Gene Symbol: ddx58
Description: DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
Alias: RIG-I, RIG-Ia, RIG-Ib, RIG-Ic, RIG-Id, RIG-1, retinoic acid-inducible protein Ia, retinoic acid-inducible protein Ib, retinoic acid-inducible protein Ic, retinoic acid-inducible protein Id, rig1
Species: zebrafish

Top Publications

  1. Nie L, Zhang Y, Dong W, Xiang L, Shao J. Involvement of zebrafish RIG-I in NF-κB and IFN signaling pathways: insights into functional conservation of RIG-I in antiviral innate immunity. Dev Comp Immunol. 2015;48:95-101 pubmed publisher
  2. Chen H, Liu W, Wu S, Chiou P, Li Y, Chen Y, et al. RIG-I specifically mediates group II type I IFN activation in nervous necrosis virus infected zebrafish cells. Fish Shellfish Immunol. 2015;43:427-35 pubmed publisher
    ..Taken together, our results indicate that RIG-I plays an essential role in zebrafish group II type I IFN induction and the inflammatory response to NNV infection. ..
  3. Nie L, Xu X, Xiang L, Shao J, Chen J. Mutual Regulation of NOD2 and RIG-I in Zebrafish Provides Insights into the Coordination between Innate Antibacterial and Antiviral Signaling Pathways. Int J Mol Sci. 2017;18: pubmed publisher
    ..This mechanism reflects the coordination between cytosolic antibacterial and antiviral PRRs in the complex network of innate immunity. ..
  4. Biacchesi S, LeBerre M, Lamoureux A, Louise Y, Lauret E, Boudinot P, et al. Mitochondrial antiviral signaling protein plays a major role in induction of the fish innate immune response against RNA and DNA viruses. J Virol. 2009;83:7815-27 pubmed publisher
    ..This report provides the first demonstration that teleost fish possess a functional RLR pathway in which MAVS may play a central role in the induction of the innate immune response...
  5. López Muñoz A, Roca F, Sepulcre M, Meseguer J, Mulero V. Zebrafish larvae are unable to mount a protective antiviral response against waterborne infection by spring viremia of carp virus. Dev Comp Immunol. 2010;34:546-52 pubmed publisher
    ..This model, in combination with the powerful gene overexpression and morpholino-mediated knockdown techniques, will help to illuminate the IFN system of teleost fish...
  6. Varela M, Romero A, Dios S, van der Vaart M, Figueras A, Meijer A, et al. Cellular visualization of macrophage pyroptosis and interleukin-1? release in a viral hemorrhagic infection in zebrafish larvae. J Virol. 2014;88:12026-40 pubmed publisher
    ..The use of this animal model with other pathogens could improve the current knowledge on host-pathogen interactions and increase the potential for the discovery of new therapeutic targets against diverse viral diseases. ..
  7. Chen W, Hu Y, Zou P, Ren S, Nie P, Chang M. MAVS splicing variants contribute to the induction of interferon and interferon-stimulated genes mediated by RIG-I-like receptors. Dev Comp Immunol. 2015;49:19-30 pubmed publisher
    ..Collectively, these data suggest the molecular mechanisms of fish MAVS variants in antiviral immunity. ..
  8. Wang W, Asim M, Yi L, Hegazy A, Hu X, Zhou Y, et al. Abortive infection of snakehead fish vesiculovirus in ZF4 cells was associated with the RLRs pathway activation by viral replicative intermediates. Int J Mol Sci. 2015;16:6235-50 pubmed publisher
    ..Taken together, the abortive infection of SHVV in ZF4 cells was associated with the activation of RLRs pathway, which was activated by viral replicative intermediates. ..
  9. Zou P, Chang M, Li Y, Xue N, Li J, Chen S, et al. NOD2 in zebrafish functions in antibacterial and also antiviral responses via NF-?B, and also MDA5, RIG-I and MAVS. Fish Shellfish Immunol. 2016;55:173-85 pubmed publisher
    ..It is concluded that teleost fish NOD2 can not only sense MDP for activating innate immunity as reported in mammals, but can also interact with other PRRs to form a network in antiviral innate response. ..

More Information


  1. Li S, Lu L, Wang Z, Chen D, Zhang Y. Fish IRF6 is a positive regulator of IFN expression and involved in both of the MyD88 and TBK1 pathways. Fish Shellfish Immunol. 2016;57:262-268 pubmed publisher
  2. Li S, Lu L, LaPatra S, Chen D, Zhang Y. Zebrafish STAT6 negatively regulates IFNφ1 production by attenuating the kinase activity of TANK-binding kinase 1. Dev Comp Immunol. 2017;67:189-201 pubmed publisher
    ..These results indicate that fish STAT6 can attenuate the kinase activity of TBK1, leading to suppression of IFNφ1 expression which may in turn facilitate virus replication. ..
  3. Liu X, Cai X, Zhang D, Xu C, Xiao W. Zebrafish foxo3b Negatively Regulates Antiviral Response through Suppressing the Transactivity of irf3 and irf7. J Immunol. 2016;197:4736-4749 pubmed
    ..Our findings suggest that by suppressing irf3/irf7 activity, zebrafish foxo3b negatively regulates the antiviral response, implicating the vital role of the FOXO gene family in innate immunity. ..
  4. Zou P, Chang M, Li Y, Huan Zhang S, Fu J, Chen S, et al. Higher antiviral response of RIG-I through enhancing RIG-I/MAVS-mediated signaling by its long insertion variant in zebrafish. Fish Shellfish Immunol. 2015;43:13-24 pubmed publisher