comp Biochem Physiol B Biochem Mol Biol. 2013;166:91-8 pubmed publisher
    ..The results suggest that ma?D-1 and ma?D-2 may play important roles in protecting blunt snout bream embryos, fry and juveniles from pathogenic microbe invading. ..
  4. Zhang H, Shen B, Wu H, Gao L, Liu Q, Wang Q, et al. Th17-like immune response in fish mucosal tissues after administration of live attenuated Vibrio anguillarum via different vaccination routes. Fish Shellfish Immunol. 2014;37:229-38 pubmed publisher
    ..In turbot, effective immune protection against wild-type V. anguillarum was obtained by bath-vaccinated and the Th17-like responses were found in mucosal and systemic tissues. ..
  5. Udayangani R, Dananjaya S, Fronte B, Kim C, Lee J, De Zoysa M. Feeding of nano scale oats ?-glucan enhances the host resistance against Edwardsiella tarda and protective immune modulation in zebrafish larvae. Fish Shellfish Immunol. 2017;60:72-77 pubmed publisher
    ..Thus, non-toxic, water soluble and biodegradable NBG from oats could be considered as the potential immunostimulant for larval aquaculture. ..