Gene Symbol: ddc
Description: dopa decarboxylase
Alias: wu:fa56d05, wu:fd59h03, wu:fk20h01, zgc:65801, zgc:76929, aromatic-L-amino-acid decarboxylase, aromatic amino acid decarboxylase
Species: zebrafish
Products:     ddc

Top Publications

  1. Yamamoto K, Ruuskanen J, Wullimann M, Vernier P. Two tyrosine hydroxylase genes in vertebrates New dopaminergic territories revealed in the zebrafish brain. Mol Cell Neurosci. 2010;43:394-402 pubmed publisher
    ..dopamine-uptaking cells in previous studies, the expression of other monoaminergic markers such as aromatic amino acid decarboxylase (AADC), dopamine transporter (DAT), and vesicular monoamine transporter 2 (VMAT2) suggests that ..
  2. Yamamoto K, Ruuskanen J, Wullimann M, Vernier P. Differential expression of dopaminergic cell markers in the adult zebrafish forebrain. J Comp Neurol. 2011;519:576-98 pubmed publisher
    Although the simultaneous presence of tyrosine hydroxylase (TH), aromatic amino acid decarboxylase (AADC), dopamine transporter (DAT), and vesicular monoamine transporter 2 (VMAT2) is considered as a phenotypic signature of dopamine (DA) ..
  3. Filippi A, Mahler J, Schweitzer J, Driever W. Expression of the paralogous tyrosine hydroxylase encoding genes th1 and th2 reveals the full complement of dopaminergic and noradrenergic neurons in zebrafish larval and juvenile brain. J Comp Neurol. 2010;518:423-38 pubmed publisher
    ..Our data also confirm that there are no mesencephalic DA neurons in zebrafish. ..
  4. Shih D, Hsiao C, Min M, Lai W, Yang C, Lee W, et al. Aromatic L-amino acid decarboxylase (AADC) is crucial for brain development and motor functions. PLoS ONE. 2013;8:e71741 pubmed publisher
    ..We identified an aadc gene homolog, dopa decarboxylase (ddc), in the zebrafish genome...
  5. Wirbisky S, Sepúlveda M, Weber G, Jannasch A, Horzmann K, Freeman J. Embryonic Atrazine Exposure Elicits Alterations in Genes Associated with Neuroendocrine Function in Adult Male Zebrafish. Toxicol Sci. 2016;153:149-64 pubmed publisher
    ..Overall, this data indicate future studies should focus on additional neuroendocrine endpoints to determine potential functional impairments. ..
  6. Yokogawa T, Marin W, Faraco J, Pezeron G, Appelbaum L, Zhang J, et al. Characterization of sleep in zebrafish and insomnia in hypocretin receptor mutants. PLoS Biol. 2007;5:e277 pubmed
    ..Our study validates the use of zebrafish for the study of sleep and indicates molecular diversity in sleep regulatory networks across vertebrates. ..
  7. Flinn L, Mortiboys H, Volkmann K, Köster R, Ingham P, Bandmann O. Complex I deficiency and dopaminergic neuronal cell loss in parkin-deficient zebrafish (Danio rerio). Brain. 2009;132:1613-23 pubmed publisher
  8. Wang Z, Nishimura Y, Shimada Y, Umemoto N, Hirano M, Zang L, et al. Zebrafish beta-adrenergic receptor mRNA expression and control of pigmentation. Gene. 2009;446:18-27 pubmed publisher
    ..Our data suggest that adrb2a may regulate pigmentation, partly by modulating F1F0-ATPase. ..
  9. Fujimoto E, Stevenson T, Chien C, Bonkowsky J. Identification of a dopaminergic enhancer indicates complexity in vertebrate dopamine neuron phenotype specification. Dev Biol. 2011;352:393-404 pubmed publisher
    ..We conclude that regulation of dopaminergic neuron phenotype in vertebrates is regulated by dispersed regulatory elements. ..

More Information


  1. Pavlidis M, Sundvik M, Chen Y, Panula P. Adaptive changes in zebrafish brain in dominant-subordinate behavioral context. Behav Brain Res. 2011;225:529-37 pubmed publisher
    ..AVT), in the biosynthesis and catabolism of catecholamines (tyrosine hydroxylase, TH1 and TH2; DOPA decarboxylase, DDC), dopamine ?-hydroxylase, DBH; catechol-O-methyl transferase, COMT), in the biosynthesis of histamine (histidine ..
  2. Ren G, Li S, Zhong H, Lin S. Zebrafish tyrosine hydroxylase 2 gene encodes tryptophan hydroxylase. J Biol Chem. 2013;288:22451-9 pubmed publisher
    ..Based on these in vivo and in vitro results, we conclude that th2 is a gene encoding for tryptophan hydroxylase and should be used as a marker gene of serotonergic neurons. ..